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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 36930

FusionGeneSummary for SYNJ1_PDE9A

check button Fusion gene summary
Fusion gene informationFusion gene name: SYNJ1_PDE9A
Fusion gene ID: 36930
HgeneTgene
Gene symbol

SYNJ1

PDE9A

Gene ID

8867

5152

Gene namesynaptojanin 1phosphodiesterase 9A
SynonymsEIEE53|INPP5G|PARK20HSPDE9A2
Cytomap

21q22.11

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionsynaptojanin-1inositol 5'-phosphatase (synaptojanin 1)inositol polyphosphate-5-phosphatase Gphosphoinositide 5-phosphatasesynaptic inositol 1,4,5-trisphosphate 5-phosphatase 1synaptojanin-1, polyphosphoinositide phosphatasehigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9ACGMP-specific 3',5'-cyclic phosphodiesterase type 9phosphodiesterase PDE9A21
Modification date2018052320180519
UniProtAcc

O43426

O76083

Ensembl transtripts involved in fusion geneENST00000382491, ENST00000357345, 
ENST00000382499, ENST00000433931, 
ENST00000322229, ENST00000464778, 
ENST00000335512, ENST00000539837, 
ENST00000470987, ENST00000291539, 
ENST00000398236, ENST00000398229, 
ENST00000398234, ENST00000398232, 
ENST00000398227, ENST00000398225, 
ENST00000380328, ENST00000328862, 
ENST00000335440, ENST00000398224, 
ENST00000349112, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 4 X 5=100
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYNJ1 [Title/Abstract] AND PDE9A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYNJ1

GO:0046856

phosphatidylinositol dephosphorylation

18093523

TgenePDE9A

GO:0046068

cGMP metabolic process

9624146

TgenePDE9A

GO:0046069

cGMP catabolic process

25799991


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-HT-7603-01ASYNJ1chr21

34099083

-PDE9Achr21

44163886

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000382491ENST00000335512SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
Frame-shiftENST00000382491ENST00000539837SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000470987SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000291539SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000398236SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000398229SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000398234SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000398232SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000398227SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000398225SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000380328SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000328862SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000335440SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000398224SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382491ENST00000349112SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
Frame-shiftENST00000357345ENST00000335512SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
Frame-shiftENST00000357345ENST00000539837SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000470987SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000291539SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000398236SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000398229SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000398234SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000398232SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000398227SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000398225SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000380328SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000328862SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000335440SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000398224SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000357345ENST00000349112SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
Frame-shiftENST00000382499ENST00000335512SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
Frame-shiftENST00000382499ENST00000539837SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000470987SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000291539SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000398236SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000398229SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000398234SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000398232SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000398227SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000398225SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000380328SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000328862SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000335440SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000398224SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000382499ENST00000349112SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
In-frameENST00000433931ENST00000335512SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
In-frameENST00000433931ENST00000539837SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000470987SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000291539SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000398236SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000398229SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000398234SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000398232SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000398227SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000398225SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000380328SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000328862SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000335440SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000398224SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000433931ENST00000349112SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
Frame-shiftENST00000322229ENST00000335512SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
Frame-shiftENST00000322229ENST00000539837SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000470987SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000291539SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000398236SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000398229SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000398234SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000398232SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000398227SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000398225SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000380328SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000328862SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000335440SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000398224SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000322229ENST00000349112SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3CDSENST00000464778ENST00000335512SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3CDSENST00000464778ENST00000539837SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000470987SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000291539SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000398236SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000398229SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000398234SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000398232SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000398227SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000398225SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000380328SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000328862SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000335440SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000398224SYNJ1chr21

34099083

-PDE9Achr21

44163886

+
intron-3UTRENST00000464778ENST00000349112SYNJ1chr21

34099083

-PDE9Achr21

44163886

+

Top

FusionProtFeatures for SYNJ1_PDE9A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SYNJ1

O43426

PDE9A

O76083

Phosphatase that acts on various phosphoinositides,including phosphatidylinositol 4-phosphate, phosphatidylinositol(4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate(PubMed:27435091). Has a role in clathrin-mediated endocytosis (Bysimilarity). Hydrolyzes PIP2 bound to actin regulatory proteinsresulting in the rearrangement of actin filaments downstream oftyrosine kinase and ASH/GRB2 (By similarity).{ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910,ECO:0000269|PubMed:27435091}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SYNJ1_PDE9A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SYNJ1_ENST00000433931_chr21_34099083_-_PDE9A_ENST00000335512_chr21_44163886_+_485aa
MRKRWACWSGSDAPGGCGGGCGRRRRRSRRKRAASEERRMAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLLEGLKVVEIE
KCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFS
INPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDIS
PLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRP
MEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDA

>In-frame_SYNJ1_ENST00000433931_chr21_34099083_-_PDE9A_ENST00000539837_chr21_44163886_+_485aa
MRKRWACWSGSDAPGGCGGGCGRRRRRSRRKRAASEERRMAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLLEGLKVVEIE
KCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFS
INPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDIS
PLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRP
MEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SYNJ1_ENST00000433931_chr21_34099083_-_PDE9A_ENST00000335512_chr21_44163886_+_1455nt
ATGCGGAAGAGATGGGCCTGCTGGAGCGGAAGTGACGCTCCCGGCGGCTGTGGCGGCGGCTGCGGGAGAAGGAGGAGGAGGAGCCGGAGG
AAGAGGGCTGCCTCCGAAGAAAGGAGAATGGCGTTCAGTAAAGGATTCCGGATCTATCACAAATTGGATCCCCCACCTTTCAGCCTCATA
GTGGAAACTAGGCATAAGGAAGAATGTCTCATGTTCGAGTCTGGGGCTGTCGCTGTGCTCTTGGAAGGACTAAAAGTGGTGGAGATTGAG
AAATGCAAGAGTGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGAAGCAGCAGGACCAACTGCCCCTGTAAGTACAGTTTTTTGGAT
AACCACAAGAAGTTGACTCCTCGACGCGATGTTCCCACTTACCCCAAGTACCTGCTCTCTCCAGAGACCATCGAGGCCCTGCGGAAGCCG
ACCTTTGACGTCTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTGGAGCACATGTACCACGACCTCGGGCTGGTCAGGGACTTCAGC
ATCAACCCTGTCACCCTCAGGAGGTGGCTGTTCTGCGTCCACGACAACTACAGAAACAACCCCTTCCACAACTTCCGGCACTGCTTCTGC
GTGGCCCAGATGATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAGAAGTTCTCACAAACGGATATCCTGATCCTAATGACAGCGGCC
ATCTGCCACGATCTGGACCATCCCGGCTACAACAACACGTACCAGATCAATGCCCGCACAGAGCTGGCGGTCCGCTACAATGACATCTCA
CCGCTGGAGAACCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAGCCTGAGTGCAACATCTTCTCCAACATCCCACCTGATGGGTTC
AAGCAGATCCGACAGGGAATGATCACATTAATCTTGGCCACTGACATGGCAAGACATGCAGAAATTATGGATTCTTTCAAAGAGAAAATG
GAGAATTTTGACTACAGCAACGAGGAGCACATGACCCTGCTGAAGATGATTTTGATAAAATGCTGTGATATCTCTAACGAGGTCCGTCCA
ATGGAAGTCGCAGAGCCTTGGGTGGACTGTTTATTAGAGGAATATTTTATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTCCTGTGGCA
CCGTTCATGGACCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGGTTCATCAAGTTTGTCCTGATCCCAATGTTTGAAACAGTGACC
AAGCTCTTCCCCATGGTTGAGGAGATCATGCTGCAGCCACTTTGGGAATCCCGAGATCGCTACGAGGAGCTGAAGCGGATAGATGACGCC
ATGAAAGAGTTACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACCGAGAAGTCCAGAGAGAGAAGCAGAGATGTGAAAAACAGTGAA

>In-frame_SYNJ1_ENST00000433931_chr21_34099083_-_PDE9A_ENST00000539837_chr21_44163886_+_1455nt
ATGCGGAAGAGATGGGCCTGCTGGAGCGGAAGTGACGCTCCCGGCGGCTGTGGCGGCGGCTGCGGGAGAAGGAGGAGGAGGAGCCGGAGG
AAGAGGGCTGCCTCCGAAGAAAGGAGAATGGCGTTCAGTAAAGGATTCCGGATCTATCACAAATTGGATCCCCCACCTTTCAGCCTCATA
GTGGAAACTAGGCATAAGGAAGAATGTCTCATGTTCGAGTCTGGGGCTGTCGCTGTGCTCTTGGAAGGACTAAAAGTGGTGGAGATTGAG
AAATGCAAGAGTGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGAAGCAGCAGGACCAACTGCCCCTGTAAGTACAGTTTTTTGGAT
AACCACAAGAAGTTGACTCCTCGACGCGATGTTCCCACTTACCCCAAGTACCTGCTCTCTCCAGAGACCATCGAGGCCCTGCGGAAGCCG
ACCTTTGACGTCTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTGGAGCACATGTACCACGACCTCGGGCTGGTCAGGGACTTCAGC
ATCAACCCTGTCACCCTCAGGAGGTGGCTGTTCTGCGTCCACGACAACTACAGAAACAACCCCTTCCACAACTTCCGGCACTGCTTCTGC
GTGGCCCAGATGATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAGAAGTTCTCACAAACGGATATCCTGATCCTAATGACAGCGGCC
ATCTGCCACGATCTGGACCATCCCGGCTACAACAACACGTACCAGATCAATGCCCGCACAGAGCTGGCGGTCCGCTACAATGACATCTCA
CCGCTGGAGAACCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAGCCTGAGTGCAACATCTTCTCCAACATCCCACCTGATGGGTTC
AAGCAGATCCGACAGGGAATGATCACATTAATCTTGGCCACTGACATGGCAAGACATGCAGAAATTATGGATTCTTTCAAAGAGAAAATG
GAGAATTTTGACTACAGCAACGAGGAGCACATGACCCTGCTGAAGATGATTTTGATAAAATGCTGTGATATCTCTAACGAGGTCCGTCCA
ATGGAAGTCGCAGAGCCTTGGGTGGACTGTTTATTAGAGGAATATTTTATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTCCTGTGGCA
CCGTTCATGGACCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGGTTCATCAAGTTTGTCCTGATCCCAATGTTTGAAACAGTGACC
AAGCTCTTCCCCATGGTTGAGGAGATCATGCTGCAGCCACTTTGGGAATCCCGAGATCGCTACGAGGAGCTGAAGCGGATAGATGACGCC
ATGAAAGAGTTACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACCGAGAAGTCCAGAGAGAGAAGCAGAGATGTGAAAAACAGTGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SYNJ1_ENST00000433931_chr21_34099083_-_PDE9A_ENST00000335512_chr21_44163886_+_1679nt
GCGGCGCAATGCGGAAGAGATGGGCCTGCTGGAGCGGAAGTGACGCTCCCGGCGGCTGTGGCGGCGGCTGCGGGAGAAGGAGGAGGAGGA
GCCGGAGGAAGAGGGCTGCCTCCGAAGAAAGGAGAATGGCGTTCAGTAAAGGATTCCGGATCTATCACAAATTGGATCCCCCACCTTTCA
GCCTCATAGTGGAAACTAGGCATAAGGAAGAATGTCTCATGTTCGAGTCTGGGGCTGTCGCTGTGCTCTTGGAAGGACTAAAAGTGGTGG
AGATTGAGAAATGCAAGAGTGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGAAGCAGCAGGACCAACTGCCCCTGTAAGTACAGTT
TTTTGGATAACCACAAGAAGTTGACTCCTCGACGCGATGTTCCCACTTACCCCAAGTACCTGCTCTCTCCAGAGACCATCGAGGCCCTGC
GGAAGCCGACCTTTGACGTCTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTGGAGCACATGTACCACGACCTCGGGCTGGTCAGGG
ACTTCAGCATCAACCCTGTCACCCTCAGGAGGTGGCTGTTCTGCGTCCACGACAACTACAGAAACAACCCCTTCCACAACTTCCGGCACT
GCTTCTGCGTGGCCCAGATGATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAGAAGTTCTCACAAACGGATATCCTGATCCTAATGA
CAGCGGCCATCTGCCACGATCTGGACCATCCCGGCTACAACAACACGTACCAGATCAATGCCCGCACAGAGCTGGCGGTCCGCTACAATG
ACATCTCACCGCTGGAGAACCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAGCCTGAGTGCAACATCTTCTCCAACATCCCACCTG
ATGGGTTCAAGCAGATCCGACAGGGAATGATCACATTAATCTTGGCCACTGACATGGCAAGACATGCAGAAATTATGGATTCTTTCAAAG
AGAAAATGGAGAATTTTGACTACAGCAACGAGGAGCACATGACCCTGCTGAAGATGATTTTGATAAAATGCTGTGATATCTCTAACGAGG
TCCGTCCAATGGAAGTCGCAGAGCCTTGGGTGGACTGTTTATTAGAGGAATATTTTATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTC
CTGTGGCACCGTTCATGGACCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGGTTCATCAAGTTTGTCCTGATCCCAATGTTTGAAA
CAGTGACCAAGCTCTTCCCCATGGTTGAGGAGATCATGCTGCAGCCACTTTGGGAATCCCGAGATCGCTACGAGGAGCTGAAGCGGATAG
ATGACGCCATGAAAGAGTTACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACCGAGAAGTCCAGAGAGAGAAGCAGAGATGTGAAAA
ACAGTGAAGGAGACTGTGCCTGAGGAAAGCGGGGGGCGTGGCTGCAGTTCTGGACGGGCTGGCCGAGCTGCGCGGGATCCTTGTGCAGGG
AAGAGCTGCCCTGGGCACCTGGCACCACAAGACCATGTTTTCTAAGAACCATTTTGTTCACTGATACAAAAAAAAAAAAAGGAATTCATG

>In-frame_SYNJ1_ENST00000433931_chr21_34099083_-_PDE9A_ENST00000539837_chr21_44163886_+_1676nt
GCGGCGCAATGCGGAAGAGATGGGCCTGCTGGAGCGGAAGTGACGCTCCCGGCGGCTGTGGCGGCGGCTGCGGGAGAAGGAGGAGGAGGA
GCCGGAGGAAGAGGGCTGCCTCCGAAGAAAGGAGAATGGCGTTCAGTAAAGGATTCCGGATCTATCACAAATTGGATCCCCCACCTTTCA
GCCTCATAGTGGAAACTAGGCATAAGGAAGAATGTCTCATGTTCGAGTCTGGGGCTGTCGCTGTGCTCTTGGAAGGACTAAAAGTGGTGG
AGATTGAGAAATGCAAGAGTGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGAAGCAGCAGGACCAACTGCCCCTGTAAGTACAGTT
TTTTGGATAACCACAAGAAGTTGACTCCTCGACGCGATGTTCCCACTTACCCCAAGTACCTGCTCTCTCCAGAGACCATCGAGGCCCTGC
GGAAGCCGACCTTTGACGTCTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTGGAGCACATGTACCACGACCTCGGGCTGGTCAGGG
ACTTCAGCATCAACCCTGTCACCCTCAGGAGGTGGCTGTTCTGCGTCCACGACAACTACAGAAACAACCCCTTCCACAACTTCCGGCACT
GCTTCTGCGTGGCCCAGATGATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAGAAGTTCTCACAAACGGATATCCTGATCCTAATGA
CAGCGGCCATCTGCCACGATCTGGACCATCCCGGCTACAACAACACGTACCAGATCAATGCCCGCACAGAGCTGGCGGTCCGCTACAATG
ACATCTCACCGCTGGAGAACCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAGCCTGAGTGCAACATCTTCTCCAACATCCCACCTG
ATGGGTTCAAGCAGATCCGACAGGGAATGATCACATTAATCTTGGCCACTGACATGGCAAGACATGCAGAAATTATGGATTCTTTCAAAG
AGAAAATGGAGAATTTTGACTACAGCAACGAGGAGCACATGACCCTGCTGAAGATGATTTTGATAAAATGCTGTGATATCTCTAACGAGG
TCCGTCCAATGGAAGTCGCAGAGCCTTGGGTGGACTGTTTATTAGAGGAATATTTTATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTC
CTGTGGCACCGTTCATGGACCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGGTTCATCAAGTTTGTCCTGATCCCAATGTTTGAAA
CAGTGACCAAGCTCTTCCCCATGGTTGAGGAGATCATGCTGCAGCCACTTTGGGAATCCCGAGATCGCTACGAGGAGCTGAAGCGGATAG
ATGACGCCATGAAAGAGTTACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACCGAGAAGTCCAGAGAGAGAAGCAGAGATGTGAAAA
ACAGTGAAGGAGACTGTGCCTGAGGAAAGCGGGGGGCGTGGCTGCAGTTCTGGACGGGCTGGCCGAGCTGCGCGGGATCCTTGTGCAGGG
AAGAGCTGCCCTGGGCACCTGGCACCACAAGACCATGTTTTCTAAGAACCATTTTGTTCACTGATACAAAAAAAAAAAAAGGAATTCATG


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FusionGenePPI for SYNJ1_PDE9A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SYNJ1SH3KBP1, AMPH, SH3GL2, PACSIN3, PACSIN2, PACSIN1, SH3GL1, ITSN1, AP2A1, AP2M1, CLTC, CLTA, GRB2, GTSE1, CDH1, SNX9, ALKBH2PDE9ATRIM32, PHYHIPL, PDE9A, CLK1, CRY2, LMO2, SULT1E1, LAGE3, BAG3, GORASP2, TRPV6, KRTAP9-2, UTP23, NAA38, KRTAP4-2, KRTAP10-8, KRTAP10-3, NOTCH2NL, C9orf106, UNC119, TFAP4, C12orf75, PRKG2, RSPRY1, NPHP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SYNJ1_PDE9A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SYNJ1_PDE9A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSYNJ1C3809824PARKINSON DISEASE 20, EARLY-ONSET1UNIPROT
TgenePDE9AC0005586Bipolar Disorder1PSYGENET