	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 36944

FusionGeneSummary for SYNPO_NFYC

Fusion gene summary

Fusion gene information	Fusion gene name: SYNPO_NFYC
	Fusion gene ID: 36944
		Hgene	Tgene
	Gene symbol	SYNPO	NFYC
	Gene ID	11346	4802
	Gene name	synaptopodin	nuclear transcription factor Y subunit gamma
	Synonyms	-	CBF-C\|CBFC\|H1TF2A\|HAP5\|HSM\|NF-YC
	Cytomap	5q33.1	1p34.2
	Type of gene	protein-coding	protein-coding
	Description	synaptopodin	nuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cn
	Modification date	20180523	20180523
	UniProtAcc	Q8N3V7	Q13952
	Ensembl transtripts involved in fusion gene	ENST00000394243, ENST00000522122, ENST00000518872, ENST00000307662, ENST00000519664,	ENST00000427410, ENST00000447388, ENST00000425457, ENST00000456393, ENST00000372654, ENST00000372653, ENST00000372652, ENST00000372651, ENST00000440226, ENST00000308733, ENST00000483091,
Fusion gene scores	* DoF score	3 X 3 X 2=18	8 X 5 X 6=240
	# samples	3	9
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SYNPO [Title/Abstract] AND NFYC [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SYNPO	GO:0098886	modification of dendritic spine	25164660
Tgene	NFYC	GO:0006355	regulation of transcription, DNA-templated	15243141

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	OV	TCGA-09-2054-01A	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000394243	ENST00000427410	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000394243	ENST00000447388	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000394243	ENST00000425457	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000394243	ENST00000456393	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000394243	ENST00000372654	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000394243	ENST00000372653	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000394243	ENST00000372652	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000394243	ENST00000372651	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000394243	ENST00000440226	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000394243	ENST00000308733	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000394243	ENST00000483091	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000522122	ENST00000427410	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000522122	ENST00000447388	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000522122	ENST00000425457	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000522122	ENST00000456393	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000522122	ENST00000372654	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000522122	ENST00000372653	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000522122	ENST00000372652	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000522122	ENST00000372651	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000522122	ENST00000440226	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000522122	ENST00000308733	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000522122	ENST00000483091	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000518872	ENST00000427410	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000518872	ENST00000447388	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000518872	ENST00000425457	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000518872	ENST00000456393	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000518872	ENST00000372654	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000518872	ENST00000372653	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000518872	ENST00000372652	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000518872	ENST00000372651	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000518872	ENST00000440226	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000518872	ENST00000308733	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000518872	ENST00000483091	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000307662	ENST00000427410	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000307662	ENST00000447388	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000307662	ENST00000425457	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000307662	ENST00000456393	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000307662	ENST00000372654	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000307662	ENST00000372653	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000307662	ENST00000372652	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000307662	ENST00000372651	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000307662	ENST00000440226	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000307662	ENST00000308733	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000307662	ENST00000483091	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000519664	ENST00000427410	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000519664	ENST00000447388	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000519664	ENST00000425457	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000519664	ENST00000456393	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-3CDS	ENST00000519664	ENST00000372654	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000519664	ENST00000372653	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000519664	ENST00000372652	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000519664	ENST00000372651	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000519664	ENST00000440226	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000519664	ENST00000308733	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+
intron-intron	ENST00000519664	ENST00000483091	SYNPO	chr5	150004469	+	NFYC	chr1	41228560	+

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FusionProtFeatures for SYNPO_NFYC

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SYNPO Q8N3V7	NFYC Q13952
Actin-associated protein that may play a role inmodulating actin-based shape and motility of dendritic spines andrenal podocyte foot processes. Seems to be essential for theformation of spine apparatuses in spines of telencephalic neurons,which is involved in synaptic plasticity (By similarity).{ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for SYNPO_NFYC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SYNPO_NFYC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
SYNPO	MAGI1, YWHAG, YWHAZ, SH3KBP1, NONO, NCK1, NCK2, MOV10, NXF1, ACTB, ACTN4, ACTN1, ADD3, AP2A1, ANXA2, APC, CAMK2G, CAPZA2, CAPZB, CD44, CD59, CFL1, CFL2, AP2M1, CLIC1, CLTA, CLTB, CLTC, CPM, CSNK1G3, DAB2, DAPK3, DBN1, DSG2, EEF1D, CTTN, EPS15, FLII, FLNA, FLNB, FLOT2, GNAI2, GNAI3, GNAS, GNB1, GNB2, GSN, HMGB2, ITPR1, ITPR3, JUP, ABLIM1, LMO7, MYO1B, MYO1C, MYO1E, MYO5A, MYO5B, MYO6, PPP1R12A, PPP1R12B, NAP1L4, PALM, PIK3C2A, PLEC, PPL, PPP1CA, PPP1CB, PPP1CC, TWF1, RAF1, HLTF, SPTAN1, SPTBN1, SPTBN2, SVIL, TMOD1, TNFAIP1, TPM1, TPM2, CORO2A, LUZP1, SORBS2, GPRC5A, LRRFIP2, ABCG2, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC5, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, ARPC2, FARP1, FLOT1, BASP1, AKAP2, TWF2, CDK2, CENPE, GAK, MYH9, DNAJC7, IQGAP1, PDLIM7, BAG3, MAPRE1, LIMA1, ANLN, MYO5C, MYO19, MYO18A, RRAS2, CEP162, SIPA1L3, MPRIP, COBL, SPECC1L, CORO1C, POC1A, ZDHHC5, SIPA1L1, RAI14, ZBTB20, PACSIN3, TMOD3, BMP2K, PPP1R9A, CORO1B, CGN, ARHGAP21, AFAP1, INF2, CYBRD1, ARPC5L, LZTS2, PPP1R9B, STON2, SSH2, PHLDB2, NEXN, SPECC1, PLCD3, MISP, CD109, PPP1R18, TMEM201, TPRN, TRIM25	NFYC	MYC, SMAD3, SMAD2, TBP, ATF6, ATF6B, TP73, DST, CSN2, DR1, NFYA, NFYB, SP1, SREBF2, LMO4, ADNP2, POGZ, CIC, ZDHHC17, GLTSCR1L, GLTSCR1, ARID2, KIAA2018, TRIM27, TBPL2, HDAC1, TAF12, TAF11, TAF6, KAT2B, GAPDH, ELAVL1, CDK2, SNX2, FCGR2A, CORO1B, CORO1C, FOXJ2, FOXK2, NFATC2, PON1, ENDOG, PON3, NFKB1, COMMD1, PRR20E

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for SYNPO_NFYC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SYNPO_NFYC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 36944

FusionGeneSummary for SYNPO_NFYC

FusionProtFeatures for SYNPO_NFYC

FusionGeneSequence for SYNPO_NFYC

FusionGenePPI for SYNPO_NFYC

RelatedDrugs for SYNPO_NFYC

RelatedDiseases for SYNPO_NFYC