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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3695

FusionGeneSummary for B2M_RASGRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: B2M_RASGRF1
Fusion gene ID: 3695
HgeneTgene
Gene symbol

B2M

RASGRF1

Gene ID

567

5923

Gene namebeta-2-microglobulinRas protein specific guanine nucleotide releasing factor 1
SynonymsIMD43CDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1
Cytomap

15q21.1

15q25.1

Type of geneprotein-codingprotein-coding
Descriptionbeta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobinras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re
Modification date2018052320180519
UniProtAcc

P61769

Q13972

Ensembl transtripts involved in fusion geneENST00000558401, ENST00000559916, 
ENST00000544417, ENST00000559220, 
ENST00000558480, ENST00000419573, 
ENST00000560334, ENST00000394745, 
Fusion gene scores* DoF score11 X 16 X 5=8803 X 4 X 3=36
# samples 203
** MAII scorelog2(20/880*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: B2M [Title/Abstract] AND RASGRF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneB2M

GO:0002726

positive regulation of T cell cytokine production

24643698

HgeneB2M

GO:1900121

negative regulation of receptor binding

9465039


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A3TO-01AB2Mchr15

45003811

+RASGRF1chr15

79265762

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000558401ENST00000558480B2Mchr15

45003811

+RASGRF1chr15

79265762

-
Frame-shiftENST00000558401ENST00000419573B2Mchr15

45003811

+RASGRF1chr15

79265762

-
5CDS-intronENST00000558401ENST00000560334B2Mchr15

45003811

+RASGRF1chr15

79265762

-
5CDS-intronENST00000558401ENST00000394745B2Mchr15

45003811

+RASGRF1chr15

79265762

-
Frame-shiftENST00000559916ENST00000558480B2Mchr15

45003811

+RASGRF1chr15

79265762

-
Frame-shiftENST00000559916ENST00000419573B2Mchr15

45003811

+RASGRF1chr15

79265762

-
5CDS-intronENST00000559916ENST00000560334B2Mchr15

45003811

+RASGRF1chr15

79265762

-
5CDS-intronENST00000559916ENST00000394745B2Mchr15

45003811

+RASGRF1chr15

79265762

-
Frame-shiftENST00000544417ENST00000558480B2Mchr15

45003811

+RASGRF1chr15

79265762

-
Frame-shiftENST00000544417ENST00000419573B2Mchr15

45003811

+RASGRF1chr15

79265762

-
5CDS-intronENST00000544417ENST00000560334B2Mchr15

45003811

+RASGRF1chr15

79265762

-
5CDS-intronENST00000544417ENST00000394745B2Mchr15

45003811

+RASGRF1chr15

79265762

-
intron-3CDSENST00000559220ENST00000558480B2Mchr15

45003811

+RASGRF1chr15

79265762

-
intron-3CDSENST00000559220ENST00000419573B2Mchr15

45003811

+RASGRF1chr15

79265762

-
intron-intronENST00000559220ENST00000560334B2Mchr15

45003811

+RASGRF1chr15

79265762

-
intron-intronENST00000559220ENST00000394745B2Mchr15

45003811

+RASGRF1chr15

79265762

-

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FusionProtFeatures for B2M_RASGRF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B2M

P61769

RASGRF1

Q13972

Component of the class I major histocompatibilitycomplex (MHC). Involved in the presentation of peptide antigens tothe immune system. Exogenously applied M.tuberculosis EsxA orEsxA-EsxB (or EsxA expressed in host) binds B2M and decreases itsexport to the cell surface (total protein levels do not change),probably leading to defects in class I antigen presentation(PubMed:25356553). {ECO:0000269|PubMed:25356553}. Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000269|PubMed:11389730}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for B2M_RASGRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for B2M_RASGRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
B2MPRSS23, BAG6, HLA-E, A2M, CD1D, GRB2, TAP1, TAPBP, HLA-B, B2M, HFE, HLA-A, TAP2, MAPK15, CRYAB, CXCR4, CD1B, HLA-C, HLA-F, MAP1S, PTTG1, HSPB2, CALR, ERBB3, RGPD2, FCGRT, RGPD5, DLGAP5, TPST1, RANBP2, RANGAP1, CD1E, KPNA4, CDCA2, UBE2I, NUSAP1, KPNB1, TMEM194A, PPAT, RANGRF, KPNA3RASGRF1MARK3, YWHAB, HRAS, PPP1R9B, MYC, EHD4, ADRBK1, CEBPA, SNRNP70, SRC, SRPK2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for B2M_RASGRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneB2MP61769DB00254DoxycyclineBeta-2-microglobulinsmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for B2M_RASGRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneB2MC0022658Kidney Diseases3CTD_human;HPO
HgeneB2MC2609414Acute kidney injury2CTD_human
HgeneB2MC0004364Autoimmune Diseases1CTD_human
HgeneB2MC0018799Heart Diseases1CTD_human
HgeneB2MC0020455Hypergammaglobulinemia1CTD_human
HgeneB2MC0033578Prostatic Neoplasms1CTD_human
HgeneB2MC0036341Schizophrenia1PSYGENET
HgeneB2MC0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgeneB2MC0079774Peripheral T-Cell Lymphoma1CTD_human
HgeneB2MC0268389Amyloidosis, familial visceral1UNIPROT
HgeneB2MC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneB2MC1855796Hypoproteinemia, Hypercatabolic1CTD_human;UNIPROT
TgeneRASGRF1C0005586Bipolar Disorder1PSYGENET
TgeneRASGRF1C0013386Dyskinesia, Drug-Induced1CTD_human
TgeneRASGRF1C0027092Myopia1CTD_human
TgeneRASGRF1C0034951Refractive Errors1CTD_human