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Fusion gene ID: 37085 |
FusionGeneSummary for TAF1B_SGCZ |
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Fusion gene information | Fusion gene name: TAF1B_SGCZ | Fusion gene ID: 37085 | Hgene | Tgene | Gene symbol | TAF1B | SGCZ | Gene ID | 9014 | 137868 |
Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit B | sarcoglycan zeta | |
Synonyms | MGC:9349|RAF1B|RAFI63|SL1|TAFI63 | ZSG1 | |
Cytomap | 2p25.1 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | TATA box-binding protein-associated factor RNA polymerase I subunit BRNA polymerase I-specific TBP-associated factor 63 kDaSL1, 63kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDTATA box binding protein (TBP)-assoc | zeta-sarcoglycanzeta-SG | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q53T94 | Q96LD1 | |
Ensembl transtripts involved in fusion gene | ENST00000263663, ENST00000402170, ENST00000396242, | ENST00000382080, ENST00000421524, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 5 X 4 X 5=100 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TAF1B [Title/Abstract] AND SGCZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAF1B | GO:0001188 | RNA polymerase I transcriptional preinitiation complex assembly | 21921199 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | MESO | TCGA-TS-A8AY-01A | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000263663 | ENST00000382080 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
In-frame | ENST00000263663 | ENST00000421524 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
3UTR-3CDS | ENST00000402170 | ENST00000382080 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
3UTR-3CDS | ENST00000402170 | ENST00000421524 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
5UTR-3CDS | ENST00000396242 | ENST00000382080 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
5UTR-3CDS | ENST00000396242 | ENST00000421524 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
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FusionProtFeatures for TAF1B_SGCZ |
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Hgene | Tgene |
TAF1B | SGCZ |
Component of RNA polymerase I core factor complex thatacts as a GTF2B/TFIIB-like factor and plays a key role in multiplesteps during transcription initiation such as pre-initiationcomplex (PIC) assembly and postpolymerase recruitment events inpolymerase I (Pol I) transcription. Binds rDNA promoters and playsa role in Pol I recruitment as a component of the SL1/TIF-IBcomplex and, possibly, directly through its interaction with RRN3.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:21921198,ECO:0000269|PubMed:21921199, ECO:0000269|PubMed:7491500,ECO:0000269|PubMed:7801123, ECO:0000269|PubMed:7801130}. | Component of the sarcoglycan complex, a subcomplex ofthe dystrophin-glycoprotein complex which forms a link between theF-actin cytoskeleton and the extracellular matrix. May play a rolein the maintenance of striated muscle membrane stability (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 4_39 | 39 | 589 | Zinc finger | Note=RRN7-type |
Tgene | >SGCZ | chr2:9985447 | chr8:14412435 | ENST00000382080 | - | 0 | 8 | 252_263 | 13 | 313 | Compositional bias | Note=Poly-Ser |
Tgene | >SGCZ | chr2:9985447 | chr8:14412435 | ENST00000382080 | - | 0 | 8 | 59_299 | 13 | 313 | Topological domain | Extracellular |
Tgene | >SGCZ | chr2:9985447 | chr8:14412435 | ENST00000382080 | - | 0 | 8 | 38_58 | 13 | 313 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 262_372 | 39 | 589 | Region | Note=C-terminal cyclin fold |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 40_68 | 39 | 589 | Region | Note=B-reader |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 69_73 | 39 | 589 | Region | Note=B-linker |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 74_261 | 39 | 589 | Region | Note=N-terminal cyclin fold |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 262_372 | -208 | 334 | Region | Note=C-terminal cyclin fold |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 40_68 | -208 | 334 | Region | Note=B-reader |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 69_73 | -208 | 334 | Region | Note=B-linker |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 74_261 | -208 | 334 | Region | Note=N-terminal cyclin fold |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 4_39 | -208 | 334 | Zinc finger | Note=RRN7-type |
Tgene | SGCZ | chr2:9985447 | chr8:14412435 | ENST00000382080 | - | 0 | 8 | 1_37 | 13 | 313 | Topological domain | Cytoplasmic |
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FusionGeneSequence for TAF1B_SGCZ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000382080_chr8_14412435_-_339aa MDLEEAEEFKERCTQCAAVSWGLTDEGKYYCTSCHNVTEMTREQYILATQQNNLPRTENAQLYPVGIYGWRKRCLYFFVLLLLVTMIVNL AMTIWILKVMNFTVDGMGNLRVTKKGIRLEGISEFLLPLYVKEIHSRKDSPLVLQSDRNVTVNARNHMGQLTGQLTIGADAVEAQCKRFE VRASEDGRVLFSADEDEITIGAEKLKVTGTEGAVFGHSVETPHIRAEPSQDLRLESPTRSLIMEAPRGVQVSAAAGDFKATCRKELHLQS >In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000421524_chr8_14412435_-_39aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000382080_chr8_14412435_-_1017nt ATGGACCTCGAGGAGGCGGAAGAGTTTAAAGAACGCTGTACTCAGTGTGCTGCTGTCTCATGGGGTCTTACTGATGAAGGCAAATATTAT TGCACTTCTTGCCACAATGTTACAGAGATGACACGAGAACAATACATACTAGCAACCCAACAGAATAACCTGCCAAGGACTGAGAATGCA CAACTTTACCCAGTGGGAATTTATGGATGGCGAAAGAGGTGCTTATACTTCTTTGTCCTTCTGCTGTTGGTTACCATGATAGTTAACTTA GCCATGACAATATGGATATTGAAAGTTATGAATTTCACTGTGGATGGTATGGGAAATCTGAGAGTCACCAAGAAGGGAATCCGACTTGAA GGTATATCTGAGTTTCTACTTCCATTGTATGTGAAAGAAATTCATTCTCGAAAGGATAGTCCGCTGGTCTTACAGTCTGACAGGAATGTC ACAGTGAATGCAAGAAATCACATGGGGCAGTTAACCGGACAGCTGACCATAGGAGCTGATGCTGTGGAAGCTCAGTGTAAAAGATTTGAA GTGAGAGCCAGTGAAGATGGCAGGGTGCTGTTTTCTGCAGATGAAGATGAGATTACCATTGGGGCTGAAAAGCTGAAAGTTACAGGCACT GAAGGAGCCGTATTTGGGCACTCTGTGGAGACGCCGCACATCAGAGCAGAGCCATCCCAAGATCTCAGGCTTGAATCACCCACCAGATCC TTGATCATGGAAGCTCCCCGTGGGGTCCAGGTGAGTGCTGCTGCAGGAGACTTCAAGGCCACCTGCAGGAAGGAGCTCCATCTGCAATCT ACAGAAGGGGAGATATTTTTAAATGCAGAGACAATCAAGCTGGGAAATCTACCAACTGGCTCCTTCTCATCTTCTTCACCCAGCTCCTCA AGTTCTCGACAGACAGTGTATGAACTCTGCGTCTGCCCCAATGGCAAACTTTACCTTTCTCCAGCAGGAGTAGGTTCCACTTGTCAGTCC >In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000421524_chr8_14412435_-_117nt ATGGACCTCGAGGAGGCGGAAGAGTTTAAAGAACGCTGTACTCAGTGTGCTGCTGTCTCATGGGGTCTTACTGATGAAGGCAAATATTAT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000382080_chr8_14412435_-_1784nt GTCCGCGAGGGGTCTGCGAGCTTTGCGGAGCCTCGCCCCCGAGCGCGCGGTTTCCCTGCCGCGCAGGCGCACGGAATCCTAGGCGCGGAT CTCGCGTTTCCGGCCGGAAGCTTCTCCAGCCTTTCCCGGAAGCTGCGCTCGCTACCCGGGTAACGGGTCCCGGCTGTGGAAGCTCCCGCG GCGCCGCGATGGACCTCGAGGAGGCGGAAGAGTTTAAAGAACGCTGTACTCAGTGTGCTGCTGTCTCATGGGGTCTTACTGATGAAGGCA AATATTATTGCACTTCTTGCCACAATGTTACAGAGATGACACGAGAACAATACATACTAGCAACCCAACAGAATAACCTGCCAAGGACTG AGAATGCACAACTTTACCCAGTGGGAATTTATGGATGGCGAAAGAGGTGCTTATACTTCTTTGTCCTTCTGCTGTTGGTTACCATGATAG TTAACTTAGCCATGACAATATGGATATTGAAAGTTATGAATTTCACTGTGGATGGTATGGGAAATCTGAGAGTCACCAAGAAGGGAATCC GACTTGAAGGTATATCTGAGTTTCTACTTCCATTGTATGTGAAAGAAATTCATTCTCGAAAGGATAGTCCGCTGGTCTTACAGTCTGACA GGAATGTCACAGTGAATGCAAGAAATCACATGGGGCAGTTAACCGGACAGCTGACCATAGGAGCTGATGCTGTGGAAGCTCAGTGTAAAA GATTTGAAGTGAGAGCCAGTGAAGATGGCAGGGTGCTGTTTTCTGCAGATGAAGATGAGATTACCATTGGGGCTGAAAAGCTGAAAGTTA CAGGCACTGAAGGAGCCGTATTTGGGCACTCTGTGGAGACGCCGCACATCAGAGCAGAGCCATCCCAAGATCTCAGGCTTGAATCACCCA CCAGATCCTTGATCATGGAAGCTCCCCGTGGGGTCCAGGTGAGTGCTGCTGCAGGAGACTTCAAGGCCACCTGCAGGAAGGAGCTCCATC TGCAATCTACAGAAGGGGAGATATTTTTAAATGCAGAGACAATCAAGCTGGGAAATCTACCAACTGGCTCCTTCTCATCTTCTTCACCCA GCTCCTCAAGTTCTCGACAGACAGTGTATGAACTCTGCGTCTGCCCCAATGGCAAACTTTACCTTTCTCCAGCAGGAGTAGGTTCCACTT GTCAGTCCAGTAGCAACATCTGCCTGTGGAGCTGAAGTGACTGATTTCTCCTCACACCAGAATAGCCTTTTGTTCCTGTCCGTCTGCTTC ACAGTTCTGCTCGGTTTCCCTTGTGATCAGTCCAGAGCTTCTTCGAATGGTCCACAGAGCAACTTCCAGTGTGAGCAGGGATTCGCCACC ACCTTCTCTTGTGATTTACTGTACTGCTCAACACAGAGGGTGTGATTGACACAGCAGTGGAAAAAGCGTCGTCAGCAGGAAAACTGGATC ATGACTTTTGCTCGAAAGGGAGAATAACATAGGTGCCTTTGCTACGCGAAGTGAAGCACACAGTTTTAGATTTTTGCAGGACCTGGATAT GAACTGCACATATATACATTACATAAATGAAATTCCCAGTATCCAATGGCAAGATGAAATGGTTAACCCTGTAAGAAAACTTATTCTACA TTCTGAAAGCACAATTTTCCATTCATCTTTTTGGATGTAAACTTTTATCCCCGACTTTTAAAATTTTAAAGCATTATGTAATGCTTGCTT >In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000421524_chr8_14412435_-_1172nt GTCCGCGAGGGGTCTGCGAGCTTTGCGGAGCCTCGCCCCCGAGCGCGCGGTTTCCCTGCCGCGCAGGCGCACGGAATCCTAGGCGCGGAT CTCGCGTTTCCGGCCGGAAGCTTCTCCAGCCTTTCCCGGAAGCTGCGCTCGCTACCCGGGTAACGGGTCCCGGCTGTGGAAGCTCCCGCG GCGCCGCGATGGACCTCGAGGAGGCGGAAGAGTTTAAAGAACGCTGTACTCAGTGTGCTGCTGTCTCATGGGGTCTTACTGATGAAGGCA AATATTATTGCACTTCTTGCCACAATGTTACAGAGATGACACGAGAACAATACATACTAGCAACCCAACAGAATAACCTGCCAAGGACTG AGAATGCACAACTTTACCCAGTGGGAATTTATGGATGGCGAAAGAGGTGCTTATACTTCTTTGTCCTTCTGCTGTTGGTTACCATGATAG TTAACTTAGCCATGACAATATGGATATTGAAAGTTATGAATTTCACTGTGGATAGTCCGCTGGTCTTACAGTCTGACAGGAATGTCACAG TGAATGCAAGAAATCACATGGGGCAGTTAACCGGACAGCTGACCATAGGAGCTGATGCTGTGGAAGCTCAGTGTAAAAGATTTGAAGTGA GAGCCAGTGAAGATGGCAGGGTGCTGTTTTCTGCAGATGAAGATGAGATTACCATTGGGGCTGAAAAGCTGAAAGTTACAGGCACTGAAG GAGCCGTATTTGGGCACTCTGTGGAGACGCCGCACATCAGAGCAGAGCCATCCCAAGATCTCAGGCTTGAATCACCCACCAGATCCTTGA TCATGGAAGCTCCCCGTGGGGTCCAGGTGAGTGCTGCTGCAGGAGACTTCAAGGCCACCTGCAGGAAGGAGCTCCATCTGCAATCTACAG AAGGGGAGATATTTTTAAATGCAGAGACAATCAAGCTGGGAAATCTACCAACTGGCTCCTTCTCATCTTCTTCACCCAGCTCCTCAAGTT CTCGACAGACAGTGTATGAACTCTGCGTCTGCCCCAATGGCAAACTTTACCTTTCTCCAGCAGGAGTAGGTTCCACTTGTCAGTCCAGTA GCAACATCTGCCTGTGGAGCTGAAGTGACTGATTTCTCCTCACACCAGAATAGCCTTTTGTTCCTGTCCGTCTGCTTCACAGTTCTGCTC |
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FusionGenePPI for TAF1B_SGCZ |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAF1B | TBP, TAF1A, TAF1C, RRN3, TP53, UBTF, EP300, TAF1D, HIST2H2BE, HIST2H2AC, HIST2H3C, HIST2H4A, THAP7, ESR1, TRB, RXRA, PGR, HIST1H3A, HIST1H4A, HDAC1, NEDD4, NEDD4L, APP, HIST3H3, NAPB, SRPK1, KAT2B, EAF1, NIFK, MPP1, OAZ1, POLR1A, FERMT3, NAF1, BRCA1, TRIM44, ZNF2, RRP8, MECP2 | SGCZ | SGCB, HARS, REEP5, GK, ACACA, GNPTAB, RANGRF, ATP5F1, C4orf32, SP3, RTN4, DAGLB, ATP5B |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF1B_SGCZ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF1B_SGCZ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SGCZ | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |