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Fusion gene ID: 37268 |
FusionGeneSummary for TAS2R41_IGHJ4 |
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Fusion gene information | Fusion gene name: TAS2R41_IGHJ4 | Fusion gene ID: 37268 | Hgene | Tgene | Gene symbol | TAS2R41 | IGHJ4 | Gene ID | 259287 | 28477 |
Gene name | taste 2 receptor member 41 | immunoglobulin heavy joining 4 | |
Synonyms | T2R41|T2R59 | JH4b | |
Cytomap | 7q35 | 14q32.33 | |
Type of gene | protein-coding | other | |
Description | taste receptor type 2 member 41taste receptor type 2 member 59taste receptor, type 2, member 41 | - | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | P59536 | ||
Ensembl transtripts involved in fusion gene | ENST00000408916, | ENST00000461719, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 12 X 7 X 6=504 |
# samples | 1 | 12 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TAS2R41 [Title/Abstract] AND IGHJ4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAS2R41 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | 20022913 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-L9-A444-01A | TAS2R41 | chr7 | 143175077 | + | IGHJ4 | chr14 | 106330468 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000408916 | ENST00000461719 | TAS2R41 | chr7 | 143175077 | + | IGHJ4 | chr14 | 106330468 | - |
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FusionProtFeatures for TAS2R41_IGHJ4 |
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Hgene | Tgene |
TAS2R41 | IGHJ4 |
Receptor that may play a role in the perception ofbitterness and is gustducin-linked. May play a role in sensing thechemical composition of the gastrointestinal content. The activityof this receptor may stimulate alpha gustducin, mediate PLC-beta-2activation and lead to the gating of TRPM5 (By similarity).{ECO:0000250}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAS2R41_IGHJ4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAS2R41_IGHJ4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAS2R41 | YKT6, PAK1, LASP1, SNX3, NIPSNAP3A, SEPHS1, CBFB, SCRN2, MECR, CHRAC1, SERPINB1, FAHD2A, SYAP1, ATP5B, THUMPD1, GAMT | IGHJ4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAS2R41_IGHJ4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAS2R41_IGHJ4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |