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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37012

FusionGeneSummary for SZT2_PLAGL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SZT2_PLAGL1
Fusion gene ID: 37012
HgeneTgene
Gene symbol

SZT2

PLAGL1

Gene ID

23334

5325

Gene nameSZT2, KICSTOR complex subunitPLAG1 like zinc finger 1
SynonymsC1orf84|EIEE18|KIAA0467|SZT2A|SZT2BLOT1|ZAC|ZAC1
Cytomap

1p34.2

6q24.2

Type of geneprotein-codingprotein-coding
DescriptionKICSTOR complex protein SZT2protein SZT2seizure threshold 2 homologseizure threshold 2 protein homologzinc finger protein PLAGL1PLAG-like 1lost on transformation 1pleiomorphic adenoma gene-like 1tumor suppressor ZAC
Modification date2018052320180523
UniProtAcc

Q5T011

Q9UM63

Ensembl transtripts involved in fusion geneENST00000562955, ENST00000372442, 
ENST00000310739, ENST00000372450, 
ENST00000471177, 		ENST00000429150, 
ENST00000416623, ENST00000392309, 
ENST00000392307, ENST00000437412, 
ENST00000444202, ENST00000493898, 
ENST00000360537, ENST00000354765, 
ENST00000367572, ENST00000367571, 
Fusion gene scores* DoF score5 X 6 X 2=606 X 4 X 4=96
# samples 66
** MAII scorelog2(6/60*10)=0log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SZT2 [Title/Abstract] AND PLAGL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLAGL1

GO:0045944

positive regulation of transcription by RNA polymerase II

9671765|15888726


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N76235SZT2chr1

43897466

+PLAGL1chr6

144324493

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000562955ENST00000429150SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000416623SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000392309SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000392307SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000437412SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000444202SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000493898SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000360537SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000354765SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000367572SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000562955ENST00000367571SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000429150SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000416623SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000392309SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000392307SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000437412SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000444202SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000493898SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000360537SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000354765SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000367572SZT2chr1

43897466

+PLAGL1chr6

144324493

-
5CDS-intronENST00000372442ENST00000367571SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000429150SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000416623SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000392309SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000392307SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000437412SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000444202SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000493898SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000360537SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000354765SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000367572SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000310739ENST00000367571SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000429150SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000416623SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000392309SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000392307SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000437412SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000444202SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000493898SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000360537SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000354765SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000367572SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000372450ENST00000367571SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000429150SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000416623SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000392309SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000392307SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000437412SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000444202SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000493898SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000360537SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000354765SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000367572SZT2chr1

43897466

+PLAGL1chr6

144324493

-
intron-intronENST00000471177ENST00000367571SZT2chr1

43897466

+PLAGL1chr6

144324493

-

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FusionProtFeatures for SZT2_PLAGL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SZT2

Q5T011

PLAGL1

Q9UM63


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SZT2_PLAGL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SZT2_PLAGL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SZT2_PLAGL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SZT2_PLAGL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLAGL1C0038356Stomach Neoplasms1CTD_human