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Fusion gene ID: 37020 |
FusionGeneSummary for TAB2_CCNG2 |
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Fusion gene information | Fusion gene name: TAB2_CCNG2 | Fusion gene ID: 37020 | Hgene | Tgene | Gene symbol | TAB2 | CCNG2 | Gene ID | 23118 | 901 |
Gene name | TGF-beta activated kinase 1 (MAP3K7) binding protein 2 | cyclin G2 | |
Synonyms | CHTD2|MAP3K7IP2|TAB-2 | - | |
Cytomap | 6q25.1 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2TAK1-binding protein 2mitogen-activated protein kinase kinase kinase 7-interacting protein 2 | cyclin-G2 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9NYJ8 | Q16589 | |
Ensembl transtripts involved in fusion gene | ENST00000536230, ENST00000392282, ENST00000538427, ENST00000367456, ENST00000461481, ENST00000286332, | ENST00000497512, ENST00000316355, ENST00000354403, ENST00000502280, ENST00000395640, ENST00000509972, | |
Fusion gene scores | * DoF score | 11 X 9 X 5=495 | 3 X 2 X 2=12 |
# samples | 10 | 3 | |
** MAII score | log2(10/495*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TAB2 [Title/Abstract] AND CCNG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TAB2 | GO:0045860 | positive regulation of protein kinase activity | 11460167 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-86-8056-01A | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000536230 | ENST00000497512 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000536230 | ENST00000316355 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000536230 | ENST00000354403 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000536230 | ENST00000502280 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000536230 | ENST00000395640 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000536230 | ENST00000509972 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
5UTR-3UTR | ENST00000392282 | ENST00000497512 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
5UTR-3UTR | ENST00000392282 | ENST00000316355 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
5UTR-3UTR | ENST00000392282 | ENST00000354403 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
5UTR-3UTR | ENST00000392282 | ENST00000502280 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
5UTR-3UTR | ENST00000392282 | ENST00000395640 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
5UTR-3UTR | ENST00000392282 | ENST00000509972 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000538427 | ENST00000497512 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000538427 | ENST00000316355 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000538427 | ENST00000354403 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000538427 | ENST00000502280 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000538427 | ENST00000395640 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000538427 | ENST00000509972 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000367456 | ENST00000497512 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000367456 | ENST00000316355 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000367456 | ENST00000354403 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000367456 | ENST00000502280 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000367456 | ENST00000395640 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000367456 | ENST00000509972 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000461481 | ENST00000497512 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000461481 | ENST00000316355 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000461481 | ENST00000354403 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000461481 | ENST00000502280 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000461481 | ENST00000395640 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000461481 | ENST00000509972 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000286332 | ENST00000497512 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000286332 | ENST00000316355 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000286332 | ENST00000354403 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000286332 | ENST00000502280 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000286332 | ENST00000395640 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
intron-3UTR | ENST00000286332 | ENST00000509972 | TAB2 | chr6 | 149639151 | + | CCNG2 | chr4 | 78079686 | + |
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FusionProtFeatures for TAB2_CCNG2 |
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Hgene | Tgene |
TAB2 | CCNG2 |
Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylationof MAP3K7 at 'Thr-187'. Involved in heart development.{ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167,ECO:0000269|PubMed:20493459}. | May play a role in growth regulation and in negativeregulation of cell cycle progression. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TAB2_CCNG2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TAB2_CCNG2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TAB2 | CS, TAB1, MAP3K7, TAB3, TAB2, TRAF6, NCOR1, HDAC3, HDAC1, HDAC5, TBL1X, NFKB1, TNFRSF11A, XIAP, TRAF2, NUMBL, RIPK1, IRAK1, TNF, UBC, RIPK2, PPP6C, TRAF3IP1, TIRAP, CHUK, BNIP3P6, TLR3, ERBB4, BECN1, ESR1, RBCK1, TANK, PDLIM7, NR2C2, IKBKG, SMAD7, EDARADD, MAP3K8, NLK, TRIM5, ATG5, ATG13, TGFBR1, AR, TBL1XR1, MBD3, SIN3A, APP, WDR34, BST2, MALT1, HSP90AA1, IKBKB, NPM1, TRIM22, ZBTB16, CST9L, TGM2, VIM, FN1, GTF2I, PPP2CB, YWHAZ, FOSL1, SLC19A3, SIK1, SIK3, TRIM38, UBE2I, PIAS3, RFPL4B, CARD8, C9orf41, CNTROB, XPO1, DBN1, ARRB2, LITAF, MCM2, RNF4, F2R, MAPK14, USP18, CTDSP1, EMILIN1, SCRN1, CCDC102B, MANSC1, IL17RC, CYLD, TNIK | CCNG2 | PPP2R5B, PPP2R5C, PPP2CA, SKP1, SKP2, NRIP2, FAM208B, EFHC2, PPP2R5D, NME2, PPP2R5E |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TAB2_CCNG2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAB2_CCNG2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TAB2 | C3554279 | CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 2 | 1 | UNIPROT |