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Fusion gene ID: 36941 |
FusionGeneSummary for SYNPO2_METTL14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYNPO2_METTL14 | Fusion gene ID: 36941 | Hgene | Tgene | Gene symbol | SYNPO2 | METTL14 | Gene ID | 171024 | 57721 |
| Gene name | synaptopodin 2 | methyltransferase like 14 | |
| Synonyms | - | hMETTL14 | |
| Cytomap | 4q26 | 4q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | synaptopodin-2genethonin-2myopodin | N6-adenosine-methyltransferase non-catalytic subunitN6-adenosine-methyltransferase subunit METTL14methyltransferase-like protein 14 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9UMS6 | Q9HCE5 | |
| Ensembl transtripts involved in fusion gene | ENST00000307142, ENST00000448416, ENST00000429713, ENST00000434046, | ENST00000388822, ENST00000506780, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SYNPO2 [Title/Abstract] AND METTL14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | METTL14 | GO:0080009 | mRNA methylation | 27281194|27373337|27627798 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PCPG | TCGA-QR-A707-01A | SYNPO2 | chr4 | 119810296 | + | METTL14 | chr4 | 119621705 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000307142 | ENST00000388822 | SYNPO2 | chr4 | 119810296 | + | METTL14 | chr4 | 119621705 | + |
| In-frame | ENST00000307142 | ENST00000506780 | SYNPO2 | chr4 | 119810296 | + | METTL14 | chr4 | 119621705 | + |
| In-frame | ENST00000448416 | ENST00000388822 | SYNPO2 | chr4 | 119810296 | + | METTL14 | chr4 | 119621705 | + |
| In-frame | ENST00000448416 | ENST00000506780 | SYNPO2 | chr4 | 119810296 | + | METTL14 | chr4 | 119621705 | + |
| In-frame | ENST00000429713 | ENST00000388822 | SYNPO2 | chr4 | 119810296 | + | METTL14 | chr4 | 119621705 | + |
| In-frame | ENST00000429713 | ENST00000506780 | SYNPO2 | chr4 | 119810296 | + | METTL14 | chr4 | 119621705 | + |
| In-frame | ENST00000434046 | ENST00000388822 | SYNPO2 | chr4 | 119810296 | + | METTL14 | chr4 | 119621705 | + |
| In-frame | ENST00000434046 | ENST00000506780 | SYNPO2 | chr4 | 119810296 | + | METTL14 | chr4 | 119621705 | + |
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FusionProtFeatures for SYNPO2_METTL14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYNPO2 | METTL14 |
| Has an actin-binding and actin-bundling activity. Caninduce the formation of F-actin networks in an isoform-specificmanner (PubMed:24005909, PubMed:23225103). At the sarcomeric Zlines is proposed to act as adapter protein that links nascentmyofibers to the sarcolemma via ZYX and may play a role in earlyassembly and stabilization of the Z lines. Involved inautophagosome formation. May play a role in chaperone-assistedselective autophagy (CASA) involved in Z lines maintenance instriated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering andfusion complex providing autophagosome membranes (By similarity).Involved in regulation of cell migration (PubMed:22915763,PubMed:25883213). May be a tumor suppressor (PubMed:16885336).{ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8,ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103,ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213,ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}. Isoform 1: Involved in regulation of cell migration. Caninduce formation of thick, irregular actin bundles in the cellbody. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}. Isoform 2: Involved in regulation of cell migration. Caninduce long, well-organized actin bundles frequently orientated inparallel along the long axis of the cell showing characteristicsof contractile ventral stress fibers.{ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}. Isoform 3: Involved in regulation of cell migration. Caninduce an amorphous actin meshwork throughout the cell bodycontaining a mixture of long and short, randomly organized thickand thin actin bundles. {ECO:0000269|PubMed:22915763,ECO:0000269|PubMed:24005909}. Isoform 4: Can induce long, well-organized actin bundlesfrequently orientated in parallel along the long axis of the cellshowing characteristics of contractile ventral stress fibers.{ECO:0000269|PubMed:24005909}. Isoform 5: Involved in regulation of cell migration inpart dependent on the Rho-ROCK cascade; can promote formation ofnascent focal adhesions, actin bundles at the leading cell edgeand lamellipodia (PubMed:22915763, PubMed:25883213). Can induceformation of thick, irregular actin bundles in the cell body; theinduced actin network is associated with enhanced cell migrationin vitro. {ECO:0000269|PubMed:22915763,ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues atthe N(6) position of some mRNAs and regulates the circadian clock,differentiation of embryonic stem cells and cortical neurogenesis(PubMed:24316715, PubMed:24407421, PubMed:25719671,PubMed:29348140, PubMed:27373337, PubMed:27281194). In theheterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than thecatalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194,PubMed:29348140). N6-methyladenosine (m6A), which takes place atthe 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role inmRNA stability and processing (PubMed:24316715, PubMed:24407421,PubMed:25719671). M6A acts as a key regulator of mRNA stability bypromoting mRNA destabilization and degradation (By similarity). Inembryonic stem cells (ESCs), m6A methylation of mRNAs encoding keynaive pluripotency-promoting transcripts results in transcriptdestabilization (By similarity). M6A regulates spermatogonialdifferentiation and meiosis and is essential for male fertilityand spermatogenesis (By similarity). M6A also regulates corticalneurogenesis: m6A methylation of transcripts related totranscription factors, neural stem cells, the cell cycle andneuronal differentiation during brain development promotes theirdestabilization and decay, promoting differentiation of radialglial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4,ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421,ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798,ECO:0000269|PubMed:29348140}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >METTL14 | chr4:119810296 | chr4:119621705 | ENST00000388822 | + | 6 | 11 | 409_452 | 215 | 457 | Compositional bias | Note=Gly-rich |
| Tgene | >METTL14 | chr4:119810296 | chr4:119621705 | ENST00000388822 | + | 6 | 11 | 245_254 | 215 | 457 | Region | Positively charged region required for RNA-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 400_405 | 35 | 1262 | Compositional bias | Note=Poly-Arg |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 423_426 | 35 | 1262 | Compositional bias | Note=Poly-Glu |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 591_658 | 35 | 1262 | Compositional bias | Note=Pro-rich |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 756_818 | 35 | 1262 | Compositional bias | Note=Pro-rich |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 767_770 | 35 | 1262 | Compositional bias | Note=Poly-Ser |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 400_405 | 35 | 1094 | Compositional bias | Note=Poly-Arg |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 423_426 | 35 | 1094 | Compositional bias | Note=Poly-Glu |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 591_658 | 35 | 1094 | Compositional bias | Note=Pro-rich |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 756_818 | 35 | 1094 | Compositional bias | Note=Pro-rich |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 767_770 | 35 | 1094 | Compositional bias | Note=Poly-Ser |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 400_405 | 35 | 1110 | Compositional bias | Note=Poly-Arg |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 423_426 | 35 | 1110 | Compositional bias | Note=Poly-Glu |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 591_658 | 35 | 1110 | Compositional bias | Note=Pro-rich |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 756_818 | 35 | 1110 | Compositional bias | Note=Pro-rich |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 767_770 | 35 | 1110 | Compositional bias | Note=Poly-Ser |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 6_88 | 35 | 1262 | Domain | PDZ |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 6_88 | 35 | 1094 | Domain | PDZ |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 6_88 | 35 | 1110 | Domain | PDZ |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 398_406 | 35 | 1262 | Motif | Nuclear localization signal |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 619_622 | 35 | 1262 | Motif | PPPY motif |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 398_406 | 35 | 1094 | Motif | Nuclear localization signal |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 619_622 | 35 | 1094 | Motif | PPPY motif |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 398_406 | 35 | 1110 | Motif | Nuclear localization signal |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 619_622 | 35 | 1110 | Motif | PPPY motif |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 534_663 | 35 | 1262 | Region | F-actin binding |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 664_803 | 35 | 1262 | Region | F-actin binding |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 664_916 | 35 | 1262 | Region | F-actin bundling activity |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 751_900 | 35 | 1262 | Region | Actin binding |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 534_663 | 35 | 1094 | Region | F-actin binding |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 664_803 | 35 | 1094 | Region | F-actin binding |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 664_916 | 35 | 1094 | Region | F-actin bundling activity |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 751_900 | 35 | 1094 | Region | Actin binding |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 534_663 | 35 | 1110 | Region | F-actin binding |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 664_803 | 35 | 1110 | Region | F-actin binding |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 664_916 | 35 | 1110 | Region | F-actin bundling activity |
| Hgene | >SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 751_900 | 35 | 1110 | Region | Actin binding |
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FusionGeneSequence for SYNPO2_METTL14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_277aa MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR >In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_277aa MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR >In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_277aa MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR >In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_277aa MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR >In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_277aa MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR >In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_277aa MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR >In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_277aa MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR >In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_277aa MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV GPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_831nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA >In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_831nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA >In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_831nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA >In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_831nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA >In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_831nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA >In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_831nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA >In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_831nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA >In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_831nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_6158nt GAGCCCATTAGCCGCACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCA GTCTTGCGTCCTCGGCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCC CAACTAAAAGGAAAACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAA GGAGCAGAAGCAGCCCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTG TGGTTCTGGGGAGGGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAA TAAAAACAATCCTGGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAAC TGTGAAGCGTAGCACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGA AAAACCTGTAGAAATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACC AGGCTGGCTCACAGTTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTT GACTGGTTGTACAGAAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGG TGGAGGAAGAGGTGGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCG TGGAGGAGCACACAGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATT AAATTTCAAGTGGGAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGC CTTGCTTGCAGTTGTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAAC AACTCAAGTAGCTTCATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATA ATGGAAAAAGATCCAGTCTGTGGTATCATGCTAGTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGG TTTTAACATTTTCTTGATGAAACAATAAAAAGAGGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAA TACTGAAGAAATTAAGAGACTTTGAACAAAAACTCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAA GAGATAGAACTTAGCAGGCAGACTTAAAAAAAAAAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTC CTAAGAAGCAAAGGAGGACAAATATTCATGTGCTAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTC AAATAAAAGAGAGGCAGCGACAAGATACCTCATTATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACAT ACACCTTTAAACTTGTTATGGAGATAGTTTAATGTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTG CAATTGCCTTTTATTAAAACCATATGGTGTGATGTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAA TTCATGTTTTAAATGAATTTGATAATGAAATTATACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAAC TTTAAACTTTTGAGATTTGAGAGTCTGTTTTCTATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCT TCTTTTGGTCTGTGATGGATTTTAATGGCCGTTCTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTG AAGATAAGGAATGAGTGATAGAAGAAATAAGGCTGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGT ACAAGACCCCTTTTTTTTTGCTGAAATTATGGTATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCA TTGACCTGGGAATGAAGTCAGGATAGAGAAATTCCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATA CACAGGGCTCTCTATTACGTTCCATACCCTGGGCCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTG TCACAATTTCATCTTAGAAAGAGGTAGGTATGGCTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGT TATTTAAAAAAGAGCAGATGGTGGAAAAAGAATGTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATG GAATTGATTCACTAGTTTTTGCTAACTTTCACTTTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGT TTCCAATGAAATTTCATTACTCTGACCTCTTCTAATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAAT GCTGGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCT GACCAATATGGAGAAATCCCATCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGG AGGCTGTGGCAGGAGAATTGCCTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAG TGAGACTCTGTCTCAAAAAAAAAAAAAAAAATTGTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGC TAATTATTGTGAAATAACCTAGTTTAGAAGTTAGAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAAC TGTTGTTATTTATTTCCAGTGAGAACCATTTTCCCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGA GTAGGAATACTTTTTTACTCTTCTTCACTGTGGAGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAA TACCATACCTAAACACAAATGAATCAGATTAGACCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACA GTGTGAGAGGTCAAGGTGTCAACCTGGGAAGTGAGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGA TCACTACTGCAGCAGTTCTGCTCTGTTACTCTGGTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCC AGGTCAGTGATATGCTATAGTTTCATTTAAGTTAATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGC TGCTACTAGGAGTTACTCCTTTTCATGTCTTTTAAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTT AATTTAAAACCTGTACTGTTTTCATCCTGAATTTAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAAT ATAATCCTTATTAACATGACAAAATGAAAGCCCTGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGA TCTATTAGAAACATAAACCTTTGCTTATGCAGAAGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCC TCTCTTTGATGTTGGGTAATAGAGGCTGAACTTTTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATT AGAACATTTATCCAGTAAACTGACTCCATTGAAGACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACT CGTATAAATATTGCTAGCTGTAATGCACAGAGAAAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTT CCACTACTGGATAAAATATTAAAATGATCAGTTTGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCA GATAAGGTAGGTTTTTCCAAAAATACTTCTAAATAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAG AGAAGCAGGCCAAGAACTTTTTAATGGGATAATTGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATT TACTTTCATCCATCTATCTGTGCTTTTTCTCACTTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTG CGTTAGTAAATGGCCACTGACTCTTGGTCTCAGGCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGT GGACATCACTTGTCAGCTCCAGCTAATTGTCACCACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAG GTTGACAAAATAGTTTGTGACTTTTGCTTACATTTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATAT TTTCTTTTTTATTTTTATTTTTTGAGACAGAGTCTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCC TCCAGGGTTGAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCT TAGTAGAGACAGGATTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCA GGATTACAGGCGTGAGCCTCTGCAACTGGCCAACATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACT TAAAAAAGAGGAAAAAAGGTTACTTGCTTGAGACAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACA GTAGACTGAAAATGTGAACTAATACTTTAAAATTGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGA GGTCTAGGCTTGTGTTGTCACAAAATACACCTTTTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGC TACATCATTATCCTGCCTTTTCTGGGTGTTTATTTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCC AGTTTAGTAGTTTATGCTGGTTAAATGATCAAAGTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGG >In-frame_SYNPO2_ENST00000307142_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_1328nt GAGCCCATTAGCCGCACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCA GTCTTGCGTCCTCGGCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCC CAACTAAAAGGAAAACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAA GGAGCAGAAGCAGCCCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTG TGGTTCTGGGGAGGGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAA TAAAAACAATCCTGGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAAC TGTGAAGCGTAGCACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGA AAAACCTGTAGAAATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACC AGGCTGGCTCACAGTTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTT GACTGGTTGTACAGAAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGG TGGAGGAAGAGGTGGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCG TGGAGGAGCACACAGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATT AAATTTCAAGTGGGAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGC CTTGCTTGCAGTTGTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAAC >In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_6145nt GCACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCAGTCTTGCGTCCTC GGCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCCCAACTAAAAGGAA AACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAG CCCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAG GGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCT GGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGC ACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAA ATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACA GTTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACA GAAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGT GGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACAC AGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGG GAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTT GTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCT TCATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATC CAGTCTGTGGTATCATGCTAGTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTC TTGATGAAACAATAAAAAGAGGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATT AAGAGACTTTGAACAAAAACTCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTA GCAGGCAGACTTAAAAAAAAAAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAG GAGGACAAATATTCATGTGCTAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAG GCAGCGACAAGATACCTCATTATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACT TGTTATGGAGATAGTTTAATGTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTA TTAAAACCATATGGTGTGATGTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAA TGAATTTGATAATGAAATTATACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGA GATTTGAGAGTCTGTTTTCTATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGT GATGGATTTTAATGGCCGTTCTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATG AGTGATAGAAGAAATAAGGCTGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTT TTTTTTGCTGAAATTATGGTATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAAT GAAGTCAGGATAGAGAAATTCCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCT ATTACGTTCCATACCCTGGGCCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATC TTAGAAAGAGGTAGGTATGGCTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGA GCAGATGGTGGAAAAAGAATGTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACT AGTTTTTGCTAACTTTCACTTTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATT TCATTACTCTGACCTCTTCTAATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTG GCTCATGCCTGTAATCCCAGCACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAG AAATCCCATCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGG AGAATTGCCTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCT CAAAAAAAAAAAAAAAAATTGTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAA ATAACCTAGTTTAGAAGTTAGAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTAT TTCCAGTGAGAACCATTTTCCCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTT TTTACTCTTCTTCACTGTGGAGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAA CACAAATGAATCAGATTAGACCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCA AGGTGTCAACCTGGGAAGTGAGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGC AGTTCTGCTCTGTTACTCTGGTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATAT GCTATAGTTTCATTTAAGTTAATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGT TACTCCTTTTCATGTCTTTTAAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTG TACTGTTTTCATCCTGAATTTAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTA ACATGACAAAATGAAAGCCCTGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACA TAAACCTTTGCTTATGCAGAAGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTT GGGTAATAGAGGCTGAACTTTTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCC AGTAAACTGACTCCATTGAAGACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTG CTAGCTGTAATGCACAGAGAAAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATA AAATATTAAAATGATCAGTTTGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTT TTTCCAAAAATACTTCTAAATAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAA GAACTTTTTAATGGGATAATTGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATTTACTTTCATCCAT CTATCTGTGCTTTTTCTCACTTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGG CCACTGACTCTTGGTCTCAGGCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGT CAGCTCCAGCTAATTGTCACCACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAG TTTGTGACTTTTGCTTACATTTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATT TTTATTTTTTGAGACAGAGTCTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAG CGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGG ATTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGT GAGCCTCTGCAACTGGCCAACATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAA AAAAGGTTACTTGCTTGAGACAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAAT GTGAACTAATACTTTAAAATTGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGT GTTGTCACAAAATACACCTTTTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCC TGCCTTTTCTGGGTGTTTATTTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTT ATGCTGGTTAAATGATCAAAGTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGGTGGGTACCTTAAT >In-frame_SYNPO2_ENST00000448416_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_1315nt GCACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCAGTCTTGCGTCCTC GGCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCCCAACTAAAAGGAA AACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAG CCCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAG GGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCT GGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGC ACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAA ATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACA GTTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACA GAAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGT GGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACAC AGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGG GAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTT GTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCT >In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_6144nt CACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCAGTCTTGCGTCCTCG GCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCCCAACTAAAAGGAAA ACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGC CCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGG GGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTG GGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCA CAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAA TTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAG TTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAG AAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTG GAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACA GAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGG AGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTG TCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTT CATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATCC AGTCTGTGGTATCATGCTAGTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTCT TGATGAAACAATAAAAAGAGGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATTA AGAGACTTTGAACAAAAACTCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTAG CAGGCAGACTTAAAAAAAAAAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAGG AGGACAAATATTCATGTGCTAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAGG CAGCGACAAGATACCTCATTATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACTT GTTATGGAGATAGTTTAATGTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTAT TAAAACCATATGGTGTGATGTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAAT GAATTTGATAATGAAATTATACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGAG ATTTGAGAGTCTGTTTTCTATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGTG ATGGATTTTAATGGCCGTTCTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATGA GTGATAGAAGAAATAAGGCTGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTTT TTTTTGCTGAAATTATGGTATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAATG AAGTCAGGATAGAGAAATTCCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCTA TTACGTTCCATACCCTGGGCCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATCT TAGAAAGAGGTAGGTATGGCTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGAG CAGATGGTGGAAAAAGAATGTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACTA GTTTTTGCTAACTTTCACTTTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATTT CATTACTCTGACCTCTTCTAATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTGG CTCATGCCTGTAATCCCAGCACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAGA AATCCCATCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGGA GAATTGCCTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTC AAAAAAAAAAAAAAAAATTGTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAAA TAACCTAGTTTAGAAGTTAGAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTATT TCCAGTGAGAACCATTTTCCCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTTT TTACTCTTCTTCACTGTGGAGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAAC ACAAATGAATCAGATTAGACCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCAA GGTGTCAACCTGGGAAGTGAGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGCA GTTCTGCTCTGTTACTCTGGTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATATG CTATAGTTTCATTTAAGTTAATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGTT ACTCCTTTTCATGTCTTTTAAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTGT ACTGTTTTCATCCTGAATTTAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTAA CATGACAAAATGAAAGCCCTGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACAT AAACCTTTGCTTATGCAGAAGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTTG GGTAATAGAGGCTGAACTTTTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCCA GTAAACTGACTCCATTGAAGACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTGC TAGCTGTAATGCACAGAGAAAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATAA AATATTAAAATGATCAGTTTGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTTT TTCCAAAAATACTTCTAAATAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAAG AACTTTTTAATGGGATAATTGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATTTACTTTCATCCATC TATCTGTGCTTTTTCTCACTTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGGC CACTGACTCTTGGTCTCAGGCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGTC AGCTCCAGCTAATTGTCACCACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAGT TTGTGACTTTTGCTTACATTTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATTT TTATTTTTTGAGACAGAGTCTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAGC GATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGGA TTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGTG AGCCTCTGCAACTGGCCAACATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAAA AAAGGTTACTTGCTTGAGACAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAATG TGAACTAATACTTTAAAATTGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGTG TTGTCACAAAATACACCTTTTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCCT GCCTTTTCTGGGTGTTTATTTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTTA TGCTGGTTAAATGATCAAAGTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGGTGGGTACCTTAATA >In-frame_SYNPO2_ENST00000429713_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_1314nt CACAAATTCGCAGCAGGCGGCTGGGGCGGCGGCTGGGGCAGCGGCTGCAGCAGCGGCGGACGCTCTGCATTACCCAGTCTTGCGTCCTCG GCAGGCGCCCGAAGCTGAGTGCGCATCCTCTACCGCACCCAAGCTTCGTCTGTCTCGTCAAGCTCTTCATGCTGCCCAACTAAAAGGAAA ACATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGC CCTTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGG GGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTG GGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCA CAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAA TTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAG TTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAG AAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTG GAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACA GAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGG AGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTG TCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTT >In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000388822_chr4_119621705_+_5962nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA GGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGGAG ACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTGTC ACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTTCA TCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATCCAG TCTGTGGTATCATGCTAGTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTCTTG ATGAAACAATAAAAAGAGGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATTAAG AGACTTTGAACAAAAACTCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTAGCA GGCAGACTTAAAAAAAAAAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAGGAG GACAAATATTCATGTGCTAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAGGCA GCGACAAGATACCTCATTATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACTTGT TATGGAGATAGTTTAATGTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTATTA AAACCATATGGTGTGATGTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAATGA ATTTGATAATGAAATTATACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGAGAT TTGAGAGTCTGTTTTCTATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGTGAT GGATTTTAATGGCCGTTCTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATGAGT GATAGAAGAAATAAGGCTGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTTTTT TTTGCTGAAATTATGGTATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAATGAA GTCAGGATAGAGAAATTCCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCTATT ACGTTCCATACCCTGGGCCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATCTTA GAAAGAGGTAGGTATGGCTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGAGCA GATGGTGGAAAAAGAATGTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACTAGT TTTTGCTAACTTTCACTTTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATTTCA TTACTCTGACCTCTTCTAATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTGGCT CATGCCTGTAATCCCAGCACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAGAAA TCCCATCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGGAGA ATTGCCTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAA AAAAAAAAAAAAAAATTGTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAAATA ACCTAGTTTAGAAGTTAGAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTATTTC CAGTGAGAACCATTTTCCCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTTTTT ACTCTTCTTCACTGTGGAGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAACAC AAATGAATCAGATTAGACCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCAAGG TGTCAACCTGGGAAGTGAGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGCAGT TCTGCTCTGTTACTCTGGTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATATGCT ATAGTTTCATTTAAGTTAATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGTTAC TCCTTTTCATGTCTTTTAAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTGTAC TGTTTTCATCCTGAATTTAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTAACA TGACAAAATGAAAGCCCTGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACATAA ACCTTTGCTTATGCAGAAGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTTGGG TAATAGAGGCTGAACTTTTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCCAGT AAACTGACTCCATTGAAGACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTGCTA GCTGTAATGCACAGAGAAAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATAAAA TATTAAAATGATCAGTTTGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTTTTT CCAAAAATACTTCTAAATAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAAGAA CTTTTTAATGGGATAATTGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATTTACTTTCATCCATCTA TCTGTGCTTTTTCTCACTTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGGCCA CTGACTCTTGGTCTCAGGCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGTCAG CTCCAGCTAATTGTCACCACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAGTTT GTGACTTTTGCTTACATTTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATTTTT ATTTTTTGAGACAGAGTCTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAGCGA TTCTTCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGGATT TCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGTGAG CCTCTGCAACTGGCCAACATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAAAAA AGGTTACTTGCTTGAGACAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAATGTG AACTAATACTTTAAAATTGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGTGTT GTCACAAAATACACCTTTTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCCTGC CTTTTCTGGGTGTTTATTTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTTATG CTGGTTAAATGATCAAAGTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGGTGGGTACCTTAATAAT >In-frame_SYNPO2_ENST00000434046_chr4_119810296_+_METTL14_ENST00000506780_chr4_119621705_+_1132nt ATGGGCACAGGGGATTTTATCTGCATTTCCATGACTGGAGGGGCGCCCTGGGGGTTCAGATTGCAAGGTGGCAAGGAGCAGAAGCAGCCC TTACAAGTTGCAAAGATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGG TTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGG AAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACA GACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATT TTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTT GGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCATCCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAA GAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAATCTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGA ACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGA GGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGGAG ACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTGTC ACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTTCA |
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FusionGenePPI for SYNPO2_METTL14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SYNPO2 | YWHAG, YWHAZ, IPO13, CDK6, BAG3, HSPA8, SQSTM1, FLNA, VPS18, ATG16L1, MAP1LC3A, STX7, FLNC, ACTN2, NTRK1, RHOA, PLK4, POLK | METTL14 | METTL3, SNX15, SNF8, DDI2, TACC3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | METTL14 | chr4:119810296 | chr4:119621705 | ENST00000388822 | + | 6 | 11 | 237_238 | 215 | 457 | METTL3 |
| Tgene | METTL14 | chr4:119810296 | chr4:119621705 | ENST00000388822 | + | 6 | 11 | 255_258 | 215 | 457 | METTL3 |
| Tgene | METTL14 | chr4:119810296 | chr4:119621705 | ENST00000388822 | + | 6 | 11 | 278_287 | 215 | 457 | METTL3 |
| Tgene | METTL14 | chr4:119810296 | chr4:119621705 | ENST00000388822 | + | 6 | 11 | 308_312 | 215 | 457 | METTL3 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 481_663 | 35 | 1262 | ACTN2 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 664_924 | 35 | 1262 | ACTN2 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 901_1093 | 35 | 1262 | ACTN2 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 481_663 | 35 | 1094 | ACTN2 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 664_924 | 35 | 1094 | ACTN2 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 901_1093 | 35 | 1094 | ACTN2 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 481_663 | 35 | 1110 | ACTN2 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 664_924 | 35 | 1110 | ACTN2 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 901_1093 | 35 | 1110 | ACTN2 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 615_626 | 35 | 1262 | BAG3 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 615_626 | 35 | 1094 | BAG3 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 615_626 | 35 | 1110 | BAG3 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 810_1093 | 35 | 1262 | FLNC |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 810_1093 | 35 | 1094 | FLNC |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 810_1093 | 35 | 1110 | FLNC |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 1_180 | 35 | 1262 | VPS18 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 1_180 | 35 | 1094 | VPS18 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 1_180 | 35 | 1110 | VPS18 |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 607_811 | 35 | 1262 | YWHAB |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 607_811 | 35 | 1094 | YWHAB |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 607_811 | 35 | 1110 | YWHAB |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000307142 | + | 1 | 5 | 1000_1019 | 35 | 1262 | ZYX |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000429713 | + | 1 | 4 | 1000_1019 | 35 | 1094 | ZYX |
| Hgene | SYNPO2 | chr4:119810296 | chr4:119621705 | ENST00000434046 | + | 1 | 5 | 1000_1019 | 35 | 1110 | ZYX |
| Tgene | METTL14 | chr4:119810296 | chr4:119621705 | ENST00000388822 | + | 6 | 11 | 135_136 | 215 | 457 | METTL3 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SYNPO2_METTL14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SYNPO2_METTL14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SYNPO2 | C0677886 | Epithelial ovarian cancer | 1 | CTD_human |
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