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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37017

FusionGeneSummary for TAB1_PHF21B

check button Fusion gene summary
Fusion gene informationFusion gene name: TAB1_PHF21B
Fusion gene ID: 37017
HgeneTgene
Gene symbol

TAB1

PHF21B

Gene ID

10454

112885

Gene nameTGF-beta activated kinase 1 (MAP3K7) binding protein 1PHD finger protein 21B
Synonyms3'-Tab1|MAP3K7IP1BHC80L|PHF4
Cytomap

22q13.1

22q13.31

Type of geneprotein-codingprotein-coding
DescriptionTGF-beta-activated kinase 1 and MAP3K7-binding protein 1TAK1-binding protein 1mitogen-activated protein kinase kinase kinase 7-interacting protein 1transforming growth factor beta-activated kinase-binding protein 1PHD finger protein 21BPHD finger protein 4
Modification date2018052220180519
UniProtAcc

Q15750

Q96EK2

Ensembl transtripts involved in fusion geneENST00000216160, ENST00000331454, 
ENST00000488859, 		ENST00000403565, 
ENST00000313237, ENST00000396103, 
ENST00000404079, ENST00000447824, 
ENST00000462631, 
Fusion gene scores* DoF score5 X 4 X 5=1002 X 2 X 1=4
# samples 52
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: TAB1 [Title/Abstract] AND PHF21B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A19C-06ATAB1chr22

39813854

+PHF21Bchr22

45281818

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000216160ENST00000403565TAB1chr22

39813854

+PHF21Bchr22

45281818

-
Frame-shiftENST00000216160ENST00000313237TAB1chr22

39813854

+PHF21Bchr22

45281818

-
Frame-shiftENST00000216160ENST00000396103TAB1chr22

39813854

+PHF21Bchr22

45281818

-
Frame-shiftENST00000216160ENST00000404079TAB1chr22

39813854

+PHF21Bchr22

45281818

-
5CDS-intronENST00000216160ENST00000447824TAB1chr22

39813854

+PHF21Bchr22

45281818

-
5CDS-intronENST00000216160ENST00000462631TAB1chr22

39813854

+PHF21Bchr22

45281818

-
Frame-shiftENST00000331454ENST00000403565TAB1chr22

39813854

+PHF21Bchr22

45281818

-
Frame-shiftENST00000331454ENST00000313237TAB1chr22

39813854

+PHF21Bchr22

45281818

-
Frame-shiftENST00000331454ENST00000396103TAB1chr22

39813854

+PHF21Bchr22

45281818

-
Frame-shiftENST00000331454ENST00000404079TAB1chr22

39813854

+PHF21Bchr22

45281818

-
5CDS-intronENST00000331454ENST00000447824TAB1chr22

39813854

+PHF21Bchr22

45281818

-
5CDS-intronENST00000331454ENST00000462631TAB1chr22

39813854

+PHF21Bchr22

45281818

-
intron-3CDSENST00000488859ENST00000403565TAB1chr22

39813854

+PHF21Bchr22

45281818

-
intron-3CDSENST00000488859ENST00000313237TAB1chr22

39813854

+PHF21Bchr22

45281818

-
intron-3CDSENST00000488859ENST00000396103TAB1chr22

39813854

+PHF21Bchr22

45281818

-
intron-3CDSENST00000488859ENST00000404079TAB1chr22

39813854

+PHF21Bchr22

45281818

-
intron-intronENST00000488859ENST00000447824TAB1chr22

39813854

+PHF21Bchr22

45281818

-
intron-intronENST00000488859ENST00000462631TAB1chr22

39813854

+PHF21Bchr22

45281818

-

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FusionProtFeatures for TAB1_PHF21B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TAB1

Q15750

PHF21B

Q96EK2

May be an important signaling intermediate between TGFBreceptors and MAP3K7/TAK1. May play an important role in mammalianembryogenesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TAB1_PHF21B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TAB1_PHF21B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TAB1TAB2, TRAF2, MAP3K7, TAB3, SMAD7, XIAP, SMAD6, MAPK14, ZMYND11, TRAF6, TNF, AGO3, RIPK2, MORF4L1, MORF4L2, MTG2, PHACTR3, C9orf78, CARD11, PDCD6IP, CASP6, PPP1R7, GIT1, XPO7, NXPH3, URB1, PHC2, POLR3D, RPL10, ACAP3, SERPINA4, CKB, CFL1, DBN1, MICAL1, KIFC2, MON1A, LAP3, ASRGL1, RBX1, MAPKAPK5, POLDIP2, FADD, LCMT1, PTPMT1, EPRS, C2orf44, HNRNPR, ARAP1, RPLP1, SNRNP35, TSSC4, TRPC4AP, PRKAR1A, ARRB2, NR2C2, OGT, GRK5, EGFR, IKBKB, NOTCH1, BST2, HSP90AA1, MAPK12, MAPK8IP1, GRB2, BIRC3, NPM1, TRIP6, CDK5RAP3, WTAP, PPP2CB, PPP2R1A, FN1, CORO1A, SLMAP, MDM2, TIRAP, BAG2, MAGED1, NAIP, BIRC7, SHMT2, MOV10, NXF1, IKBKG, MAP3K1, C11orf70, MAMDC2, RFPL4B, CARD8, PRMT2, C9orf41, TMEM52B, SSX2IP, CNTROB, XPO1, HSPA1L, MAPK11, ITCH, ALKBH3, MCM2, USP18, F2R, SMURF1, MTMR8, EMILIN1, SYNC, AARSD1, SERPINB2, SCRN1, CCDC102B, MANSC1, PCDH20, TBL1Y, HSPA8, CYB5A, GANAB, HSPBP1, TH, PCDHGB4, PSMC3, KLHL10, CCL22, C6orf141, CRYBB3, UBC, AATK, ERBB4, ROR2, CYLD, PARK7, SOD1PHF21BHDAC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TAB1_PHF21B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TAB1_PHF21B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAB1C0032460Polycystic Ovary Syndrome1CTD_human