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Fusion gene ID: 37087 |
FusionGeneSummary for TAF1D_ERMN |
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Fusion gene information | Fusion gene name: TAF1D_ERMN | Fusion gene ID: 37087 | Hgene | Tgene | Gene symbol | TAF1D | ERMN | Gene ID | 79101 | 57471 |
Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit D | ermin | |
Synonyms | JOSD3|RAFI41|TAF(I)41|TAFI41 | JN|KIAA1189 | |
Cytomap | 11q21 | 2q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | TATA box-binding protein-associated factor RNA polymerase I subunit DJosephin domain containing 3RNA polymerase I-specific TBP-associated factor 41 kDaTATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDaTATA box-binding protein | erminermin, ERM-like proteinjuxtanodin | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9H5J8 | Q8TAM6 | |
Ensembl transtripts involved in fusion gene | ENST00000546088, ENST00000448108, | ENST00000410096, ENST00000397283, ENST00000535935, ENST00000420719, ENST00000409216, ENST00000409925, | |
Fusion gene scores | * DoF score | 8 X 9 X 2=144 | 1 X 1 X 1=1 |
# samples | 8 | 1 | |
** MAII score | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: TAF1D [Title/Abstract] AND ERMN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ERMN | GO:0007015 | actin filament organization | 20934411 |
Tgene | ERMN | GO:0008360 | regulation of cell shape | 20934411 |
Tgene | ERMN | GO:0031344 | regulation of cell projection organization | 20934411 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA340713 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000546088 | ENST00000410096 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-3UTR | ENST00000546088 | ENST00000397283 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-intron | ENST00000546088 | ENST00000535935 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-intron | ENST00000546088 | ENST00000420719 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-intron | ENST00000546088 | ENST00000409216 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-intron | ENST00000546088 | ENST00000409925 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-3UTR | ENST00000448108 | ENST00000410096 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-3UTR | ENST00000448108 | ENST00000397283 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-intron | ENST00000448108 | ENST00000535935 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-intron | ENST00000448108 | ENST00000420719 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-intron | ENST00000448108 | ENST00000409216 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
intron-intron | ENST00000448108 | ENST00000409925 | TAF1D | chr11 | 93464672 | - | ERMN | chr2 | 158177168 | - |
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FusionProtFeatures for TAF1D_ERMN |
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Hgene | Tgene |
TAF1D | ERMN |
Component of the transcription factor SL1/TIF-IBcomplex, which is involved in the assembly of the PIC(preinitiation complex) during RNA polymerase I-dependenttranscription. The rate of PIC formation probably is primarilydependent on the rate of association of SL1/TIF-IB with the rDNApromoter. SL1/TIF-IB is involved in stabilization of nucleolartranscription factor 1/UBTF on rDNA. Formation of SL1/TIF-IBexcludes the association of TBP with TFIID subunits.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. | Plays a role in cytoskeletal rearrangements during thelate wrapping and/or compaction phases of myelinogenesis as wellas in maintenance and stability of myelin sheath in the adult. Mayplay an important role in late-stage oligodendroglia maturation,myelin/Ranvier node formation during CNS development, and in themaintenance and plasticity of related structures in the mature CNS(By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF1D_ERMN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAF1D_ERMN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF1D_ERMN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF1D_ERMN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TAF1D | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | TAF1D | C0311375 | Arsenic Poisoning | 1 | CTD_human |