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Fusion gene ID: 37078 |
FusionGeneSummary for TAF15_PARM1 |
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Fusion gene information | Fusion gene name: TAF15_PARM1 | Fusion gene ID: 37078 | Hgene | Tgene | Gene symbol | TAF15 | PARM1 | Gene ID | 8148 | 25849 |
Gene name | TATA-box binding protein associated factor 15 | prostate androgen-regulated mucin-like protein 1 | |
Synonyms | Npl3|RBP56|TAF2N|TAFII68 | Cipar1|DKFZP564O0823|PARM-1|WSC4 | |
Cytomap | 17q12 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | TATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-bin | prostate androgen-regulated mucin-like protein 1WSC4, cell wall integrity and stress response component 4 homologcastration-induced prostatic apoptosis-related protein 1prostatic androgen-regulated mucin-like protein 1prostatic androgen-repressed mess | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | Q92804 | Q6UWI2 | |
Ensembl transtripts involved in fusion gene | ENST00000588240, ENST00000592237, ENST00000311979, | ENST00000513238, ENST00000307428, | |
Fusion gene scores | * DoF score | 9 X 7 X 4=252 | 4 X 4 X 2=32 |
# samples | 15 | 7 | |
** MAII score | log2(15/252*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/32*10)=1.12928301694497 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TAF15 [Title/Abstract] AND PARM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AV752989 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + | ||
ChiTaRS3.1 | AV752143 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + | ||
ChiTaRS3.1 | AV752672 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + | ||
ChiTaRS3.1 | AV752590 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000588240 | ENST00000513238 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + |
5CDS-intron | ENST00000588240 | ENST00000307428 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + |
5CDS-intron | ENST00000592237 | ENST00000513238 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + |
5CDS-intron | ENST00000592237 | ENST00000307428 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + |
5CDS-intron | ENST00000311979 | ENST00000513238 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + |
5CDS-intron | ENST00000311979 | ENST00000307428 | TAF15 | chr17 | 34171548 | + | PARM1 | chr4 | 75937702 | + |
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FusionProtFeatures for TAF15_PARM1 |
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Hgene | Tgene |
TAF15 | PARM1 |
RNA and ssDNA-binding protein that may play specificroles during transcription initiation at distinct promoters. Canenter the preinitiation complex together with the RNA polymeraseII (Pol II). {ECO:0000269|PubMed:19124016}. | May regulate TLP1 expression and telomerase activity,thus enabling certain prostatic cells to resist apoptosis.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF15_PARM1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAF15_PARM1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF15_PARM1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF15_PARM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TAF15 | C0029463 | Osteosarcoma | 1 | CTD_human |
Hgene | TAF15 | C0038356 | Stomach Neoplasms | 1 | CTD_human |