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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37165

FusionGeneSummary for TANC2_ACE

check button Fusion gene summary
Fusion gene informationFusion gene name: TANC2_ACE
Fusion gene ID: 37165
HgeneTgene
Gene symbol

TANC2

ACE

Gene ID

26115

1636

Gene nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2angiotensin I converting enzyme
SynonymsROLSA|rolsACE1|CD143|DCP|DCP1
Cytomap

17q23.2-q23.3

17q23.3

Type of geneprotein-codingprotein-coding
Descriptionprotein TANC2putative ankyrin-repeat containing proteinrolling pebbles homolog Btetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2angiotensin-converting enzymeCD143 antigenangiotensin I converting enzyme (peptidyl-dipeptidase A) 1angiotensin converting enzyme, somatic isoformcarboxycathepsindipeptidyl carboxypeptidase 1dipeptidyl carboxypeptidase Ikininase IIpeptidase P
Modification date2018051920180527
UniProtAcc

Q9HCD6

P12821

Ensembl transtripts involved in fusion geneENST00000424789, ENST00000389520, 
ENST00000538928, ENST00000584529, 
ENST00000290866, ENST00000428043, 
ENST00000490216, ENST00000577647, 
ENST00000290863, ENST00000421982, 
ENST00000413513, 
Fusion gene scores* DoF score26 X 12 X 11=34325 X 5 X 4=100
# samples 275
** MAII scorelog2(27/3432*10)=-3.66801824044871
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TANC2 [Title/Abstract] AND ACE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACE

GO:0042447

hormone catabolic process

7876104

TgeneACE

GO:0043171

peptide catabolic process

4322742|15283675

TgeneACE

GO:0050435

amyloid-beta metabolic process

18495113|19773553

TgeneACE

GO:0050482

arachidonic acid secretion

17077303

TgeneACE

GO:0060177

regulation of angiotensin metabolic process

1851160


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1JJ-01ATANC2chr17

61457187

+ACEchr17

61563918

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000424789ENST00000538928TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000424789ENST00000584529TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000424789ENST00000290866TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000424789ENST00000428043TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000424789ENST00000490216TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000424789ENST00000577647TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000424789ENST00000290863TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-5UTRENST00000424789ENST00000421982TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-5UTRENST00000424789ENST00000413513TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000389520ENST00000538928TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000389520ENST00000584529TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000389520ENST00000290866TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000389520ENST00000428043TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000389520ENST00000490216TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000389520ENST00000577647TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-intronENST00000389520ENST00000290863TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-5UTRENST00000389520ENST00000421982TANC2chr17

61457187

+ACEchr17

61563918

+
5CDS-5UTRENST00000389520ENST00000413513TANC2chr17

61457187

+ACEchr17

61563918

+

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FusionProtFeatures for TANC2_ACE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TANC2

Q9HCD6

ACE

P12821

Converts angiotensin I to angiotensin II by release ofthe terminal His-Leu, this results in an increase of thevasoconstrictor activity of angiotensin. Also able to inactivatebradykinin, a potent vasodilator. Has also a glycosidase activitywhich releases GPI-anchored proteins from the membrane by cleavingthe mannose linkage in the GPI moiety.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TANC2_ACE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TANC2_ACE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TANC2LATS2, YWHAB, PPP1CC, PPP1CA, XPO1, NR2C2, BRAP, CDC5L, ZYX, PAK7, KCTD3, KIF13B, CGN, ZBTB21, KSR1, GIGYF1, LPIN3, MAPRE1, LRFN1, RTKN, DENND4C, MAST3, SH3RF3, DENND1A, SH3PXD2A, SRGAP2, PPM1H, PTPN13, RALGPS2, EIF4E2, SIPA1L1, NF1, CDC25C, CBY1, GIGYF2, INPP5EACEMYH9, CSNK2A1, ACTB, BDKRB2, LMNA, AGT, EWSR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TANC2_ACE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneACEP12821DB00178RamiprilAngiotensin-converting enzymesmall moleculeapproved
TgeneACEP12821DB00492FosinoprilAngiotensin-converting enzymesmall moleculeapproved
TgeneACEP12821DB00519TrandolaprilAngiotensin-converting enzymesmall moleculeapproved
TgeneACEP12821DB00691MoexiprilAngiotensin-converting enzymesmall moleculeapproved
TgeneACEP12821DB00790PerindoprilAngiotensin-converting enzymesmall moleculeapproved
TgeneACEP12821DB01180RescinnamineAngiotensin-converting enzymesmall moleculeapproved
TgeneACEP12821DB01197CaptoprilAngiotensin-converting enzymesmall moleculeapproved
TgeneACEP12821DB01340CilazaprilAngiotensin-converting enzymesmall moleculeapproved
TgeneACEP12821DB01348SpiraprilAngiotensin-converting enzymesmall moleculeapproved
TgeneACEP12821DB00542BenazeprilAngiotensin-converting enzymesmall moleculeapproved|investigational
TgeneACEP12821DB00722LisinoprilAngiotensin-converting enzymesmall moleculeapproved|investigational
TgeneACEP12821DB00881QuinaprilAngiotensin-converting enzymesmall moleculeapproved|investigational
TgeneACEP12821DB00584EnalaprilAngiotensin-converting enzymesmall moleculeapproved|vet_approved

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RelatedDiseases for TANC2_ACE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneACEC0002395Alzheimer's Disease4CTD_human
TgeneACEC0005586Bipolar Disorder4PSYGENET
TgeneACEC0011881Diabetic Nephropathy4CTD_human
TgeneACEC0036341Schizophrenia4PSYGENET
TgeneACEC0001973Alcoholic Intoxication, Chronic3PSYGENET
TgeneACEC0007222Cardiovascular Diseases3CTD_human
TgeneACEC0344315Depressed mood3PSYGENET
TgeneACEC0010200Coughing2CTD_human
TgeneACEC0017661IGA Glomerulonephritis2CTD_human
TgeneACEC0020538Hypertensive disease2CTD_human
TgeneACEC0022661Kidney Failure, Chronic2CTD_human
TgeneACEC0027051Myocardial Infarction2CTD_human
TgeneACEC0041696Unipolar Depression2PSYGENET
TgeneACEC0266313Allanson Pantzar McLeod syndrome2CTD_human;HPO;ORPHANET
TgeneACEC1269683Major Depressive Disorder2PSYGENET
TgeneACEC0001418Adenocarcinoma1CTD_human
TgeneACEC0001925Albuminuria1CTD_human
TgeneACEC0003811Cardiac Arrhythmia1CTD_human
TgeneACEC0004238Atrial Fibrillation1CTD_human
TgeneACEC0004352Autistic Disorder1CTD_human
TgeneACEC0005138Berylliosis1CTD_human
TgeneACEC0007786Brain Ischemia1CTD_human
TgeneACEC0010068Coronary heart disease1CTD_human
TgeneACEC0011071Sudden death1CTD_human
TgeneACEC0011581Depressive disorder1PSYGENET
TgeneACEC0011853Diabetes Mellitus, Experimental1CTD_human
TgeneACEC0013182Drug Allergy1CTD_human
TgeneACEC0017205Gaucher Disease1CTD_human
TgeneACEC0017924Glycogen Storage Disease Type V1CTD_human
TgeneACEC0018801Heart failure1CTD_human
TgeneACEC0020542Pulmonary Hypertension1CTD_human
TgeneACEC0020649Hypotension1CTD_human;HPO
TgeneACEC0021295Infant, Premature, Diseases1CTD_human
TgeneACEC0021364Male infertility1CTD_human
TgeneACEC0022658Kidney Diseases1CTD_human
TgeneACEC0024115Lung diseases1CTD_human
TgeneACEC0024121Lung Neoplasms1CTD_human
TgeneACEC0025303Meningococcal Infections1CTD_human
TgeneACEC0027627Neoplasm Metastasis1CTD_human
TgeneACEC0032310Pneumonia, Viral1CTD_human
TgeneACEC0032914Pre-Eclampsia1CTD_human
TgeneACEC0033578Prostatic Neoplasms1CTD_human
TgeneACEC0033941Psychoses, Substance-Induced1CTD_human
TgeneACEC0035242Respiratory Tract Diseases1CTD_human
TgeneACEC0038160Staphylococcal Infections1CTD_human
TgeneACEC0038356Stomach Neoplasms1CTD_human
TgeneACEC0038454Cerebrovascular accident1CTD_human
TgeneACEC0043094Weight Gain1CTD_human
TgeneACEC0086132Depressive Symptoms1PSYGENET
TgeneACEC0149721Left Ventricular Hypertrophy1CTD_human
TgeneACEC0221765Chronic schizophrenia1PSYGENET
TgeneACEC0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneACEC0455503H/O: depression1PSYGENET
TgeneACEC0948480Coronary Restenosis1CTD_human
TgeneACEC1175175Severe Acute Respiratory Syndrome1CTD_human
TgeneACEC1565489Renal Insufficiency1CTD_human
TgeneACEC1839839MAJOR AFFECTIVE DISORDER 21PSYGENET
TgeneACEC1956346Coronary Artery Disease1CTD_human
TgeneACEC2239176Liver carcinoma1CTD_human
TgeneACEC2937358Cerebral Hemorrhage1CTD_human