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Fusion gene ID: 37230 |
FusionGeneSummary for TAOK1_VMP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAOK1_VMP1 | Fusion gene ID: 37230 | Hgene | Tgene | Gene symbol | TAOK1 | VMP1 | Gene ID | 57551 | 81671 |
| Gene name | TAO kinase 1 | vacuole membrane protein 1 | |
| Synonyms | KFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1 | EPG3|TANGO5|TMEM49 | |
| Cytomap | 17q11.2 | 17q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kin | vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7L7X3 | Q96GC9 | |
| Ensembl transtripts involved in fusion gene | ENST00000261716, ENST00000536202, | ENST00000262291, ENST00000537567, ENST00000539763, ENST00000536180, ENST00000545362, ENST00000588617, | |
| Fusion gene scores | * DoF score | 27 X 13 X 16=5616 | 24 X 11 X 12=3168 |
| # samples | 28 | 27 | |
| ** MAII score | log2(28/5616*10)=-4.32604420335959 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/3168*10)=-3.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAOK1 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAOK1 | GO:0006974 | cellular response to DNA damage stimulus | 17396146 |
| Hgene | TAOK1 | GO:0046330 | positive regulation of JNK cascade | 16407310 |
| Hgene | TAOK1 | GO:0097194 | execution phase of apoptosis | 16407310 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-AZ-4323-01A | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261716 | ENST00000262291 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| In-frame | ENST00000261716 | ENST00000537567 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| 5CDS-5UTR | ENST00000261716 | ENST00000539763 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| 5CDS-5UTR | ENST00000261716 | ENST00000536180 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| 5CDS-intron | ENST00000261716 | ENST00000545362 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| 5CDS-intron | ENST00000261716 | ENST00000588617 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| intron-3CDS | ENST00000536202 | ENST00000262291 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| intron-3CDS | ENST00000536202 | ENST00000537567 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| intron-5UTR | ENST00000536202 | ENST00000539763 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| intron-5UTR | ENST00000536202 | ENST00000536180 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| intron-intron | ENST00000536202 | ENST00000545362 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
| intron-intron | ENST00000536202 | ENST00000588617 | TAOK1 | chr17 | 27844674 | + | VMP1 | chr17 | 57842332 | + |
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FusionProtFeatures for TAOK1_VMP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAOK1 | VMP1 |
| Serine/threonine-protein kinase involved in variousprocesses such as p38/MAPK14 stress-activated MAPK cascade, DNAdamage response and regulation of cytoskeleton stability.Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator ofthe p38/MAPK14 stress-activated MAPK cascade by mediatingphosphorylation and subsequent activation of the upstream MAP2K3and MAP2K6 kinases. Involved in G-protein coupled receptorsignaling to p38/MAPK14. In response to DNA damage, involved inthe G2/M transition DNA damage checkpoint by activating thep38/MAPK14 stress-activated MAPK cascade, probably by mediatingphosphorylation of MAP2K3 and MAP2K6. Acts as a regulator ofcytoskeleton stability by phosphorylating 'Thr-208' of MARK2,leading to activate MARK2 kinase activity and subsequentphosphorylation and detachment of MAPT/TAU from microtubules. Alsoacts as a regulator of apoptosis: regulates apoptoticmorphological changes, including cell contraction, membraneblebbing and apoptotic bodies formation via activation of theMAPK8/JNK cascade. {ECO:0000269|PubMed:12665513,ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310,ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936}. | Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000261716 | + | 16 | 20 | 330_334 | 636 | 1002 | Compositional bias | Note=Poly-Glu |
| Hgene | TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000261716 | + | 16 | 20 | 347_379 | 636 | 1002 | Compositional bias | Note=Ser-rich |
| Hgene | TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000261716 | + | 16 | 20 | 28_281 | 636 | 1002 | Domain | Protein kinase |
| Hgene | TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000261716 | + | 16 | 20 | 34_42 | 636 | 1002 | Nucleotide binding | ATP |
| Tgene | >VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 272_273 | 138 | 407 | Topological domain | Cytoplasmic |
| Tgene | >VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 295_305 | 138 | 407 | Topological domain | Extracellular |
| Tgene | >VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 327_363 | 138 | 407 | Topological domain | Cytoplasmic |
| Tgene | >VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 385_406 | 138 | 407 | Topological domain | Extracellular |
| Tgene | >VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 251_271 | 138 | 407 | Transmembrane | Helical |
| Tgene | >VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 274_294 | 138 | 407 | Transmembrane | Helical |
| Tgene | >VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 306_326 | 138 | 407 | Transmembrane | Helical |
| Tgene | >VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 364_384 | 138 | 407 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000261716 | + | 16 | 20 | 458_651 | 636 | 1002 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000261716 | + | 16 | 20 | 754_877 | 636 | 1002 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000536202 | + | 1 | 18 | 458_651 | -63 | 854 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000536202 | + | 1 | 18 | 754_877 | -63 | 854 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000536202 | + | 1 | 18 | 330_334 | -63 | 854 | Compositional bias | Note=Poly-Glu |
| Hgene | >TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000536202 | + | 1 | 18 | 347_379 | -63 | 854 | Compositional bias | Note=Ser-rich |
| Hgene | >TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000536202 | + | 1 | 18 | 28_281 | -63 | 854 | Domain | Protein kinase |
| Hgene | >TAOK1 | chr17:27844674 | chr17:57842332 | ENST00000536202 | + | 1 | 18 | 34_42 | -63 | 854 | Nucleotide binding | ATP |
| Tgene | VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 131_250 | 138 | 407 | Topological domain | Extracellular |
| Tgene | VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 2_43 | 138 | 407 | Topological domain | Cytoplasmic |
| Tgene | VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 65_77 | 138 | 407 | Topological domain | Extracellular |
| Tgene | VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 99_109 | 138 | 407 | Topological domain | Cytoplasmic |
| Tgene | VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 110_130 | 138 | 407 | Transmembrane | Helical |
| Tgene | VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 44_64 | 138 | 407 | Transmembrane | Helical |
| Tgene | VMP1 | chr17:27844674 | chr17:57842332 | ENST00000262291 | + | 4 | 12 | 78_98 | 138 | 407 | Transmembrane | Helical |
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FusionGeneSequence for TAOK1_VMP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TAOK1_ENST00000261716_chr17_27844674_+_VMP1_ENST00000262291_chr17_57842332_+_905aa MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVTFARDVRTNEVVAIKKMSTSGKQSTEKWQDIIKEVKFLQRIKHPNSIE YKGCTLREHTAWLVMETCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN SFVGTPTWMAPEVILAMDEGQTDGKVDVWSLGITCIELAERKPPLFNMNAMSALTHIAQNESPTLQSNEWSDTFRNFVDSCLQKIPQDRP TSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQTRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS ASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHTRNREHFATIRTASLVTRQ MQEHEQDSELREQMSGTKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHI QAQQKKELNSFLESQKRETKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLE QDLVREGPHIASVTLAATECNSVNFPEPPTPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPTFMARAARLSGAEPDDE ETQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITF SKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSTAKRIQQRLNSE >In-frame_TAOK1_ENST00000261716_chr17_27844674_+_VMP1_ENST00000537567_chr17_57842332_+_905aa MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVTFARDVRTNEVVAIKKMSTSGKQSTEKWQDIIKEVKFLQRIKHPNSIE YKGCTLREHTAWLVMETCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN SFVGTPTWMAPEVILAMDEGQTDGKVDVWSLGITCIELAERKPPLFNMNAMSALTHIAQNESPTLQSNEWSDTFRNFVDSCLQKIPQDRP TSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQTRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS ASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHTRNREHFATIRTASLVTRQ MQEHEQDSELREQMSGTKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHI QAQQKKELNSFLESQKRETKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLE QDLVREGPHIASVTLAATECNSVNFPEPPTPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPTFMARAARLSGAEPDDE ETQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITF SKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSTAKRIQQRLNSE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TAOK1_ENST00000261716_chr17_27844674_+_VMP1_ENST00000262291_chr17_57842332_+_2715nt ATGCCATCAACTAACAGAGCAGGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGAT CTCAGAGAAATTGGCCATGGAAGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCT TATAGTGGAAAGCAGTCTACTGAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAA TACAAAGGCTGTTATTTACGTGAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAA AAGCCATTACAAGAAGTGGAAATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGA GATATCAAAGCAGGAAATATCCTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAAT TCCTTTGTGGGAACGCCGTATTGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCT CTTGGAATAACATGTATTGAACTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAAT GAATCCCCTACACTACAGTCTAATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCT ACATCAGAGGAACTTTTAAAGCACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCA GTAAGAGAGCTGGACAATCTGCAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAA GAAGAAGAGGAACAAGATCATGGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGT GCCAGCAGCCAAAGCAGTAGTGTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTG ATGTCTAACAGTTCTGTTATCCATTTAAAACCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAA TCTCCACCCCAAGTATCTCGTCACAAATCACACTATCGTAATCGAGAACACTTTGCTACTATACGGACAGCATCACTGGTTACGAGGCAA ATGCAAGAACATGAGCAGGACTCTGAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACT CTGGAAAACAAGCTAAAGGCTGAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAA ATGGAGAAACTTATCAAGAAACACCAGGCTGCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATT CAGGCCCAACAGAAGAAAGAACTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAGTATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTA AATGAAAACCAGAGTACCCCCAAAAAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAA GCTAACCTTCTTCGACGTCAAAGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGAAGAATGTTACTTGGGCGTCATAACTTAGAG CAGGACCTTGTCAGGGAGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTAT CCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGC ATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAA GAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGACTTTGCCTCCCGGGCCAAACTGGCAGTTCAAAAACTAGTA CAGAAAGTTGGATTTTTTGGAATTTTGGCCTGTGCTTCAATTCCAAATCCTTTATTTGATCTGGCTGGAATAACGTGTGGACACTTTCTG GTACCTTTTTGGACCTTCTTTGGTGCAACCCTAATTGGAAAAGCAATAATAAAAATGCATATCCAGAAAATTTTTGTTATAATAACATTC AGCAAGCACATAGTGGAGCAAATGGTGGCTTTCATTGGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTG GAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTC GTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAG >In-frame_TAOK1_ENST00000261716_chr17_27844674_+_VMP1_ENST00000537567_chr17_57842332_+_2715nt ATGCCATCAACTAACAGAGCAGGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGAT CTCAGAGAAATTGGCCATGGAAGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCT TATAGTGGAAAGCAGTCTACTGAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAA TACAAAGGCTGTTATTTACGTGAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAA AAGCCATTACAAGAAGTGGAAATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGA GATATCAAAGCAGGAAATATCCTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAAT TCCTTTGTGGGAACGCCGTATTGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCT CTTGGAATAACATGTATTGAACTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAAT GAATCCCCTACACTACAGTCTAATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCT ACATCAGAGGAACTTTTAAAGCACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCA GTAAGAGAGCTGGACAATCTGCAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAA GAAGAAGAGGAACAAGATCATGGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGT GCCAGCAGCCAAAGCAGTAGTGTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTG ATGTCTAACAGTTCTGTTATCCATTTAAAACCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAA TCTCCACCCCAAGTATCTCGTCACAAATCACACTATCGTAATCGAGAACACTTTGCTACTATACGGACAGCATCACTGGTTACGAGGCAA ATGCAAGAACATGAGCAGGACTCTGAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACT CTGGAAAACAAGCTAAAGGCTGAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAA ATGGAGAAACTTATCAAGAAACACCAGGCTGCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATT CAGGCCCAACAGAAGAAAGAACTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAGTATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTA AATGAAAACCAGAGTACCCCCAAAAAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAA GCTAACCTTCTTCGACGTCAAAGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGAAGAATGTTACTTGGGCGTCATAACTTAGAG CAGGACCTTGTCAGGGAGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTAT CCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGC ATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAA GAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGACTTTGCCTCCCGGGCCAAACTGGCAGTTCAAAAACTAGTA CAGAAAGTTGGATTTTTTGGAATTTTGGCCTGTGCTTCAATTCCAAATCCTTTATTTGATCTGGCTGGAATAACGTGTGGACACTTTCTG GTACCTTTTTGGACCTTCTTTGGTGCAACCCTAATTGGAAAAGCAATAATAAAAATGCATATCCAGAAAATTTTTGTTATAATAACATTC AGCAAGCACATAGTGGAGCAAATGGTGGCTTTCATTGGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTG GAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTC GTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TAOK1_ENST00000261716_chr17_27844674_+_VMP1_ENST00000262291_chr17_57842332_+_4415nt CTTACCAGGGGTGGTGTTGGTGGCGGAGGGCTGCGCGTGGGCCCGCCCGCCGAGGGGCCGCGGCGGGGGACCGAGAGGGCCTCGGCTGTG TGAGGACTAGAGGCGGCCGAGGCCCGGGCCGGTTCCCCCGAGGCGGCGACGGAGACGGCTCCCGGCACTTCCCCGCGCCATCTTAACTGA GCCCAAGCGCTGAGGGCGCCTCCTCGACCCCGGTCGTCCCCTCGCCCCCCCCCCCACCCCCCGCCGCCGCCGCCCCTTGTTGCAGAGCTT GGGCTGGGCGGCTTGCTGGGGCTCGGGGGTGGGGGGCGGCGATCTGTCGCCGGGCCCCCTCCTCCTCCTCACTCCTCACCCTCCAGGGTA GCGGCTACCGGAGCGCTGCAGGGGGCTGCGCCTGCCTGCTCCGCCCCAGACCTGTCGGCGAAAGGTAGTTTATGCCAACGTGACTTCATT CATACAGATGAACCAAGGATCGGGATAGCAGTATAAAATTAGAATCAAGACAGCTGACTGCTCAGCAGGATGCCATCAACTAACAGAGCA GGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGATCTCAGAGAAATTGGCCATGGA AGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCTTATAGTGGAAAGCAGTCTACT GAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCTGTTATTTACGT GAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAAAAGCCATTACAAGAAGTGGAA ATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGAGATATCAAAGCAGGAAATATC CTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAATTCCTTTGTGGGAACGCCGTAT TGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCTCTTGGAATAACATGTATTGAA CTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAATGAATCCCCTACACTACAGTCT AATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCTACATCAGAGGAACTTTTAAAG CACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCAGTAAGAGAGCTGGACAATCTG CAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAAGAAGAAGAGGAACAAGATCAT GGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGTGCCAGCAGCCAAAGCAGTAGT GTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTGATGTCTAACAGTTCTGTTATC CATTTAAAACCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAATCTCCACCCCAAGTATCTCGT CACAAATCACACTATCGTAATCGAGAACACTTTGCTACTATACGGACAGCATCACTGGTTACGAGGCAAATGCAAGAACATGAGCAGGAC TCTGAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACTCTGGAAAACAAGCTAAAGGCT GAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAAATGGAGAAACTTATCAAGAAA CACCAGGCTGCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATTCAGGCCCAACAGAAGAAAGAA CTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAGTATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTAAATGAAAACCAGAGTACCCCC AAAAAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAAGCTAACCTTCTTCGACGTCAA AGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGAAGAATGTTACTTGGGCGTCATAACTTAGAGCAGGACCTTGTCAGGGAGGGT CCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCA GATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCA ATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAG ATGCTGGAACATGCAGAGTCTGCACAAGACTTTGCCTCCCGGGCCAAACTGGCAGTTCAAAAACTAGTACAGAAAGTTGGATTTTTTGGA ATTTTGGCCTGTGCTTCAATTCCAAATCCTTTATTTGATCTGGCTGGAATAACGTGTGGACACTTTCTGGTACCTTTTTGGACCTTCTTT GGTGCAACCCTAATTGGAAAAGCAATAATAAAAATGCATATCCAGAAAATTTTTGTTATAATAACATTCAGCAAGCACATAGTGGAGCAA ATGGTGGCTTTCATTGGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTT CACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTC ATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAG AAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACC TGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTAT CCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATGTGATGTTCAGCAGCAAACTTGCAACAGACTGGCCTTCTGTTTGTTA CTTTCAAAAGGCCCACATGATACAATTAGAGAATTCCCACCGCACAAAAAAAGTTCCTAAGTATGTTAAATATGTCAAGCTTTTTAGGCT TGTCACAAATGATTGCTTTGTTTTCCTAAGTCATCAAAATGTATATAAATTATCTAGATTGGATAACAGTCTTGCATGTTTATCATGTTA CAATTTAATATTCCATCCTGCCCAACCCTTCCTCTCCCATCCTCAAAAAAGGGCCATTTTATGATGCATTGCACACCCTCTGGGGAAATT GATCTTTAAATTTTGAGACAGTATAAGGAAAATCTGGTTGGTGTCTTACAAGTGAGCTGACACCATTTTTTATTCTGTGTATTTAGAATG AAGTCTTGAAAAAAACTTTATAAAGACATCTTTAATCATTCCAAAATTGTGTCCGTTTTCTTGAGCGTTTTGATTTTTTACTTTTAGCTT ATACCAGCTGAATGGCAGCCTTGCCTAATCCACCTACAACAAGAATTTCTTAAGCTTTCTTTTATTTGCATGAGAGAGCCACTACCAAGG CATGTTTTGTTATGCTGAAACTGGGCTGCTGCATACTGCTAAATGGCACCTCTGGGATTGGCCTACCTGGGGATTTCTTGGTTTGTGAAA ACAGGAGAGGAGAAATATCTCATACAAGTGAAAGGATACTGGAGAGAGAAATTACCCATTTCTAAAAAAAAACCACACTCTGTCGTATCT GTGTTAATGTTTTCTAGCATGTACTCTGGTTTCAACAGACACAAATTTATATGTTAACCCAGTTTTCTTGCCGTTCTGTAAGTGTTTTAT TCTTAGTGTGATTTTTTTCCATTGGGATGTTTTTGATTGAACTTGTTCATTTTGTTTTGCTTGGGAGGAAAATAAACAATTTTACTTTTT >In-frame_TAOK1_ENST00000261716_chr17_27844674_+_VMP1_ENST00000537567_chr17_57842332_+_3494nt CTTACCAGGGGTGGTGTTGGTGGCGGAGGGCTGCGCGTGGGCCCGCCCGCCGAGGGGCCGCGGCGGGGGACCGAGAGGGCCTCGGCTGTG TGAGGACTAGAGGCGGCCGAGGCCCGGGCCGGTTCCCCCGAGGCGGCGACGGAGACGGCTCCCGGCACTTCCCCGCGCCATCTTAACTGA GCCCAAGCGCTGAGGGCGCCTCCTCGACCCCGGTCGTCCCCTCGCCCCCCCCCCCACCCCCCGCCGCCGCCGCCCCTTGTTGCAGAGCTT GGGCTGGGCGGCTTGCTGGGGCTCGGGGGTGGGGGGCGGCGATCTGTCGCCGGGCCCCCTCCTCCTCCTCACTCCTCACCCTCCAGGGTA GCGGCTACCGGAGCGCTGCAGGGGGCTGCGCCTGCCTGCTCCGCCCCAGACCTGTCGGCGAAAGGTAGTTTATGCCAACGTGACTTCATT CATACAGATGAACCAAGGATCGGGATAGCAGTATAAAATTAGAATCAAGACAGCTGACTGCTCAGCAGGATGCCATCAACTAACAGAGCA GGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGATCTCAGAGAAATTGGCCATGGA AGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCTTATAGTGGAAAGCAGTCTACT GAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCTGTTATTTACGT GAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAAAAGCCATTACAAGAAGTGGAA ATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGAGATATCAAAGCAGGAAATATC CTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAATTCCTTTGTGGGAACGCCGTAT TGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCTCTTGGAATAACATGTATTGAA CTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAATGAATCCCCTACACTACAGTCT AATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCTACATCAGAGGAACTTTTAAAG CACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCAGTAAGAGAGCTGGACAATCTG CAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAAGAAGAAGAGGAACAAGATCAT GGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGTGCCAGCAGCCAAAGCAGTAGT GTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTGATGTCTAACAGTTCTGTTATC CATTTAAAACCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAATCTCCACCCCAAGTATCTCGT CACAAATCACACTATCGTAATCGAGAACACTTTGCTACTATACGGACAGCATCACTGGTTACGAGGCAAATGCAAGAACATGAGCAGGAC TCTGAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACTCTGGAAAACAAGCTAAAGGCT GAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAAATGGAGAAACTTATCAAGAAA CACCAGGCTGCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATTCAGGCCCAACAGAAGAAAGAA CTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAGTATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTAAATGAAAACCAGAGTACCCCC AAAAAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAAGCTAACCTTCTTCGACGTCAA AGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGAAGAATGTTACTTGGGCGTCATAACTTAGAGCAGGACCTTGTCAGGGAGGGT CCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCA GATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCA ATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAG ATGCTGGAACATGCAGAGTCTGCACAAGACTTTGCCTCCCGGGCCAAACTGGCAGTTCAAAAACTAGTACAGAAAGTTGGATTTTTTGGA ATTTTGGCCTGTGCTTCAATTCCAAATCCTTTATTTGATCTGGCTGGAATAACGTGTGGACACTTTCTGGTACCTTTTTGGACCTTCTTT GGTGCAACCCTAATTGGAAAAGCAATAATAAAAATGCATATCCAGAAAATTTTTGTTATAATAACATTCAGCAAGCACATAGTGGAGCAA ATGGTGGCTTTCATTGGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTT CACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTC ATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAG AAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACC TGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTAT |
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FusionGenePPI for TAOK1_VMP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TAOK1 | STK4, CSNK1E, DYNC1I1, GEMIN7, WT1, C8orf33, SRBD1, MAP3K7, STK25, STK26, NTRK1, SNW1, FAM206A | VMP1 | HGS, ELAVL1, TJP1, KLK11, LPAR6, ERGIC3, FAF2, KRAS, TCTN2, TCTN3, TMEM216, DPEP1, CDH13, MAS1, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAOK1_VMP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAOK1_VMP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TAOK1 | C0018781 | Noise-induced hearing loss | 1 | CTD_human |
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