FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 37217

FusionGeneSummary for TAOK1_MAP2K4

check button Fusion gene summary
Fusion gene informationFusion gene name: TAOK1_MAP2K4
Fusion gene ID: 37217
HgeneTgene
Gene symbol

TAOK1

MAP2K4

Gene ID

57551

6416

Gene nameTAO kinase 1mitogen-activated protein kinase kinase 4
SynonymsKFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1
Cytomap

17q11.2

17p12

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kindual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1
Modification date2018052320180523
UniProtAcc

Q7L7X3

P45985

Ensembl transtripts involved in fusion geneENST00000261716, ENST00000536202, 
ENST00000353533, ENST00000415385, 
ENST00000581941, 
Fusion gene scores* DoF score27 X 13 X 16=56166 X 5 X 5=150
# samples 285
** MAII scorelog2(28/5616*10)=-4.32604420335959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAOK1 [Title/Abstract] AND MAP2K4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAOK1

GO:0006974

cellular response to DNA damage stimulus

17396146

HgeneTAOK1

GO:0046330

positive regulation of JNK cascade

16407310

HgeneTAOK1

GO:0097194

execution phase of apoptosis

16407310


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-97-A4LX-01ATAOK1chr17

27818883

+MAP2K4chr17

12043156

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261716ENST00000353533TAOK1chr17

27818883

+MAP2K4chr17

12043156

+
Frame-shiftENST00000261716ENST00000415385TAOK1chr17

27818883

+MAP2K4chr17

12043156

+
5CDS-intronENST00000261716ENST00000581941TAOK1chr17

27818883

+MAP2K4chr17

12043156

+
Frame-shiftENST00000536202ENST00000353533TAOK1chr17

27818883

+MAP2K4chr17

12043156

+
Frame-shiftENST00000536202ENST00000415385TAOK1chr17

27818883

+MAP2K4chr17

12043156

+
5CDS-intronENST00000536202ENST00000581941TAOK1chr17

27818883

+MAP2K4chr17

12043156

+

Top

FusionProtFeatures for TAOK1_MAP2K4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAOK1

Q7L7X3

MAP2K4

P45985

Serine/threonine-protein kinase involved in variousprocesses such as p38/MAPK14 stress-activated MAPK cascade, DNAdamage response and regulation of cytoskeleton stability.Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator ofthe p38/MAPK14 stress-activated MAPK cascade by mediatingphosphorylation and subsequent activation of the upstream MAP2K3and MAP2K6 kinases. Involved in G-protein coupled receptorsignaling to p38/MAPK14. In response to DNA damage, involved inthe G2/M transition DNA damage checkpoint by activating thep38/MAPK14 stress-activated MAPK cascade, probably by mediatingphosphorylation of MAP2K3 and MAP2K6. Acts as a regulator ofcytoskeleton stability by phosphorylating 'Thr-208' of MARK2,leading to activate MARK2 kinase activity and subsequentphosphorylation and detachment of MAPT/TAU from microtubules. Alsoacts as a regulator of apoptosis: regulates apoptoticmorphological changes, including cell contraction, membraneblebbing and apoptotic bodies formation via activation of theMAPK8/JNK cascade. {ECO:0000269|PubMed:12665513,ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310,ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936}. Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway.Essential component of the stress-activated protein kinase/c-JunN-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,is the one of the only known kinase to directly activate thestress-activated protein kinase/c-Jun N-terminal kinasesMAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 andMAP2K7/MKK7 both activate the JNKs by phosphorylation, but theydiffer in their preference for the phosphorylation site in theThr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation ofthe Tyr residue and MAP2K7/MKK7 for the Thr residue. Thephosphorylation of the Thr residue by MAP2K7/MKK7 seems to be theprerequisite for JNK activation at least in response toproinflammatory cytokines, while other stimuli activate bothMAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylateJNKs. MAP2K4 is required for maintaining peripheral lymphoidhomeostasis. The MKK/JNK signaling pathway is also involved inmitochondrial death signaling pathway, including the releasecytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7exclusively activates JNKs, MAP2K4/MKK4 additionally activates thep38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.{ECO:0000269|PubMed:7716521}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TAOK1_MAP2K4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TAOK1_MAP2K4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TAOK1STK4, CSNK1E, DYNC1I1, GEMIN7, WT1, C8orf33, SRBD1, MAP3K7, STK25, STK26, NTRK1, SNW1, FAM206AMAP2K4FLNC, SPAG9, MAPK8, MAP4K2, MAP2K7, MAP3K8, AKT1, MAPK8IP3, MAP3K11, MAP3K4, ARRB2, MAP3K2, MAP3K1, NPHS1, ITCH, MAPK9, BLNK, PML, MAPK10, MAP3K5, MAP2K6, MAP2K4, MAPK14, MAP3K3, LRRK2, APP, JUN, MAP3K7, ARRB1, MAPK1, GCH1, GEMIN5, RBBP8, EGFR, MAP3K10, NBR1, KTI12, VASP, FLNB, CDC5L, UBC, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TAOK1_MAP2K4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TAOK1_MAP2K4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAOK1C0018781Noise-induced hearing loss1CTD_human