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Fusion gene ID: 37100 |
FusionGeneSummary for TAF2_UPF2 |
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Fusion gene information | Fusion gene name: TAF2_UPF2 | Fusion gene ID: 37100 | Hgene | Tgene | Gene symbol | TAF2 | UPF2 | Gene ID | 6873 | 26019 |
Gene name | TATA-box binding protein associated factor 2 | UPF2, regulator of nonsense mediated mRNA decay | |
Synonyms | CIF150|MRT40|TAF2B|TAFII150 | HUPF2|RENT2|smg-3 | |
Cytomap | 8q24.12 | 10p14 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription initiation factor TFIID subunit 2150 kDa cofactor of initiator functionRNA polymerase II TBP-associated factor subunit BTAF(II)150TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDaTATA box binding protein ( | regulator of nonsense transcripts 2FRS2/UPF2/LEMD3 fusionLEMD3/UPF2 fusionUPF2 regulator of nonsense transcripts homolognonsense mRNA reducing factor 2smg-3 homolog, nonsense mediated mRNA decay factorup-frameshift suppressor 2 homologyeast Upf2p h | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q6P1X5 | Q9HAU5 | |
Ensembl transtripts involved in fusion gene | ENST00000378164, ENST00000519355, | ENST00000356352, ENST00000357604, ENST00000397053, ENST00000460569, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 5 X 7 X 3=105 |
# samples | 6 | 10 | |
** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/105*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TAF2 [Title/Abstract] AND UPF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAF2 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 9418870 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW994843 | TAF2 | chr8 | 120832199 | + | UPF2 | chr10 | 11962235 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000378164 | ENST00000356352 | TAF2 | chr8 | 120832199 | + | UPF2 | chr10 | 11962235 | + |
intron-3UTR | ENST00000378164 | ENST00000357604 | TAF2 | chr8 | 120832199 | + | UPF2 | chr10 | 11962235 | + |
intron-3UTR | ENST00000378164 | ENST00000397053 | TAF2 | chr8 | 120832199 | + | UPF2 | chr10 | 11962235 | + |
intron-intron | ENST00000378164 | ENST00000460569 | TAF2 | chr8 | 120832199 | + | UPF2 | chr10 | 11962235 | + |
intron-3UTR | ENST00000519355 | ENST00000356352 | TAF2 | chr8 | 120832199 | + | UPF2 | chr10 | 11962235 | + |
intron-3UTR | ENST00000519355 | ENST00000357604 | TAF2 | chr8 | 120832199 | + | UPF2 | chr10 | 11962235 | + |
intron-3UTR | ENST00000519355 | ENST00000397053 | TAF2 | chr8 | 120832199 | + | UPF2 | chr10 | 11962235 | + |
intron-intron | ENST00000519355 | ENST00000460569 | TAF2 | chr8 | 120832199 | + | UPF2 | chr10 | 11962235 | + |
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FusionProtFeatures for TAF2_UPF2 |
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Hgene | Tgene |
TAF2 | UPF2 |
Transcription factor TFIID is one of the general factorsrequired for accurate and regulated initiation by RNA polymeraseII. TFIID is a multimeric protein complex that plays a centralrole in mediating promoter responses to various activators andrepressors. It requires core promoter-specific cofactors forproductive transcription stimulation. TAF2 stabilizes TFIIDbinding to core promoter. {ECO:0000269|PubMed:9418870,ECO:0000269|PubMed:9774672}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF2_UPF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAF2_UPF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF2_UPF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF2_UPF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TAF2 | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |
Hgene | TAF2 | C3810080 | MENTAL RETARDATION, AUTOSOMAL RECESSIVE 40 | 1 | ORPHANET;UNIPROT |