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Fusion gene ID: 37091 |
FusionGeneSummary for TAF1D_TRIM49C |
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Fusion gene information | Fusion gene name: TAF1D_TRIM49C | Fusion gene ID: 37091 | Hgene | Tgene | Gene symbol | TAF1D | TRIM49C | Gene ID | 79101 | 642612 |
Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit D | tripartite motif containing 49C | |
Synonyms | JOSD3|RAFI41|TAF(I)41|TAFI41 | TRIM49L2 | |
Cytomap | 11q21 | 11q14.3 | |
Type of gene | protein-coding | protein-coding | |
Description | TATA box-binding protein-associated factor RNA polymerase I subunit DJosephin domain containing 3RNA polymerase I-specific TBP-associated factor 41 kDaTATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDaTATA box-binding protein | tripartite motif-containing protein 49CTripartite motif-containing protein LOC642612tripartite motif containing 49-like 2tripartite motif-containing protein 49-like protein 2 | |
Modification date | 20180523 | 20180331 | |
UniProtAcc | Q9H5J8 | P0CI26 | |
Ensembl transtripts involved in fusion gene | ENST00000546088, ENST00000448108, | ENST00000432771, ENST00000448984, | |
Fusion gene scores | * DoF score | 8 X 9 X 2=144 | 2 X 1 X 1=2 |
# samples | 8 | 2 | |
** MAII score | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/2*10)=3.32192809488736 | |
Context | PubMed: TAF1D [Title/Abstract] AND TRIM49C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-GM-A2DL-01A | TAF1D | chr11 | 93474488 | - | TRIM49C | chr11 | 89765565 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000546088 | ENST00000432771 | TAF1D | chr11 | 93474488 | - | TRIM49C | chr11 | 89765565 | + |
intron-5UTR | ENST00000546088 | ENST00000448984 | TAF1D | chr11 | 93474488 | - | TRIM49C | chr11 | 89765565 | + |
5UTR-5UTR | ENST00000448108 | ENST00000432771 | TAF1D | chr11 | 93474488 | - | TRIM49C | chr11 | 89765565 | + |
5UTR-5UTR | ENST00000448108 | ENST00000448984 | TAF1D | chr11 | 93474488 | - | TRIM49C | chr11 | 89765565 | + |
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FusionProtFeatures for TAF1D_TRIM49C |
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Hgene | Tgene |
TAF1D | TRIM49C |
Component of the transcription factor SL1/TIF-IBcomplex, which is involved in the assembly of the PIC(preinitiation complex) during RNA polymerase I-dependenttranscription. The rate of PIC formation probably is primarilydependent on the rate of association of SL1/TIF-IB with the rDNApromoter. SL1/TIF-IB is involved in stabilization of nucleolartranscription factor 1/UBTF on rDNA. Formation of SL1/TIF-IBexcludes the association of TBP with TFIID subunits.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF1D_TRIM49C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAF1D_TRIM49C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAF1D | POLB, PTN, HAP1, CENPB, CSNK2A1, CSNK2A2, CSNK2B, IPO5, TBP, TAF1C, TAF1B, TAF1A, POLR1C, PSME3, POLR1A, RRP15, RRN3, PPAN, POLR1E, POLR1B, TWISTNB, RPL6P1, UBTF, MYBBP1A, IMMT, CEP70, RPL36AL, ITFG1, HSP90AB1, FEZ1, TMSB4X, SMARCB1, EZH2, DDAH2, MCM3AP, FAM20C, ING5, UBE2D1, LRIF1, FAF1, NGEF, RPL14, EAF1, NPM1, MAPK8, NAF1, TRIM44, MECP2, RPL18A, RRP8, RBM34, RPS14, ZNF2, MCPH1 | TRIM49C |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF1D_TRIM49C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF1D_TRIM49C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TAF1D | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | TAF1D | C0311375 | Arsenic Poisoning | 1 | CTD_human |