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Fusion gene ID: 37248 |
FusionGeneSummary for TAPT1-AS1_NCL |
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Fusion gene information | Fusion gene name: TAPT1-AS1_NCL | Fusion gene ID: 37248 | Hgene | Tgene | Gene symbol | TAPT1-AS1 | NCL | Gene ID | 202020 | 80331 |
Gene name | TAPT1 antisense RNA 1 (head to head) | DnaJ heat shock protein family (Hsp40) member C5 | |
Synonyms | - | CLN4|CLN4B|CSP|DNAJC5A|NCL|mir-941-2|mir-941-3|mir-941-4|mir-941-5 | |
Cytomap | 4p15.32 | 20q13.33 | |
Type of gene | ncRNA | protein-coding | |
Description | - | dnaJ homolog subfamily C member 5DnaJ (Hsp40) homolog, subfamily C, member 5ceroid-lipofuscinosis neuronal protein 4cysteine string protein alpha | |
Modification date | 20180329 | 20180522 | |
UniProtAcc | P19338 | ||
Ensembl transtripts involved in fusion gene | ENST00000573308, ENST00000573950, ENST00000570786, ENST00000598538, | ENST00000322723, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 16 X 18 X 1=288 |
# samples | 2 | 20 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(20/288*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TAPT1-AS1 [Title/Abstract] AND NCL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ028497 | TAPT1-AS1 | chr4 | 16257927 | + | NCL | chr2 | 232322401 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000573308 | ENST00000322723 | TAPT1-AS1 | chr4 | 16257927 | + | NCL | chr2 | 232322401 | + |
intron-3CDS | ENST00000573950 | ENST00000322723 | TAPT1-AS1 | chr4 | 16257927 | + | NCL | chr2 | 232322401 | + |
3UTR-3CDS | ENST00000570786 | ENST00000322723 | TAPT1-AS1 | chr4 | 16257927 | + | NCL | chr2 | 232322401 | + |
intron-3CDS | ENST00000598538 | ENST00000322723 | TAPT1-AS1 | chr4 | 16257927 | + | NCL | chr2 | 232322401 | + |
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FusionProtFeatures for TAPT1-AS1_NCL |
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Hgene | Tgene |
TAPT1-AS1 | NCL |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Nucleolin is the major nucleolar protein of growingeukaryotic cells. It is found associated with intranucleolarchromatin and pre-ribosomal particles. It induces chromatindecondensation by binding to histone H1. It is thought to play arole in pre-rRNA transcription and ribosome assembly. May play arole in the process of transcriptional elongation. Binds RNAoligonucleotides with 5'-UUAGGG-3' repeats more tightly than thetelomeric single-stranded DNA 5'-TTAGGG-3' repeats.{ECO:0000269|PubMed:10393184}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAPT1-AS1_NCL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAPT1-AS1_NCL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAPT1-AS1_NCL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAPT1-AS1_NCL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NCL | C0151744 | Myocardial Ischemia | 1 | CTD_human |