FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 37170

FusionGeneSummary for TANC2_CHD6

check button Fusion gene summary
Fusion gene informationFusion gene name: TANC2_CHD6
Fusion gene ID: 37170
HgeneTgene
Gene symbol

TANC2

CHD6

Gene ID

26115

84181

Gene nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2chromodomain helicase DNA binding protein 6
SynonymsROLSA|rolsCHD-6|CHD5|RIGB
Cytomap

17q23.2-q23.3

20q12

Type of geneprotein-codingprotein-coding
Descriptionprotein TANC2putative ankyrin-repeat containing proteinrolling pebbles homolog Btetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein
Modification date2018051920180519
UniProtAcc

Q9HCD6

Q8TD26

Ensembl transtripts involved in fusion geneENST00000424789, ENST00000389520, 
ENST00000373233, ENST00000309279, 
ENST00000373222, ENST00000480022, 
Fusion gene scores* DoF score26 X 12 X 11=34328 X 9 X 4=288
# samples 2710
** MAII scorelog2(27/3432*10)=-3.66801824044871
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TANC2 [Title/Abstract] AND CHD6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A1-A0SJ-01ATANC2chr17

61086987

+CHD6chr20

40086068

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000424789ENST00000373233TANC2chr17

61086987

+CHD6chr20

40086068

-
5CDS-intronENST00000424789ENST00000309279TANC2chr17

61086987

+CHD6chr20

40086068

-
5CDS-intronENST00000424789ENST00000373222TANC2chr17

61086987

+CHD6chr20

40086068

-
5CDS-intronENST00000424789ENST00000480022TANC2chr17

61086987

+CHD6chr20

40086068

-
Frame-shiftENST00000389520ENST00000373233TANC2chr17

61086987

+CHD6chr20

40086068

-
5CDS-intronENST00000389520ENST00000309279TANC2chr17

61086987

+CHD6chr20

40086068

-
5CDS-intronENST00000389520ENST00000373222TANC2chr17

61086987

+CHD6chr20

40086068

-
5CDS-intronENST00000389520ENST00000480022TANC2chr17

61086987

+CHD6chr20

40086068

-

Top

FusionProtFeatures for TANC2_CHD6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TANC2

Q9HCD6

CHD6

Q8TD26


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TANC2_CHD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TANC2_CHD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TANC2LATS2, YWHAB, PPP1CC, PPP1CA, XPO1, NR2C2, BRAP, CDC5L, ZYX, PAK7, KCTD3, KIF13B, CGN, ZBTB21, KSR1, GIGYF1, LPIN3, MAPRE1, LRFN1, RTKN, DENND4C, MAST3, SH3RF3, DENND1A, SH3PXD2A, SRGAP2, PPM1H, PTPN13, RALGPS2, EIF4E2, SIPA1L1, NF1, CDC25C, CBY1, GIGYF2, INPP5ECHD6AIRE, ARAF, TOLLIP, CHD3, ATXN1L, ZFYVE9, SOX2, HIST3H3, HIST1H2BG, SEC16A, RACGAP1, PAPD5, CDCA5, ESR1, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TANC2_CHD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TANC2_CHD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHD6C0005695Bladder Neoplasm1CTD_human
TgeneCHD6C0007138Carcinoma, Transitional Cell1CTD_human
TgeneCHD6C0027819Neuroblastoma1CTD_human