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Fusion gene ID: 37151 |
FusionGeneSummary for TAL1_TGM2 |
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Fusion gene information | Fusion gene name: TAL1_TGM2 | Fusion gene ID: 37151 | Hgene | Tgene | Gene symbol | TAL1 | TGM2 | Gene ID | 6886 | 7052 |
Gene name | TAL bHLH transcription factor 1, erythroid differentiation factor | transglutaminase 2 | |
Synonyms | SCL|TCL5|bHLHa17|tal-1 | TG(C)|TGC | |
Cytomap | 1p33 | 20q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | T-cell acute lymphocytic leukemia protein 1T-cell acute lymphocytic leukemia 1T-cell leukemia/lymphoma protein 5class A basic helix-loop-helix protein 17stem cell proteintal-1 product | protein-glutamine gamma-glutamyltransferase 2C polypeptide, protein-glutamine-gamma-glutamyltransferaseTGase CTGase HTGase-2tissue transglutaminasetransglutaminase Ctransglutaminase H | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P17542 | P21980 | |
Ensembl transtripts involved in fusion gene | ENST00000371884, ENST00000371883, ENST00000294339, ENST00000459729, | ENST00000361475, ENST00000536701, ENST00000536724, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 10 X 3=210 |
# samples | 1 | 10 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TAL1 [Title/Abstract] AND TGM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAL1 | GO:0031334 | positive regulation of protein complex assembly | 20855495 |
Hgene | TAL1 | GO:0045648 | positive regulation of erythrocyte differentiation | 20028976 |
Hgene | TAL1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20028976 |
Hgene | TAL1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20855495 |
Tgene | TGM2 | GO:0043277 | apoptotic cell clearance | 19628791 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | R97066 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000371884 | ENST00000361475 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-intron | ENST00000371884 | ENST00000536701 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-intron | ENST00000371884 | ENST00000536724 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-3UTR | ENST00000371883 | ENST00000361475 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-intron | ENST00000371883 | ENST00000536701 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-intron | ENST00000371883 | ENST00000536724 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-3UTR | ENST00000294339 | ENST00000361475 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-intron | ENST00000294339 | ENST00000536701 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-intron | ENST00000294339 | ENST00000536724 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-3UTR | ENST00000459729 | ENST00000361475 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-intron | ENST00000459729 | ENST00000536701 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
intron-intron | ENST00000459729 | ENST00000536724 | TAL1 | chr1 | 47694111 | + | TGM2 | chr20 | 36757621 | + |
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FusionProtFeatures for TAL1_TGM2 |
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Hgene | Tgene |
TAL1 | TGM2 |
Implicated in the genesis of hemopoietic malignancies.It may play an important role in hemopoietic differentiation.Serves as a positive regulator of erythroid differentiation (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:1396592}. | Catalyzes the cross-linking of proteins and theconjugation of polyamines to proteins. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAL1_TGM2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAL1_TGM2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAL1_TGM2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAL1_TGM2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TAL1 | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 2 | CTD_human |
Tgene | TGM2 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | TGM2 | C0017636 | Glioblastoma | 2 | CTD_human |
Tgene | TGM2 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | TGM2 | C0006118 | Brain Neoplasms | 1 | CTD_human |
Tgene | TGM2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | TGM2 | C0007570 | Celiac Disease | 1 | CTD_human |
Tgene | TGM2 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | TGM2 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | TGM2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | TGM2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |