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Fusion gene ID: 37051 |
FusionGeneSummary for TACR1_TACR1 |
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Fusion gene information | Fusion gene name: TACR1_TACR1 | Fusion gene ID: 37051 | Hgene | Tgene | Gene symbol | TACR1 | TACR1 | Gene ID | 6869 | 6869 |
Gene name | tachykinin receptor 1 | tachykinin receptor 1 | |
Synonyms | NK1R|NKIR|SPR|TAC1R | NK1R|NKIR|SPR|TAC1R | |
Cytomap | 2p12 | 2p12 | |
Type of gene | protein-coding | protein-coding | |
Description | substance-P receptorNK-1 receptorNK-1Rtachykinin receptor 1 (substance P receptor; neurokinin-1 receptor) | substance-P receptorNK-1 receptorNK-1Rtachykinin receptor 1 (substance P receptor; neurokinin-1 receptor) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P25103 | P25103 | |
Ensembl transtripts involved in fusion gene | ENST00000305249, ENST00000409848, ENST00000497764, | ENST00000305249, ENST00000409848, ENST00000497764, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TACR1 [Title/Abstract] AND TACR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TACR1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 12716968 |
Hgene | TACR1 | GO:0007217 | tachykinin receptor signaling pathway | 17986524 |
Tgene | TACR1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 12716968 |
Tgene | TACR1 | GO:0007217 | tachykinin receptor signaling pathway | 17986524 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | W28380 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000305249 | ENST00000305249 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
intron-intron | ENST00000305249 | ENST00000409848 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
intron-intron | ENST00000305249 | ENST00000497764 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
intron-intron | ENST00000409848 | ENST00000305249 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
intron-intron | ENST00000409848 | ENST00000409848 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
intron-intron | ENST00000409848 | ENST00000497764 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
intron-intron | ENST00000497764 | ENST00000305249 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
intron-intron | ENST00000497764 | ENST00000409848 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
intron-intron | ENST00000497764 | ENST00000497764 | TACR1 | chr2 | 75382550 | - | TACR1 | chr2 | 75382163 | + |
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FusionProtFeatures for TACR1_TACR1 |
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Hgene | Tgene |
TACR1 | TACR1 |
This is a receptor for the tachykinin neuropeptidesubstance P. It is probably associated with G proteins thatactivate a phosphatidylinositol-calcium second messenger system.The rank order of affinity of this receptor to tachykinins is:substance P > substance K > neuromedin-K. | This is a receptor for the tachykinin neuropeptidesubstance P. It is probably associated with G proteins thatactivate a phosphatidylinositol-calcium second messenger system.The rank order of affinity of this receptor to tachykinins is:substance P > substance K > neuromedin-K. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TACR1_TACR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TACR1_TACR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TACR1_TACR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | TACR1 | P25103 | DB00673 | Aprepitant | Substance-P receptor | small molecule | approved|investigational |
Hgene | TACR1 | P25103 | DB04894 | Vapreotide | Substance-P receptor | small molecule | approved|investigational |
Hgene | TACR1 | P25103 | DB01221 | Ketamine | Substance-P receptor | small molecule | approved|vet_approved |
Tgene | TACR1 | P25103 | DB00673 | Aprepitant | Substance-P receptor | small molecule | approved|investigational |
Tgene | TACR1 | P25103 | DB04894 | Vapreotide | Substance-P receptor | small molecule | approved|investigational |
Tgene | TACR1 | P25103 | DB01221 | Ketamine | Substance-P receptor | small molecule | approved|vet_approved |
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RelatedDiseases for TACR1_TACR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TACR1 | C0001973 | Alcoholic Intoxication, Chronic | 5 | CTD_human;PSYGENET |
Hgene | TACR1 | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | TACR1 | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | TACR1 | C0525045 | Mood Disorders | 5 | PSYGENET |
Hgene | TACR1 | C0005586 | Bipolar Disorder | 3 | CTD_human;PSYGENET |
Hgene | TACR1 | C0020429 | Hyperalgesia | 2 | CTD_human |
Hgene | TACR1 | C0600467 | Neurogenic Inflammation | 2 | CTD_human |
Hgene | TACR1 | C0006261 | Bronchial Diseases | 1 | CTD_human |
Hgene | TACR1 | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | TACR1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | TACR1 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Hgene | TACR1 | C0042963 | Vomiting | 1 | CTD_human |
Hgene | TACR1 | C0428977 | Bradycardia | 1 | CTD_human |
Hgene | TACR1 | C1263846 | Attention deficit hyperactivity disorder | 1 | CTD_human |
Tgene | TACR1 | C0001973 | Alcoholic Intoxication, Chronic | 5 | CTD_human;PSYGENET |
Tgene | TACR1 | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | TACR1 | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | TACR1 | C0525045 | Mood Disorders | 5 | PSYGENET |
Tgene | TACR1 | C0005586 | Bipolar Disorder | 3 | CTD_human;PSYGENET |
Tgene | TACR1 | C0020429 | Hyperalgesia | 2 | CTD_human |
Tgene | TACR1 | C0600467 | Neurogenic Inflammation | 2 | CTD_human |
Tgene | TACR1 | C0006261 | Bronchial Diseases | 1 | CTD_human |
Tgene | TACR1 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | TACR1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | TACR1 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Tgene | TACR1 | C0042963 | Vomiting | 1 | CTD_human |
Tgene | TACR1 | C0428977 | Bradycardia | 1 | CTD_human |
Tgene | TACR1 | C1263846 | Attention deficit hyperactivity disorder | 1 | CTD_human |