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Fusion gene ID: 37233 |
FusionGeneSummary for TAOK2_CPB1 |
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Fusion gene information | Fusion gene name: TAOK2_CPB1 | Fusion gene ID: 37233 | Hgene | Tgene | Gene symbol | TAOK2 | CPB1 | Gene ID | 9344 | 1360 |
Gene name | TAO kinase 2 | carboxypeptidase B1 | |
Synonyms | MAP3K17|PSK|PSK1|PSK1-BETA|TAO1|TAO2 | CPB|PASP|PCPB | |
Cytomap | 16p11.2 | 3q24 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase TAO2PSK-1hKFC-Ckinase from chicken homolog Cprostate derived STE20-like kinase PSKprostate-derived STE20-like kinase 1prostate-derived sterile 20-like kinase 1thousand and one amino acid protein kinase 2 | carboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UL54 | P15086 | |
Ensembl transtripts involved in fusion gene | ENST00000308893, ENST00000543033, ENST00000279394, ENST00000416441, | ENST00000491148, ENST00000282957, ENST00000498639, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 21 X 24 X 3=1512 |
# samples | 1 | 19 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(19/1512*10)=-2.99238681589013 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TAOK2 [Title/Abstract] AND CPB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAOK2 | GO:0000186 | activation of MAPKK activity | 10660600 |
Hgene | TAOK2 | GO:0006974 | cellular response to DNA damage stimulus | 17396146 |
Hgene | TAOK2 | GO:0008360 | regulation of cell shape | 10660600 |
Hgene | TAOK2 | GO:0030036 | actin cytoskeleton organization | 10660600 |
Hgene | TAOK2 | GO:0046330 | positive regulation of JNK cascade | 10660600 |
Hgene | TAOK2 | GO:0048041 | focal adhesion assembly | 10660600 |
Hgene | TAOK2 | GO:0051403 | stress-activated MAPK cascade | 11279118 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-GM-A2DM-01A | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000308893 | ENST00000491148 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
5CDS-intron | ENST00000308893 | ENST00000282957 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
5CDS-intron | ENST00000308893 | ENST00000498639 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
intron-intron | ENST00000543033 | ENST00000491148 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
intron-intron | ENST00000543033 | ENST00000282957 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
intron-intron | ENST00000543033 | ENST00000498639 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
intron-intron | ENST00000279394 | ENST00000491148 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
intron-intron | ENST00000279394 | ENST00000282957 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
intron-intron | ENST00000279394 | ENST00000498639 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
5CDS-intron | ENST00000416441 | ENST00000491148 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
5CDS-intron | ENST00000416441 | ENST00000282957 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
5CDS-intron | ENST00000416441 | ENST00000498639 | TAOK2 | chr16 | 29998091 | + | CPB1 | chr3 | 148572233 | + |
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FusionProtFeatures for TAOK2_CPB1 |
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Hgene | Tgene |
TAOK2 | CPB1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAOK2_CPB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAOK2_CPB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAOK2 | MAP2K3, MAP2K6, TUBB, TUBA1A, MAP3K7, KLHL12, RCHY1, STK25, LTBR, MAPRE1, SLC39A8, KCNS3, NMUR2, FAM206A, PCDHB16, TH, ZDHHC1 | CPB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAOK2_CPB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CPB1 | P15086 | DB04272 | Citric Acid | Carboxypeptidase B | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for TAOK2_CPB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |