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Fusion gene ID: 37082 |
FusionGeneSummary for TAF1A_RRP15 |
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Fusion gene information | Fusion gene name: TAF1A_RRP15 | Fusion gene ID: 37082 | Hgene | Tgene | Gene symbol | TAF1A | RRP15 | Gene ID | 9015 | 51018 |
Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit A | ribosomal RNA processing 15 homolog | |
Synonyms | MGC:17061|RAFI48|SL1|TAFI48 | CGI-115|KIAA0507 | |
Cytomap | 1q41 | 1q41 | |
Type of gene | protein-coding | protein-coding | |
Description | TATA box-binding protein-associated factor RNA polymerase I subunit ARNA polymerase I-specific TBP-associated factor 48 kDaSL1, 48kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDTATA box binding protein (TBP)-assoc | RRP15-like proteinribosomal RNA-processing protein 15 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q15573 | Q9Y3B9 | |
Ensembl transtripts involved in fusion gene | ENST00000366890, ENST00000350027, ENST00000352967, ENST00000391882, ENST00000543857, ENST00000465263, | ENST00000366932, ENST00000491428, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 2 X 3=24 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TAF1A [Title/Abstract] AND RRP15 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A7EI-01A | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000366890 | ENST00000366932 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-intron | ENST00000366890 | ENST00000491428 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-3CDS | ENST00000350027 | ENST00000366932 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-intron | ENST00000350027 | ENST00000491428 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-3CDS | ENST00000352967 | ENST00000366932 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-intron | ENST00000352967 | ENST00000491428 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-3CDS | ENST00000391882 | ENST00000366932 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-intron | ENST00000391882 | ENST00000491428 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-3CDS | ENST00000543857 | ENST00000366932 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-intron | ENST00000543857 | ENST00000491428 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-3CDS | ENST00000465263 | ENST00000366932 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
5UTR-intron | ENST00000465263 | ENST00000491428 | TAF1A | chr1 | 222763069 | - | RRP15 | chr1 | 218504290 | + |
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FusionProtFeatures for TAF1A_RRP15 |
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Hgene | Tgene |
TAF1A | RRP15 |
Component of the transcription factor SL1/TIF-IBcomplex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependenttranscription. The rate of PIC formation probably is primarilydependent on the rate of association of SL1/TIF-IB with the rDNApromoter. SL1/TIF-IB is involved in stabilization of nucleolartranscription factor 1/UBTF on rDNA. Formation of SL1/TIF-IBexcludes the association of TBP with TFIID subunits.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:7801123}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF1A_RRP15 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAF1A_RRP15 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAF1A | TBP, TAF1B, TAF1C, RRN3, TP53, UBTF, SET, ANP32A, HIST4H4, HIST3H3, TAF1D, ESR1, HIST2H2AC, HIST1H4A, HIST1H3A, HIST2H2BE, TAF12, JMJD6, C11orf57, RPL14, EAF1, NIFK, VWA9, NAF1, TRIM44, RBM34, ZNF512, RPL37A, MECP2, RPL30 | RRP15 | EIF6, TAF1D, USP2, SART3, CUL3, COPS5, APP, CLN8, SRPK3, CUL7, OBSL1, DDX27, DDX54, NIFK, PAK1IP1, RBM28, RPF2, DDX18, MRTO4, RRS1, UTP11L, EWSR1, HNRNPU, RPL10, SYNCRIP, NOP56, SGTB, PPAN, WDR46, FOXA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF1A_RRP15 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF1A_RRP15 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |