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Fusion gene ID: 37006 |
FusionGeneSummary for SYTL4_GPCPD1 |
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Fusion gene information | Fusion gene name: SYTL4_GPCPD1 | Fusion gene ID: 37006 | Hgene | Tgene | Gene symbol | SYTL4 | GPCPD1 | Gene ID | 94121 | 56261 |
Gene name | synaptotagmin like 4 | glycerophosphocholine phosphodiesterase 1 | |
Synonyms | SLP4 | EDI3|GDE5|GDPD6|PREI4 | |
Cytomap | Xq22.1 | 20p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | synaptotagmin-like protein 4exophilin-2granuphilin-a | glycerophosphocholine phosphodiesterase GPCPD1endometrial differential 3glycerophosphocholine phosphodiesterase GDE1 homologglycerophosphodiester phosphodiesterase 5preimplantation protein 4putative glycerophosphocholine phosphodiesterase GPCPD1puta | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96C24 | Q9NPB8 | |
Ensembl transtripts involved in fusion gene | ENST00000372989, ENST00000491602, ENST00000454200, ENST00000276141, ENST00000455616, ENST00000263033, ENST00000372981, | ENST00000481038, ENST00000379019, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 3=48 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SYTL4 [Title/Abstract] AND GPCPD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW813838 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000372989 | ENST00000481038 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000372989 | ENST00000379019 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000491602 | ENST00000481038 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000491602 | ENST00000379019 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000454200 | ENST00000481038 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000454200 | ENST00000379019 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000276141 | ENST00000481038 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000276141 | ENST00000379019 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000455616 | ENST00000481038 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000455616 | ENST00000379019 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000263033 | ENST00000481038 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000263033 | ENST00000379019 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000372981 | ENST00000481038 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
intron-intron | ENST00000372981 | ENST00000379019 | SYTL4 | chrX | 99972080 | + | GPCPD1 | chr20 | 5568875 | - |
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FusionProtFeatures for SYTL4_GPCPD1 |
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Hgene | Tgene |
SYTL4 | GPCPD1 |
Modulates exocytosis of dense-core granules andsecretion of hormones in the pancreas and the pituitary. Interactswith vesicles containing negatively charged phospholipids in aCa(2+)-independent manner (By similarity). {ECO:0000250}. | May be involved in the negative regulation of skeletalmuscle differentiation, independently of its glycerophosphocholinephosphodiesterase activity. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SYTL4_GPCPD1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SYTL4_GPCPD1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SYTL4_GPCPD1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SYTL4 | Q96C24 | DB00071 | Insulin Pork | Synaptotagmin-like protein 4 | biotech | approved |
Hgene | SYTL4 | Q96C24 | DB00030 | Insulin Human | Synaptotagmin-like protein 4 | biotech | approved|investigational |
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RelatedDiseases for SYTL4_GPCPD1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GPCPD1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |