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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37020

FusionGeneSummary for TAB2_CCNG2

check button Fusion gene summary
Fusion gene informationFusion gene name: TAB2_CCNG2
Fusion gene ID: 37020
HgeneTgene
Gene symbol

TAB2

CCNG2

Gene ID

23118

901

Gene nameTGF-beta activated kinase 1 (MAP3K7) binding protein 2cyclin G2
SynonymsCHTD2|MAP3K7IP2|TAB-2-
Cytomap

6q25.1

4q21.1

Type of geneprotein-codingprotein-coding
DescriptionTGF-beta-activated kinase 1 and MAP3K7-binding protein 2TAK1-binding protein 2mitogen-activated protein kinase kinase kinase 7-interacting protein 2cyclin-G2
Modification date2018052220180523
UniProtAcc

Q9NYJ8

Q16589

Ensembl transtripts involved in fusion geneENST00000536230, ENST00000392282, 
ENST00000538427, ENST00000367456, 
ENST00000461481, ENST00000286332, 
ENST00000497512, ENST00000316355, 
ENST00000354403, ENST00000502280, 
ENST00000395640, ENST00000509972, 
Fusion gene scores* DoF score11 X 9 X 5=4953 X 2 X 2=12
# samples 103
** MAII scorelog2(10/495*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TAB2 [Title/Abstract] AND CCNG2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAB2

GO:0045860

positive regulation of protein kinase activity

11460167


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-86-8056-01ATAB2chr6

149639151

+CCNG2chr4

78079686

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000536230ENST00000497512TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000536230ENST00000316355TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000536230ENST00000354403TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000536230ENST00000502280TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000536230ENST00000395640TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000536230ENST00000509972TAB2chr6

149639151

+CCNG2chr4

78079686

+
5UTR-3UTRENST00000392282ENST00000497512TAB2chr6

149639151

+CCNG2chr4

78079686

+
5UTR-3UTRENST00000392282ENST00000316355TAB2chr6

149639151

+CCNG2chr4

78079686

+
5UTR-3UTRENST00000392282ENST00000354403TAB2chr6

149639151

+CCNG2chr4

78079686

+
5UTR-3UTRENST00000392282ENST00000502280TAB2chr6

149639151

+CCNG2chr4

78079686

+
5UTR-3UTRENST00000392282ENST00000395640TAB2chr6

149639151

+CCNG2chr4

78079686

+
5UTR-3UTRENST00000392282ENST00000509972TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000538427ENST00000497512TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000538427ENST00000316355TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000538427ENST00000354403TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000538427ENST00000502280TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000538427ENST00000395640TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000538427ENST00000509972TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000367456ENST00000497512TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000367456ENST00000316355TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000367456ENST00000354403TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000367456ENST00000502280TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000367456ENST00000395640TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000367456ENST00000509972TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000461481ENST00000497512TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000461481ENST00000316355TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000461481ENST00000354403TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000461481ENST00000502280TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000461481ENST00000395640TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000461481ENST00000509972TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000286332ENST00000497512TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000286332ENST00000316355TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000286332ENST00000354403TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000286332ENST00000502280TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000286332ENST00000395640TAB2chr6

149639151

+CCNG2chr4

78079686

+
intron-3UTRENST00000286332ENST00000509972TAB2chr6

149639151

+CCNG2chr4

78079686

+

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FusionProtFeatures for TAB2_CCNG2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAB2

Q9NYJ8

CCNG2

Q16589

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylationof MAP3K7 at 'Thr-187'. Involved in heart development.{ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167,ECO:0000269|PubMed:20493459}. May play a role in growth regulation and in negativeregulation of cell cycle progression.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAB2_CCNG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAB2_CCNG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TAB2CS, TAB1, MAP3K7, TAB3, TAB2, TRAF6, NCOR1, HDAC3, HDAC1, HDAC5, TBL1X, NFKB1, TNFRSF11A, XIAP, TRAF2, NUMBL, RIPK1, IRAK1, TNF, UBC, RIPK2, PPP6C, TRAF3IP1, TIRAP, CHUK, BNIP3P6, TLR3, ERBB4, BECN1, ESR1, RBCK1, TANK, PDLIM7, NR2C2, IKBKG, SMAD7, EDARADD, MAP3K8, NLK, TRIM5, ATG5, ATG13, TGFBR1, AR, TBL1XR1, MBD3, SIN3A, APP, WDR34, BST2, MALT1, HSP90AA1, IKBKB, NPM1, TRIM22, ZBTB16, CST9L, TGM2, VIM, FN1, GTF2I, PPP2CB, YWHAZ, FOSL1, SLC19A3, SIK1, SIK3, TRIM38, UBE2I, PIAS3, RFPL4B, CARD8, C9orf41, CNTROB, XPO1, DBN1, ARRB2, LITAF, MCM2, RNF4, F2R, MAPK14, USP18, CTDSP1, EMILIN1, SCRN1, CCDC102B, MANSC1, IL17RC, CYLD, TNIKCCNG2PPP2R5B, PPP2R5C, PPP2CA, SKP1, SKP2, NRIP2, FAM208B, EFHC2, PPP2R5D, NME2, PPP2R5E


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAB2_CCNG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAB2_CCNG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAB2C3554279CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 21UNIPROT