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Fusion gene ID: 37088 |
FusionGeneSummary for TAF1D_SCAF8 |
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Fusion gene information | Fusion gene name: TAF1D_SCAF8 | Fusion gene ID: 37088 | Hgene | Tgene | Gene symbol | TAF1D | SCAF8 | Gene ID | 79101 | 22828 |
Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit D | SR-related CTD associated factor 8 | |
Synonyms | JOSD3|RAFI41|TAF(I)41|TAFI41 | RBM16 | |
Cytomap | 11q21 | 6q25.2 | |
Type of gene | protein-coding | protein-coding | |
Description | TATA box-binding protein-associated factor RNA polymerase I subunit DJosephin domain containing 3RNA polymerase I-specific TBP-associated factor 41 kDaTATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDaTATA box-binding protein | protein SCAF8CDC5L complex-associated protein 7RNA-binding motif protein 16SR-like CTD-associated factor 8SR-related and CTD-associated factor 8 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H5J8 | Q9UPN6 | |
Ensembl transtripts involved in fusion gene | ENST00000546088, ENST00000448108, | ENST00000367178, ENST00000461219, ENST00000417268, ENST00000367186, | |
Fusion gene scores | * DoF score | 8 X 9 X 2=144 | 6 X 6 X 1=36 |
# samples | 8 | 6 | |
** MAII score | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TAF1D [Title/Abstract] AND SCAF8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | H09708 | TAF1D | chr11 | 93465579 | - | SCAF8 | chr6 | 155153340 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000546088 | ENST00000367178 | TAF1D | chr11 | 93465579 | - | SCAF8 | chr6 | 155153340 | + |
intron-intron | ENST00000546088 | ENST00000461219 | TAF1D | chr11 | 93465579 | - | SCAF8 | chr6 | 155153340 | + |
intron-intron | ENST00000546088 | ENST00000417268 | TAF1D | chr11 | 93465579 | - | SCAF8 | chr6 | 155153340 | + |
intron-intron | ENST00000546088 | ENST00000367186 | TAF1D | chr11 | 93465579 | - | SCAF8 | chr6 | 155153340 | + |
intron-3CDS | ENST00000448108 | ENST00000367178 | TAF1D | chr11 | 93465579 | - | SCAF8 | chr6 | 155153340 | + |
intron-intron | ENST00000448108 | ENST00000461219 | TAF1D | chr11 | 93465579 | - | SCAF8 | chr6 | 155153340 | + |
intron-intron | ENST00000448108 | ENST00000417268 | TAF1D | chr11 | 93465579 | - | SCAF8 | chr6 | 155153340 | + |
intron-intron | ENST00000448108 | ENST00000367186 | TAF1D | chr11 | 93465579 | - | SCAF8 | chr6 | 155153340 | + |
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FusionProtFeatures for TAF1D_SCAF8 |
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Hgene | Tgene |
TAF1D | SCAF8 |
Component of the transcription factor SL1/TIF-IBcomplex, which is involved in the assembly of the PIC(preinitiation complex) during RNA polymerase I-dependenttranscription. The rate of PIC formation probably is primarilydependent on the rate of association of SL1/TIF-IB with the rDNApromoter. SL1/TIF-IB is involved in stabilization of nucleolartranscription factor 1/UBTF on rDNA. Formation of SL1/TIF-IBexcludes the association of TBP with TFIID subunits.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. | May play a role in mRNA processing.{ECO:0000269|PubMed:11101529}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF1D_SCAF8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAF1D_SCAF8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF1D_SCAF8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF1D_SCAF8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TAF1D | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | TAF1D | C0311375 | Arsenic Poisoning | 1 | CTD_human |