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Fusion gene ID: 36946 |
FusionGeneSummary for SYNPO_TRIOBP |
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Fusion gene information | Fusion gene name: SYNPO_TRIOBP | Fusion gene ID: 36946 | Hgene | Tgene | Gene symbol | SYNPO | TRIOBP | Gene ID | 11346 | 11078 |
Gene name | synaptopodin | TRIO and F-actin binding protein | |
Synonyms | - | DFNB28|HRIHFB2122|TAP68|TARA|dJ37E16.4 | |
Cytomap | 5q33.1 | 22q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | synaptopodin | TRIO and F-actin-binding proteinprotein Taratara-like proteintrio-associated repeat on actin | |
Modification date | 20180523 | 20180520 | |
UniProtAcc | Q8N3V7 | Q9H2D6 | |
Ensembl transtripts involved in fusion gene | ENST00000394243, ENST00000522122, ENST00000518872, ENST00000307662, ENST00000519664, | ENST00000406386, ENST00000407319, ENST00000403663, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 9 X 5=360 |
# samples | 3 | 11 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SYNPO [Title/Abstract] AND TRIOBP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SYNPO | GO:0098886 | modification of dendritic spine | 25164660 |
Tgene | TRIOBP | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 11148140 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB265417 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000394243 | ENST00000406386 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-intron | ENST00000394243 | ENST00000407319 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-3UTR | ENST00000394243 | ENST00000403663 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-3UTR | ENST00000522122 | ENST00000406386 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-intron | ENST00000522122 | ENST00000407319 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-3UTR | ENST00000522122 | ENST00000403663 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
intron-3UTR | ENST00000518872 | ENST00000406386 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
intron-intron | ENST00000518872 | ENST00000407319 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
intron-3UTR | ENST00000518872 | ENST00000403663 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-3UTR | ENST00000307662 | ENST00000406386 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-intron | ENST00000307662 | ENST00000407319 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-3UTR | ENST00000307662 | ENST00000403663 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-3UTR | ENST00000519664 | ENST00000406386 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-intron | ENST00000519664 | ENST00000407319 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
5CDS-3UTR | ENST00000519664 | ENST00000403663 | SYNPO | chr5 | 150029343 | + | TRIOBP | chr22 | 38169889 | + |
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FusionProtFeatures for SYNPO_TRIOBP |
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Hgene | Tgene |
SYNPO | TRIOBP |
Actin-associated protein that may play a role inmodulating actin-based shape and motility of dendritic spines andrenal podocyte foot processes. Seems to be essential for theformation of spine apparatuses in spines of telencephalic neurons,which is involved in synaptic plasticity (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SYNPO_TRIOBP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SYNPO_TRIOBP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SYNPO_TRIOBP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SYNPO_TRIOBP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TRIOBP | C1853276 | Deafness, Autosomal Recessive 28 | 1 | CTD_human;UNIPROT |