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Fusion gene ID: 37207 |
FusionGeneSummary for TAOK1_ACER3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAOK1_ACER3 | Fusion gene ID: 37207 | Hgene | Tgene | Gene symbol | TAOK1 | ACER3 | Gene ID | 57551 | 55331 |
| Gene name | TAO kinase 1 | alkaline ceramidase 3 | |
| Synonyms | KFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1 | APHC|PHCA|PLDECO | |
| Cytomap | 17q11.2 | 11q13.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kin | alkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkaline | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q7L7X3 | Q9NUN7 | |
| Ensembl transtripts involved in fusion gene | ENST00000261716, ENST00000536202, | ENST00000532485, ENST00000530182, ENST00000526597, ENST00000533873, ENST00000538157, ENST00000544113, | |
| Fusion gene scores | * DoF score | 27 X 13 X 16=5616 | 7 X 5 X 4=140 |
| # samples | 28 | 7 | |
| ** MAII score | log2(28/5616*10)=-4.32604420335959 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAOK1 [Title/Abstract] AND ACER3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAOK1 | GO:0006974 | cellular response to DNA damage stimulus | 17396146 |
| Hgene | TAOK1 | GO:0046330 | positive regulation of JNK cascade | 16407310 |
| Hgene | TAOK1 | GO:0097194 | execution phase of apoptosis | 16407310 |
| Tgene | ACER3 | GO:0046512 | sphingosine biosynthetic process | 20068046 |
| Tgene | ACER3 | GO:0071602 | phytosphingosine biosynthetic process | 11356846|20068046 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A1-A0SM-01A | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261716 | ENST00000532485 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-3UTR | ENST00000261716 | ENST00000530182 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000261716 | ENST00000526597 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000261716 | ENST00000533873 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000261716 | ENST00000538157 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-intron | ENST00000261716 | ENST00000544113 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| In-frame | ENST00000536202 | ENST00000532485 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-3UTR | ENST00000536202 | ENST00000530182 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000536202 | ENST00000526597 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000536202 | ENST00000533873 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000536202 | ENST00000538157 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-intron | ENST00000536202 | ENST00000544113 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
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FusionProtFeatures for TAOK1_ACER3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAOK1 | ACER3 |
| Serine/threonine-protein kinase involved in variousprocesses such as p38/MAPK14 stress-activated MAPK cascade, DNAdamage response and regulation of cytoskeleton stability.Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator ofthe p38/MAPK14 stress-activated MAPK cascade by mediatingphosphorylation and subsequent activation of the upstream MAP2K3and MAP2K6 kinases. Involved in G-protein coupled receptorsignaling to p38/MAPK14. In response to DNA damage, involved inthe G2/M transition DNA damage checkpoint by activating thep38/MAPK14 stress-activated MAPK cascade, probably by mediatingphosphorylation of MAP2K3 and MAP2K6. Acts as a regulator ofcytoskeleton stability by phosphorylating 'Thr-208' of MARK2,leading to activate MARK2 kinase activity and subsequentphosphorylation and detachment of MAPT/TAU from microtubules. Alsoacts as a regulator of apoptosis: regulates apoptoticmorphological changes, including cell contraction, membraneblebbing and apoptotic bodies formation via activation of theMAPK8/JNK cascade. {ECO:0000269|PubMed:12665513,ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310,ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936}. | Hydrolyzes only phytoceramide into phytosphingosine andfree fatty acid. Does not have reverse activity. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000261716 | + | 12 | 20 | 330_334 | 401 | 1002 | Compositional bias | Note=Poly-Glu |
| Hgene | TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000261716 | + | 12 | 20 | 347_379 | 401 | 1002 | Compositional bias | Note=Ser-rich |
| Hgene | TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000536202 | + | 12 | 18 | 330_334 | 401 | 854 | Compositional bias | Note=Poly-Glu |
| Hgene | TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000536202 | + | 12 | 18 | 347_379 | 401 | 854 | Compositional bias | Note=Ser-rich |
| Hgene | TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000261716 | + | 12 | 20 | 28_281 | 401 | 1002 | Domain | Protein kinase |
| Hgene | TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000536202 | + | 12 | 18 | 28_281 | 401 | 854 | Domain | Protein kinase |
| Hgene | TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000261716 | + | 12 | 20 | 34_42 | 401 | 1002 | Nucleotide binding | ATP |
| Hgene | TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000536202 | + | 12 | 18 | 34_42 | 401 | 854 | Nucleotide binding | ATP |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000532485 | + | 2 | 11 | 118_137 | 89 | 268 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000532485 | + | 2 | 11 | 147_169 | 89 | 268 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000532485 | + | 2 | 11 | 174_196 | 89 | 268 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000532485 | + | 2 | 11 | 216_238 | 89 | 268 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000532485 | + | 2 | 11 | 94_111 | 89 | 268 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000544113 | + | 0 | 6 | 118_137 | 0 | 135 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000544113 | + | 0 | 6 | 147_169 | 0 | 135 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000544113 | + | 0 | 6 | 174_196 | 0 | 135 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000544113 | + | 0 | 6 | 216_238 | 0 | 135 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000544113 | + | 0 | 6 | 29_51 | 0 | 135 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000544113 | + | 0 | 6 | 63_84 | 0 | 135 | Transmembrane | Helical |
| Tgene | >ACER3 | chr17:27825539 | chr11:76687333 | ENST00000544113 | + | 0 | 6 | 94_111 | 0 | 135 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000261716 | + | 12 | 20 | 458_651 | 401 | 1002 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000261716 | + | 12 | 20 | 754_877 | 401 | 1002 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000536202 | + | 12 | 18 | 458_651 | 401 | 854 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TAOK1 | chr17:27825539 | chr11:76687333 | ENST00000536202 | + | 12 | 18 | 754_877 | 401 | 854 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | ACER3 | chr17:27825539 | chr11:76687333 | ENST00000532485 | + | 2 | 11 | 29_51 | 89 | 268 | Transmembrane | Helical |
| Tgene | ACER3 | chr17:27825539 | chr11:76687333 | ENST00000532485 | + | 2 | 11 | 63_84 | 89 | 268 | Transmembrane | Helical |
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FusionGeneSequence for TAOK1_ACER3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TAOK1_ENST00000261716_chr17_27825539_+_ACER3_ENST00000532485_chr11_76687333_+_580aa MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIE YKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRP TSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS ASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLK VKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGS >In-frame_TAOK1_ENST00000536202_chr17_27825539_+_ACER3_ENST00000532485_chr11_76687333_+_580aa MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIE YKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRP TSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS ASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLK VKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TAOK1_ENST00000261716_chr17_27825539_+_ACER3_ENST00000532485_chr11_76687333_+_1740nt ATGCCATCAACTAACAGAGCAGGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGAT CTCAGAGAAATTGGCCATGGAAGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCT TATAGTGGAAAGCAGTCTACTGAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAA TACAAAGGCTGTTATTTACGTGAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAA AAGCCATTACAAGAAGTGGAAATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGA GATATCAAAGCAGGAAATATCCTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAAT TCCTTTGTGGGAACGCCGTATTGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCT CTTGGAATAACATGTATTGAACTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAAT GAATCCCCTACACTACAGTCTAATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCT ACATCAGAGGAACTTTTAAAGCACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCA GTAAGAGAGCTGGACAATCTGCAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAA GAAGAAGAGGAACAAGATCATGGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGT GCCAGCAGCCAAAGCAGTAGTGTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTG ATGTCTAACAGTTCTGTTATCCATTTAAAACCACTATTGGATGAACTCCCAATGATATACAGCTGTTGCATATTTGTGTACTGCATGTTT GAATGTTTCAAGATCAAGAACTCAGTAAACTACCATCTGCTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTTACCTTAAG GTAAAAGAGCCGATATTCCATCAGGTCATGTATGGAATGTTGGTCTTTACATTAGTACTTCGATCTATTTATATTGTTACATGGGTTTAT CCATGGCTTAGAGGACTGGGTTATACATCATTGGGTATATTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTTGTGAGTCA CTGAGGAACTTTCGAAAGAAGGTACCACCTATCATAGGTATTACCACACAATTTCATGCATGGTGGCATATTTTAACTGGCCTTGGTTCC TATCTTCACATCCTTTTCAGTTTGTATACAAGAACACTTTACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCTGGCCAGTG >In-frame_TAOK1_ENST00000536202_chr17_27825539_+_ACER3_ENST00000532485_chr11_76687333_+_1740nt ATGCCATCAACTAACAGAGCAGGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGAT CTCAGAGAAATTGGCCATGGAAGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCT TATAGTGGAAAGCAGTCTACTGAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAA TACAAAGGCTGTTATTTACGTGAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAA AAGCCATTACAAGAAGTGGAAATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGA GATATCAAAGCAGGAAATATCCTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAAT TCCTTTGTGGGAACGCCGTATTGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCT CTTGGAATAACATGTATTGAACTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAAT GAATCCCCTACACTACAGTCTAATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCT ACATCAGAGGAACTTTTAAAGCACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCA GTAAGAGAGCTGGACAATCTGCAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAA GAAGAAGAGGAACAAGATCATGGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGT GCCAGCAGCCAAAGCAGTAGTGTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTG ATGTCTAACAGTTCTGTTATCCATTTAAAACCACTATTGGATGAACTCCCAATGATATACAGCTGTTGCATATTTGTGTACTGCATGTTT GAATGTTTCAAGATCAAGAACTCAGTAAACTACCATCTGCTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTTACCTTAAG GTAAAAGAGCCGATATTCCATCAGGTCATGTATGGAATGTTGGTCTTTACATTAGTACTTCGATCTATTTATATTGTTACATGGGTTTAT CCATGGCTTAGAGGACTGGGTTATACATCATTGGGTATATTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTTGTGAGTCA CTGAGGAACTTTCGAAAGAAGGTACCACCTATCATAGGTATTACCACACAATTTCATGCATGGTGGCATATTTTAACTGGCCTTGGTTCC TATCTTCACATCCTTTTCAGTTTGTATACAAGAACACTTTACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCTGGCCAGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TAOK1_ENST00000261716_chr17_27825539_+_ACER3_ENST00000532485_chr11_76687333_+_8729nt CTTACCAGGGGTGGTGTTGGTGGCGGAGGGCTGCGCGTGGGCCCGCCCGCCGAGGGGCCGCGGCGGGGGACCGAGAGGGCCTCGGCTGTG TGAGGACTAGAGGCGGCCGAGGCCCGGGCCGGTTCCCCCGAGGCGGCGACGGAGACGGCTCCCGGCACTTCCCCGCGCCATCTTAACTGA GCCCAAGCGCTGAGGGCGCCTCCTCGACCCCGGTCGTCCCCTCGCCCCCCCCCCCACCCCCCGCCGCCGCCGCCCCTTGTTGCAGAGCTT GGGCTGGGCGGCTTGCTGGGGCTCGGGGGTGGGGGGCGGCGATCTGTCGCCGGGCCCCCTCCTCCTCCTCACTCCTCACCCTCCAGGGTA GCGGCTACCGGAGCGCTGCAGGGGGCTGCGCCTGCCTGCTCCGCCCCAGACCTGTCGGCGAAAGGTAGTTTATGCCAACGTGACTTCATT CATACAGATGAACCAAGGATCGGGATAGCAGTATAAAATTAGAATCAAGACAGCTGACTGCTCAGCAGGATGCCATCAACTAACAGAGCA GGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGATCTCAGAGAAATTGGCCATGGA AGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCTTATAGTGGAAAGCAGTCTACT GAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCTGTTATTTACGT GAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAAAAGCCATTACAAGAAGTGGAA ATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGAGATATCAAAGCAGGAAATATC CTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAATTCCTTTGTGGGAACGCCGTAT TGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCTCTTGGAATAACATGTATTGAA CTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAATGAATCCCCTACACTACAGTCT AATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCTACATCAGAGGAACTTTTAAAG CACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCAGTAAGAGAGCTGGACAATCTG CAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAAGAAGAAGAGGAACAAGATCAT GGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGTGCCAGCAGCCAAAGCAGTAGT GTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTGATGTCTAACAGTTCTGTTATC CATTTAAAACCACTATTGGATGAACTCCCAATGATATACAGCTGTTGCATATTTGTGTACTGCATGTTTGAATGTTTCAAGATCAAGAAC TCAGTAAACTACCATCTGCTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTTACCTTAAGGTAAAAGAGCCGATATTCCAT CAGGTCATGTATGGAATGTTGGTCTTTACATTAGTACTTCGATCTATTTATATTGTTACATGGGTTTATCCATGGCTTAGAGGACTGGGT TATACATCATTGGGTATATTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTTGTGAGTCACTGAGGAACTTTCGAAAGAAG GTACCACCTATCATAGGTATTACCACACAATTTCATGCATGGTGGCATATTTTAACTGGCCTTGGTTCCTATCTTCACATCCTTTTCAGT TTGTATACAAGAACACTTTACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCTGGCCAGTGATCCTGTTTGAGCCTCTCAGG AAGCATTGATGAATCATTCCACCAAGAAAACAAACAAGCACCTACCATAGACCTGGCAGAATAAATAAGGAAATCCTTAAAGATCTACAA GTTCAAATATGTCATGACCATCACAGCAGAGGAGTGACTTTCTGACTAATGCTGCCACCCACACAGAGAATAAGGAGTAGGGCCTGCTGG GTGTTTAGCTCATGGCTTTATCTTATTTGTCCCCCTCCTCCTTTCACGCTCCAGTTTATAAAGAAACAGAGATGATGTGTGTGTATGCCT CAAATGCAGAAACAGTTGGGCTTTTCTTAACAGGTTAACAGTTTGTGCTGGTTATAAGAAATTAACCTTCTTTTCTTTTTGCCAAGGGTT GCATGTGAATTATACCTTTCTTAATATTTGATTAAATAATGCAGTCAGCTAAGAGCCAACAAAACCCCATATCCAGATAGTTAGCTGTGA GCCAGCACTCAGCTGTGTCAGATTTGATTAATATTGTATTAATCTCATGGATGGTTCTCAAAGGTAAAAAAAGAGAGAGAAAGAGAGAGA GCTAGCTGTGGGATTCTGTGTAGTTCTTCACTATCTGTTCCAGGGCTAGTCGGAGGATCATAAGCAAGCTCAGACCTGCCCCCAGTTCAG TACTTGACCACATCCCAGGATTTATGGTGTCTGTCTATGGCCACAGCCAACCAGAATGAGTGGGTCATCTTATAACCTTTCTGAAGCTCC ATGAGGACATGTATAGAATGCTGCACCTTCAGCCAGCTCTGCTCTGATCTTTGCAGATCTTTAAGTTGTCACTGTTTCTACGGCTAGACA AATATGACTGGTGGTCTAGACTACCCATAGTTCATCCTCCTCACATAACTTATTTGAAGTTGTCAGGGAATGTCATTACACTCTGATTTT TAAAATTATGCAGTATTTTCCAGTTCTCAGAGAGGTCATGGTTGTGCCCAGGGAAGTGTGTTGCATTAACTAAAGCTAAAATTATCAGAA TCCTATTTACATAAAGCATATTAAAATATCTGCTCCTTAATTTTCTGAAGGAAATAGATGTAAGTTTCTGCTACTTGAAACCTACAGAAC CGACAAAAATTAGGGTGCTAAAAAAATGACAGTGAAATCTCATCGTAAGGCAGCTAGTTCTAATTTGCATTTGAATGTATAACAAATTGC ATCACTTTTCACAAACTTAACACCTGCCTGGAGTAAAAATCTGATTTGACCCCTCTGCTCATGTTTCATCATATTTGTAGCTCTGCATCA TTTAGCATTTTTATGACTTTTTTTGCTTTATATAAATTATTGTAAAATCCAGATTGTTTTTACCACATGATGACGTGACTCAGGATTAAA TCCTGAGCTACAGTTTCAAAAGGAAAATCATTTTTTTCTTATGCAAAGATGGTAAAACACTGTTGTCATTTTTTCCAGTATTCAATAAGT AGCCTTTGTACAAATTTAAAACCAAAAACTATTCTGTTGTTTTTCTTCACCTACTAGCCTTAGTTTTTAACCAAGTATCCAAGGATGTCA ACTTGACATCCTTCCCTTAGCATGCCAACAAGCCATTAGACTGATTCTTCCACCTATTTTTATGAACCTCCAGGAAGAAAAACACTTGCC AAAACATTAAGAGAACTTTGATTCTGCCTTAAGAGGGTATAAAACTAAACCATTTGAAGGCACAGCCCATAAGACTATACTTGATTTTGC CCCAAGATTCTGACTTCTGGCTACATTTCACCTGCAGTTACCTGGGCTATCGGCCGTGATACATTTTTTAATTCATTTGTTTTCCACCAT TATATTTTTATACTTTTCAGTTAGATATACTTCTGCATAAAGAGTATATATACAGTGTAGGATAAAGGCATATCGTACATGGCAATGCTG TTAAACATGGTAAGACTGAGGTTCTGCAGGATTAAAGTCAGATTAAGGGTACAGAAAGCACACCTTGATACTGAGGCCATTTAGAGCAAT TTGTTTAATGAGTGGTTCAGCCATCACCACCAGTGGCCACCTGTTCAATAAAATTGCCTAGCACCACAGTGGAGAGTCATCTACACCCCA AGGTGAGCTGTAAGACTGGCCAATTCTTTGAAGACCTTTTTTTCTGTTGGGAGAATGGAAAGCAGAAAGGGAAGCCAGGCTCTTTAATGT TCCAAGTCAGCTGTGCCTCACACAAGGCTCTCTTTTTAGCTACTAAGTAACATACTCAAGACTTTGTATCTGTGCAGCATTTTATGGAAA TCACTGGTGACCTATAGGATATTACTAAATTATTTCAATAGCTTTATTTTTTTCCTACTTGGATTCTAGGTGGACATTACAGAGTTGAAT TCCTCACTACCCCCTCCCGCTGTCATTTGTTTTATTGGAAAACTTCATGTTAACTAGAGTGTACAAAAAGTCTGTTTCCTGCTGAGCCAA TAGTGATTTGTTTGCATATCACCTAATGTGAAAAGTGCTCATCTGTGAACTCTACAGCAAATTATATTTTAGAAAATACTTTGTGAGGCC GGGCATGGTGGCAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAAGAAAATATAAGGATGTAAAAGAAGCA ATTTGCTTGCACATCTGAATATCCTTCTTGTGCCTCCATTTTCACTCTTGAAAACTGAAAGCAATTTGACTTTTATTTTTGTTTTTCTAA AGAACAGCTAGGTGAAAGGAGGTTAAGCTGATTGTCACTCTGCCTGCCCACTACCTACTCCCCACCATGGTGTTTCATGAAACATCCCCA CCACCTGAAGTGATCTTTTTAATCCTTGTGATAGTAAATGCATTGATAATTAACAGGAAAAACATGTTTTTAAATAATCTACAAATGAGA ACCCAAATAGTAGTGTTTTGTTTGACAGAAGTAAATCAAATATTATGGTTTAAATATAATGCAAAATTTCAGGACAGTTAATTTGGACTT CCCTTACCCTAAGAGGGTTTTTCTTATAATAAGGAGAAGAGGTGTGGTTCAAAGAAAATTAAGAGACAAAACCTTCAGGTACATAATGCA TGAAAATCTTTAAATGCCTGCAAAAATTAAGTTCTGTTATAATACCAGCCAATTCTGAATTAGCCAATGCCCTAAAAGCATCTAACAATT TAAGGTTATCTTATGAGTCCTATGAAAACAATTATTTGTTGCTAAATTTGAGTTTTAGCTACCAACGCCATGTTTACGTGACAAGAAATT GTTTTGGCCCTGTGGTTTATGACGTGCTGCTGGATAAGCATTTATGTAAAACTGAGTATTTCAAAGAGAACCATTTACAATTGGAATTTC CACCTGTGTGGCTGTTTGCAGACCTACCTCTGTCTTCCATTTTGCATCCTGTCAGTGCTATAATTAGTTTGATCACTTTGTCTTGTTTTT CAGTGTCTACAATTATAGCTTATTCACTATGTTCTAACTATTTAAAAATAATGGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCAC TTTGGGAGGCCGAGGTGAGCAGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACA AAAAAATTAGTCGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCAGA GCTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAA AAAGACTAAAATTTGATTTAAAGTAGTTAAACCCCTTTATGGAAGGAGCTGCAAAATGAAAAAAAAAAAAAAAAGGAATCATGTCATCTT GACCCAGCTGACTGGAAATTTTCAATACTGTCTTTTAACTGTTGTACTCCAGCCAGCCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAA AAAAAAAAAAAAAAAAAAAAAAAGAATTAGGAAATACTTGTTAAAATATCTAACTACGTAATTGCTACATGGGGGAGCTGCTGGTGTTGT TGAGGTCCTTGGGAGCATTCCACTGGACTTCACCATTTCTCCAAAATTATCAGCCCAGTCAGCTTCATATACCCAGATATGGACACTTCT ACACGTGAAATTCAAACTGAAGATAAAACTCTGACTTTGGAGTATAAACTTTTGCCTTGAGTATGAAACCTTGACATTGCTGAAAGAAAA GTGGAAACTGTAAGGGACAACAAGTTTCACCAAGGCACAGTCTTCTCTGATAGGCCAGCAGAGCAGCTAAGGAGAAGACAGATCATTCAA GAACTTAAGTCGTTTGTTAGCTACAGCATTTCCATTGCTGTGATACACATTCAGCCATTTTGGAGGAAAGCTAAGCAGGTTCTGACCACC CATTTTCATGTACTTTAAATAACAAATATTATTTCTCAAGGTCTTCATTTTATCATTAAATTCAGCTAATTACTACCTGATTTCAAAGGC AGCTAGTGTAGAAGACTGGTCACAAGAATTTTTTTTTAAATAGAAAACCCTAAAATGCAAATCAAGAAATTCAGTTACAGGCTGCAAGTG ACCTAAAATTCCCCTACTCTAGCTCAGCAGCCATCAGTCAGTATAGCATCAGCCACAGGTCACTGCTCTGCATACAGTTCCTTTTCAACC CTTACAAGACCTGCTTCATTGCTTTAAAAATGTAGTGTTGATACTTGAACTGAATTTAGTCATTGGTAACTTAAATATTCACAAAATTGT CATAAAGCTTCTGAAACATCTGGCAATGCCAGATCTGTAATCATCACTTTTAAATTGAATTTGCAGAATTAACTCTAAAGTTGCAGCAAC CATATTTATTAGAGAAATCTTTAAGCATATACATATGGTTCCCTATAAGCATTCATTCAGAGATCATCTGTGCCTAAAAGAAAATGATAA AAATGTGTCATAATATCAAAGGGGTCTAGATCAGGGGTTGGTAAACTACAACCCATGGGCCAAATTCAGGCTGCGTTGTATGGCCTGCAA GGTAAGAATGGTTATTTTATTTTATTTTATTCTTTATATATATATATATATATTTATTTATTTTTTTGAGACAGAGTCTCTCTCTGTCAC CCACGCTGGAGTGCAGTGGCAGGATCTCAACTCATTGCAACCTCCGCCTCCCAAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTA GCTGGGACTACAGGCACATGCCACCATGCCACCATGCCTGGCTGATTTTTGTATTTTTAGTAGAGCTGGGTTGGCCAGGCTGGTCTTGAA CTCCTGACCTCAAGTGATTCACCTGCCTTGGCCTCCCAAAGTCCTGGAATTACAGGCGTGAGCTACCGTGCCCAGCTGGTTTTTACATTT TAAAAACGTTTAGAGAAAGAAGAATATGCAACAGAAACTGTATGTAGCCTGCAAAGCCTAAAATGTTTACTCTCTGGCTTGGGAGTTTGT CTCCCCTGCTCTAGACTGTCAGCAAGTGGTACAGTGGTACAGTACAGTGGTACTGCCCAACTGCACTTCTCTGCAAGGTGATTCTAGTGT GCACTTGTCAGAATGAAAATATGTTATTCATTTAAGACATCTCATGTCTTTGAATGTAATCACATGATTTGTATTTAATATTTACATGAC CTAATTATTTTTTCACGTCAGTTTTTCTAGATTGGCAATAGCCTGTTGCAAAGTGCCTAAACCTTTGAGAAAAATTACTATGAGCAAGGT CCATGATTTAGTTTTCAATATAAAGGGAATTCCATTCTATACTGTAAAATCCAAAAATGCTAGTTGCCCTCAGCTTTTGAGTTGACTTCC AGAAAGTTGAGATCTTTTGACCATTTTTTCTCATGTCATATAAAATGTGCCACATGGTAGTTGTCAAGCTGTGGTAGTCATGTACACTTT TTTTCTTTTTTTTAACTTTCTAAAAGGAAAAGTTCAAAGTCCTTTCCACAGTTAGTCTTCGCTTCTTTTGGATTTTTCTTTTTAGAGCTA AATTATTCATACCAATGAATAAGTGAGTCTGTTCTAAGATATAGGGGCCATTATCTATTTTTGCTTAATGGACTCATGTGGCATTGTTCA CTATCATGCCTTTCCATACTTGTAATATTTCTGAGTCACTTATTAATGTGACCAACAGATAAACTGTTCAAGCTAATACAGCATTTCCTA ACTTCATAGTTGTCGCAGATGTTTGTTCTAGTAGCGATTATTTAATAAACATACATTGTACTGAATCTTACTAGCAACTAACTATTTTCA GGTAATCTCAGTCTGCTTATTCACTTTTTCCATTTGATTTGCTAATGCCACAATCATTTTTCTAGAAAATAGTAGGATAATGTATTTTTT >In-frame_TAOK1_ENST00000536202_chr17_27825539_+_ACER3_ENST00000532485_chr11_76687333_+_8398nt CTCCTCCTCACTCCTCACCCTCCAGGGTAGCGGCTACCGGAGCGCTGCAGGGGGCTGCGCCTGCCTGCTCCGCCCCAGACCTGTCGGCGA AAGGTAGTTTATGCCAACGTGACTTCATTCATACAGATGAACCAAGGATCGGGATAGCAGTATAAAATTAGAATCAAGACAGCTGACTGC TCAGCAGGATGCCATCAACTAACAGAGCAGGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCT TCACAGATCTCAGAGAAATTGGCCATGGAAGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGA AAATGTCTTATAGTGGAAAGCAGTCTACTGAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACA GTATAGAATACAAAGGCTGTTATTTACGTGAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAG TTCACAAAAAGCCATTACAAGAAGTGGAAATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGA TTCATAGAGATATCAAAGCAGGAAATATCCTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCAC CTGCCAATTCCTTTGTGGGAACGCCGTATTGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATG TGTGGTCTCTTGGAATAACATGTATTGAACTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAG CCCAAAATGAATCCCCTACACTACAGTCTAATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAG ATCGACCTACATCAGAGGAACTTTTAAAGCACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAA AGGATGCAGTAAGAGAGCTGGACAATCTGCAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAG CACAGGAAGAAGAAGAGGAACAAGATCATGGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGT CCATCAGTGCCAGCAGCCAAAGCAGTAGTGTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACC ACACAGTGATGTCTAACAGTTCTGTTATCCATTTAAAACCACTATTGGATGAACTCCCAATGATATACAGCTGTTGCATATTTGTGTACT GCATGTTTGAATGTTTCAAGATCAAGAACTCAGTAAACTACCATCTGCTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTT ACCTTAAGGTAAAAGAGCCGATATTCCATCAGGTCATGTATGGAATGTTGGTCTTTACATTAGTACTTCGATCTATTTATATTGTTACAT GGGTTTATCCATGGCTTAGAGGACTGGGTTATACATCATTGGGTATATTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTT GTGAGTCACTGAGGAACTTTCGAAAGAAGGTACCACCTATCATAGGTATTACCACACAATTTCATGCATGGTGGCATATTTTAACTGGCC TTGGTTCCTATCTTCACATCCTTTTCAGTTTGTATACAAGAACACTTTACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCT GGCCAGTGATCCTGTTTGAGCCTCTCAGGAAGCATTGATGAATCATTCCACCAAGAAAACAAACAAGCACCTACCATAGACCTGGCAGAA TAAATAAGGAAATCCTTAAAGATCTACAAGTTCAAATATGTCATGACCATCACAGCAGAGGAGTGACTTTCTGACTAATGCTGCCACCCA CACAGAGAATAAGGAGTAGGGCCTGCTGGGTGTTTAGCTCATGGCTTTATCTTATTTGTCCCCCTCCTCCTTTCACGCTCCAGTTTATAA AGAAACAGAGATGATGTGTGTGTATGCCTCAAATGCAGAAACAGTTGGGCTTTTCTTAACAGGTTAACAGTTTGTGCTGGTTATAAGAAA TTAACCTTCTTTTCTTTTTGCCAAGGGTTGCATGTGAATTATACCTTTCTTAATATTTGATTAAATAATGCAGTCAGCTAAGAGCCAACA AAACCCCATATCCAGATAGTTAGCTGTGAGCCAGCACTCAGCTGTGTCAGATTTGATTAATATTGTATTAATCTCATGGATGGTTCTCAA AGGTAAAAAAAGAGAGAGAAAGAGAGAGAGCTAGCTGTGGGATTCTGTGTAGTTCTTCACTATCTGTTCCAGGGCTAGTCGGAGGATCAT AAGCAAGCTCAGACCTGCCCCCAGTTCAGTACTTGACCACATCCCAGGATTTATGGTGTCTGTCTATGGCCACAGCCAACCAGAATGAGT GGGTCATCTTATAACCTTTCTGAAGCTCCATGAGGACATGTATAGAATGCTGCACCTTCAGCCAGCTCTGCTCTGATCTTTGCAGATCTT TAAGTTGTCACTGTTTCTACGGCTAGACAAATATGACTGGTGGTCTAGACTACCCATAGTTCATCCTCCTCACATAACTTATTTGAAGTT GTCAGGGAATGTCATTACACTCTGATTTTTAAAATTATGCAGTATTTTCCAGTTCTCAGAGAGGTCATGGTTGTGCCCAGGGAAGTGTGT TGCATTAACTAAAGCTAAAATTATCAGAATCCTATTTACATAAAGCATATTAAAATATCTGCTCCTTAATTTTCTGAAGGAAATAGATGT AAGTTTCTGCTACTTGAAACCTACAGAACCGACAAAAATTAGGGTGCTAAAAAAATGACAGTGAAATCTCATCGTAAGGCAGCTAGTTCT AATTTGCATTTGAATGTATAACAAATTGCATCACTTTTCACAAACTTAACACCTGCCTGGAGTAAAAATCTGATTTGACCCCTCTGCTCA TGTTTCATCATATTTGTAGCTCTGCATCATTTAGCATTTTTATGACTTTTTTTGCTTTATATAAATTATTGTAAAATCCAGATTGTTTTT ACCACATGATGACGTGACTCAGGATTAAATCCTGAGCTACAGTTTCAAAAGGAAAATCATTTTTTTCTTATGCAAAGATGGTAAAACACT GTTGTCATTTTTTCCAGTATTCAATAAGTAGCCTTTGTACAAATTTAAAACCAAAAACTATTCTGTTGTTTTTCTTCACCTACTAGCCTT AGTTTTTAACCAAGTATCCAAGGATGTCAACTTGACATCCTTCCCTTAGCATGCCAACAAGCCATTAGACTGATTCTTCCACCTATTTTT ATGAACCTCCAGGAAGAAAAACACTTGCCAAAACATTAAGAGAACTTTGATTCTGCCTTAAGAGGGTATAAAACTAAACCATTTGAAGGC ACAGCCCATAAGACTATACTTGATTTTGCCCCAAGATTCTGACTTCTGGCTACATTTCACCTGCAGTTACCTGGGCTATCGGCCGTGATA CATTTTTTAATTCATTTGTTTTCCACCATTATATTTTTATACTTTTCAGTTAGATATACTTCTGCATAAAGAGTATATATACAGTGTAGG ATAAAGGCATATCGTACATGGCAATGCTGTTAAACATGGTAAGACTGAGGTTCTGCAGGATTAAAGTCAGATTAAGGGTACAGAAAGCAC ACCTTGATACTGAGGCCATTTAGAGCAATTTGTTTAATGAGTGGTTCAGCCATCACCACCAGTGGCCACCTGTTCAATAAAATTGCCTAG CACCACAGTGGAGAGTCATCTACACCCCAAGGTGAGCTGTAAGACTGGCCAATTCTTTGAAGACCTTTTTTTCTGTTGGGAGAATGGAAA GCAGAAAGGGAAGCCAGGCTCTTTAATGTTCCAAGTCAGCTGTGCCTCACACAAGGCTCTCTTTTTAGCTACTAAGTAACATACTCAAGA CTTTGTATCTGTGCAGCATTTTATGGAAATCACTGGTGACCTATAGGATATTACTAAATTATTTCAATAGCTTTATTTTTTTCCTACTTG GATTCTAGGTGGACATTACAGAGTTGAATTCCTCACTACCCCCTCCCGCTGTCATTTGTTTTATTGGAAAACTTCATGTTAACTAGAGTG TACAAAAAGTCTGTTTCCTGCTGAGCCAATAGTGATTTGTTTGCATATCACCTAATGTGAAAAGTGCTCATCTGTGAACTCTACAGCAAA TTATATTTTAGAAAATACTTTGTGAGGCCGGGCATGGTGGCAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAAAGA AAAGAAAATATAAGGATGTAAAAGAAGCAATTTGCTTGCACATCTGAATATCCTTCTTGTGCCTCCATTTTCACTCTTGAAAACTGAAAG CAATTTGACTTTTATTTTTGTTTTTCTAAAGAACAGCTAGGTGAAAGGAGGTTAAGCTGATTGTCACTCTGCCTGCCCACTACCTACTCC CCACCATGGTGTTTCATGAAACATCCCCACCACCTGAAGTGATCTTTTTAATCCTTGTGATAGTAAATGCATTGATAATTAACAGGAAAA ACATGTTTTTAAATAATCTACAAATGAGAACCCAAATAGTAGTGTTTTGTTTGACAGAAGTAAATCAAATATTATGGTTTAAATATAATG CAAAATTTCAGGACAGTTAATTTGGACTTCCCTTACCCTAAGAGGGTTTTTCTTATAATAAGGAGAAGAGGTGTGGTTCAAAGAAAATTA AGAGACAAAACCTTCAGGTACATAATGCATGAAAATCTTTAAATGCCTGCAAAAATTAAGTTCTGTTATAATACCAGCCAATTCTGAATT AGCCAATGCCCTAAAAGCATCTAACAATTTAAGGTTATCTTATGAGTCCTATGAAAACAATTATTTGTTGCTAAATTTGAGTTTTAGCTA CCAACGCCATGTTTACGTGACAAGAAATTGTTTTGGCCCTGTGGTTTATGACGTGCTGCTGGATAAGCATTTATGTAAAACTGAGTATTT CAAAGAGAACCATTTACAATTGGAATTTCCACCTGTGTGGCTGTTTGCAGACCTACCTCTGTCTTCCATTTTGCATCCTGTCAGTGCTAT AATTAGTTTGATCACTTTGTCTTGTTTTTCAGTGTCTACAATTATAGCTTATTCACTATGTTCTAACTATTTAAAAATAATGGGCCGGGC GCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGAGCAGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACAC AGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGTCGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGC AGGAGAATGGCGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTG TCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAGACTAAAATTTGATTTAAAGTAGTTAAACCCCTTTATGGAAGGAGCTGCAAAATGAAA AAAAAAAAAAAAAGGAATCATGTCATCTTGACCCAGCTGACTGGAAATTTTCAATACTGTCTTTTAACTGTTGTACTCCAGCCAGCCTGG GCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAATTAGGAAATACTTGTTAAAATATCTAACTACGTAA TTGCTACATGGGGGAGCTGCTGGTGTTGTTGAGGTCCTTGGGAGCATTCCACTGGACTTCACCATTTCTCCAAAATTATCAGCCCAGTCA GCTTCATATACCCAGATATGGACACTTCTACACGTGAAATTCAAACTGAAGATAAAACTCTGACTTTGGAGTATAAACTTTTGCCTTGAG TATGAAACCTTGACATTGCTGAAAGAAAAGTGGAAACTGTAAGGGACAACAAGTTTCACCAAGGCACAGTCTTCTCTGATAGGCCAGCAG AGCAGCTAAGGAGAAGACAGATCATTCAAGAACTTAAGTCGTTTGTTAGCTACAGCATTTCCATTGCTGTGATACACATTCAGCCATTTT GGAGGAAAGCTAAGCAGGTTCTGACCACCCATTTTCATGTACTTTAAATAACAAATATTATTTCTCAAGGTCTTCATTTTATCATTAAAT TCAGCTAATTACTACCTGATTTCAAAGGCAGCTAGTGTAGAAGACTGGTCACAAGAATTTTTTTTTAAATAGAAAACCCTAAAATGCAAA TCAAGAAATTCAGTTACAGGCTGCAAGTGACCTAAAATTCCCCTACTCTAGCTCAGCAGCCATCAGTCAGTATAGCATCAGCCACAGGTC ACTGCTCTGCATACAGTTCCTTTTCAACCCTTACAAGACCTGCTTCATTGCTTTAAAAATGTAGTGTTGATACTTGAACTGAATTTAGTC ATTGGTAACTTAAATATTCACAAAATTGTCATAAAGCTTCTGAAACATCTGGCAATGCCAGATCTGTAATCATCACTTTTAAATTGAATT TGCAGAATTAACTCTAAAGTTGCAGCAACCATATTTATTAGAGAAATCTTTAAGCATATACATATGGTTCCCTATAAGCATTCATTCAGA GATCATCTGTGCCTAAAAGAAAATGATAAAAATGTGTCATAATATCAAAGGGGTCTAGATCAGGGGTTGGTAAACTACAACCCATGGGCC AAATTCAGGCTGCGTTGTATGGCCTGCAAGGTAAGAATGGTTATTTTATTTTATTTTATTCTTTATATATATATATATATATTTATTTAT TTTTTTGAGACAGAGTCTCTCTCTGTCACCCACGCTGGAGTGCAGTGGCAGGATCTCAACTCATTGCAACCTCCGCCTCCCAAGGTTCAA GCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACATGCCACCATGCCACCATGCCTGGCTGATTTTTGTATTTTTAGT AGAGCTGGGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATTCACCTGCCTTGGCCTCCCAAAGTCCTGGAATTACAGGCGTGA GCTACCGTGCCCAGCTGGTTTTTACATTTTAAAAACGTTTAGAGAAAGAAGAATATGCAACAGAAACTGTATGTAGCCTGCAAAGCCTAA AATGTTTACTCTCTGGCTTGGGAGTTTGTCTCCCCTGCTCTAGACTGTCAGCAAGTGGTACAGTGGTACAGTACAGTGGTACTGCCCAAC TGCACTTCTCTGCAAGGTGATTCTAGTGTGCACTTGTCAGAATGAAAATATGTTATTCATTTAAGACATCTCATGTCTTTGAATGTAATC ACATGATTTGTATTTAATATTTACATGACCTAATTATTTTTTCACGTCAGTTTTTCTAGATTGGCAATAGCCTGTTGCAAAGTGCCTAAA CCTTTGAGAAAAATTACTATGAGCAAGGTCCATGATTTAGTTTTCAATATAAAGGGAATTCCATTCTATACTGTAAAATCCAAAAATGCT AGTTGCCCTCAGCTTTTGAGTTGACTTCCAGAAAGTTGAGATCTTTTGACCATTTTTTCTCATGTCATATAAAATGTGCCACATGGTAGT TGTCAAGCTGTGGTAGTCATGTACACTTTTTTTCTTTTTTTTAACTTTCTAAAAGGAAAAGTTCAAAGTCCTTTCCACAGTTAGTCTTCG CTTCTTTTGGATTTTTCTTTTTAGAGCTAAATTATTCATACCAATGAATAAGTGAGTCTGTTCTAAGATATAGGGGCCATTATCTATTTT TGCTTAATGGACTCATGTGGCATTGTTCACTATCATGCCTTTCCATACTTGTAATATTTCTGAGTCACTTATTAATGTGACCAACAGATA AACTGTTCAAGCTAATACAGCATTTCCTAACTTCATAGTTGTCGCAGATGTTTGTTCTAGTAGCGATTATTTAATAAACATACATTGTAC TGAATCTTACTAGCAACTAACTATTTTCAGGTAATCTCAGTCTGCTTATTCACTTTTTCCATTTGATTTGCTAATGCCACAATCATTTTT CTAGAAAATAGTAGGATAATGTATTTTTTCCTGTCTGCTATAATGGAGACTATATTTCTGCATTCATTACCTCTCATAGGTGAAAATATT |
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FusionGenePPI for TAOK1_ACER3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TAOK1 | STK4, CSNK1E, DYNC1I1, GEMIN7, WT1, C8orf33, SRBD1, MAP3K7, STK25, STK26, NTRK1, SNW1, FAM206A | ACER3 | ELAVL1, MLH1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAOK1_ACER3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAOK1_ACER3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TAOK1 | C0018781 | Noise-induced hearing loss | 1 | CTD_human |
| Tgene | ACER3 | C0025202 | melanoma | 1 | CTD_human |
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