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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36964

FusionGeneSummary for SYP_CYFIP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SYP_CYFIP2
Fusion gene ID: 36964
HgeneTgene
Gene symbol

SYP

CYFIP2

Gene ID

6855

26999

Gene namesynaptophysincytoplasmic FMR1 interacting protein 2
SynonymsMRX96|MRXSYPPIR121
Cytomap

Xp11.23

5q33.3

Type of geneprotein-codingprotein-coding
Descriptionsynaptophysinmajor synaptic vesicle protein P38cytoplasmic FMR1-interacting protein 2p53-inducible protein 121
Modification date2018052320180523
UniProtAcc

P08247

Q96F07

Ensembl transtripts involved in fusion geneENST00000263233, ENST00000538567, 
ENST00000479808, 		ENST00000442283, 
ENST00000318218, ENST00000522463, 
ENST00000521420, ENST00000347377, 
ENST00000377576, ENST00000541131, 
ENST00000435847, ENST00000520960, 
Fusion gene scores* DoF score3 X 3 X 1=94 X 4 X 1=16
# samples 56
** MAII scorelog2(5/9*10)=2.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/16*10)=1.90689059560852
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SYP [Title/Abstract] AND CYFIP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCYFIP2

GO:0006915

apoptotic process

10449408

TgeneCYFIP2

GO:0045862

positive regulation of proteolysis

18387192

TgeneCYFIP2

GO:0097202

activation of cysteine-type endopeptidase activity

18387192

TgeneCYFIP2

GO:0098609

cell-cell adhesion

15048733


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW952111SYPchrX

49045445

-CYFIP2chr5

156816341

+
ChiTaRS3.1AA317589SYPchrX

49045445

-CYFIP2chr5

156816341

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000263233ENST00000442283SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000263233ENST00000318218SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000263233ENST00000522463SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000263233ENST00000521420SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000263233ENST00000347377SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000263233ENST00000377576SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000263233ENST00000541131SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000263233ENST00000435847SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-intronENST00000263233ENST00000520960SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000538567ENST00000442283SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000538567ENST00000318218SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000538567ENST00000522463SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000538567ENST00000521420SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000538567ENST00000347377SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000538567ENST00000377576SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000538567ENST00000541131SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000538567ENST00000435847SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-intronENST00000538567ENST00000520960SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000479808ENST00000442283SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000479808ENST00000318218SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000479808ENST00000522463SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000479808ENST00000521420SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000479808ENST00000347377SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000479808ENST00000377576SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000479808ENST00000541131SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-3UTRENST00000479808ENST00000435847SYPchrX

49045445

-CYFIP2chr5

156816341

+
intron-intronENST00000479808ENST00000520960SYPchrX

49045445

-CYFIP2chr5

156816341

+

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FusionProtFeatures for SYP_CYFIP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SYP

P08247

CYFIP2

Q96F07

Possibly involved in structural functions as organizingother membrane components or in targeting the vesicles to theplasma membrane. Involved in the regulation of short-term andlong-term synaptic plasticity (By similarity). {ECO:0000250}. Involved in T-cell adhesion and p53/TP53-dependentinduction of apoptosis. Does not bind RNA. As component of theWAVE1 complex, required for BDNF-NTRK2 endocytic trafficking andsignaling from early endosomes (By similarity).{ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408,ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SYP_CYFIP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SYP_CYFIP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SYP_CYFIP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SYP_CYFIP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSYPC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneSYPC0023186Learning Disorders1CTD_human
HgeneSYPC0025261Memory Disorders1CTD_human
HgeneSYPC0036341Schizophrenia1CTD_human
HgeneSYPC1136249Mental Retardation, X-Linked1CTD_human
HgeneSYPC1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human
HgeneSYPC2931673Ceroid lipofuscinosis, neuronal 1, infantile1CTD_human
HgeneSYPC3275408MENTAL RETARDATION, X-LINKED 961CTD_human;UNIPROT