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Fusion gene ID: 37113 |
FusionGeneSummary for TAF4_GATA5 |
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Fusion gene information | Fusion gene name: TAF4_GATA5 | Fusion gene ID: 37113 | Hgene | Tgene | Gene symbol | TAF4 | GATA5 | Gene ID | 6874 | 140628 |
Gene name | TATA-box binding protein associated factor 4 | GATA binding protein 5 | |
Synonyms | TAF2C|TAF2C1|TAF4A|TAFII130|TAFII135 | CHTD5|GATAS|bB379O24.1 | |
Cytomap | 20q13.33 | 20q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription initiation factor TFIID subunit 4RNA polymerase II TBP-associated factor subunit CTAF(II)130TAF(II)135TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDaTAF4A RNA polymerase II, TATA box binding protein (TBP | transcription factor GATA-5GATA binding factor-5 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O00268 | Q9BWX5 | |
Ensembl transtripts involved in fusion gene | ENST00000252996, ENST00000609045, | ENST00000252997, | |
Fusion gene scores | * DoF score | 10 X 5 X 5=250 | 2 X 2 X 1=4 |
# samples | 13 | 2 | |
** MAII score | log2(13/250*10)=-0.943416471633632 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: TAF4 [Title/Abstract] AND GATA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAF4 | GO:0006352 | DNA-templated transcription, initiation | 9603525 |
Hgene | TAF4 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 9603525 |
Hgene | TAF4 | GO:0045893 | positive regulation of transcription, DNA-templated | 12771217 |
Tgene | GATA5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14986113 |
Tgene | GATA5 | GO:0060575 | intestinal epithelial cell differentiation | 9566909 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-A7-A13D-01A | TAF4 | chr20 | 60639507 | - | GATA5 | chr20 | 61040977 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000252996 | ENST00000252997 | TAF4 | chr20 | 60639507 | - | GATA5 | chr20 | 61040977 | - |
intron-3CDS | ENST00000609045 | ENST00000252997 | TAF4 | chr20 | 60639507 | - | GATA5 | chr20 | 61040977 | - |
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FusionProtFeatures for TAF4_GATA5 |
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Hgene | Tgene |
TAF4 | GATA5 |
Part of the TFIID complex, a multimeric protein complexthat plays a central role in mediating promoter responses tovarious activators and repressors. Potentiates transcriptionalactivation by the AF-2S of the retinoic acid, vitamin D3 andthyroid hormone. | Transcription factor required during cardiovasculardevelopment (PubMed:23289003). Plays an important role in thetranscriptional program(s) that underlies smooth muscle celldiversity (By similarity). Binds to the functionally importantCEF-1 nuclear protein binding site in the cardiac-specificslow/cardiac troponin C transcriptional enhancer(PubMed:25543888). {ECO:0000250|UniProtKB:P97489,ECO:0000269|PubMed:23289003, ECO:0000269|PubMed:25543888}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 142_148 | 453 | 1086 | Compositional bias | Note=Poly-Ala |
Hgene | TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 270_277 | 453 | 1086 | Compositional bias | Note=Poly-Pro |
Hgene | TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 333_339 | 453 | 1086 | Compositional bias | Note=Poly-Ala |
Hgene | TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 39_42 | 453 | 1086 | Compositional bias | Note=Poly-His |
Hgene | TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 52_57 | 453 | 1086 | Compositional bias | Note=Poly-Ala |
Hgene | TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 98_101 | 453 | 1086 | Compositional bias | Note=Poly-Gly |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 682_685 | 453 | 1086 | Compositional bias | Note=Poly-Pro |
Hgene | >TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 810_815 | 453 | 1086 | Compositional bias | Note=Poly-Ala |
Hgene | >TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 830_833 | 453 | 1086 | Compositional bias | Note=Poly-Asp |
Hgene | >TAF4 | chr20:60639507 | chr20:61040977 | ENST00000252996 | - | 1 | 15 | 590_687 | 453 | 1086 | Domain | TAFH |
Tgene | GATA5 | chr20:60639507 | chr20:61040977 | ENST00000252997 | - | 3 | 7 | 189_213 | 275 | 398 | Zinc finger | GATA-type 1 |
Tgene | GATA5 | chr20:60639507 | chr20:61040977 | ENST00000252997 | - | 3 | 7 | 243_267 | 275 | 398 | Zinc finger | GATA-type 2 |
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FusionGeneSequence for TAF4_GATA5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TAF4_ENST00000252996_chr20_60639507_-_GATA5_ENST00000252997_chr20_61040977_-_576aa MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPP PAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGP GPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAP PPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQT LAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQ LPPGAAASGYEEGKHPDTEAEAKDHRQGQGLLRIHKECLGLPICCRQHXQLSSHFESQAQPGVPSVPWAQHGPPGLWPGGXLSCPRPLGV |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TAF4_ENST00000252996_chr20_60639507_-_GATA5_ENST00000252997_chr20_61040977_-_1729nt ATGGCGGCGGGCTCGGATCTGCTGGACGAGGTCTTCTTCAACAGCGAGGTGGACGAGAAAGTGGTGAGCGACCTGGTGGGCTCGCTGGAG TCGCAGCTGGCGGCCAGCGCGGCCCACCACCACCACCTCGCGCCGCGCACGCCCGAGGTGCGGGCCGCGGCCGCCGGCGCGCTCGGGAAC CATGTTGTGAGCGGCAGCCCGGCCGGAGCCGCGGGCGCAGGGCCGGCCGCCCCCGCCGAGGGCGCGCCCGGAGCGGCGCCGGAGCCGCCC CCCGCAGGTAGAGCGCGGCCGGGGGGCGGGGGGCCGCAGCGCCCGGGCCCCCCCTCACCGCGCCGCCCCCTTGTCCCCGCAGGGCCCGCG CCGCCCGCCGCGAAGCTGAGGCCGCCGCCCGAGGGCAGCGCGGGGTCCTGCGCCCCGGTGCCCGCCGCCGCCGCCGTCGCCGCGGGGCCC GAGCCCGCCCCCGCCGGCCCCGCCAAGCCCGCCGGCCCCGCCGCGCTGGCCGCCCGCGCCGGCCCCGGCCCCGGGCCCGGCCCCGGCCCC GGCCCCGGCCCTGGCCCTGGCAAGCCCGCCGGCCCCGGCGCCGCGCAAACTTTGAATGGGAGCGCCGCGCTGCTGAACTCGCACCACGCC GCCGCACCTGCTGTCAGCCTGGTCAACAACGGGCCCGCCGCGCTGCTGCCGCTGCCCAAGCCCGCCGCCCCCGGCACTGTCATCCAGACG CCCCCCTTCGTGGGCGCCGCCGCGCCCCCCGCGCCCGCCGCGCCCTCGCCCCCCGCCGCCCCCGCGCCCGCCGCCCCCGCCGCCGCCCCG CCCCCGCCACCCCCCGCGCCCGCCACTCTGGCCCGGCCGCCCGGCCACCCCGCCGGACCCCCGACCGCCGCGCCCGCCGTGCCGCCCCCC GCCGCCGCCCAGAACGGGGGCAGCGCCGGGGCAGCCCCCGCCCCCGCCCCGGCCGCCGGGGGCCCCGCGGGGGTCAGCGGCCAACCCGGG CCCGGCGCGGCGGCTGCGGCGCCGGCGCCGGGGGTCAAGGCCGAGTCGCCCAAGAGGGTGGTGCAGGCGGCGCCCCCGGCGGCGCAGACC CTGGCGGCCAGCGGCCCGGCCAGCACGGCGGCCAGCATGGTCATCGGGCCAACTATGCAAGGGGCGCTGCCCAGCCCGGCCGCCGTCCCG CCGCCCGCCCCCGGGACCCCCACCGGGCTGCCCAAAGGCGCGGCCGGCGCAGTGACCCAGAGCCTGTCCCGGACGCCCACGGCCACCACC AGCGGGATTCGGGCCACCCTGACGCCCACCGTGCTGGCCCCCCGCTTGCCGCAGCCGCCTCAGAACCCGACCAACATCCAGAACTTCCAG CTGCCCCCAGGTGCCGCGGCCTCTGGCTATGAAGAAGGAAAGCATCCAGACACGGAAGCGGAAGCCAAAGACCATCGCCAAGGCCAGGGG CTCCTCAGGATCCACAAGGAATGCCTCGGCCTCCCCATCTGCTGTCGCCAGCACTGACAGCTCAGCAGCCACTTCGAAAGCCAAGCCCAG CCTGGCGTCCCCAGTGTGCCCTGGGCCCAGCATGGCCCCCCAGGCCTCTGGCCAGGAGGATGACTCTCTTGCCCCCGGCCACTTGGAGTT CAAGTTCGAGCCTGAGGACTTTGCCTTCCCCTCCACGGCCCCAAGCCCCCAGGCTGGCCTCAGGGGGGCTCTGCGCCAAGAGGCCTGGTG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TAF4_ENST00000252996_chr20_60639507_-_GATA5_ENST00000252997_chr20_61040977_-_3068nt ATGGCGGCGGGCTCGGATCTGCTGGACGAGGTCTTCTTCAACAGCGAGGTGGACGAGAAAGTGGTGAGCGACCTGGTGGGCTCGCTGGAG TCGCAGCTGGCGGCCAGCGCGGCCCACCACCACCACCTCGCGCCGCGCACGCCCGAGGTGCGGGCCGCGGCCGCCGGCGCGCTCGGGAAC CATGTTGTGAGCGGCAGCCCGGCCGGAGCCGCGGGCGCAGGGCCGGCCGCCCCCGCCGAGGGCGCGCCCGGAGCGGCGCCGGAGCCGCCC CCCGCAGGTAGAGCGCGGCCGGGGGGCGGGGGGCCGCAGCGCCCGGGCCCCCCCTCACCGCGCCGCCCCCTTGTCCCCGCAGGGCCCGCG CCGCCCGCCGCGAAGCTGAGGCCGCCGCCCGAGGGCAGCGCGGGGTCCTGCGCCCCGGTGCCCGCCGCCGCCGCCGTCGCCGCGGGGCCC GAGCCCGCCCCCGCCGGCCCCGCCAAGCCCGCCGGCCCCGCCGCGCTGGCCGCCCGCGCCGGCCCCGGCCCCGGGCCCGGCCCCGGCCCC GGCCCCGGCCCTGGCCCTGGCAAGCCCGCCGGCCCCGGCGCCGCGCAAACTTTGAATGGGAGCGCCGCGCTGCTGAACTCGCACCACGCC GCCGCACCTGCTGTCAGCCTGGTCAACAACGGGCCCGCCGCGCTGCTGCCGCTGCCCAAGCCCGCCGCCCCCGGCACTGTCATCCAGACG CCCCCCTTCGTGGGCGCCGCCGCGCCCCCCGCGCCCGCCGCGCCCTCGCCCCCCGCCGCCCCCGCGCCCGCCGCCCCCGCCGCCGCCCCG CCCCCGCCACCCCCCGCGCCCGCCACTCTGGCCCGGCCGCCCGGCCACCCCGCCGGACCCCCGACCGCCGCGCCCGCCGTGCCGCCCCCC GCCGCCGCCCAGAACGGGGGCAGCGCCGGGGCAGCCCCCGCCCCCGCCCCGGCCGCCGGGGGCCCCGCGGGGGTCAGCGGCCAACCCGGG CCCGGCGCGGCGGCTGCGGCGCCGGCGCCGGGGGTCAAGGCCGAGTCGCCCAAGAGGGTGGTGCAGGCGGCGCCCCCGGCGGCGCAGACC CTGGCGGCCAGCGGCCCGGCCAGCACGGCGGCCAGCATGGTCATCGGGCCAACTATGCAAGGGGCGCTGCCCAGCCCGGCCGCCGTCCCG CCGCCCGCCCCCGGGACCCCCACCGGGCTGCCCAAAGGCGCGGCCGGCGCAGTGACCCAGAGCCTGTCCCGGACGCCCACGGCCACCACC AGCGGGATTCGGGCCACCCTGACGCCCACCGTGCTGGCCCCCCGCTTGCCGCAGCCGCCTCAGAACCCGACCAACATCCAGAACTTCCAG CTGCCCCCAGGTGCCGCGGCCTCTGGCTATGAAGAAGGAAAGCATCCAGACACGGAAGCGGAAGCCAAAGACCATCGCCAAGGCCAGGGG CTCCTCAGGATCCACAAGGAATGCCTCGGCCTCCCCATCTGCTGTCGCCAGCACTGACAGCTCAGCAGCCACTTCGAAAGCCAAGCCCAG CCTGGCGTCCCCAGTGTGCCCTGGGCCCAGCATGGCCCCCCAGGCCTCTGGCCAGGAGGATGACTCTCTTGCCCCCGGCCACTTGGAGTT CAAGTTCGAGCCTGAGGACTTTGCCTTCCCCTCCACGGCCCCAAGCCCCCAGGCTGGCCTCAGGGGGGCTCTGCGCCAAGAGGCCTGGTG TGCGCTGGCCTTGGCCTAGGTCCCCAGGCCAGCCCATGTCAGGGGAACAGCCTGGAACAGACCACCCACTGAGTCACCTCCGTGCCTGCT TTGCTCCAGCACAGCAGAGACCAGCAGGCCCCCCAACCCAGAGACTGGGTCTGCTGGAGTCTCCACACAGTGGTGGGGAGGCCTTCTGGA CAGACGGCAGTCGGGCCCCAGAGCAAGAAGGCTGGTGAGGGAAGGGCTCAGCTTCCCACCCCACGTACAGCAAGGGACTCCCCAGGTGCG GCCCAAGGCTCCGGACCACACTGGCCCCCTGCGGCGGAGGCCAACGCAGGGCACCACCACCACCAACTTGAATTCCGTCATCAATGCTCA CCGTCAATATGTTTACAAGTTGTAGCAGTTGGGGGAAAACAGTCAACCTCCCAGTGTAAAACCAAGATTCCCAGTGAAGCACCTGAGGCC AAGCAGGGGAGAGGAATGAGGGGAGCAGCTGGACATGGGCCTCCTGAGGCCTCGGGGCTGTCCTTCATTGCCCACATGGATAGACGGAGC TGTGGTGCAGAGAACTTTTCCCGCAACAGGTGCAGGACTGCCAGGGATCGGAGTGCGGGCCGCGCACGGTGCCAGGATTCCGCCGAGGGG AAGCCGCTCACATTGCAGTCATCACAGACTTACGCACTTGTTTGGACAGTTTTTCCAGAGGGGATGGGAAAGGGCCTTGTTCTAGCTGAA TCTGTGTATCATGACCATTTCTGACAGGCAGAATGAATTGTCTGGTAGCCCTGTCCTGACCCATCCAAGCGCTGTTGGGGCTGGTGGTGA CGTGGTCACATGTCCTGGCATATCTGGGGCCACGCAGTTTAGTCTCTTGTCCCAGGAGAATTGTTAGTGACCCCTCTTTCTCTTGCAAGC CCCCTCCACACTGGGTTGGATGATACCTTAATGAGTGACGCTGGCGAGAGGCACCCTACCCGACGCAGCTGTGAATGGCCGGTGATGTAT GTCAGGAGGCCACAGGGAGCAGAGGAGCGGGGCAGGCAGCCACAGGGCCCTGCGGGGAGCACATCCTCGCCTCCGTCCGGCTGCTGCCCT TCAACAACAAGCCCTGATTTTTCCAGCAATGCCAGAAACCTGGATTTTAAGTCTTCCAATTTGATTCAAAAATATTTTTAACATTGTGAG CCAGCTAGACCCCCAGTGCACCACCCCATATTGAAAAACAGTTGTCTGGCATCAGCTTCAGGAGCGGGTCCGGTCATTCTGAAACTGTCC CTCCAGAGGTTCTTCCAGCCCCACTTCTATGCGATGTCATCTTTTCTAAAAGAGACAAATGAAGCCACAGGGAAAGTGAAATAAAGCCTT |
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FusionGenePPI for TAF4_GATA5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAF4 | TBP, CBX5, TAF1, GTF2A2, TAF4, TAF12, TAF8, TAF5, KAT2A, SUPT3H, TAF10, CREM, SP1, TAF9, TAF13, TBPL1, GTF2A1, ATF7, CREB1, TCF12, ELAVL1, TAF6, TAF7, TRRAP, TAF3, TAF9B, TAF1L, AHR, HTT, JUN, GTF2F2, HIST3H3, MED26, FBXO6, SOX6, EGFR, NUP50, ANAPC1, ANAPC7, CDC16, NAP1L4, ANAPC13, CDC23, CDC27, NCL, SF3B3, EWSR1, HIST1H3E, KIFAP3, TAF7L, TAF11 | GATA5 | KLF2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF4_GATA5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF4_GATA5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GATA5 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |