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Fusion gene ID: 37136 |
FusionGeneSummary for TAF9_ADAMTS6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAF9_ADAMTS6 | Fusion gene ID: 37136 | Hgene | Tgene | Gene symbol | TAF9 | ADAMTS6 | Gene ID | 6880 | 11174 |
| Gene name | TATA-box binding protein associated factor 9 | ADAM metallopeptidase with thrombospondin type 1 motif 6 | |
| Synonyms | MGC:5067|STAF31/32|TAF2G|TAFII-31|TAFII-32|TAFII31|TAFII32|TAFIID32 | ADAM-TS 6|ADAM-TS6|ADAMTS-6 | |
| Cytomap | 5q13.2 | 5q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription initiation factor TFIID subunit 9RNA polymerase II TBP-associated factor subunit GTAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDatranscription initiation factor TFIID 31 kD subunittranscription initiation | A disintegrin and metalloproteinase with thrombospondin motifs 6a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q16594 | Q9UKP5 | |
| Ensembl transtripts involved in fusion gene | ENST00000380822, ENST00000502819, ENST00000380818, ENST00000512561, ENST00000506736, ENST00000328663, ENST00000217893, | ENST00000314351, ENST00000536360, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TAF9 [Title/Abstract] AND ADAMTS6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAF9 | GO:0000492 | box C/D snoRNP assembly | 17636026 |
| Hgene | TAF9 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 11278372 |
| Hgene | TAF9 | GO:0043966 | histone H3 acetylation | 9674425|11564863 |
| Hgene | TAF9 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11278372 |
| Hgene | TAF9 | GO:0050821 | protein stabilization | 15899866 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-44-6147-01A | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000380822 | ENST00000314351 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5CDS-intron | ENST00000380822 | ENST00000536360 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5UTR-intron | ENST00000502819 | ENST00000314351 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5UTR-intron | ENST00000502819 | ENST00000536360 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5CDS-intron | ENST00000380818 | ENST00000314351 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5CDS-intron | ENST00000380818 | ENST00000536360 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| intron-intron | ENST00000512561 | ENST00000314351 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| intron-intron | ENST00000512561 | ENST00000536360 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5UTR-intron | ENST00000506736 | ENST00000314351 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5UTR-intron | ENST00000506736 | ENST00000536360 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5UTR-intron | ENST00000328663 | ENST00000314351 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5UTR-intron | ENST00000328663 | ENST00000536360 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5UTR-intron | ENST00000217893 | ENST00000314351 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
| 5UTR-intron | ENST00000217893 | ENST00000536360 | TAF9 | chr5 | 68662330 | - | ADAMTS6 | chr5 | 64625310 | - |
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FusionProtFeatures for TAF9_ADAMTS6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAF9 | ADAMTS6 |
| Essential for cell viability. TAF9 and TAF9B areinvolved in transcriptional activation as well as repression ofdistinct but overlapping sets of genes. May have a role in generegulation associated with apoptosis. TAFs are components of thetranscription factor IID (TFIID) complex, the TBP-free TAFIIcomplex (TFTC), the PCAF histone acetylase complex and the STAGAtranscription coactivator-HAT complex. TFIID or TFTC are essentialfor the regulation of RNA polymerase II-mediated transcription.{ECO:0000269|PubMed:15899866}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF9_ADAMTS6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAF9_ADAMTS6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TAF9 | RPS14, DRAP1, MYC, RBM48, EEF1A1, TBP, TAF5, TP53, SUPT3H, TRRAP, TAF6L, TAF5L, TADA3, SF3B3, KAT2A, SUPT7L, TAF10, TAF12, TAF1, TAF2, TAF4, TAF6, TAF7, TADA1, USP22, TAF13, SIN3A, SMARCA2, ATXN7, RELA, NCOR1, GTF2B, NR1D2, KLF6, NUFIP1, RUVBL2, RUVBL1, FBL, TAF8, CEBPB, ELF3, HSF1, NFATC2, COIL, KPNA1, KPNA6, RNF138, UBA1, CIITA, APP, TAF9B, TAF1L, DHX8, FKBP4, AHR, HIST3H3, KAT2B, MED26, HNF4A, FBLN1, GALNT6, FEZ1, RPS24, TBCA, ANK2, NCOA2, NDRG1, LAMTOR5, TADA2B, ATXN7L3, ALDH3B1, CHD2, ELP2, KMT2A, CD14, LLGL2, AURKA, KIAA1107, YIPF5, FOXL1, FBXW7, FOXS1, TAF7L, TFEB, TRPC5, MYCL, TAF11 | ADAMTS6 | SNTA1, RNF2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF9_ADAMTS6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF9_ADAMTS6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TAF9 | C0019693 | HIV Infections | 1 | CTD_human |
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