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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 36941

FusionGeneSummary for SYNPO2_METTL14

check button Fusion gene summary
Fusion gene informationFusion gene name: SYNPO2_METTL14
Fusion gene ID: 36941
HgeneTgene
Gene symbol

SYNPO2

METTL14

Gene ID

171024

57721

Gene namesynaptopodin 2methyltransferase like 14
Synonyms-hMETTL14
Cytomap

4q26

4q26

Type of geneprotein-codingprotein-coding
Descriptionsynaptopodin-2genethonin-2myopodinN6-adenosine-methyltransferase non-catalytic subunitN6-adenosine-methyltransferase subunit METTL14methyltransferase-like protein 14
Modification date2018052320180522
UniProtAcc

Q9UMS6

Q9HCE5

Ensembl transtripts involved in fusion geneENST00000307142, ENST00000448416, 
ENST00000429713, ENST00000434046, 
ENST00000388822, ENST00000506780, 
Fusion gene scores* DoF score3 X 2 X 3=181 X 1 X 1=1
# samples 41
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: SYNPO2 [Title/Abstract] AND METTL14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMETTL14

GO:0080009

mRNA methylation

27281194|27373337|27627798


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPCPGTCGA-QR-A707-01ASYNPO2chr4

119810296

+METTL14chr4

119621705

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000307142ENST00000388822SYNPO2chr4

119810296

+METTL14chr4

119621705

+
In-frameENST00000307142ENST00000506780SYNPO2chr4

119810296

+METTL14chr4

119621705

+
In-frameENST00000448416ENST00000388822SYNPO2chr4

119810296

+METTL14chr4

119621705

+
In-frameENST00000448416ENST00000506780SYNPO2chr4

119810296

+METTL14chr4

119621705

+
In-frameENST00000429713ENST00000388822SYNPO2chr4

119810296

+METTL14chr4

119621705

+
In-frameENST00000429713ENST00000506780SYNPO2chr4

119810296

+METTL14chr4

119621705

+
In-frameENST00000434046ENST00000388822SYNPO2chr4

119810296

+METTL14chr4

119621705

+
In-frameENST00000434046ENST00000506780SYNPO2chr4

119810296

+METTL14chr4

119621705

+

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FusionProtFeatures for SYNPO2_METTL14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SYNPO2

Q9UMS6

METTL14

Q9HCE5

Has an actin-binding and actin-bundling activity. Caninduce the formation of F-actin networks in an isoform-specificmanner (PubMed:24005909, PubMed:23225103). At the sarcomeric Zlines is proposed to act as adapter protein that links nascentmyofibers to the sarcolemma via ZYX and may play a role in earlyassembly and stabilization of the Z lines. Involved inautophagosome formation. May play a role in chaperone-assistedselective autophagy (CASA) involved in Z lines maintenance instriated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering andfusion complex providing autophagosome membranes (By similarity).Involved in regulation of cell migration (PubMed:22915763,PubMed:25883213). May be a tumor suppressor (PubMed:16885336).{ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8,ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103,ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213,ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}. Isoform 1: Involved in regulation of cell migration. Caninduce formation of thick, irregular actin bundles in the cellbody. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}. Isoform 2: Involved in regulation of cell migration. Caninduce long, well-organized actin bundles frequently orientated inparallel along the long axis of the cell showing characteristicsof contractile ventral stress fibers.{ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}. Isoform 3: Involved in regulation of cell migration. Caninduce an amorphous actin meshwork throughout the cell bodycontaining a mixture of long and short, randomly organized thickand thin actin bundles. {ECO:0000269|PubMed:22915763,ECO:0000269|PubMed:24005909}. Isoform 4: Can induce long, well-organized actin bundlesfrequently orientated in parallel along the long axis of the cellshowing characteristics of contractile ventral stress fibers.{ECO:0000269|PubMed:24005909}. Isoform 5: Involved in regulation of cell migration inpart dependent on the Rho-ROCK cascade; can promote formation ofnascent focal adhesions, actin bundles at the leading cell edgeand lamellipodia (PubMed:22915763, PubMed:25883213). Can induceformation of thick, irregular actin bundles in the cell body; theinduced actin network is associated with enhanced cell migrationin vitro. {ECO:0000269|PubMed:22915763,ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues atthe N(6) position of some mRNAs and regulates the circadian clock,differentiation of embryonic stem cells and cortical neurogenesis(PubMed:24316715, PubMed:24407421, PubMed:25719671,PubMed:29348140, PubMed:27373337, PubMed:27281194). In theheterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than thecatalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194,PubMed:29348140). N6-methyladenosine (m6A), which takes place atthe 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role inmRNA stability and processing (PubMed:24316715, PubMed:24407421,PubMed:25719671). M6A acts as a key regulator of mRNA stability bypromoting mRNA destabilization and degradation (By similarity). Inembryonic stem cells (ESCs), m6A methylation of mRNAs encoding keynaive pluripotency-promoting transcripts results in transcriptdestabilization (By similarity). M6A regulates spermatogonialdifferentiation and meiosis and is essential for male fertilityand spermatogenesis (By similarity). M6A also regulates corticalneurogenesis: m6A methylation of transcripts related totranscription factors, neural stem cells, the cell cycle andneuronal differentiation during brain development promotes theirdestabilization and decay, promoting differentiation of radialglial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4,ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421,ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798,ECO:0000269|PubMed:29348140}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETTL14chr4:119810296chr4:119621705ENST00000388822+611409_452215457Compositional biasNote=Gly-rich
TgeneMETTL14chr4:119810296chr4:119621705ENST00000388822+611245_254215457RegionPositively charged region required for RNA-binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15400_405351262Compositional biasNote=Poly-Arg
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15423_426351262Compositional biasNote=Poly-Glu
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15591_658351262Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15756_818351262Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15767_770351262Compositional biasNote=Poly-Ser
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14400_405351094Compositional biasNote=Poly-Arg
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14423_426351094Compositional biasNote=Poly-Glu
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14591_658351094Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14756_818351094Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14767_770351094Compositional biasNote=Poly-Ser
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15400_405351110Compositional biasNote=Poly-Arg
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15423_426351110Compositional biasNote=Poly-Glu
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15591_658351110Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15756_818351110Compositional biasNote=Pro-rich
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15767_770351110Compositional biasNote=Poly-Ser
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+156_88351262DomainPDZ
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+146_88351094DomainPDZ
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+156_88351110DomainPDZ
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15398_406351262MotifNuclear localization signal
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15619_622351262MotifPPPY motif
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14398_406351094MotifNuclear localization signal
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14619_622351094MotifPPPY motif
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15398_406351110MotifNuclear localization signal
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15619_622351110MotifPPPY motif
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15534_663351262RegionF-actin binding
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15664_803351262RegionF-actin binding
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15664_916351262RegionF-actin bundling activity
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15751_900351262RegionActin binding
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14534_663351094RegionF-actin binding
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14664_803351094RegionF-actin binding
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14664_916351094RegionF-actin bundling activity
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14751_900351094RegionActin binding
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15534_663351110RegionF-actin binding
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15664_803351110RegionF-actin binding
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15664_916351110RegionF-actin bundling activity
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15751_900351110RegionActin binding


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FusionGeneSequence for SYNPO2_METTL14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_277aa
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

>In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_277aa
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

>In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_277aa
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

>In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_277aa
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

>In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_277aa
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

>In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_277aa
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

>In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_277aa
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR

>In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_277aa
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG
KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_831nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA

>In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_831nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA

>In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_831nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA

>In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_831nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA

>In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_831nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA

>In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_831nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA

>In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_831nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA

>In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_831nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_6158nt
GAGCCCATTAGCCGCACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCA
GTCTTGCGTCCTCGGCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCC
CAACTAAAAGGAAAACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAA
GGAGCAGAAGCAGCCCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTG
TGGTTCTGGGGAGGGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAA
TAAAAACAATCCTGGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAAC
TGTGAAGCGTAGCACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGA
AAAACCTGTAGAAATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACC
AGGCTGGCTCACAGTTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTT
GACTGGTTGTACAGAAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGG
TGGAGGAAGAGGTGGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCG
TGGAGGAGCACACAGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATT
AAATTTCAAGTGGGAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGC
CTTGCTTGCAGTTGTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAAC
AACTCAAGTAGCTTCATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATA
ATGGAAAAAGATCCAGTCTGTGGTATCATGCTAGTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGG
TTTTAACATTTTCTTGATGAAACAATAAAAAGAGGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAA
TACTGAAGAAATTAAGAGACTTTGAACAAAAACTCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAA
GAGATAGAACTTAGCAGGCAGACTTAAAAAAAAAAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTC
CTAAGAAGCAAAGGAGGACAAATATTCATGTGCTAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTC
AAATAAAAGAGAGGCAGCGACAAGATACCTCATTATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACAT
ACACCTTTAAACTTGTTATGGAGATAGTTTAATGTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTG
CAATTGCCTTTTATTAAAACCATATGGTGTGATGTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAA
TTCATGTTTTAAATGAATTTGATAATGAAATTATACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAAC
TTTAAACTTTTGAGATTTGAGAGTCTGTTTTCTATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCT
TCTTTTGGTCTGTGATGGATTTTAATGGCCGTTCTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTG
AAGATAAGGAATGAGTGATAGAAGAAATAAGGCTGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGT
ACAAGACCCCTTTTTTTTTGCTGAAATTATGGTATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCA
TTGACCTGGGAATGAAGTCAGGATAGAGAAATTCCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATA
CACAGGGCTCTCTATTACGTTCCATACCCTGGGCCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTG
TCACAATTTCATCTTAGAAAGAGGTAGGTATGGCTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGT
TATTTAAAAAAGAGCAGATGGTGGAAAAAGAATGTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATG
GAATTGATTCACTAGTTTTTGCTAACTTTCACTTTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGT
TTCCAATGAAATTTCATTACTCTGACCTCTTCTAATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAAT
GCTGGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCT
GACCAATATGGAGAAATCCCATCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGG
AGGCTGTGGCAGGAGAATTGCCTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAG
TGAGACTCTGTCTCAAAAAAAAAAAAAAAAATTGTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGC
TAATTATTGTGAAATAACCTAGTTTAGAAGTTAGAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAAC
TGTTGTTATTTATTTCCAGTGAGAACCATTTTCCCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGA
GTAGGAATACTTTTTTACTCTTCTTCACTGTGGAGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAA
TACCATACCTAAACACAAATGAATCAGATTAGACCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACA
GTGTGAGAGGTCAAGGTGTCAACCTGGGAAGTGAGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGA
TCACTACTGCAGCAGTTCTGCTCTGTTACTCTGGTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCC
AGGTCAGTGATATGCTATAGTTTCATTTAAGTTAATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGC
TGCTACTAGGAGTTACTCCTTTTCATGTCTTTTAAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTT
AATTTAAAACCTGTACTGTTTTCATCCTGAATTTAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAAT
ATAATCCTTATTAACATGACAAAATGAAAGCCCTGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGA
TCTATTAGAAACATAAACCTTTGCTTATGCAGAAGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCC
TCTCTTTGATGTTGGGTAATAGAGGCTGAACTTTTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATT
AGAACATTTATCCAGTAAACTGACTCCATTGAAGACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACT
CGTATAAATATTGCTAGCTGTAATGCACAGAGAAAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTT
CCACTACTGGATAAAATATTAAAATGATCAGTTTGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCA
GATAAGGTAGGTTTTTCCAAAAATACTTCTAAATAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAG
AGAAGCAGGCCAAGAACTTTTTAATGGGATAATTGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATT
TACTTTCATCCATCTATCTGTGCTTTTTCTCACTTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTG
CGTTAGTAAATGGCCACTGACTCTTGGTCTCAGGCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGT
GGACATCACTTGTCAGCTCCAGCTAATTGTCACCACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAG
GTTGACAAAATAGTTTGTGACTTTTGCTTACATTTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATAT
TTTCTTTTTTATTTTTATTTTTTGAGACAGAGTCTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCC
TCCAGGGTTGAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCT
TAGTAGAGACAGGATTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCA
GGATTACAGGCGTGAGCCTCTGCAACTGGCCAACATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACT
TAAAAAAGAGGAAAAAAGGTTACTTGCTTGAGACAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACA
GTAGACTGAAAATGTGAACTAATACTTTAAAATTGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGA
GGTCTAGGCTTGTGTTGTCACAAAATACACCTTTTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGC
TACATCATTATCCTGCCTTTTCTGGGTGTTTATTTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCC
AGTTTAGTAGTTTATGCTGGTTAAATGATCAAAGTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGG

>In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_1328nt
GAGCCCATTAGCCGCACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCA
GTCTTGCGTCCTCGGCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCC
CAACTAAAAGGAAAACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAA
GGAGCAGAAGCAGCCCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTG
TGGTTCTGGGGAGGGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAA
TAAAAACAATCCTGGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAAC
TGTGAAGCGTAGCACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGA
AAAACCTGTAGAAATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACC
AGGCTGGCTCACAGTTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTT
GACTGGTTGTACAGAAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGG
TGGAGGAAGAGGTGGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCG
TGGAGGAGCACACAGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATT
AAATTTCAAGTGGGAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGC
CTTGCTTGCAGTTGTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAAC

>In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_6145nt
GCACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCAGTCTTGCGTCCTC
GGCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCCCAACTAAAAGGAA
AACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAG
CCCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAG
GGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCT
GGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGC
ACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAA
ATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACA
GTTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACA
GAAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGT
GGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACAC
AGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGG
GAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTT
GTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCT
TCATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATC
CAGTCTGTGGTATCATGCTAGTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTC
TTGATGAAACAATAAAAAGAGGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATT
AAGAGACTTTGAACAAAAACTCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTA
GCAGGCAGACTTAAAAAAAAAAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAG
GAGGACAAATATTCATGTGCTAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAG
GCAGCGACAAGATACCTCATTATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACT
TGTTATGGAGATAGTTTAATGTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTA
TTAAAACCATATGGTGTGATGTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAA
TGAATTTGATAATGAAATTATACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGA
GATTTGAGAGTCTGTTTTCTATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGT
GATGGATTTTAATGGCCGTTCTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATG
AGTGATAGAAGAAATAAGGCTGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTT
TTTTTTGCTGAAATTATGGTATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAAT
GAAGTCAGGATAGAGAAATTCCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCT
ATTACGTTCCATACCCTGGGCCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATC
TTAGAAAGAGGTAGGTATGGCTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGA
GCAGATGGTGGAAAAAGAATGTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACT
AGTTTTTGCTAACTTTCACTTTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATT
TCATTACTCTGACCTCTTCTAATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTG
GCTCATGCCTGTAATCCCAGCACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAG
AAATCCCATCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGG
AGAATTGCCTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCT
CAAAAAAAAAAAAAAAAATTGTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAA
ATAACCTAGTTTAGAAGTTAGAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTAT
TTCCAGTGAGAACCATTTTCCCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTT
TTTACTCTTCTTCACTGTGGAGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAA
CACAAATGAATCAGATTAGACCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCA
AGGTGTCAACCTGGGAAGTGAGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGC
AGTTCTGCTCTGTTACTCTGGTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATAT
GCTATAGTTTCATTTAAGTTAATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGT
TACTCCTTTTCATGTCTTTTAAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTG
TACTGTTTTCATCCTGAATTTAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTA
ACATGACAAAATGAAAGCCCTGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACA
TAAACCTTTGCTTATGCAGAAGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTT
GGGTAATAGAGGCTGAACTTTTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCC
AGTAAACTGACTCCATTGAAGACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTG
CTAGCTGTAATGCACAGAGAAAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATA
AAATATTAAAATGATCAGTTTGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTT
TTTCCAAAAATACTTCTAAATAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAA
GAACTTTTTAATGGGATAATTGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATTTACTTTCATCCAT
CTATCTGTGCTTTTTCTCACTTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGG
CCACTGACTCTTGGTCTCAGGCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGT
CAGCTCCAGCTAATTGTCACCACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAG
TTTGTGACTTTTGCTTACATTTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATT
TTTATTTTTTGAGACAGAGTCTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAG
CGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGG
ATTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGT
GAGCCTCTGCAACTGGCCAACATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAA
AAAAGGTTACTTGCTTGAGACAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAAT
GTGAACTAATACTTTAAAATTGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGT
GTTGTCACAAAATACACCTTTTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCC
TGCCTTTTCTGGGTGTTTATTTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTT
ATGCTGGTTAAATGATCAAAGTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGGTGGGTACCTTAAT

>In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_1315nt
GCACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCAGTCTTGCGTCCTC
GGCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCCCAACTAAAAGGAA
AACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAG
CCCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAG
GGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCT
GGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGC
ACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAA
ATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACA
GTTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACA
GAAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGT
GGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACAC
AGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGG
GAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTT
GTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCT

>In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_6144nt
CACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCAGTCTTGCGTCCTCG
GCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCCCAACTAAAAGGAAA
ACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGC
CCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGG
GGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTG
GGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCA
CAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAA
TTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAG
TTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAG
AAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTG
GAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACA
GAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGG
AGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTG
TCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTT
CATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATCC
AGTCTGTGGTATCATGCTAGTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTCT
TGATGAAACAATAAAAAGAGGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATTA
AGAGACTTTGAACAAAAACTCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTAG
CAGGCAGACTTAAAAAAAAAAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAGG
AGGACAAATATTCATGTGCTAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAGG
CAGCGACAAGATACCTCATTATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACTT
GTTATGGAGATAGTTTAATGTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTAT
TAAAACCATATGGTGTGATGTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAAT
GAATTTGATAATGAAATTATACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGAG
ATTTGAGAGTCTGTTTTCTATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGTG
ATGGATTTTAATGGCCGTTCTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATGA
GTGATAGAAGAAATAAGGCTGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTTT
TTTTTGCTGAAATTATGGTATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAATG
AAGTCAGGATAGAGAAATTCCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCTA
TTACGTTCCATACCCTGGGCCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATCT
TAGAAAGAGGTAGGTATGGCTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGAG
CAGATGGTGGAAAAAGAATGTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACTA
GTTTTTGCTAACTTTCACTTTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATTT
CATTACTCTGACCTCTTCTAATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTGG
CTCATGCCTGTAATCCCAGCACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAGA
AATCCCATCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGGA
GAATTGCCTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTC
AAAAAAAAAAAAAAAAATTGTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAAA
TAACCTAGTTTAGAAGTTAGAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTATT
TCCAGTGAGAACCATTTTCCCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTTT
TTACTCTTCTTCACTGTGGAGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAAC
ACAAATGAATCAGATTAGACCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCAA
GGTGTCAACCTGGGAAGTGAGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGCA
GTTCTGCTCTGTTACTCTGGTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATATG
CTATAGTTTCATTTAAGTTAATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGTT
ACTCCTTTTCATGTCTTTTAAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTGT
ACTGTTTTCATCCTGAATTTAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTAA
CATGACAAAATGAAAGCCCTGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACAT
AAACCTTTGCTTATGCAGAAGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTTG
GGTAATAGAGGCTGAACTTTTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCCA
GTAAACTGACTCCATTGAAGACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTGC
TAGCTGTAATGCACAGAGAAAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATAA
AATATTAAAATGATCAGTTTGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTTT
TTCCAAAAATACTTCTAAATAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAAG
AACTTTTTAATGGGATAATTGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATTTACTTTCATCCATC
TATCTGTGCTTTTTCTCACTTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGGC
CACTGACTCTTGGTCTCAGGCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGTC
AGCTCCAGCTAATTGTCACCACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAGT
TTGTGACTTTTGCTTACATTTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATTT
TTATTTTTTGAGACAGAGTCTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAGC
GATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGGA
TTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGTG
AGCCTCTGCAACTGGCCAACATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAAA
AAAGGTTACTTGCTTGAGACAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAATG
TGAACTAATACTTTAAAATTGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGTG
TTGTCACAAAATACACCTTTTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCCT
GCCTTTTCTGGGTGTTTATTTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTTA
TGCTGGTTAAATGATCAAAGTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGGTGGGTACCTTAATA

>In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_1314nt
CACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCAGTCTTGCGTCCTCG
GCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCCCAACTAAAAGGAAA
ACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGC
CCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGG
GGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTG
GGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCA
CAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAA
TTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAG
TTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAG
AAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTG
GAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACA
GAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGG
AGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTG
TCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTT

>In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_5962nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA
GGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGGAG
ACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTGTC
ACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTTCA
TCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATCCAG
TCTGTGGTATCATGCTAGTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTCTTG
ATGAAACAATAAAAAGAGGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATTAAG
AGACTTTGAACAAAAACTCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTAGCA
GGCAGACTTAAAAAAAAAAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAGGAG
GACAAATATTCATGTGCTAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAGGCA
GCGACAAGATACCTCATTATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACTTGT
TATGGAGATAGTTTAATGTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTATTA
AAACCATATGGTGTGATGTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAATGA
ATTTGATAATGAAATTATACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGAGAT
TTGAGAGTCTGTTTTCTATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGTGAT
GGATTTTAATGGCCGTTCTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATGAGT
GATAGAAGAAATAAGGCTGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTTTTT
TTTGCTGAAATTATGGTATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAATGAA
GTCAGGATAGAGAAATTCCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCTATT
ACGTTCCATACCCTGGGCCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATCTTA
GAAAGAGGTAGGTATGGCTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGAGCA
GATGGTGGAAAAAGAATGTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACTAGT
TTTTGCTAACTTTCACTTTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATTTCA
TTACTCTGACCTCTTCTAATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTGGCT
CATGCCTGTAATCCCAGCACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAGAAA
TCCCATCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGGAGA
ATTGCCTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAA
AAAAAAAAAAAAAAATTGTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAAATA
ACCTAGTTTAGAAGTTAGAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTATTTC
CAGTGAGAACCATTTTCCCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTTTTT
ACTCTTCTTCACTGTGGAGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAACAC
AAATGAATCAGATTAGACCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCAAGG
TGTCAACCTGGGAAGTGAGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGCAGT
TCTGCTCTGTTACTCTGGTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATATGCT
ATAGTTTCATTTAAGTTAATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGTTAC
TCCTTTTCATGTCTTTTAAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTGTAC
TGTTTTCATCCTGAATTTAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTAACA
TGACAAAATGAAAGCCCTGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACATAA
ACCTTTGCTTATGCAGAAGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTTGGG
TAATAGAGGCTGAACTTTTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCCAGT
AAACTGACTCCATTGAAGACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTGCTA
GCTGTAATGCACAGAGAAAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATAAAA
TATTAAAATGATCAGTTTGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTTTTT
CCAAAAATACTTCTAAATAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAAGAA
CTTTTTAATGGGATAATTGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATTTACTTTCATCCATCTA
TCTGTGCTTTTTCTCACTTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGGCCA
CTGACTCTTGGTCTCAGGCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGTCAG
CTCCAGCTAATTGTCACCACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAGTTT
GTGACTTTTGCTTACATTTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATTTTT
ATTTTTTGAGACAGAGTCTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAGCGA
TTCTTCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGGATT
TCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGTGAG
CCTCTGCAACTGGCCAACATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAAAAA
AGGTTACTTGCTTGAGACAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAATGTG
AACTAATACTTTAAAATTGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGTGTT
GTCACAAAATACACCTTTTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCCTGC
CTTTTCTGGGTGTTTATTTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTTATG
CTGGTTAAATGATCAAAGTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGGTGGGTACCTTAATAAT

>In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_1132nt
ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC
TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG
TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG
AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA
GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT
TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT
GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA
GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA
ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA
GGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGGAG
ACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTGTC
ACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTTCA


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FusionGenePPI for SYNPO2_METTL14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SYNPO2YWHAG, YWHAZ, IPO13, CDK6, BAG3, HSPA8, SQSTM1, FLNA, VPS18, ATG16L1, MAP1LC3A, STX7, FLNC, ACTN2, NTRK1, RHOA, PLK4, POLKMETTL14METTL3, SNX15, SNF8, DDI2, TACC3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMETTL14chr4:119810296chr4:119621705ENST00000388822+611237_238215457METTL3
TgeneMETTL14chr4:119810296chr4:119621705ENST00000388822+611255_258215457METTL3
TgeneMETTL14chr4:119810296chr4:119621705ENST00000388822+611278_287215457METTL3
TgeneMETTL14chr4:119810296chr4:119621705ENST00000388822+611308_312215457METTL3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15481_663351262ACTN2
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15664_924351262ACTN2
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15901_1093351262ACTN2
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14481_663351094ACTN2
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14664_924351094ACTN2
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14901_1093351094ACTN2
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15481_663351110ACTN2
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15664_924351110ACTN2
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15901_1093351110ACTN2
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15615_626351262BAG3
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14615_626351094BAG3
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15615_626351110BAG3
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15810_1093351262FLNC
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14810_1093351094FLNC
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15810_1093351110FLNC
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+151_180351262VPS18
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+141_180351094VPS18
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+151_180351110VPS18
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+15607_811351262YWHAB
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+14607_811351094YWHAB
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+15607_811351110YWHAB
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000307142+151000_1019351262ZYX
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000429713+141000_1019351094ZYX
HgeneSYNPO2chr4:119810296chr4:119621705ENST00000434046+151000_1019351110ZYX
TgeneMETTL14chr4:119810296chr4:119621705ENST00000388822+611135_136215457METTL3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SYNPO2_METTL14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SYNPO2_METTL14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSYNPO2C0677886Epithelial ovarian cancer1CTD_human