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Fusion gene ID: 37070 |
FusionGeneSummary for TAF12_TPRG1 |
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Fusion gene information | Fusion gene name: TAF12_TPRG1 | Fusion gene ID: 37070 | Hgene | Tgene | Gene symbol | TAF12 | TPRG1 | Gene ID | 6883 | 285386 |
Gene name | TATA-box binding protein associated factor 12 | tumor protein p63 regulated 1 | |
Synonyms | TAF2J|TAFII20 | FAM79B | |
Cytomap | 1p35.3 | 3q28 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription initiation factor TFIID subunit 12TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDaTAFII-20/TAFII-15TAFII20/TAFII15TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kDtranscription | tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B | |
Modification date | 20180523 | 20180403 | |
UniProtAcc | Q16514 | Q6ZUI0 | |
Ensembl transtripts involved in fusion gene | ENST00000373824, ENST00000263974, ENST00000471683, | ENST00000433971, ENST00000345063, ENST00000488841, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 12 X 6 X 6=432 |
# samples | 3 | 13 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TAF12 [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAF12 | GO:0006352 | DNA-templated transcription, initiation | 9603525 |
Hgene | TAF12 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 9603525 |
Hgene | TAF12 | GO:0043966 | histone H3 acetylation | 11564863 |
Hgene | TAF12 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 15735663 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-98-A53A-01A | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000373824 | ENST00000433971 | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000373824 | ENST00000345063 | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
5CDS-intron | ENST00000373824 | ENST00000488841 | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000263974 | ENST00000433971 | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000263974 | ENST00000345063 | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
5CDS-intron | ENST00000263974 | ENST00000488841 | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
5UTR-3CDS | ENST00000471683 | ENST00000433971 | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
5UTR-3CDS | ENST00000471683 | ENST00000345063 | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
5UTR-intron | ENST00000471683 | ENST00000488841 | TAF12 | chr1 | 28944465 | - | TPRG1 | chr3 | 189028175 | + |
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FusionProtFeatures for TAF12_TPRG1 |
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Hgene | Tgene |
TAF12 | TPRG1 |
TAFs are components of the transcription factor IID(TFIID) complex, PCAF histone acetylase complex and TBP-free TAFIIcomplex (TFTC). TAFs components-TIIFD are essential for mediatingregulation of RNA polymerase transcription. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAF12_TPRG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAF12_TPRG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAF12 | TAF4, TAF5, SUPT3H, TAF9, ATXN7, TAF6, TBP, ATF7, NFYB, NFYC, NFYA, TAF1A, TAF1C, TAF3, CPSF1, TAF10, ELAVL1, ERCC1, HIST3H3, KAT2B, TAF4B, UBE2I, PRKAR2B, CCDC101, TAF8, TADA1, PNKD, TADA2B, ATXN7L3, TADA3, MYC, FGFR1OP, XPO1, KIF22, RAB5A, TSNAX, ZWINT, KIF21B, CDKN2AIPNL, TAF7L, TAF6L, VASN, RFC4, TAF11, TAF7 | TPRG1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAF12_TPRG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAF12_TPRG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |