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Fusion gene ID: 37240 |
FusionGeneSummary for TAOK3_VSIG10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAOK3_VSIG10 | Fusion gene ID: 37240 | Hgene | Tgene | Gene symbol | TAOK3 | VSIG10 | Gene ID | 51347 | 54621 |
| Gene name | TAO kinase 3 | V-set and immunoglobulin domain containing 10 | |
| Synonyms | DPK|JIK|MAP3K18|hKFC-A | - | |
| Cytomap | 12q24.23 | 12q24.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase TAO3CTCL-associated antigen HD-CL-09JNK/SAPK-inhibitory kinaseSTE20-like kinasecutaneous T-cell lymphoma-associated antigen HD-CL-09dendritic cell-derived protein kinasejun kinase-inhibitory kinasekinase from chicken | V-set and immunoglobulin domain-containing protein 10 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H2K8 | Q8N0Z9 | |
| Ensembl transtripts involved in fusion gene | ENST00000419821, ENST00000392533, ENST00000537952, ENST00000543709, ENST00000536979, | ENST00000359236, ENST00000536905, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 3 X 4 X 3=36 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TAOK3 [Title/Abstract] AND VSIG10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAOK3 | GO:0006468 | protein phosphorylation | 10559204 |
| Hgene | TAOK3 | GO:0006974 | cellular response to DNA damage stimulus | 17396146 |
| Hgene | TAOK3 | GO:0046329 | negative regulation of JNK cascade | 10559204 |
| Hgene | TAOK3 | GO:0046777 | protein autophosphorylation | 10559204 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-LC-A66R-01A | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| TCGA | LD | LUSC | TCGA-60-2724-01A | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000419821 | ENST00000359236 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| 5CDS-intron | ENST00000419821 | ENST00000536905 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| Frame-shift | ENST00000392533 | ENST00000359236 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| 5CDS-intron | ENST00000392533 | ENST00000536905 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| intron-3CDS | ENST00000537952 | ENST00000359236 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| intron-intron | ENST00000537952 | ENST00000536905 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| intron-3CDS | ENST00000543709 | ENST00000359236 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| intron-intron | ENST00000543709 | ENST00000536905 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| intron-3CDS | ENST00000536979 | ENST00000359236 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| intron-intron | ENST00000536979 | ENST00000536905 | TAOK3 | chr12 | 118636856 | - | VSIG10 | chr12 | 118504499 | - |
| intron-3CDS | ENST00000419821 | ENST00000359236 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| intron-5UTR | ENST00000419821 | ENST00000536905 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| 5UTR-3CDS | ENST00000392533 | ENST00000359236 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| 5UTR-5UTR | ENST00000392533 | ENST00000536905 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| intron-3CDS | ENST00000537952 | ENST00000359236 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| intron-5UTR | ENST00000537952 | ENST00000536905 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| intron-3CDS | ENST00000543709 | ENST00000359236 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| intron-5UTR | ENST00000543709 | ENST00000536905 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| intron-3CDS | ENST00000536979 | ENST00000359236 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
| intron-5UTR | ENST00000536979 | ENST00000536905 | TAOK3 | chr12 | 118810453 | - | VSIG10 | chr12 | 118520234 | - |
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FusionProtFeatures for TAOK3_VSIG10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAOK3 | VSIG10 |
| Serine/threonine-protein kinase that acts as a regulatorof the p38/MAPK14 stress-activated MAPK cascade and of theMAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in theG2/M transition DNA damage checkpoint by activating the p38/MAPK14stress-activated MAPK cascade, probably by mediatingphosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibitsbasal activity of MAPK8/JNK cascade and diminishes its activationin response epidermal growth factor (EGF).{ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369,ECO:0000269|PubMed:17396146}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000392533 | - | 13 | 21 | 343_393 | 398 | 899 | Compositional bias | Note=Ser-rich |
| Hgene | TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000419821 | - | 13 | 21 | 343_393 | 398 | 899 | Compositional bias | Note=Ser-rich |
| Hgene | TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000392533 | - | 13 | 21 | 24_277 | 398 | 899 | Domain | Protein kinase |
| Hgene | TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000419821 | - | 13 | 21 | 24_277 | 398 | 899 | Domain | Protein kinase |
| Hgene | TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000392533 | - | 13 | 21 | 30_38 | 398 | 899 | Nucleotide binding | ATP |
| Hgene | TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000419821 | - | 13 | 21 | 30_38 | 398 | 899 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000392533 | - | 13 | 21 | 452_502 | 398 | 899 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000392533 | - | 13 | 21 | 548_649 | 398 | 899 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000392533 | - | 13 | 21 | 754_879 | 398 | 899 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000419821 | - | 13 | 21 | 452_502 | 398 | 899 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000419821 | - | 13 | 21 | 548_649 | 398 | 899 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK3 | chr12:118636856 | chr12:118504499 | ENST00000419821 | - | 13 | 21 | 754_879 | 398 | 899 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | VSIG10 | chr12:118636856 | chr12:118504499 | ENST00000359236 | - | 7 | 9 | 421_426 | 522 | 541 | Compositional bias | Note=Poly-Leu |
| Tgene | VSIG10 | chr12:118636856 | chr12:118504499 | ENST00000359236 | - | 7 | 9 | 463_493 | 522 | 541 | Compositional bias | Note=Glu-rich |
| Tgene | VSIG10 | chr12:118636856 | chr12:118504499 | ENST00000359236 | - | 7 | 9 | 123_215 | 522 | 541 | Domain | Note=Ig-like C2-type 2 |
| Tgene | VSIG10 | chr12:118636856 | chr12:118504499 | ENST00000359236 | - | 7 | 9 | 223_309 | 522 | 541 | Domain | Note=Ig-like C2-type 3 |
| Tgene | VSIG10 | chr12:118636856 | chr12:118504499 | ENST00000359236 | - | 7 | 9 | 311_404 | 522 | 541 | Domain | Note=Ig-like C2-type 4 |
| Tgene | VSIG10 | chr12:118636856 | chr12:118504499 | ENST00000359236 | - | 7 | 9 | 31_119 | 522 | 541 | Domain | Note=Ig-like C2-type 1 |
| Tgene | VSIG10 | chr12:118636856 | chr12:118504499 | ENST00000359236 | - | 7 | 9 | 31_413 | 522 | 541 | Topological domain | Extracellular |
| Tgene | VSIG10 | chr12:118636856 | chr12:118504499 | ENST00000359236 | - | 7 | 9 | 435_540 | 522 | 541 | Topological domain | Cytoplasmic |
| Tgene | VSIG10 | chr12:118636856 | chr12:118504499 | ENST00000359236 | - | 7 | 9 | 414_434 | 522 | 541 | Transmembrane | Helical |
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FusionGeneSequence for TAOK3_VSIG10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TAOK3_ENST00000419821_chr12_118636856_-_VSIG10_ENST00000359236_chr12_118504499_-_416aa MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGC YLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVG TPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAE LLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TAOK3_ENST00000419821_chr12_118636856_-_VSIG10_ENST00000359236_chr12_118504499_-_1250nt ATGCGTAAAGGGGTGCTGAAGGACCCAGAGATTGCCGATCTATTCTACAAAGATGATCCTGAGGAACTTTTTATTGGTTTGCATGAAATT GGACATGGAAGTTTTGGAGCAGTTTATTTTGCTACAAATGCTCACACCAGTGAGGTGGTGGCAATTAAGAAGATGTCCTATAGTGGGAAG CAGACCCATGAGAAATGGCAAGATATTCTTAAGGAAGTTAAATTTTTACGACAATTGAAGCATCCTAATACTATTGAGTACAAAGGCTGT TACTTGAAAGAACACACTGCTTGGTTGGTGATGGAATATTGCTTAGGCTCAGCCTCTGATTTATTAGAAGTTCATAAAAAACCACTTCAG GAAGTGGAGATCGCTGCCATTACTCATGGAGCCTTGCATGGACTAGCCTACCTACATTCTCATGCATTGATTCATAGGGATATTAAAGCA GGAAATATTCTTCTAACAGAGCCAGGTCAGGTAAAACTAGCTGATTTTGGATCTGCTTCAATGGCTTCTCCTGCCAACTCCTTCGTGGGC ACACCTTACTGGATGGCTCCAGAGGTGATCTTAGCTATGGATGAAGGACAGTATGATGGGAAAGTTGATATTTGGTCACTTGGCATCACT TGTATTGAATTGGCGGAACGGAAGCCGCCCCTTTTCAACATGAATGCAATGAGTGCCTTATATCACATTGCCCAGAATGACTCCCCAACG TTACAGTCTAATGAATGGACAGACTCCTTTAGGAGATTTGTTGATTACTGCTTGCAGAAAATACCTCAGGAAAGGCCAACATCAGCAGAA CTATTAAGGCATGACTTTGTTCGACGAGACCGGCCACTACGTGTCCTCATTGACCTCATACAGAGGACAAAAGATGCAGTTCGTGAGCTA GATAACCTACAGTACCGAAAAATGAAAAAAATACTTTTCCAAGAGACACGGAATGGACCCTTGAATGAGTCACAGGAGGATGAGGAAGAC AGTGAACATGGAACCAGCCTGAACAGGGAAATGGACAGCCTGGGCAGCAACCATTCCATTCCAAGCATGTCCGTGAGCACAGGCAGCCAG AGCAGCAGTGTGAACAGCATGCAGGAAGTCATGGACGAGAGCAGTTCCGAACTTGTCATGATGCACGATGACGAAAGCACAATCAATTCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TAOK3_ENST00000419821_chr12_118636856_-_VSIG10_ENST00000359236_chr12_118504499_-_4704nt GTTGTAACAGGAAATACTTCAGCTTGCAATACTGATAGTAATGTGTGGCACCCAGATCACGCTGTTTTTATCTGCAGTTCCTTTTTAGTA TTGTACAAAGTTTCTTGAAGATTTTTAAATACATAAGTTTAAAAGAGAATTAACTTTCAATTTGCAAATTAAAATGAGAATGGTTGCCTT TTCTTCATTATCAAGAGATGGTGAGTTGTCCTCCTGTTGCATCATAAATACAAAGGACTGAAGTTATAAAAGAGAAAAGAGAAGTTTGCT GCTAAAATGAATCTGAGCAATATGGAATATTTTGTGCCACACACAAAAAGGTACTGAAGATTTACCCCCCAAAAAAAATTGTCAATGAGA AATAAAGCTAACTGATATCAAAAAGCAGAGCCTGCTCTACTGGCCATCATGCGTAAAGGGGTGCTGAAGGACCCAGAGATTGCCGATCTA TTCTACAAAGATGATCCTGAGGAACTTTTTATTGGTTTGCATGAAATTGGACATGGAAGTTTTGGAGCAGTTTATTTTGCTACAAATGCT CACACCAGTGAGGTGGTGGCAATTAAGAAGATGTCCTATAGTGGGAAGCAGACCCATGAGAAATGGCAAGATATTCTTAAGGAAGTTAAA TTTTTACGACAATTGAAGCATCCTAATACTATTGAGTACAAAGGCTGTTACTTGAAAGAACACACTGCTTGGTTGGTGATGGAATATTGC TTAGGCTCAGCCTCTGATTTATTAGAAGTTCATAAAAAACCACTTCAGGAAGTGGAGATCGCTGCCATTACTCATGGAGCCTTGCATGGA CTAGCCTACCTACATTCTCATGCATTGATTCATAGGGATATTAAAGCAGGAAATATTCTTCTAACAGAGCCAGGTCAGGTAAAACTAGCT GATTTTGGATCTGCTTCAATGGCTTCTCCTGCCAACTCCTTCGTGGGCACACCTTACTGGATGGCTCCAGAGGTGATCTTAGCTATGGAT GAAGGACAGTATGATGGGAAAGTTGATATTTGGTCACTTGGCATCACTTGTATTGAATTGGCGGAACGGAAGCCGCCCCTTTTCAACATG AATGCAATGAGTGCCTTATATCACATTGCCCAGAATGACTCCCCAACGTTACAGTCTAATGAATGGACAGACTCCTTTAGGAGATTTGTT GATTACTGCTTGCAGAAAATACCTCAGGAAAGGCCAACATCAGCAGAACTATTAAGGCATGACTTTGTTCGACGAGACCGGCCACTACGT GTCCTCATTGACCTCATACAGAGGACAAAAGATGCAGTTCGTGAGCTAGATAACCTACAGTACCGAAAAATGAAAAAAATACTTTTCCAA GAGACACGGAATGGACCCTTGAATGAGTCACAGGAGGATGAGGAAGACAGTGAACATGGAACCAGCCTGAACAGGGAAATGGACAGCCTG GGCAGCAACCATTCCATTCCAAGCATGTCCGTGAGCACAGGCAGCCAGAGCAGCAGTGTGAACAGCATGCAGGAAGTCATGGACGAGAGC AGTTCCGAACTTGTCATGATGCACGATGACGAAAGCACAATCAATTCCAGCTCCTCCGTCGTGCATAAGAAAATGACAGCAGTGAGGAGC AAAGTGACATTGTTCAAGAAGAAGACAGGCCAGTCTGAAGAAGAGGATGGTCCATGGTTGTCTTGCTCTGAAAGCTTGGAGAGCTACATT GAAGACGAGCTCTTCATTCAGCTTTGACTCCACCTGCACCCCTGGCGGGGGCTTGCACTAACAATGTTTGGGTCTCAGCAAAAAACAAAA CCAAGCACACACATCTTTCCTTCCATGTATTGAAAAACATTGGTTTGATTTGCTCTAAGTTTTCCCAATGATGTTTAAAAGCTTTGAGAA GGAAAGCTGCTTTGGTGTCTGAGGTGCCACTTCTGCTGTGAATCCTGGCTTTATCCAGGTTGATCTACTGTGATAGATGCTGATTTAGAG GGAACAGAGGTCAGGGAAGCACTGGGTCTTGGTGCCTTTTGCCGCTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCCCTCTA TTGCCCAGGCTGGAGTGCAATGGCACGATCTTGGCTCACCACAACTTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCACGGCA CCTTGCAAATATCAGCTCCTTGGAACAGGTGAAGTTCCAGGTACCAATGCCAATCAGAGGAAGGCAGTTTGGTTCAGGCTTTGGAGTTAG AAACACCTGAAGTTGAATCTGGGCTCTGTTGCTTCCTTCTTTCATGGGCTAGAGCACGACTCTTTACCTCTCTCTTGGCCTCAATTTCCT CACCTGTAAAATAGATGAGGAAGCTGCTCACTTATTATTGTCTCGTTCTGAAAGCTTGGAAAGCTACATCGAAGATGAGCTCTTCATTCA GCTTTGATTTGACCTGTACCCCTGGTGGGGGATTGCACTGGCAACATTTGGGTCTCAGCAAAAAAACCAAGCACACACATCTTTCCTTCC ATTTATTGAAAAACATCTTTGTAAGATCCATTCATTGAAAAACATAATCCATTTATTGAAAAATATCTTTGTAAGATCACCTGCTAAATA TGAAAATCTGACTTGAATTTGTACTCTTTAAAGTTGCGTATCTGCTCTAGTGGGCAGGACCTAGGGCTTAAAGGGGAACTTCCTTTCTCC ATTTCTAAGAACTGGGACTCTAAAATGAGAAGCTGGTTGTCTGAAGTAACCCTGCAGGTGTGGTTGGGGAAGGTCTGTTTTCTTGGATGA AGGAACTAAACTAAGCATATCAGAGCACTGTCTTAACCAGTTTTATTTCCCTGGAGATAGAATTCTTTTAAAAAGAGTTAGGGAGCTGGT AATAGGAAGTGCCTTTCATTATAACTACATTTTGCAGAGCTTCATATTTATATACAAGCCTCCTAGGTGATACACTGTTAGCTTGCAGAC TTTCCTATGCTTCATTTCTCCTGTTGCTTTCAAAGAAGGCAGGAGACACGTTTAATAACGGAGTATCTGGTGATAAGAATTGCTTGGGCA AACCAGCTCATCTGGACTCTTTCTCAGTCTTGGAAGTGGGAAGAGGAAAACTTGTTTCCTTCCTGCTTCTTAAGGATATTCTGAGGGTAC ACTGATCAATAACACTAAATTTGGAATGAAAATACCATGTGATGAGTTTAGCCTGCTGATGCTTCCAGTAGATCCTTGTATAGTTTCAAG ATTTAAGTTTTCCGATTTCATATAAATTTCTTAAAGTCGAGGACCTTATAAGGGTGCAATGGATGTTTGCTAAATATGAAAAACTGACTT GAATTTGCACTCTTTAATGTTGCGTATCTGCTCTAGTGGGCAGGACCTAGGGCTTAAAGGGGAACTTCCTTTCTCCAATTCTAGGAACTG GGACTCTAAAATGAGAAGCTGGTTGTCTGAAGTAACCCTGCAGGTGTGGTTGGGGAAGGTCTGTTTTCTTGGATGAAGGGATTAAACTGA GCAAATCACTAGAAGTATGCCCTGTCCCCTGCTCAGAACACTGGGGAGCTCAAGAGTGGGCTGCAATGTGCACCCCTCAGGAATAGCTGT GAATTGCAGGTCTACTGGCTTTTTGCTTTTTGTCTTTTGCTGCAAGGTACCCCACGTACTTAACCATTCTCAACAGTGTAAATCAGTGTC ATTTTAGAATGAGATACTCAGCTTGCTTCTAAAGTCACTGAATTACTGAGTGAGTCTCTCCTTTAGAGTCTTCGGCAACCAAATTCCAGA ATTGAAGAGTCTACTACTCAGAGGCAACAAGATTAAAAAAAGAAAACACAAAAACTGTTGAGGTGAAAAAAAAAAAAAACCCTAGCTAGG AACACAGAGAATGTTTTGTAGGATCACTGGGATATTTTCCACAACTTCCTCTTCTCTAGCACACACATCTGTTGATAGGAAATATTTGAG GGTTTTTCCACTACCAAATGGGAGCTTCATGGTCCTGGTGTCAAACACTATAAACCTTTGACCAGCTGAGCTGTGACTGCTGTCACATAT CTGAGTCCTGTGTGCACAGTAATATCCTGGGTCAGGTAAAATCCAGGTCTTCAAGTTTTAAGGATTTTTTGAAGAATTCGGGCTTCTTTA AGACGATCCATGCCCAAATCCACAAGCTTGTTGACAGTGGATTACAGTTTGTGTGGCAAAGTCCAAGTTGTTACACTGTGCTTTAAAAAA AATCTTATCTGCATGTATTGTTAACTTAGAGACCATGAGATCTATTTATCAGGACCAGGAAGATACACACTTCAGGTCCATTGCAACTGA CTTTTTTCTTGTTTTTCTCAAACCCTGGTGGAGCCTGGGAAGGGGGCCTCCACAATTCTGTGGCTTTGATATTAGCCCCAATTCTCACAA GCACATACAAGCCCCATAATTGCCGCAGGAAAACACAAGATGGAAAATTGCAATAACCCATGCACTGAGACTTAGAAAATCATCCTTACT AGGCAAAATGTATTATGATGCAATAAGTGCCAACTGATATTTCTCACGTTGGGACTGGCCAGGAACTGCTGCAAAGAAAAATAAGCAGCT CCTTCTCCATTATTTACATTTTAAGATGTGGTGGGGGGAGGTTGGGAGAAATTAGTTCTGAGGTTATCATATGCCTTTTTTAAAAGATAA |
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FusionGenePPI for TAOK3_VSIG10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TAOK3 | TRAF2, ERN1, ATM, LRRK2, HSP90AA1, ATF7, CTR9, SMURF1, TRIM25 | VSIG10 | ELAVL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAOK3_VSIG10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAOK3_VSIG10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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