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Fusion gene ID: 37106 |
FusionGeneSummary for TAF3_ZDHHC14 |
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Fusion gene information | Fusion gene name: TAF3_ZDHHC14 | Fusion gene ID: 37106 | Hgene | Tgene | Gene symbol | TAF3 | ZDHHC14 | Gene ID | 83860 | 79683 |
Gene name | TATA-box binding protein associated factor 3 | zinc finger DHHC-type containing 14 | |
Synonyms | TAF140|TAFII-140|TAFII140 | NEW1CP | |
Cytomap | 10p14 | 6q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription initiation factor TFIID subunit 3140 kDa TATA box-binding protein-associated factorRNA polymerase II transcription factor TAFII140TAF(II)140TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDaTBP-associated f | probable palmitoyltransferase ZDHHC14DHHC-14NEW1 domain-containing proteinzinc finger DHHC domain-containing protein 14zinc finger, DHHC domain containing 14 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q5VWG9 | Q8IZN3 | |
Ensembl transtripts involved in fusion gene | ENST00000344293, | ENST00000414563, ENST00000359775, ENST00000341375, | |
Fusion gene scores | * DoF score | 7 X 3 X 6=126 | 7 X 5 X 7=245 |
# samples | 8 | 8 | |
** MAII score | log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/245*10)=-1.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TAF3 [Title/Abstract] AND ZDHHC14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAF3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 18549481 |
Hgene | TAF3 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 18549481 |
Hgene | TAF3 | GO:0051457 | maintenance of protein location in nucleus | 15870280 |
Tgene | ZDHHC14 | GO:0018345 | protein palmitoylation | 23034182 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | THCA | TCGA-CE-A13K-01A | TAF3 | chr10 | 7866523 | + | ZDHHC14 | chr6 | 157963617 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000344293 | ENST00000414563 | TAF3 | chr10 | 7866523 | + | ZDHHC14 | chr6 | 157963617 | + |
Frame-shift | ENST00000344293 | ENST00000359775 | TAF3 | chr10 | 7866523 | + | ZDHHC14 | chr6 | 157963617 | + |
5CDS-intron | ENST00000344293 | ENST00000341375 | TAF3 | chr10 | 7866523 | + | ZDHHC14 | chr6 | 157963617 | + |
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FusionProtFeatures for TAF3_ZDHHC14 |
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Hgene | Tgene |
TAF3 | ZDHHC14 |
Transcription factor TFIID is one of the general factorsrequired for accurate and regulated initiation by RNA polymeraseII. TFIID is a multimeric protein complex that plays a centralrole in mediating promoter responses to various activators andrepressors. Required in complex with TBPL2 for the differentiationof myoblasts into myocytes. The complex replaces TFIID at specificpromoters at an early stage in the differentiation process. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF3_ZDHHC14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAF3_ZDHHC14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAF3 | KHDRBS2, TAF10, TBP, TBPL2, KAT2A, TAF12, TAF13, SAP130, TAF7, CTCF, TAF5, TAF4, TAF6, TAF1, KPNA2, KPNB1, HIST3H3, HIST2H4A, MED26, NPM1, CDC23, NAP1L4, ANAPC10, CDC16, MZT1, TAF7L, TAF8, TAF11 | ZDHHC14 | ELAVL1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF3_ZDHHC14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF3_ZDHHC14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |