![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 3695 |
FusionGeneSummary for B2M_RASGRF1 |
![]() |
Fusion gene information | Fusion gene name: B2M_RASGRF1 | Fusion gene ID: 3695 | Hgene | Tgene | Gene symbol | B2M | RASGRF1 | Gene ID | 567 | 5923 |
Gene name | beta-2-microglobulin | Ras protein specific guanine nucleotide releasing factor 1 | |
Synonyms | IMD43 | CDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1 | |
Cytomap | 15q21.1 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | beta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin | ras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P61769 | Q13972 | |
Ensembl transtripts involved in fusion gene | ENST00000558401, ENST00000559916, ENST00000544417, ENST00000559220, | ENST00000558480, ENST00000419573, ENST00000560334, ENST00000394745, | |
Fusion gene scores | * DoF score | 11 X 16 X 5=880 | 3 X 4 X 3=36 |
# samples | 20 | 3 | |
** MAII score | log2(20/880*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: B2M [Title/Abstract] AND RASGRF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | B2M | GO:0002726 | positive regulation of T cell cytokine production | 24643698 |
Hgene | B2M | GO:1900121 | negative regulation of receptor binding | 9465039 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-FX-A3TO-01A | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000558401 | ENST00000558480 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
Frame-shift | ENST00000558401 | ENST00000419573 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
5CDS-intron | ENST00000558401 | ENST00000560334 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
5CDS-intron | ENST00000558401 | ENST00000394745 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
Frame-shift | ENST00000559916 | ENST00000558480 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
Frame-shift | ENST00000559916 | ENST00000419573 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
5CDS-intron | ENST00000559916 | ENST00000560334 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
5CDS-intron | ENST00000559916 | ENST00000394745 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
Frame-shift | ENST00000544417 | ENST00000558480 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
Frame-shift | ENST00000544417 | ENST00000419573 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
5CDS-intron | ENST00000544417 | ENST00000560334 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
5CDS-intron | ENST00000544417 | ENST00000394745 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
intron-3CDS | ENST00000559220 | ENST00000558480 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
intron-3CDS | ENST00000559220 | ENST00000419573 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
intron-intron | ENST00000559220 | ENST00000560334 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
intron-intron | ENST00000559220 | ENST00000394745 | B2M | chr15 | 45003811 | + | RASGRF1 | chr15 | 79265762 | - |
Top |
FusionProtFeatures for B2M_RASGRF1 |
![]() |
Hgene | Tgene |
B2M | RASGRF1 |
Component of the class I major histocompatibilitycomplex (MHC). Involved in the presentation of peptide antigens tothe immune system. Exogenously applied M.tuberculosis EsxA orEsxA-EsxB (or EsxA expressed in host) binds B2M and decreases itsexport to the cell surface (total protein levels do not change),probably leading to defects in class I antigen presentation(PubMed:25356553). {ECO:0000269|PubMed:25356553}. | Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000269|PubMed:11389730}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for B2M_RASGRF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for B2M_RASGRF1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
B2M | PRSS23, BAG6, HLA-E, A2M, CD1D, GRB2, TAP1, TAPBP, HLA-B, B2M, HFE, HLA-A, TAP2, MAPK15, CRYAB, CXCR4, CD1B, HLA-C, HLA-F, MAP1S, PTTG1, HSPB2, CALR, ERBB3, RGPD2, FCGRT, RGPD5, DLGAP5, TPST1, RANBP2, RANGAP1, CD1E, KPNA4, CDCA2, UBE2I, NUSAP1, KPNB1, TMEM194A, PPAT, RANGRF, KPNA3 | RASGRF1 | MARK3, YWHAB, HRAS, PPP1R9B, MYC, EHD4, ADRBK1, CEBPA, SNRNP70, SRC, SRPK2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for B2M_RASGRF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | B2M | P61769 | DB00254 | Doxycycline | Beta-2-microglobulin | small molecule | approved|investigational|vet_approved |
Top |
RelatedDiseases for B2M_RASGRF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | B2M | C0022658 | Kidney Diseases | 3 | CTD_human;HPO |
Hgene | B2M | C2609414 | Acute kidney injury | 2 | CTD_human |
Hgene | B2M | C0004364 | Autoimmune Diseases | 1 | CTD_human |
Hgene | B2M | C0018799 | Heart Diseases | 1 | CTD_human |
Hgene | B2M | C0020455 | Hypergammaglobulinemia | 1 | CTD_human |
Hgene | B2M | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | B2M | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | B2M | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
Hgene | B2M | C0079774 | Peripheral T-Cell Lymphoma | 1 | CTD_human |
Hgene | B2M | C0268389 | Amyloidosis, familial visceral | 1 | UNIPROT |
Hgene | B2M | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | B2M | C1855796 | Hypoproteinemia, Hypercatabolic | 1 | CTD_human;UNIPROT |
Tgene | RASGRF1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | RASGRF1 | C0013386 | Dyskinesia, Drug-Induced | 1 | CTD_human |
Tgene | RASGRF1 | C0027092 | Myopia | 1 | CTD_human |
Tgene | RASGRF1 | C0034951 | Refractive Errors | 1 | CTD_human |