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Fusion gene ID: 37085 |
FusionGeneSummary for TAF1B_SGCZ |
Fusion gene summary |
Fusion gene information | Fusion gene name: TAF1B_SGCZ | Fusion gene ID: 37085 | Hgene | Tgene | Gene symbol | TAF1B | SGCZ | Gene ID | 9014 | 137868 |
Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit B | sarcoglycan zeta | |
Synonyms | MGC:9349|RAF1B|RAFI63|SL1|TAFI63 | ZSG1 | |
Cytomap | 2p25.1 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | TATA box-binding protein-associated factor RNA polymerase I subunit BRNA polymerase I-specific TBP-associated factor 63 kDaSL1, 63kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDTATA box binding protein (TBP)-assoc | zeta-sarcoglycanzeta-SG | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q53T94 | Q96LD1 | |
Ensembl transtripts involved in fusion gene | ENST00000263663, ENST00000402170, ENST00000396242, | ENST00000382080, ENST00000421524, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 5 X 4 X 5=100 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TAF1B [Title/Abstract] AND SGCZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAF1B | GO:0001188 | RNA polymerase I transcriptional preinitiation complex assembly | 21921199 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | MESO | TCGA-TS-A8AY-01A | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000263663 | ENST00000382080 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
In-frame | ENST00000263663 | ENST00000421524 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
3UTR-3CDS | ENST00000402170 | ENST00000382080 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
3UTR-3CDS | ENST00000402170 | ENST00000421524 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
5UTR-3CDS | ENST00000396242 | ENST00000382080 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
5UTR-3CDS | ENST00000396242 | ENST00000421524 | TAF1B | chr2 | 9985447 | + | SGCZ | chr8 | 14412435 | - |
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FusionProtFeatures for TAF1B_SGCZ |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TAF1B | SGCZ |
Component of RNA polymerase I core factor complex thatacts as a GTF2B/TFIIB-like factor and plays a key role in multiplesteps during transcription initiation such as pre-initiationcomplex (PIC) assembly and postpolymerase recruitment events inpolymerase I (Pol I) transcription. Binds rDNA promoters and playsa role in Pol I recruitment as a component of the SL1/TIF-IBcomplex and, possibly, directly through its interaction with RRN3.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:21921198,ECO:0000269|PubMed:21921199, ECO:0000269|PubMed:7491500,ECO:0000269|PubMed:7801123, ECO:0000269|PubMed:7801130}. | Component of the sarcoglycan complex, a subcomplex ofthe dystrophin-glycoprotein complex which forms a link between theF-actin cytoskeleton and the extracellular matrix. May play a rolein the maintenance of striated muscle membrane stability (Bysimilarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 4_39 | 39 | 589 | Zinc finger | Note=RRN7-type |
Tgene | >SGCZ | chr2:9985447 | chr8:14412435 | ENST00000382080 | - | 0 | 8 | 252_263 | 13 | 313 | Compositional bias | Note=Poly-Ser |
Tgene | >SGCZ | chr2:9985447 | chr8:14412435 | ENST00000382080 | - | 0 | 8 | 59_299 | 13 | 313 | Topological domain | Extracellular |
Tgene | >SGCZ | chr2:9985447 | chr8:14412435 | ENST00000382080 | - | 0 | 8 | 38_58 | 13 | 313 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 262_372 | 39 | 589 | Region | Note=C-terminal cyclin fold |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 40_68 | 39 | 589 | Region | Note=B-reader |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 69_73 | 39 | 589 | Region | Note=B-linker |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000263663 | + | 2 | 15 | 74_261 | 39 | 589 | Region | Note=N-terminal cyclin fold |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 262_372 | -208 | 334 | Region | Note=C-terminal cyclin fold |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 40_68 | -208 | 334 | Region | Note=B-reader |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 69_73 | -208 | 334 | Region | Note=B-linker |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 74_261 | -208 | 334 | Region | Note=N-terminal cyclin fold |
Hgene | >TAF1B | chr2:9985447 | chr8:14412435 | ENST00000396242 | + | 2 | 15 | 4_39 | -208 | 334 | Zinc finger | Note=RRN7-type |
Tgene | SGCZ | chr2:9985447 | chr8:14412435 | ENST00000382080 | - | 0 | 8 | 1_37 | 13 | 313 | Topological domain | Cytoplasmic |
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FusionGeneSequence for TAF1B_SGCZ |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000382080_chr8_14412435_-_339aa MDLEEAEEFKERCTQCAAVSWGLTDEGKYYCTSCHNVTEMTREQYILATQQNNLPRTENAQLYPVGIYGWRKRCLYFFVLLLLVTMIVNL AMTIWILKVMNFTVDGMGNLRVTKKGIRLEGISEFLLPLYVKEIHSRKDSPLVLQSDRNVTVNARNHMGQLTGQLTIGADAVEAQCKRFE VRASEDGRVLFSADEDEITIGAEKLKVTGTEGAVFGHSVETPHIRAEPSQDLRLESPTRSLIMEAPRGVQVSAAAGDFKATCRKELHLQS >In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000421524_chr8_14412435_-_39aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000382080_chr8_14412435_-_1017nt ATGGACCTCGAGGAGGCGGAAGAGTTTAAAGAACGCTGTACTCAGTGTGCTGCTGTCTCATGGGGTCTTACTGATGAAGGCAAATATTAT TGCACTTCTTGCCACAATGTTACAGAGATGACACGAGAACAATACATACTAGCAACCCAACAGAATAACCTGCCAAGGACTGAGAATGCA CAACTTTACCCAGTGGGAATTTATGGATGGCGAAAGAGGTGCTTATACTTCTTTGTCCTTCTGCTGTTGGTTACCATGATAGTTAACTTA GCCATGACAATATGGATATTGAAAGTTATGAATTTCACTGTGGATGGTATGGGAAATCTGAGAGTCACCAAGAAGGGAATCCGACTTGAA GGTATATCTGAGTTTCTACTTCCATTGTATGTGAAAGAAATTCATTCTCGAAAGGATAGTCCGCTGGTCTTACAGTCTGACAGGAATGTC ACAGTGAATGCAAGAAATCACATGGGGCAGTTAACCGGACAGCTGACCATAGGAGCTGATGCTGTGGAAGCTCAGTGTAAAAGATTTGAA GTGAGAGCCAGTGAAGATGGCAGGGTGCTGTTTTCTGCAGATGAAGATGAGATTACCATTGGGGCTGAAAAGCTGAAAGTTACAGGCACT GAAGGAGCCGTATTTGGGCACTCTGTGGAGACGCCGCACATCAGAGCAGAGCCATCCCAAGATCTCAGGCTTGAATCACCCACCAGATCC TTGATCATGGAAGCTCCCCGTGGGGTCCAGGTGAGTGCTGCTGCAGGAGACTTCAAGGCCACCTGCAGGAAGGAGCTCCATCTGCAATCT ACAGAAGGGGAGATATTTTTAAATGCAGAGACAATCAAGCTGGGAAATCTACCAACTGGCTCCTTCTCATCTTCTTCACCCAGCTCCTCA AGTTCTCGACAGACAGTGTATGAACTCTGCGTCTGCCCCAATGGCAAACTTTACCTTTCTCCAGCAGGAGTAGGTTCCACTTGTCAGTCC >In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000421524_chr8_14412435_-_117nt ATGGACCTCGAGGAGGCGGAAGAGTTTAAAGAACGCTGTACTCAGTGTGCTGCTGTCTCATGGGGTCTTACTGATGAAGGCAAATATTAT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000382080_chr8_14412435_-_1784nt GTCCGCGAGGGGTCTGCGAGCTTTGCGGAGCCTCGCCCCCGAGCGCGCGGTTTCCCTGCCGCGCAGGCGCACGGAATCCTAGGCGCGGAT CTCGCGTTTCCGGCCGGAAGCTTCTCCAGCCTTTCCCGGAAGCTGCGCTCGCTACCCGGGTAACGGGTCCCGGCTGTGGAAGCTCCCGCG GCGCCGCGATGGACCTCGAGGAGGCGGAAGAGTTTAAAGAACGCTGTACTCAGTGTGCTGCTGTCTCATGGGGTCTTACTGATGAAGGCA AATATTATTGCACTTCTTGCCACAATGTTACAGAGATGACACGAGAACAATACATACTAGCAACCCAACAGAATAACCTGCCAAGGACTG AGAATGCACAACTTTACCCAGTGGGAATTTATGGATGGCGAAAGAGGTGCTTATACTTCTTTGTCCTTCTGCTGTTGGTTACCATGATAG TTAACTTAGCCATGACAATATGGATATTGAAAGTTATGAATTTCACTGTGGATGGTATGGGAAATCTGAGAGTCACCAAGAAGGGAATCC GACTTGAAGGTATATCTGAGTTTCTACTTCCATTGTATGTGAAAGAAATTCATTCTCGAAAGGATAGTCCGCTGGTCTTACAGTCTGACA GGAATGTCACAGTGAATGCAAGAAATCACATGGGGCAGTTAACCGGACAGCTGACCATAGGAGCTGATGCTGTGGAAGCTCAGTGTAAAA GATTTGAAGTGAGAGCCAGTGAAGATGGCAGGGTGCTGTTTTCTGCAGATGAAGATGAGATTACCATTGGGGCTGAAAAGCTGAAAGTTA CAGGCACTGAAGGAGCCGTATTTGGGCACTCTGTGGAGACGCCGCACATCAGAGCAGAGCCATCCCAAGATCTCAGGCTTGAATCACCCA CCAGATCCTTGATCATGGAAGCTCCCCGTGGGGTCCAGGTGAGTGCTGCTGCAGGAGACTTCAAGGCCACCTGCAGGAAGGAGCTCCATC TGCAATCTACAGAAGGGGAGATATTTTTAAATGCAGAGACAATCAAGCTGGGAAATCTACCAACTGGCTCCTTCTCATCTTCTTCACCCA GCTCCTCAAGTTCTCGACAGACAGTGTATGAACTCTGCGTCTGCCCCAATGGCAAACTTTACCTTTCTCCAGCAGGAGTAGGTTCCACTT GTCAGTCCAGTAGCAACATCTGCCTGTGGAGCTGAAGTGACTGATTTCTCCTCACACCAGAATAGCCTTTTGTTCCTGTCCGTCTGCTTC ACAGTTCTGCTCGGTTTCCCTTGTGATCAGTCCAGAGCTTCTTCGAATGGTCCACAGAGCAACTTCCAGTGTGAGCAGGGATTCGCCACC ACCTTCTCTTGTGATTTACTGTACTGCTCAACACAGAGGGTGTGATTGACACAGCAGTGGAAAAAGCGTCGTCAGCAGGAAAACTGGATC ATGACTTTTGCTCGAAAGGGAGAATAACATAGGTGCCTTTGCTACGCGAAGTGAAGCACACAGTTTTAGATTTTTGCAGGACCTGGATAT GAACTGCACATATATACATTACATAAATGAAATTCCCAGTATCCAATGGCAAGATGAAATGGTTAACCCTGTAAGAAAACTTATTCTACA TTCTGAAAGCACAATTTTCCATTCATCTTTTTGGATGTAAACTTTTATCCCCGACTTTTAAAATTTTAAAGCATTATGTAATGCTTGCTT >In-frame_TAF1B_ENST00000263663_chr2_9985447_+_SGCZ_ENST00000421524_chr8_14412435_-_1172nt GTCCGCGAGGGGTCTGCGAGCTTTGCGGAGCCTCGCCCCCGAGCGCGCGGTTTCCCTGCCGCGCAGGCGCACGGAATCCTAGGCGCGGAT CTCGCGTTTCCGGCCGGAAGCTTCTCCAGCCTTTCCCGGAAGCTGCGCTCGCTACCCGGGTAACGGGTCCCGGCTGTGGAAGCTCCCGCG GCGCCGCGATGGACCTCGAGGAGGCGGAAGAGTTTAAAGAACGCTGTACTCAGTGTGCTGCTGTCTCATGGGGTCTTACTGATGAAGGCA AATATTATTGCACTTCTTGCCACAATGTTACAGAGATGACACGAGAACAATACATACTAGCAACCCAACAGAATAACCTGCCAAGGACTG AGAATGCACAACTTTACCCAGTGGGAATTTATGGATGGCGAAAGAGGTGCTTATACTTCTTTGTCCTTCTGCTGTTGGTTACCATGATAG TTAACTTAGCCATGACAATATGGATATTGAAAGTTATGAATTTCACTGTGGATAGTCCGCTGGTCTTACAGTCTGACAGGAATGTCACAG TGAATGCAAGAAATCACATGGGGCAGTTAACCGGACAGCTGACCATAGGAGCTGATGCTGTGGAAGCTCAGTGTAAAAGATTTGAAGTGA GAGCCAGTGAAGATGGCAGGGTGCTGTTTTCTGCAGATGAAGATGAGATTACCATTGGGGCTGAAAAGCTGAAAGTTACAGGCACTGAAG GAGCCGTATTTGGGCACTCTGTGGAGACGCCGCACATCAGAGCAGAGCCATCCCAAGATCTCAGGCTTGAATCACCCACCAGATCCTTGA TCATGGAAGCTCCCCGTGGGGTCCAGGTGAGTGCTGCTGCAGGAGACTTCAAGGCCACCTGCAGGAAGGAGCTCCATCTGCAATCTACAG AAGGGGAGATATTTTTAAATGCAGAGACAATCAAGCTGGGAAATCTACCAACTGGCTCCTTCTCATCTTCTTCACCCAGCTCCTCAAGTT CTCGACAGACAGTGTATGAACTCTGCGTCTGCCCCAATGGCAAACTTTACCTTTCTCCAGCAGGAGTAGGTTCCACTTGTCAGTCCAGTA GCAACATCTGCCTGTGGAGCTGAAGTGACTGATTTCTCCTCACACCAGAATAGCCTTTTGTTCCTGTCCGTCTGCTTCACAGTTCTGCTC |
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FusionGenePPI for TAF1B_SGCZ |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAF1B | TBP, TAF1A, TAF1C, RRN3, TP53, UBTF, EP300, TAF1D, HIST2H2BE, HIST2H2AC, HIST2H3C, HIST2H4A, THAP7, ESR1, TRB, RXRA, PGR, HIST1H3A, HIST1H4A, HDAC1, NEDD4, NEDD4L, APP, HIST3H3, NAPB, SRPK1, KAT2B, EAF1, NIFK, MPP1, OAZ1, POLR1A, FERMT3, NAF1, BRCA1, TRIM44, ZNF2, RRP8, MECP2 | SGCZ | SGCB, HARS, REEP5, GK, ACACA, GNPTAB, RANGRF, ATP5F1, C4orf32, SP3, RTN4, DAGLB, ATP5B |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF1B_SGCZ |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF1B_SGCZ |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SGCZ | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |