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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37268

FusionGeneSummary for TAS2R41_IGHJ4

check button Fusion gene summary
Fusion gene informationFusion gene name: TAS2R41_IGHJ4
Fusion gene ID: 37268
HgeneTgene
Gene symbol

TAS2R41

IGHJ4

Gene ID

259287

28477

Gene nametaste 2 receptor member 41immunoglobulin heavy joining 4
SynonymsT2R41|T2R59JH4b
Cytomap

7q35

14q32.33

Type of geneprotein-codingother
Descriptiontaste receptor type 2 member 41taste receptor type 2 member 59taste receptor, type 2, member 41-
Modification date2018052320180329
UniProtAcc

P59536

Ensembl transtripts involved in fusion geneENST00000408916, ENST00000461719, 
Fusion gene scores* DoF score1 X 1 X 1=112 X 7 X 6=504
# samples 112
** MAII scorelog2(1/1*10)=3.32192809488736log2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAS2R41 [Title/Abstract] AND IGHJ4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAS2R41

GO:0001580

detection of chemical stimulus involved in sensory perception of bitter taste

20022913


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-L9-A444-01ATAS2R41chr7

143175077

+IGHJ4chr14

106330468

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000408916ENST00000461719TAS2R41chr7

143175077

+IGHJ4chr14

106330468

-

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FusionProtFeatures for TAS2R41_IGHJ4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAS2R41

P59536

IGHJ4

Receptor that may play a role in the perception ofbitterness and is gustducin-linked. May play a role in sensing thechemical composition of the gastrointestinal content. The activityof this receptor may stimulate alpha gustducin, mediate PLC-beta-2activation and lead to the gating of TRPM5 (By similarity).{ECO:0000250}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAS2R41_IGHJ4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAS2R41_IGHJ4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TAS2R41YKT6, PAK1, LASP1, SNX3, NIPSNAP3A, SEPHS1, CBFB, SCRN2, MECR, CHRAC1, SERPINB1, FAHD2A, SYAP1, ATP5B, THUMPD1, GAMTIGHJ4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAS2R41_IGHJ4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAS2R41_IGHJ4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource