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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37027

FusionGeneSummary for TAB2_SLC9B2

check button Fusion gene summary
Fusion gene informationFusion gene name: TAB2_SLC9B2
Fusion gene ID: 37027
HgeneTgene
Gene symbol

TAB2

SLC9B2

Gene ID

23118

133308

Gene nameTGF-beta activated kinase 1 (MAP3K7) binding protein 2solute carrier family 9 member B2
SynonymsCHTD2|MAP3K7IP2|TAB-2NHA2|NHE10|NHEDC2
Cytomap

6q25.1

4q24

Type of geneprotein-codingprotein-coding
DescriptionTGF-beta-activated kinase 1 and MAP3K7-binding protein 2TAK1-binding protein 2mitogen-activated protein kinase kinase kinase 7-interacting protein 2sodium/hydrogen exchanger 9B2NHE domain-containing protein 2Na(+)/H(+) exchanger NHA2Na(+)/H(+) exchanger-like domain-containing protein 2Na+/H+ exchanger domain containing 2mitochondrial Na(+)/H(+) exchanger NHA2mitochondrial sodium/hydrogen exchan
Modification date2018052220180523
UniProtAcc

Q9NYJ8

Q86UD5

Ensembl transtripts involved in fusion geneENST00000536230, ENST00000392282, 
ENST00000538427, ENST00000367456, 
ENST00000461481, ENST00000286332, 
ENST00000362026, ENST00000339611, 
ENST00000394785, ENST00000503103, 
ENST00000503230, ENST00000505838, 
Fusion gene scores* DoF score11 X 9 X 5=4952 X 2 X 2=8
# samples 102
** MAII scorelog2(10/495*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TAB2 [Title/Abstract] AND SLC9B2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAB2

GO:0045860

positive regulation of protein kinase activity

11460167

TgeneSLC9B2

GO:0006814

sodium ion transport

18508966


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF814363TAB2chr6

149732229

-SLC9B2chr4

103946729

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000536230ENST00000362026TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000536230ENST00000339611TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-3UTRENST00000536230ENST00000394785TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000536230ENST00000503103TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000536230ENST00000503230TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000536230ENST00000505838TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000392282ENST00000362026TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000392282ENST00000339611TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-3UTRENST00000392282ENST00000394785TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000392282ENST00000503103TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000392282ENST00000503230TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000392282ENST00000505838TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000538427ENST00000362026TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000538427ENST00000339611TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-3UTRENST00000538427ENST00000394785TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000538427ENST00000503103TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000538427ENST00000503230TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000538427ENST00000505838TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000367456ENST00000362026TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000367456ENST00000339611TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-3UTRENST00000367456ENST00000394785TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000367456ENST00000503103TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000367456ENST00000503230TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000367456ENST00000505838TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000461481ENST00000362026TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000461481ENST00000339611TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-3UTRENST00000461481ENST00000394785TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000461481ENST00000503103TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000461481ENST00000503230TAB2chr6

149732229

-SLC9B2chr4

103946729

+
intron-intronENST00000461481ENST00000505838TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000286332ENST00000362026TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000286332ENST00000339611TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-3UTRENST00000286332ENST00000394785TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000286332ENST00000503103TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000286332ENST00000503230TAB2chr6

149732229

-SLC9B2chr4

103946729

+
3UTR-intronENST00000286332ENST00000505838TAB2chr6

149732229

-SLC9B2chr4

103946729

+

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FusionProtFeatures for TAB2_SLC9B2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAB2

Q9NYJ8

SLC9B2

Q86UD5

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylationof MAP3K7 at 'Thr-187'. Involved in heart development.{ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167,ECO:0000269|PubMed:20493459}. Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) inexchange for external protons across the membrane(PubMed:18000046, PubMed:28154142, PubMed:22948142,PubMed:18508966). Contributes to the regulation of intracellularpH, sodium homeostasis, and cell volume. Plays an important rolefor insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility(By similarity). It is controversial whether SLC9B2 plays a rolein osteoclast differentiation or not (By similarity).{ECO:0000250|UniProtKB:Q5BKR2, ECO:0000269|PubMed:18000046,ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:22948142,ECO:0000269|PubMed:28154142}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAB2_SLC9B2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAB2_SLC9B2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAB2_SLC9B2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAB2_SLC9B2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAB2C3554279CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 21UNIPROT