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Fusion gene ID: 36903 |
FusionGeneSummary for SYNE1_METTL24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYNE1_METTL24 | Fusion gene ID: 36903 | Hgene | Tgene | Gene symbol | SYNE1 | METTL24 | Gene ID | 23345 | 728464 |
| Gene name | spectrin repeat containing nuclear envelope protein 1 | methyltransferase like 24 | |
| Synonyms | 8B|ARCA1|C6orf98|CPG2|EDMD4|KASH1|MYNE1|Nesp1|SCAR8|dJ45H2.2 | C6orf186 | |
| Cytomap | 6q25.2 | 6q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nesprin-1CPG2 full lengthKASH domain-containing protein 1enaptinmyocyte nuclear envelope protein 1nesprin 1spectrin repeat containing, nuclear envelope 1synaptic nuclear envelope protein 1synaptic nuclei expressed gene 1 | methyltransferase-like protein 24UPF0624 protein C6orf186 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q8NF91 | Q5JXM2 | |
| Ensembl transtripts involved in fusion gene | ENST00000367255, ENST00000356820, ENST00000423061, ENST00000448038, ENST00000341594, ENST00000265368, ENST00000367253, ENST00000367248, ENST00000413186, ENST00000466159, ENST00000539504, ENST00000347037, ENST00000354674, ENST00000495090, | ENST00000338882, ENST00000490043, | |
| Fusion gene scores | * DoF score | 9 X 10 X 4=360 | 4 X 4 X 4=64 |
| # samples | 10 | 4 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SYNE1 [Title/Abstract] AND METTL24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SYNE1 | GO:0007030 | Golgi organization | 12808039 |
| Hgene | SYNE1 | GO:0042692 | muscle cell differentiation | 11792814 |
| Hgene | SYNE1 | GO:0090286 | cytoskeletal anchoring at nuclear membrane | 18396275 |
| Hgene | SYNE1 | GO:0090292 | nuclear matrix anchoring at nuclear membrane | 11801724 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-55-6987-01A | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000367255 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| 5CDS-intron | ENST00000367255 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| Frame-shift | ENST00000356820 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| 5CDS-intron | ENST00000356820 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| In-frame | ENST00000423061 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| 5CDS-intron | ENST00000423061 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| Frame-shift | ENST00000448038 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| 5CDS-intron | ENST00000448038 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| Frame-shift | ENST00000341594 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| 5CDS-intron | ENST00000341594 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| Frame-shift | ENST00000265368 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| 5CDS-intron | ENST00000265368 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-3CDS | ENST00000367253 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-intron | ENST00000367253 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-3CDS | ENST00000367248 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-intron | ENST00000367248 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-3CDS | ENST00000413186 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-intron | ENST00000413186 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-3CDS | ENST00000466159 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-intron | ENST00000466159 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-3CDS | ENST00000539504 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-intron | ENST00000539504 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-3CDS | ENST00000347037 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-intron | ENST00000347037 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-3CDS | ENST00000354674 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-intron | ENST00000354674 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-3CDS | ENST00000495090 | ENST00000338882 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
| intron-intron | ENST00000495090 | ENST00000490043 | SYNE1 | chr6 | 152570296 | - | METTL24 | chr6 | 110567463 | - |
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FusionProtFeatures for SYNE1_METTL24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYNE1 | METTL24 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SYNE1_METTL24 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SYNE1_ENST00000423061_chr6_152570296_-_METTL24_ENST00000338882_chr6_110567463_-_6558aa MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRMKRIHAVA NIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVDV DKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQ RKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVA SLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECY SPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACD ELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWE RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK AKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQ NEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGI LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRL EVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESE VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFL GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLT SHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEA EDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVA QLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGI QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKL EALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA FEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF NNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQ SLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHME QLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE LVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQK MIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC SELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREH ICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF DKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLED LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKARE EVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQ KEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ LREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQA QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE QYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDL DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLS TKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEIDVLKADLESAEWKVLENLILEDVLEQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SYNE1_ENST00000423061_chr6_152570296_-_METTL24_ENST00000338882_chr6_110567463_-_19674nt ATGGCAACCTCCAGAGGGGCCTCCCGGTGTCCTCGGGATATCGCCAATGTGATGCAGAGGCTGCAAGATGAGCAAGAGATAGTACAAAAA CGAACTTTCACAAAATGGATCAACTCTCATCTGGCCAAGCGGAAACCTCCAATGGTGGTGGACGATCTTTTTGAAGACATGAAAGATGGT GTTAAACTGCTTGCCCTTCTGGAGGTCCTGTCTGGGCAGAAACTGCCTTGTGAACAAGGACGCCGGATGAAGCGAATCCATGCTGTGGCT AACATTGGCACGGCACTCAAGTTCCTCGAAGGAAGAAAGTCCATGCACAGAGGATCACCGATTAAATTAGTCAACATTAACTCCACCGAT ATAGCTGATGGCCGACCCTCAATAGTTCTTGGATTGATGTGGACCATTATTCTATATTTCCAGATTGAAGAGTTGACCAGCAACCTGCCC CAGCTCCAGTCTTTGTCCAGCAGCGCATCCTCCGTGGACAGCATAGTTAGCTCTGAGACTCCCAGCCCACCAAGTAAACGGAAGGTGACC ACCAAGATCCAAGGAAATGCTAAGAAGGCTTTATTAAAGTGGGTTCAGTACACAGCTGGCAAGCAGACTGGAATAGAAGTAAAAGATTTT GGGAAGAGTTGGAGAAGCGGGGTTGCCTTTCATTCAGTTATTCATGCCATTCGACCGGAATTGGTGGACTTGGAGACAGTGAAAGGCAGA TCCAACCGAGAAAATTTGGAGGATGCTTTCACTATCGCCGAAACAGAACTGGGGATCCCAAGACTGCTAGATCCTGAAGACGTTGATGTG GATAAACCAGATGAGAAATCTATTATGACCTATGTAGCCCAGTTTCTGAAACATTATCCTGACATCCACAATGCAAGCACTGATGGGCAA GAGGATGATGAAATACTTCCAGGTTTCCCATCTTTTGCAAATTCTGTACAAAATTTTAAGAGAGAAGACAGAGTAATTTTTAAGGAAATG AAAGTTTGGATAGAACAATTTGAGAGAGATTTGACAAGAGCACAGATGGTGGAATCAAATTTACAGGATAAATATCAGTCATTTAAGCAC TTCAGAGTTCAATATGAAATGAAGAGGAAACAGATTGAACATTTAATACAACCATTACACAGAGACGGTAAATTGTCACTTGACCAAGCA TTGGTAAAACAATCTTGGGATAGAGTGACCTCCAGGCTCTTTGACTGGCATATACAGCTTGATAAATCTCTTCCTGCACCTCTGGGCACC ATAGGTGCCTGGCTGTACAGAGCGGAGGTGGCCCTGAGAGAGGAAATAACCGTTCAACAGGTCCACGAGGAAACAGCAAACACGATACAA CGGAAACTTGAGCAACATAAGGATCTGCTTCAAAACACGGATGCCCACAAAAGAGCATTCCATGAAATCTACCGGACCAGGTCTGTTAAC GGGATTCCAGTGCCACCTGATCAATTAGAGGACATGGCCGAGAGGTTTCATTTTGTTTCCTCCACATCAGAGCTACACCTAATGAAAATG GAATTTTTAGAATTAAAGTACCGTCTGCTCTCACTGCTGGTTCTTGCAGAGTCAAAGCTGAAGTCTTGGATCATTAAGTACGGGAGGAGA GAGTCAGTGGAGCAGCTTCTACAAAACTACGTGTCTTTTATAGAAAATAGCAAGTTCTTTGAACAATATGAGGTGACATACCAGATCTTG AAACAGACAGCTGAGATGTATGTCAAAGCAGATGGTTCAGTGGAAGAAGCTGAGAATGTGATGAAATTCATGAATGAAACCACCGCTCAG TGGAGGAATCTCTCAGTAGAAGTGAGGAGTGTGAGGAGCATGCTGGAAGAAGTGATCTCTAACTGGGATCGCTATGGCAATACAGTGGCT AGTCTGCAAGCCTGGCTAGAGGATGCTGAAAAAATGCTCAATCAATCAGAAAATGCCAAAAAGGATTTTTTTCGAAATTTACCTCATTGG ATTCAGCAGCATACTGCCATGAACGATGCTGGCAATTTTCTAATTGAAACCTGTGATGAGATGGTTTCCCGTGACCTGAAGCAGCAATTA CTGTTGCTAAATGGGCGGTGGAGGGAGTTGTTTATGGAAGTCAAGCAATATGCTCAAGCTGATGAGATGGACAGAATGAAGAAGGAATAC ACAGACTGTGTTGTTACCCTGTCTGCTTTTGCAACGGAAGCCCATAAGAAACTTTCTGAACCCTTAGAAGTCTCTTTTATGAATGTCAAG CTATTAATTCAAGACTTGGAGGATATTGAGCAGAGGGTGCCTGTGATGGATGCCCAATACAAGATAATTACAAAGACAGCACACCTCATT ACCAAAGAAAGCCCCCAAGAAGAAGGAAAAGAAATGTTTGCGACCATGTCAAAGCTCAAAGAGCAGCTAACCAAGGTCAAAGAATGTTAC TCCCCACTCCTTTATGAGTCTCAGCAGCTGTTGATTCCGTTGGAGGAATTAGAAAAGCAGATGACGTCCTTTTATGACTCACTTGGGAAA ATCAATGAAATTATCACAGTTCTTGAGCGTGAGGCACAATCGAGTGCCCTTTTTAAACAAAAACATCAGGAACTGTTAGCTTGTCAAGAA AACTGTAAGAAAACCTTGACACTTATTGAGAAAGGCAGTCAAAGTGTTCAAAAGTTTGTGACCTTGAGCAACGTGTTAAAGCATTTTGAT CAGACGAGGCTACAAAGACAGATTGCAGATATTCATGTTGCTTTTCAGAGTATGGTAAAGAAAACTGGAGATTGGAAGAAGCATGTGGAA ACCAACAGTCGCTTGATGAAGAAGTTTGAGGAGTCTCGAGCAGAGTTGGAGAAGGTACTGCGGATTGCTCAGGAGGGCCTGGAGGAAAAG GGGGATCCAGAGGAGCTCCTGCGGAGACACACTGAGTTTTTCAGTCAGCTGGATCAGAGGGTGCTCAATGCTTTCCTGAAAGCTTGTGAT GAACTCACCGACATCCTTCCAGAGCAGGAGCAGCAGGGGCTGCAGGAAGCTGTTCGAAAGCTCCACAAACAATGGAAGGATCTTCAAGGA GAAGCCCCTTATCATTTGCTTCATCTGAAGATTGATGTGGAGAAGAATAGGTTCTTAGCCTCTGTAGAAGAATGCAGAACTGAGCTGGAT CGAGAGACCAAGCTGATGCCCCAGGAAGGCAGTGAAAAGATAATTAAAGAGCACAGGGTTTTCTTCAGTGACAAAGGTCCTCATCATCTC TGTGAGAAAAGGTTACAGCTCATCGAGGAACTCTGTGTGAAACTCCCAGTGCGGGACCCAGTAAGGGACACACCTGGAACCTGTCACGTG ACTCTCAAAGAGCTCAGAGCTGCCATTGACAGCACCTACAGGAAGCTCATGGAAGACCCAGACAAGTGGAAGGACTACACTAGCAGATTC TCTGAGTTCTCATCTTGGATATCTACAAATGAGACACAATTAAAGGGGATCAAGGGTGAGGCCATCGATACTGCCAACCACGGAGAGGTT AAACGTGCCGTTGAAGAGATCAGAAATGGTGTTACCAAAAGGGGTGAGACCCTCAGCTGGCTGAAATCCAGGCTGAAAGTTTTGACAGAA GTTTCTTCTGAGAATGAAGCCCAAAAGCAGGGAGATGAGCTGGCAAAATTATCCAGCTCTTTCAAGGCTCTTGTGACGCTGCTGTCAGAG GTTGAAAAGATGCTAAGCAATTTTGGGGACTGTGTCCAGTACAAAGAAATAGTCAAAAATTCTCTCGAAGAATTAATTTCTGGCTCTAAA GAAGTCCAGGAACAAGCTGAGAAGATCTTGGATACTGAAAATCTGTTTGAAGCACAGCAGTTACTTCTTCATCACCAGCAAAAGACAAAG CGGATCTCAGCAAAGAAGAGAGATGTGCAGCAGCAGATCGCGCAGGCGCAGCAGGGAGAAGGGGGGCTGCCTGACCGAGGCCACGAGGAG CTGCGGAAGCTGGAGAGCACACTGGATGGCCTGGAGCGCAGCCGGGAGAGGCAGGAACGCCGCATCCAGGTCACATTAAGAAAATGGGAG CGATTTGAAACAAACAAAGAAACAGTAGTAAGATACCTTTTTCAAACAGGTTCCAGTCATGAACGCTTCTTGAGTTTTAGCAGTTTGGAA AGTTTATCTTCAGAACTGGAACAAACAAAGGAGTTTTCTAAACGGACAGAAAGTATTGCAGTCCAGGCTGAGAACCTTGTAAAGGAAGCT TCAGAGATACCGCTTGGGCCCCAAAATAAGCAGCTGCTTCAACAGCAGGCCAAGTCAATCAAAGAACAAGTCAAAAAATTAGAAGACACG CTTGAAGAAGATATTAAAACCATGGAAATGGTGAAAACCAAGTGGGATCATTTTGGCAGTAATTTTGAGACTCTGTCCGTCTGGATAACT GAGAAAGAAAAAGAACTCAATGCCTTGGAAACTTCGTCATCTGCCATGGACATGCAAATCAGCCAAATTAAGGTCACAATTCAGGAAATA GAAAGTAAGCTCAGCAGCATTGTAGGATTAGAAGAAGAAGCCCAGTCTTTTGCTCAGTTTGTTACCACTGGAGAATCTGCTCGAATTAAA GCCAAGTTGACACAAATAAGAAGATACGGGGAAGAGCTTCGAGAGCATGCACAGTGTCTGGAAGGAACAATCCTGGGACATTTATCTCAG CAGCAAAAGTTTGAAGAGAACCTTAGAAAGATCCAGCAATCTGTGTCTGAATTTGAAGATAAACTTGCTGTTCCAATTAAAATATGTTCT TCAGCTACAGAAACATACAAAGTTCTTCAAGAACATATGGATCTCTGCCAGGCCCTGGAGTCACTGAGCAGCGCGATCACTGCCTTCTCA GCCAGTGCCAGGAAGGTTGTGAACAGAGATTCCTGTGTTCAGGAGGCTGCGGCTCTACAGCAGCAATACGAGGACATCCTAAGGAGGGCG AAGGAGAGACAGACGGCGCTGGAGAATCTGCTGGCCCACTGGCAGAGGCTAGAGAAAGAACTATCATCCTTTTTGACCTGGTTAGAGCGG GGTGAAGCTAAAGCCAGTTCCCCAGAAATGGACATTTCTGCAGACAGAGTCAAAGTGGAAGGTGAACTTCAGTTAATACAGGCACTGCAA AATGAAGTTGTATCCCAGGCCTCATTCTATAGCAAACTTTTGCAATTGAAGGAATCATTGTTCTCAGTAGCCTCCAAAGATGATGTGAAA ATGATGAAACTACATTTGGAGCAGTTGGATGAGAGATGGAGAGATTTACCACAGATCATTAACAAAAGGATTAATTTTCTTCAGTCTGTG GTTGCTGAACACCAGCAATTTGATGAGCTGCTGCTTTCCTTTTCTGTCTGGATTAAACTGTTTCTCAGTGAATTACAAACTACCTCTGAG ATTAGCATAATGGACCATCAAGTAGCCCTTACTCGGCATAAGGACCACGCAGCAGAAGTAGAGAGCAAAAAGGGCGAATTGCAGAGTCTG CAGGGTCACTTAGCAAAGTTGGGTTCTCTGGGCCGTGCTGAGGACCTCCACCTCCTGCAGGGAAAGGCTGAGGACTGCTTCCAGCTGTTT GAGGAGGCCAGCCAGGTTGTGGAGAGGCGGCAGCTTGCCCTGTCCCATTTGGCAGAATTCCTCCAGAGCCATGCCTCTCTGTCCGGCATT CTCCGCCAGCTGAGGCAAACAGTGGAAGCAACCAACAGTATGAATAAGAACGAGTCTGATTTGATAGAAAAGGACCTCAATGATGCTCTT CAAAATGCTAAAGCATTAGAATCTGCTGCCGTCAGTCTGGATGGCATTCTTTCCAAAGCCCAATACCATCTGAAAATCGGGAGCTCTGAG CAAAGGACTTCCTGCAGAGCCACGGCTGATCAGCTCTGTGGAGAGGTAGAGAGGATCCAGAACCTTCTGGGAACCAAGCAGAGTGAGGCA GATGCTCTGGCAGTGTTGAAAAAAGCATTCCAAGACCAGAAAGAGGAGCTTCTGAAAAGCATTGAGGACATTGAAGAAAGGACTGACAAA GAGCGATTGAAAGAACCTACCCGCCAAGCTCTTCAGCAGAGGTTAAGAGTGTTTAATCAGCTAGAAGATGAATTGAATTCTCACGAGCAT GAACTATGTTGGTTGAAAGACAAAGCCAAGCAAATTGCCCAGAAAGATGTAGCTTTTGCACCTGAAGTTGACAGGGAGATAAACCGCTTA GAGGTCACCTGGGATGATACCAAAAGACTAATTCATGAAAATCAGGGTCAGTGCTGTGGACTTATTGACTTAATGAGAGAATATCAGAAC CTGAAATCAGCTGTATCTAAAGTCTTAGAAAATGCCAGCAGTGTGATTGTAACCAGAACTACCATAAAAGATCAGGAGGATCTTAAATGG GCTTTTTCCAAGCATGAAACTGCCAAGAACAAAATGAATTACAAACAGAAAGACTTGGATAACTTTACCAGCAAAGGAAAACACTTGTTA TCTGAGCTGAAGAAAATTCACAGTAGTGATTTCAGCTTGGTGAAAACAGACATGGAGAGCACCGTGGACAAATGGCTGGATGTATCAGAG AAACTTGAAGAAAACATGGATAGGCTGAGAGTAAGCCTGTCCATTTGGGATGATGTACTGTCAACTAGAGATGAGATTGAGGGATGGTCA AACAACTGCGTTCCACAGATGGCAGAAAACATCAGCAACCTGGATAACCACCTCAGAGCTGAAGAACTGCTTAAAGAATTTGAGTCTGAA GTTAAAAACAAAGCATTGAGATTGGAAGAACTGCATTCCAAAGTTAATGATCTGAAAGAATTAACTAAAAATCTAGAAACACCGCCAGAC CTTCAGTTTATAGAAGCAGACTTAATGCAGAAACTGGAGCATGCCAAAGAAATAACTGAAGTAGCAAAAGGAACCCTGAAGGATTTCACG GCTCAAAGTACACAAGTGGAGAAGTTTATTAATGACATAACAACATGGTTCACAAAAGTGGAAGAATCGTTGATGAACTGTGCCCAAAAT GAGACTTGTGAAGCATTGAAAAAAGTCAAGGATATACAAAAAGAACTTCAAAGTCAACAAAGCAACATCAGCTCTACCCAAGAAAATCTC AATAGCTTGTGCCGCAAGTACCACTCAGCTGAGTTGGAGAGCCTGGGCCGTGCAATGACTGGTCTGATAAAGAAACATGAAGCCGTGAGC CAGTTGTGCTCCAAAACCCAGGCCAGCCTGCAGGAATCTCTGGAAAAACACTTCAGTGAGTCTATGCAGGAATTCCAAGAATGGTTTTTG GGAGCAAAGGCAGCAGCAAAAGAATCATCAGATCGCACCGGTGACAGCAAAGTTCTAGAAGCAAAGCTCCATGATCTTCAGAACATTTTG GACTCAGTCAGTGATGGGCAGAGCAAACTTGATGCAGTGACTCAAGAAGGACAAACTTTGTATGCACATTTGTCTAAACAAATTGTCAGT AGCATTCAAGAACAAATCACAAAGGCCAATGAAGAGTTTCAAGCATTTCTGAAACAATGCCTTAAAGATAAGCAGGCTCTTCAAGACTGT GCTTCAGAACTTGGAAGCTTTGAAGATCAGCACAGAAAACTGAACTTATGGATCCATGAAATGGAAGAAAGGTTCAATACGGAAAACTTG GGAGAGAGTAAACAGCACATTCCTGAGAAGAAAAATGAAGTTCATAAAGTTGAAATGTTTTTGGGAGAACTGCTGGCTGCAAGAGAGTCT CTTGATAAGCTTTCCCAGAGAGGGCAGCTTCTGAGTGAAGAAGGCCACGGTGCTGGGCAGGAGGGCCGCCTGTGTTCCCAGCTCCTCACA AGCCACCAGAACCTACTTAGAATGACCAAAGAGAAACTCCGGAGCTGCCAGGTGGCCCTTCAGGAGCACGAAGCCCTGGAGGAAGCACTG CAAAGCATGTGGTTCTGGGTGAAGGCCATTCAGGACAGACTGGCCTGTGCAGAGAGCACTCTTGGGAGCAAAGACACCCTGGAGAAACGG CTGTCACAAATACAGGATATTCTCCTGATGAAAGGTGAAGGGGAAGTTAAGTTGAATATGGCCATTGGCAAGGGGGAACAGGCCTTGAGA AGTAGCAACAAAGAAGGTCAGAGGGTGATTCAGACTCAGTTAGAGACCCTTAAAGAAGTGTGGGCTGACATCATGAGCTCCTCCGTCCAC GCTCAAAGCACTTTAGAGTCTGTGATTAGCCAATGGAATGACTATGTAGAGAGGAAAAACCAGTTGGAGCAGTGGATGGAATCAGTGGAT CAAAAAATAGAACATCCCTTACAACCACAGCCAGGTCTGAAAGAGAAGTTCGTCCTGCTTGACCACCTCCAGTCCATCCTGTCTGAGGCA GAAGATCACACGAGAGCCCTTCACCGTCTAATTGCGAAGTCCAGGGAGCTCTACGAAAAGACAGAGGATGAGTCTTTCAAGGACACAGCT CAAGAGGAGCTGAAAACACAGTTTAATGATATAATGACTGTTGCCAAGGAAAAAATGAGGAAAGTGGAAGAGATTGTGAAAGATCATCTA ATGTATTTAGATGCGGTCCACGAGTTCACAGATTGGCTCCATTCAGCAAAGGAAGAACTTCACCGGTGGTCAGATATGTCTGGAGATTCA TCAGCCACCCAGAAAAAGTTATCAAAAATTAAGGAGCTGATAGATTCCAGAGAGATTGGTGCAAGCCGTCTCAGCAGAGTGGAGTCGCTG GCTCCCGAAGTGAAACAGAACACAACTGCCAGTGGGTGTGAGCTCATGCACACGGAGATGCAGGCCCTGCGTGCCGACTGGAAGCAGTGG GAAGACAGTGTATTCCAAACGCAGAGCTGTTTGGAGAACCTGGTCAGCCAGATGGCCCTTTCGGAGCAGGAATTCTCAGGCCAAGTGGCT CAACTGGAGCAGGCCCTGGAACAGTTCAGTGCCCTTCTGAAAACCTGGGCTCAGCAGTTAACCCTCCTGGAAGGCAAGAACACGGATGAG GAGATAGTGGAATGCTGGCACAAAGGACAAGAGATACTGGATGCTTTGCAAAAAGCAGAGCCTAGAACAGAGGATCTCAAGTCTCAGCTG AATGAACTTTGTCGATTTTCCAGAGACCTGAGTACCTACAGTGGAAAAGTTTCTGGCTTGATTAAAGAGTATAATTGTCTTTGTTTGCAA GCATCCAAGGGCTGCCAGAATAAAGAACAGATTTTACAGCAAAGATTTCGAAAGGCCTTCAGGGATTTCCAGCAGTGGTTGGTTAATGCA AAAATCACTACCGCCAAGTGTTTTGATATACCTCAAAATATAAGTGAAGTTTCAACTAGTCTTCAGAAAATACAGGAGTTTTTGTCAGAA AGTGAAAATGGACAGCACAAGCTAAACATGATGCTGTCTAAAGGGGAACTTCTGAGTACCCTGCTGACCAAAGAGAAAGCGAAAGGGATC CAGGCCAAAGTTACAGCTGCAAAAGAAGATTGGAAAAATTTTCATTCAAATCTCCACCAAAAAGAATCTGCTCTAGAGAATCTAAAGATC CAAATGAAGGACTTTGAAGTAAGTGCTGAGCCTATCCAGGACTGGCTGAGTAAAACTGAGAAGATGGTCCATGAAAGCAGCAATCGCCTC TATGATCTGCCAGCAAAGAGGAGGGAGCAGCAGAAGCTCCAGTCTGTCCTTGAGGAAATACACTGCTACGAGCCTCAGCTCAACAGGCTG AAAGAGAAAGCTCAGCAGCTGTGGGAAGGACAAGCTGCCAGCAAGAGCTTTAGGCACAGAGTGTCGCAGCTGTCTTCTCAGTATCTAGCG CTAAGCAATTTAACAAAGGAGAAAGTGTCAAGACTGGATAGAATCGTTGCAGAACACAATCAGTTCTCTCTTGGGATTAAAGAATTACAA GACTGGATGACGGATGCGATTCACATGCTGGATTCATACTGCCACCCGACATCCGACAAAAGTGTGCTGGACAGCAGGACGCTCAAGCTC GAGGCTCTATTATCAGTCAAACAGGAAAAAGAGATTCAGATGAAAATGATAGTGACCAGGGGAGAATCTGTCCTTCAGAATACTTCTCCA GAAGGCATTCCCACTATTCAGCAGCAGCTGCAGAGTGTGAAGGATATGTGGGCATCCCTTTTGTCTGCAGGGATTCGTTGTAAAAGCCAA CTCGAAGGAGCTCTCTCCAAGTGGACAAGTTATCAGGATGGCGTTCGACAGTTCTCCGGTTGGATGGATAGTATGGAAGCCAACCTGAAT GAATCAGAAAGGCAGCATGCGGAGCTGCGGGATAAAACAACGATGCTCGGAAAAGCCAAGTTATTAAATGAAGAAGTGCTGAGTTACAGC AGCTTGCTGGAGACCATCGAAGTCAAAGGGGCTGGCATGACAGAACACTATGTCACCCAGCTAGAACTCCAGGATCTACAGGAACGATAC AGAGCCATCCAAGAGAGGGCCAAGGAAGCCGTAACCAAGTCTGAAAAACTTGTCCGCCTGCACCAAGAGTATCAGAGAGACCTAAAGGCA TTTGAAGTTTGGTTGGGGCAAGAACAAGAAAAGCTCGACCAGTATTCAGTTCTTGAAGGTGATGCCCACACTCATGAGACAACATTGCGT GATCTTCAGGAGCTACAGGTACACTGTGCAGAGGGGCAGGCCCTGTTGAACTCAGTGCTGCACACCAGAGAGGATGTGATCCCATCAGGT ATCCCACAGGCAGAGGACCGGGCTTTAGAGTCTCTCCGGCAAGACTGGCAGGCTTACCAGCACAGGCTGTCCGAGACTCGAACTCAGTTC AATAACGTGGTGAACAAATTGAGGCTAATGGAGCAAAAGTTTCAGCAAGTAGATGAATGGCTCAAAACAGCAGAGGAGAAAAAGTGGCAC GAAGAAGTGACTGCATACAGAGATGAAGTTGAGGAAGTGGGAGCTAGAGCTCAGGAGATACTGGACGAGAGCCACGTGAACAGCAGAATG GGTTGCCAGGCCACCCAGCTGACTTCCAGATACCAGGCCCTGCTTCTCCAAGTGCTGGAACAAATAAAATTCCTGGAGGAGGAGATTCAG AGTTTGGAGGAATCAGAATCATCCCTCAGTTCCTATTCTGATTGGTATGGCTCTACTCATAAAAACTTCAAGAATGTGGCTACCAAGATT GACAAAGTAGATACAGTAATGATGGGGAAGAAATTGAAGACGTTGGAGGTTTTGCTCAAAGACATGGAGAAAGGTCACAGTTTGCTGAAA TCAGCCCGGGAGAAAGGAGAGAGGGCTGTTAAATACTTGGAGGAAGGCGAGGCAGAGAGGTTAAGAAAGGAGATTCATGATCACATGGAG CAGTTGAAGGAACTGACCAGCACTGTCCGGAAAGAACACATGACGCTGGAAAAAGGTCTTCATTTAGCAAAGGAATTCTCAGATAAATGC AAAGCACTGACACAGTGGATAGCAGAATACCAGGAAATTCTACATGTTCCTGAAGAACCCAAAATGGAATTATATGAGAAAAAAGCTCAG TTATCTAAATACAAGTCACTTCAACAAACGGTGCTGTCCCATGAACCATCAGTAAAGTCAGTGAGAGAGAAGGGTGAAGCTCTTTTGGAA CTGGTGCAGGACGTCACTTTAAAGGACAAAATAGATCAACTTCAAAGTGATTACCAGGACCTGTGCAGCATAGGAAAGGCAATGATGGAA GAAATTGCTGGTTTTGAAGACCGTTTGAACAATCTTCAAATGAAAGGTGATACTTTGATTGGCCAATGTGCAGACCACCTGCAAGCGAAA CTTAAACAAAACGTGCATGCTCATCTGCAGGGCACAAAGGACAGCTACTCAGCGATCTGCAGCACAGCTCAGAGGATGTACCAGAGTTTG GAACACGAACTTCAGAAGCACGTCAGCCGACAAGACACCCTGCAGCAGTGCCAGGCCTGGCTTTCTGCAGTCCAGCCGGATTTAGAGCCA AGTCCTCAACCACCTCTTAGTAGGGCAGAAGCCATTAAGCAGGTCAAACACTTCAGAGCTTTGCAAGAGCAGGCAAGGACCTACCTAGAT CTCCTTTGCTCCATGTGTGACCTGTCAAATGCTTCGGTGAAAACCACAGCAAAAGACATTCAACAAACAGAGCAAACGATTGAACAAAAG CTTGTCCAGGCCCAGAACTTAACTCAGGGCTGGGAAGAGATCAAGCACCTGAAGTCTGAGCTCTGGATTTACCTGCAAGATGCTGATCAG CAACTGCAGAACATGAAGAGGAGGCACTCTGAGCTGGAGCTGAACATTGCACAGAACATGGTTTCACAAGTTAAGGATTTTGTTAAGAAA CTACAGAGCAAACAGGCATCCGTGAACACCATAATAGAAAAGGTGAATAAGTTAACAAAGAAGGAGGAATCGCCTGAACACAAGGAAATA AATCATTTAAATGATCAGTGGCTCGATTTGTGCCGTCAGTCTAACAACCTGTGCTTGCAAAGGGAAGAGGATCTTCAGAGAACAAGAGAT TACCATGACTGTATGAATGTTGTTGAAGTGTTCCTAGAAAAATTTACTACAGAATGGGATAACTTGGCCAGATCTGATGCAGAGAGTACA GCTGTCCACCTGGAAGCTTTGAAAAAGTTAGCATTGGCATTGCAGGAGAGAAAGTATGCTATTGAAGATCTGAAAGATCAAAAGCAGAAA ATGATAGAGCATCTGAATTTAGATGACAAGGAGTTAGTCAAAGAACAGACGAGTCATTTAGAGCAACGTTGGTTTCAGCTTGAGGACCTC ATTAAAAGGAAAATCCAAGTGTCAGTCACCAACTTGGAGGAGTTAAATGTGGTGCAGTCCAGATTTCAGGAGCTAATGGAGTGGGCAGAA GAGCAACAACCCAACATCGCCGAGGCCCTTAAGCAGAGCCCTCCTCCAGATATGGCTCAGAACCTTCTCATGGATCACCTGGCCATCTGC AGTGAACTGGAGGCCAAGCAGATGCTCCTGAAATCGCTTATAAAGGACGCAGACAGGGTCATGGCAGATCTTGGTCTCAATGAGCGACAG GTCATCCAGAAGGCTCTCTCTGATGCACAAAGCCACGTGAATTGTCTCAGTGACTTAGTGGGCCAGCGAAGAAAGTACTTAAACAAAGCC TTGTCCGAGAAAACCCAGTTTCTCATGGCAGTGTTCCAGGCCACCAGCCAAATTCAGCAACATGAGCGAAAGATAATGTTCCGTGAACAC ATCTGTCTGTTACCAGATGATGTGAGCAAACAAGTCAAAACATGTAAGAGTGCACAAGCCAGCCTCAAGACTTACCAAAATGAAGTCACT GGACTTTGGGCCCAGGGTCGCGAACTAATGAAGGAAGTCACAGAGCAGGAAAAGAGTGAAGTGCTGGGGAAGCTTCAGGAATTGCAGAGT GTCTATGACAGTGTTTTACAAAAGTGCAGTCACCGGTTACAAGAACTAGAGAAGAATTTGGTTTCTAGGAAGCATTTTAAGGAAGATTTT GATAAAGCTTGCCACTGGCTAAAACAAGCAGATATTGTTACATTTCCTGAAATCAACCTAATGAATGAGAGTTCTGAGCTTCATACACAA CTGGCTAAATACCAAAACATTCTTGAACAATCTCCAGAATATGAAAATCTTCTACTTACGCTGCAGAGAACTGGGCAGACCATATTACCA TCGCTGAATGAAGTCGATCATTCCTACCTCAGTGAAAAGCTAAATGCTTTGCCTCGACAATTTAATGTAATTGTTGCCTTGGCTAAAGAC AAGTTCTATAAAGTCCAGGAAGCAATTCTTGCTCGGAAGGAATATGCTTCCTTGATTGAGTTGACAACCCAGTCTCTGAGTGAACTTGAA GCCCAATTCTTGAGGATGAGCAAAGTTCCCACCGACCTGGCCGTTGAGGAGGCTCTTTCTCTGCAAGATGGTTGCAGAGCCATTCTGGAC GAGGTGGCGGGCCTTGGGGAGGCGGTGGATGAACTGAACCAGAAAAAAGAAGGTTTTCGCAGCACAGGTCAGCCTTGGCAGCCAGACAAG ATGCTGCACCTTGTCACCTTATATCACAGGCTGAAGCGACAAACAGAACAGAGGGTTAGCTTATTAGAAGACACCACCAGTGCTTACCAA GAACACGAGAAGATGTGCCAACAGCTGGAGAGACAACTGAAGTCTGTAAAAGAGGAGCAGTCCAAAGTGAATGAGGAAACGCTGCCTGCA GAGGAGAAGCTCAAAATGTATCACTCCCTGGCAGGAAGTCTCCAGGACTCAGGGATTGTACTGAAACGAGTAACCATACATCTTGAAGAT CTTGCCCCACACCTTGACCCCTTGGCTTATGAGAAAGCCAGGCATCAGATCCAGTCCTGGCAAGGGGAGTTAAAACTGTTGACTTCTGCC ATTGGTGAGACGGTGACAGAATGTGAGAGCCGAATGGTGCAGAGTATAGACTTCCAGACTGAGATGAGTCGCTCCCTGGACTGGCTGAGG AGAGTGAAGGCAGAGCTCAGTGGGCCGGTGTACCTAGACCTCAACCTGCAGGACATCCAAGAGGAAATCAGAAAAATCCAAATTCATCAG GAAGAGGTCCAGTCCAGCTTGAGAATCATGAATGCGCTGAGTCACAAGGAAAAGGAGAAGTTCACAAAGGCCAAGGAGCTGATTTCTGCG GATTTAGAACACAGCCTCGCTGAGCTCTCAGAGCTGGATGGAGACATCCAGGAAGCCTTACGCACCAGACAGGCTACCTTGACTGAAATA TATAGCCAGTGTCAAAGGTATTATCAGGTATTTCAAGCAGCCAATGACTGGCTTGAGGATGCCCAAGAATTGTTACAGCTGGCAGGCAAT GGCCTAGACGTGGAGAGCGCAGAGGAAAATCTCAAAAGCCACATGGAATTTTTCAGTACAGAGGATCAGTTCCATAGTAACCTGGAGGAG CTCCACAGCCTGGTAGCCACCCTGGACCCACTCATCAAGCCAACCGGCAAAGAAGACCTAGAACAGAAAGTGGCTTCTCTGGAACTCAGG AGCCAGAGGATGAGCCGGGACTCTGGTGCCCAAGTGGATCTCTTGCAGAGATGCACAGCTCAATGGCACGATTACCAGAAAGCAAGGGAA GAGGTTATTGAATTGATGAATGATACAGAAAAGAAATTGTCTGAGTTTTCTTTGTTGAAGACTTCGTCTAGTCATGAAGCGGAAGAAAAA TTGTCAGAACACAAGGCTTTAGTGTCAGTGGTTAACTCTTTCCATGAGAAAATTGTGGCCCTTGAGGAAAAAGCTTCACAACTGGAGAAA ACCGGAAATGATGCCAGCAAAGCCACCCTGAGCAGGTCAATGACCACCGTCTGGCAGCGCTGGACACGCCTTCGAGCTGTGGCCCAGGAC CAGGAGAAGATCCTGGAAGATGCAGTGGATGAGTGGACGGGCTTTAACAACAAGGTTAAAAAGGCCACTGAAATGATTGATCAGCTGCAA GATAAGTTACCTGGAAGTTCAGCAGAGAAAGCATCGAAAGCAGAGCTCTTAACTCTTCTTGAATACCACGACACGTTCGTTCTGGAGCTG GAGCAGCAGCAGTCGGCCTTGGGCATGCTGCGGCAGCAAACCCTGAGCATGCTCCAGGATGGAGCCGCCCCAACCCCTGGGGAAGAGCCT CCGCTCATGCAGGAAATCACCGCCATGCAAGATCGGTGCCTGAACATGCAGGAGAAAGTGAAGACTAATGGAAAGTTGGTGAAGCAAGAG CTGAAGGACCGAGAAATGGTGGAGACTCAGATCAATTCTGTGAAATGTTGGGTTCAGGAAACGAAAGAATATTTAGGGAATCCAACAATA GAAATAGATGCTCAACTTGAAGAACTTCAGATTCTCCTAACAGAAGCCACAAATCACCGACAGAACATTGAAAAAATGGCAGAAGAACAG AAGGAGAAGTACTTAGGTCTTTATACCATATTACCTTCTGAACTCTCCCTTCAGTTGGCTGAAGTGGCGTTAGATCTAAAGATCCGAGAT CAGATCCAAGACAAAATAAAAGAAGTTGAGCAGAGCAAGGCCACGAGCCAGGAACTCAGCCGGCAAATTCAGAAGTTAGCTAAAGACCTC ACAACTATTCTAACTAAGCTGAAAGCGAAGACAGATAATGTAGTTCAAGCTAAAACTGACCAAAAGGTGCTGGGAGAGGAATTAGATGGC TGTAATTCAAAGTTAATGGAATTAGATGCAGCAGTACAGAAATTCTTGGAACAGAATGGCCAACTGGGTAAGCCACTGGCCAAGAAGATA GGAAAACTGACTGAACTTCACCAGCAGACCATTAGACAAGCTGAGAATCGGCTCTCCAAGCTCAATCAGGCAGCATCACATTTAGAAGAA TACAATGAAATGCTTGAATTAATTTTGAAGTGGATTGAAAAAGCTAAAGTCTTGGCTCATGGAACTATTGCATGGAATTCTGCAAGCCAG CTTCGGGAACAATATATTTTGCATCAGACCCTGCTAGAAGAATCCAAAGAAATTGACAGTGAGCTGGAAGCAATGACTGAGAAATTACAG TACCTCACTAGCGTGTACTGTACAGAAAAAATGTCTCAGCAAGTGGCAGAACTGGGACGGGAGACTGAGGAGTTGCGACAGATGATCAAA ATTCGTTTGCAGAACCTCCAAGATGCAGCTAAGGATATGAAAAAATTTGAAGCAGAGTTGAAAAAGTTACAAGCTGCCTTGGAGCAAGCC CAGGCAACACTGACTTCTCCAGAAGTTGGACGTCTCAGTCTCAAGGAGCAGCTCTCTCATCGGCAGCATTTGTTGTCTGAGATGGAGTCA CTGAAGCCGAAGGTGCAAGCAGTGCAGCTCTGCCAGAGTGCCCTCCGGATCCCCGAGGATGTGGTTGCCAGCTTACCTCTCTGTCATGCT GCTCTGCGGCTGCAGGAAGAGGCCAGCCGGCTGCAGCACACCGCCATCCAGCAGTGTAACATCATGCAGGCAGCTGTGGTACAATATGAA CAATATGAGCAAGAAATGAAACATCTCCAGCAACTGATAGAAGGAGCTCACAGAGAGATTGAGGATAAACCTGTTGCCACCAGTAACATA CAGGAGCTGCAGGCTCAGATTTCTCGGCATGAGGAGCTGGCGCAGAAAATTAAGGGCTACCAGGAGCAGATCGCTTCTTTGAATTCCAAG TGCAAGATGCTGACGATGAAAGCCAAGCACGCCACCATGCTGCTGACGGTGACCGAGGTCGAGGGGCTGGCGGAAGGGACAGAGGACCTG GATGGGGAGCTCCTCCCCACGCCTTCGGCCCACCCCTCTGTGGTCATGATGACTGCAGGTCGCTGTCACACTTTGCTGTCACCGGTCACT GAGGAGTCTGGGGAGGAGGGAACCAACAGTGAGATTTCCTCTCCACCTGCCTGTCGCTCCCCTTCACCTGTGGCTAATACAGATGCTTCT GTTAACCAGGACATTGCATATTACCAAGCCTTGTCTGCTGAGAGGTTGCAGACAGATGCTGCAAAAATTCACCCCAGCACATCCGCATCC CAGGAGTTCTATGAACCGGGATTGGAGCCATCCGCTACTGCCAAACTGGGTGATTTGCAGCGTTCTTGGGAAACCTTAAAGAATGTGATC AGTGAGAAGCAGCGCACACTCTATGAAGCTTTGGAACGCCAGCAGAAGTACCAGGACTCCCTCCAGTCCATCTCTACGAAGATGGAGGCC ATTGAGCTGAAACTCAGTGAGAGCCCAGAGCCTGGCAGGAGTCCAGAAAGCCAGATGGCTGAACATCAGGCATTGATGGATGAGATTCTC ATGCTCCAGGATGAAATCAATGAGCTCCAGTCCTCTCTCGCAGAGGAGCTGGTATCCGAGTCTTGTGAGGCCGACCCTGCGGAGCAGCTG GCCTTGCAGTCCACGCTCACTGTCTTAGCCGAGCGAATGTCCACCATCAGGATGAAAGCCTCGGGGAAACGGCAGCTTTTGGAGGAGAAG TTGAATGATCAGCTGGAGGAACAAAGGCAGGAACAGGCCCTGCAGAGGTATCGCTGTGAAGCCGATGAGCTGGACAGCTGGCTCTTGAGT ACCAAGGCCACTCTGGACACTGCGCTGAGTCCACCCAAGGAGCCCATGGACATGGAGGCCCAGCTTATGGACTGCCAGAATATGCTGGTG GAAATAGAGCAGAAGGTGGTGGCTTTATCAGAACTGTCAGTCCACAATGAGAACCTGCTGCTGGAGGGCAAAGCTCACACCAAGGACGAG GCCGAGCAGCTGGCTGGAAAGCTGAGAAGGCTCAAGGGGAGCCTGCTGGAGCTGCAGAGAGCCCTGCATGATAAGCAGCTCAACATGCAG GGAACAGCACAGGAGAAGGAGGAGAGCGATGTTGACCTAACAGCCACGCAGAGCCCCGGCGTCCAGGAATGGCTGGCCCAAGCTCGCACC ACATGGACCCAGCAGCGGCAGAGCAGTCTCCAGCAACAAAAAGAGTTAGAACAGGAATTAGCCGAGCAGAAGAGTCTCCTTCGCTCAGTA GCCAGTCGTGGAGAGGAGATTCTAATTCAACATTCGGCGGCAGAGACCTCTGGTGATGCTGGCGAAAAACCTGATGTGTTATCCCAGGAG TTGGGGATGGAAGGGGAGAAATCATCCGCTGAAGACCAGATGAGAATGAAATGGGAAAGCCTACATCAAGAATTTAGTACCAAGCAGAAA CTACTACAGAATGTTCTGGAACAGGAACAAGAGCAAGTGCTTTATAGCAGGCCAAATCGACTCTTGTCTGGTGTGCCACTGTACAAAGGG GACGTGCCAACCCAAGATAAATCTGCAGTTACATCTTTGCTGGATGGACTGAACCAAGCCTTCGAGGAGGTTTCATCCCAGAGTGGAGGG GCAAAGAGGCAGAGTATACACTTGGAGCAGAAGTTGTATGATGGAGTCTCAGCCACCTCTACTTGGTTGGATGACGTTGAAGAACGTTTA TTTGTTGCCACAGCACTTTTACCAGAAGAAACAGAGACTTGTCTCTTCAACCAAGAGATTCTTGCCAAAGACATTAAGGAAATGTCTGAA GAAATGGATAAGAACAAAAACTTGTTTTCCCAAGCTTTTCCAGAGAATGGTGATAATCGAGATGTTATTGAAGATACTTTGGGTTGTCTT TTGGGCAGGTTATCCTTGCTAGACTCAGTAGTGAATCAACGATGTCATCAGATGAAAGAAAGACTTCAGCAAATACTAAATTTCCAGAAT GATCTGAAAGTGCTGTTTACATCACTGGCTGACAACAAATACATCATTCTGCAAAAACTGGCAAATGTGTTTGAACAGCCCGTAGCAGAA CAAATAGAGATTGACGTTCTCAAGGCAGATCTGGAAAGTGCAGAATGGAAAGTTTTGGAAAATCTTATTCTGGAAGATGTTCTTGAGCAG ATTGGACAGCTCATCTTTGAGATCCATCTCCACTGGCCTGGGTTTGAGGTCAGTGGCAGTGACAGCAGCGTTGTGCGGTTCTGGTACAGC CTTCTCAAAGAGTTAGAACAAAAGGATTTCAGGCTTTTTCACAGTTACAAAGACTTATCTAAACCTCAGCTATTCTTGAAGAAAGACATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SYNE1_ENST00000423061_chr6_152570296_-_METTL24_ENST00000338882_chr6_110567463_-_20129nt CGGCCGCCGGCCGCAGCGGGCTGAGATTGTTGTCCTCTGTCACCAGGGCGGCTGGGCTCCCGCAGTCCTGCAGACCGCGCCCGATCCCGG CGACAGGGCGGGCGGACAGCCGCGCATCCCCGGGGTCCCGCCGAGCCTGGGCGCAGAGAGCCGGGAGGAAGCGTTCGCTCGCTTCGCCTT GCTGCTGGGAAACTGAACGAGGCCGAGAGAGAAGGTTCTTGAGTTCATGTAAGAGGACAGTCTTAAAACGGAAGAAGAAAAAGAAGCAGT TCAGTCTTTGGGAGAGCTGCCTCCTTGTTGAGTGCTGCAAAGGCCTGGAATTCATTTATGACAGAATAGATCTAGAAAAGTCCAAGCATG TTTTCTAGAGTGGTGTAGCCCTGTGCTGCCTCCAGTGAAGAGTCTCTTGGTGTTGGCTTCGTGCTTCCGGAGGGACCATGGCAACCTCCA GAGGGGCCTCCCGGTGTCCTCGGGATATCGCCAATGTGATGCAGAGGCTGCAAGATGAGCAAGAGATAGTACAAAAACGAACTTTCACAA AATGGATCAACTCTCATCTGGCCAAGCGGAAACCTCCAATGGTGGTGGACGATCTTTTTGAAGACATGAAAGATGGTGTTAAACTGCTTG CCCTTCTGGAGGTCCTGTCTGGGCAGAAACTGCCTTGTGAACAAGGACGCCGGATGAAGCGAATCCATGCTGTGGCTAACATTGGCACGG CACTCAAGTTCCTCGAAGGAAGAAAGTCCATGCACAGAGGATCACCGATTAAATTAGTCAACATTAACTCCACCGATATAGCTGATGGCC GACCCTCAATAGTTCTTGGATTGATGTGGACCATTATTCTATATTTCCAGATTGAAGAGTTGACCAGCAACCTGCCCCAGCTCCAGTCTT TGTCCAGCAGCGCATCCTCCGTGGACAGCATAGTTAGCTCTGAGACTCCCAGCCCACCAAGTAAACGGAAGGTGACCACCAAGATCCAAG GAAATGCTAAGAAGGCTTTATTAAAGTGGGTTCAGTACACAGCTGGCAAGCAGACTGGAATAGAAGTAAAAGATTTTGGGAAGAGTTGGA GAAGCGGGGTTGCCTTTCATTCAGTTATTCATGCCATTCGACCGGAATTGGTGGACTTGGAGACAGTGAAAGGCAGATCCAACCGAGAAA ATTTGGAGGATGCTTTCACTATCGCCGAAACAGAACTGGGGATCCCAAGACTGCTAGATCCTGAAGACGTTGATGTGGATAAACCAGATG AGAAATCTATTATGACCTATGTAGCCCAGTTTCTGAAACATTATCCTGACATCCACAATGCAAGCACTGATGGGCAAGAGGATGATGAAA TACTTCCAGGTTTCCCATCTTTTGCAAATTCTGTACAAAATTTTAAGAGAGAAGACAGAGTAATTTTTAAGGAAATGAAAGTTTGGATAG AACAATTTGAGAGAGATTTGACAAGAGCACAGATGGTGGAATCAAATTTACAGGATAAATATCAGTCATTTAAGCACTTCAGAGTTCAAT ATGAAATGAAGAGGAAACAGATTGAACATTTAATACAACCATTACACAGAGACGGTAAATTGTCACTTGACCAAGCATTGGTAAAACAAT CTTGGGATAGAGTGACCTCCAGGCTCTTTGACTGGCATATACAGCTTGATAAATCTCTTCCTGCACCTCTGGGCACCATAGGTGCCTGGC TGTACAGAGCGGAGGTGGCCCTGAGAGAGGAAATAACCGTTCAACAGGTCCACGAGGAAACAGCAAACACGATACAACGGAAACTTGAGC AACATAAGGATCTGCTTCAAAACACGGATGCCCACAAAAGAGCATTCCATGAAATCTACCGGACCAGGTCTGTTAACGGGATTCCAGTGC CACCTGATCAATTAGAGGACATGGCCGAGAGGTTTCATTTTGTTTCCTCCACATCAGAGCTACACCTAATGAAAATGGAATTTTTAGAAT TAAAGTACCGTCTGCTCTCACTGCTGGTTCTTGCAGAGTCAAAGCTGAAGTCTTGGATCATTAAGTACGGGAGGAGAGAGTCAGTGGAGC AGCTTCTACAAAACTACGTGTCTTTTATAGAAAATAGCAAGTTCTTTGAACAATATGAGGTGACATACCAGATCTTGAAACAGACAGCTG AGATGTATGTCAAAGCAGATGGTTCAGTGGAAGAAGCTGAGAATGTGATGAAATTCATGAATGAAACCACCGCTCAGTGGAGGAATCTCT CAGTAGAAGTGAGGAGTGTGAGGAGCATGCTGGAAGAAGTGATCTCTAACTGGGATCGCTATGGCAATACAGTGGCTAGTCTGCAAGCCT GGCTAGAGGATGCTGAAAAAATGCTCAATCAATCAGAAAATGCCAAAAAGGATTTTTTTCGAAATTTACCTCATTGGATTCAGCAGCATA CTGCCATGAACGATGCTGGCAATTTTCTAATTGAAACCTGTGATGAGATGGTTTCCCGTGACCTGAAGCAGCAATTACTGTTGCTAAATG GGCGGTGGAGGGAGTTGTTTATGGAAGTCAAGCAATATGCTCAAGCTGATGAGATGGACAGAATGAAGAAGGAATACACAGACTGTGTTG TTACCCTGTCTGCTTTTGCAACGGAAGCCCATAAGAAACTTTCTGAACCCTTAGAAGTCTCTTTTATGAATGTCAAGCTATTAATTCAAG ACTTGGAGGATATTGAGCAGAGGGTGCCTGTGATGGATGCCCAATACAAGATAATTACAAAGACAGCACACCTCATTACCAAAGAAAGCC CCCAAGAAGAAGGAAAAGAAATGTTTGCGACCATGTCAAAGCTCAAAGAGCAGCTAACCAAGGTCAAAGAATGTTACTCCCCACTCCTTT ATGAGTCTCAGCAGCTGTTGATTCCGTTGGAGGAATTAGAAAAGCAGATGACGTCCTTTTATGACTCACTTGGGAAAATCAATGAAATTA TCACAGTTCTTGAGCGTGAGGCACAATCGAGTGCCCTTTTTAAACAAAAACATCAGGAACTGTTAGCTTGTCAAGAAAACTGTAAGAAAA CCTTGACACTTATTGAGAAAGGCAGTCAAAGTGTTCAAAAGTTTGTGACCTTGAGCAACGTGTTAAAGCATTTTGATCAGACGAGGCTAC AAAGACAGATTGCAGATATTCATGTTGCTTTTCAGAGTATGGTAAAGAAAACTGGAGATTGGAAGAAGCATGTGGAAACCAACAGTCGCT TGATGAAGAAGTTTGAGGAGTCTCGAGCAGAGTTGGAGAAGGTACTGCGGATTGCTCAGGAGGGCCTGGAGGAAAAGGGGGATCCAGAGG AGCTCCTGCGGAGACACACTGAGTTTTTCAGTCAGCTGGATCAGAGGGTGCTCAATGCTTTCCTGAAAGCTTGTGATGAACTCACCGACA TCCTTCCAGAGCAGGAGCAGCAGGGGCTGCAGGAAGCTGTTCGAAAGCTCCACAAACAATGGAAGGATCTTCAAGGAGAAGCCCCTTATC ATTTGCTTCATCTGAAGATTGATGTGGAGAAGAATAGGTTCTTAGCCTCTGTAGAAGAATGCAGAACTGAGCTGGATCGAGAGACCAAGC TGATGCCCCAGGAAGGCAGTGAAAAGATAATTAAAGAGCACAGGGTTTTCTTCAGTGACAAAGGTCCTCATCATCTCTGTGAGAAAAGGT TACAGCTCATCGAGGAACTCTGTGTGAAACTCCCAGTGCGGGACCCAGTAAGGGACACACCTGGAACCTGTCACGTGACTCTCAAAGAGC TCAGAGCTGCCATTGACAGCACCTACAGGAAGCTCATGGAAGACCCAGACAAGTGGAAGGACTACACTAGCAGATTCTCTGAGTTCTCAT CTTGGATATCTACAAATGAGACACAATTAAAGGGGATCAAGGGTGAGGCCATCGATACTGCCAACCACGGAGAGGTTAAACGTGCCGTTG AAGAGATCAGAAATGGTGTTACCAAAAGGGGTGAGACCCTCAGCTGGCTGAAATCCAGGCTGAAAGTTTTGACAGAAGTTTCTTCTGAGA ATGAAGCCCAAAAGCAGGGAGATGAGCTGGCAAAATTATCCAGCTCTTTCAAGGCTCTTGTGACGCTGCTGTCAGAGGTTGAAAAGATGC TAAGCAATTTTGGGGACTGTGTCCAGTACAAAGAAATAGTCAAAAATTCTCTCGAAGAATTAATTTCTGGCTCTAAAGAAGTCCAGGAAC AAGCTGAGAAGATCTTGGATACTGAAAATCTGTTTGAAGCACAGCAGTTACTTCTTCATCACCAGCAAAAGACAAAGCGGATCTCAGCAA AGAAGAGAGATGTGCAGCAGCAGATCGCGCAGGCGCAGCAGGGAGAAGGGGGGCTGCCTGACCGAGGCCACGAGGAGCTGCGGAAGCTGG AGAGCACACTGGATGGCCTGGAGCGCAGCCGGGAGAGGCAGGAACGCCGCATCCAGGTCACATTAAGAAAATGGGAGCGATTTGAAACAA ACAAAGAAACAGTAGTAAGATACCTTTTTCAAACAGGTTCCAGTCATGAACGCTTCTTGAGTTTTAGCAGTTTGGAAAGTTTATCTTCAG AACTGGAACAAACAAAGGAGTTTTCTAAACGGACAGAAAGTATTGCAGTCCAGGCTGAGAACCTTGTAAAGGAAGCTTCAGAGATACCGC TTGGGCCCCAAAATAAGCAGCTGCTTCAACAGCAGGCCAAGTCAATCAAAGAACAAGTCAAAAAATTAGAAGACACGCTTGAAGAAGATA TTAAAACCATGGAAATGGTGAAAACCAAGTGGGATCATTTTGGCAGTAATTTTGAGACTCTGTCCGTCTGGATAACTGAGAAAGAAAAAG AACTCAATGCCTTGGAAACTTCGTCATCTGCCATGGACATGCAAATCAGCCAAATTAAGGTCACAATTCAGGAAATAGAAAGTAAGCTCA GCAGCATTGTAGGATTAGAAGAAGAAGCCCAGTCTTTTGCTCAGTTTGTTACCACTGGAGAATCTGCTCGAATTAAAGCCAAGTTGACAC AAATAAGAAGATACGGGGAAGAGCTTCGAGAGCATGCACAGTGTCTGGAAGGAACAATCCTGGGACATTTATCTCAGCAGCAAAAGTTTG AAGAGAACCTTAGAAAGATCCAGCAATCTGTGTCTGAATTTGAAGATAAACTTGCTGTTCCAATTAAAATATGTTCTTCAGCTACAGAAA CATACAAAGTTCTTCAAGAACATATGGATCTCTGCCAGGCCCTGGAGTCACTGAGCAGCGCGATCACTGCCTTCTCAGCCAGTGCCAGGA AGGTTGTGAACAGAGATTCCTGTGTTCAGGAGGCTGCGGCTCTACAGCAGCAATACGAGGACATCCTAAGGAGGGCGAAGGAGAGACAGA CGGCGCTGGAGAATCTGCTGGCCCACTGGCAGAGGCTAGAGAAAGAACTATCATCCTTTTTGACCTGGTTAGAGCGGGGTGAAGCTAAAG CCAGTTCCCCAGAAATGGACATTTCTGCAGACAGAGTCAAAGTGGAAGGTGAACTTCAGTTAATACAGGCACTGCAAAATGAAGTTGTAT CCCAGGCCTCATTCTATAGCAAACTTTTGCAATTGAAGGAATCATTGTTCTCAGTAGCCTCCAAAGATGATGTGAAAATGATGAAACTAC ATTTGGAGCAGTTGGATGAGAGATGGAGAGATTTACCACAGATCATTAACAAAAGGATTAATTTTCTTCAGTCTGTGGTTGCTGAACACC AGCAATTTGATGAGCTGCTGCTTTCCTTTTCTGTCTGGATTAAACTGTTTCTCAGTGAATTACAAACTACCTCTGAGATTAGCATAATGG ACCATCAAGTAGCCCTTACTCGGCATAAGGACCACGCAGCAGAAGTAGAGAGCAAAAAGGGCGAATTGCAGAGTCTGCAGGGTCACTTAG CAAAGTTGGGTTCTCTGGGCCGTGCTGAGGACCTCCACCTCCTGCAGGGAAAGGCTGAGGACTGCTTCCAGCTGTTTGAGGAGGCCAGCC AGGTTGTGGAGAGGCGGCAGCTTGCCCTGTCCCATTTGGCAGAATTCCTCCAGAGCCATGCCTCTCTGTCCGGCATTCTCCGCCAGCTGA GGCAAACAGTGGAAGCAACCAACAGTATGAATAAGAACGAGTCTGATTTGATAGAAAAGGACCTCAATGATGCTCTTCAAAATGCTAAAG CATTAGAATCTGCTGCCGTCAGTCTGGATGGCATTCTTTCCAAAGCCCAATACCATCTGAAAATCGGGAGCTCTGAGCAAAGGACTTCCT GCAGAGCCACGGCTGATCAGCTCTGTGGAGAGGTAGAGAGGATCCAGAACCTTCTGGGAACCAAGCAGAGTGAGGCAGATGCTCTGGCAG TGTTGAAAAAAGCATTCCAAGACCAGAAAGAGGAGCTTCTGAAAAGCATTGAGGACATTGAAGAAAGGACTGACAAAGAGCGATTGAAAG AACCTACCCGCCAAGCTCTTCAGCAGAGGTTAAGAGTGTTTAATCAGCTAGAAGATGAATTGAATTCTCACGAGCATGAACTATGTTGGT TGAAAGACAAAGCCAAGCAAATTGCCCAGAAAGATGTAGCTTTTGCACCTGAAGTTGACAGGGAGATAAACCGCTTAGAGGTCACCTGGG ATGATACCAAAAGACTAATTCATGAAAATCAGGGTCAGTGCTGTGGACTTATTGACTTAATGAGAGAATATCAGAACCTGAAATCAGCTG TATCTAAAGTCTTAGAAAATGCCAGCAGTGTGATTGTAACCAGAACTACCATAAAAGATCAGGAGGATCTTAAATGGGCTTTTTCCAAGC ATGAAACTGCCAAGAACAAAATGAATTACAAACAGAAAGACTTGGATAACTTTACCAGCAAAGGAAAACACTTGTTATCTGAGCTGAAGA AAATTCACAGTAGTGATTTCAGCTTGGTGAAAACAGACATGGAGAGCACCGTGGACAAATGGCTGGATGTATCAGAGAAACTTGAAGAAA ACATGGATAGGCTGAGAGTAAGCCTGTCCATTTGGGATGATGTACTGTCAACTAGAGATGAGATTGAGGGATGGTCAAACAACTGCGTTC CACAGATGGCAGAAAACATCAGCAACCTGGATAACCACCTCAGAGCTGAAGAACTGCTTAAAGAATTTGAGTCTGAAGTTAAAAACAAAG CATTGAGATTGGAAGAACTGCATTCCAAAGTTAATGATCTGAAAGAATTAACTAAAAATCTAGAAACACCGCCAGACCTTCAGTTTATAG AAGCAGACTTAATGCAGAAACTGGAGCATGCCAAAGAAATAACTGAAGTAGCAAAAGGAACCCTGAAGGATTTCACGGCTCAAAGTACAC AAGTGGAGAAGTTTATTAATGACATAACAACATGGTTCACAAAAGTGGAAGAATCGTTGATGAACTGTGCCCAAAATGAGACTTGTGAAG CATTGAAAAAAGTCAAGGATATACAAAAAGAACTTCAAAGTCAACAAAGCAACATCAGCTCTACCCAAGAAAATCTCAATAGCTTGTGCC GCAAGTACCACTCAGCTGAGTTGGAGAGCCTGGGCCGTGCAATGACTGGTCTGATAAAGAAACATGAAGCCGTGAGCCAGTTGTGCTCCA AAACCCAGGCCAGCCTGCAGGAATCTCTGGAAAAACACTTCAGTGAGTCTATGCAGGAATTCCAAGAATGGTTTTTGGGAGCAAAGGCAG CAGCAAAAGAATCATCAGATCGCACCGGTGACAGCAAAGTTCTAGAAGCAAAGCTCCATGATCTTCAGAACATTTTGGACTCAGTCAGTG ATGGGCAGAGCAAACTTGATGCAGTGACTCAAGAAGGACAAACTTTGTATGCACATTTGTCTAAACAAATTGTCAGTAGCATTCAAGAAC AAATCACAAAGGCCAATGAAGAGTTTCAAGCATTTCTGAAACAATGCCTTAAAGATAAGCAGGCTCTTCAAGACTGTGCTTCAGAACTTG GAAGCTTTGAAGATCAGCACAGAAAACTGAACTTATGGATCCATGAAATGGAAGAAAGGTTCAATACGGAAAACTTGGGAGAGAGTAAAC AGCACATTCCTGAGAAGAAAAATGAAGTTCATAAAGTTGAAATGTTTTTGGGAGAACTGCTGGCTGCAAGAGAGTCTCTTGATAAGCTTT CCCAGAGAGGGCAGCTTCTGAGTGAAGAAGGCCACGGTGCTGGGCAGGAGGGCCGCCTGTGTTCCCAGCTCCTCACAAGCCACCAGAACC TACTTAGAATGACCAAAGAGAAACTCCGGAGCTGCCAGGTGGCCCTTCAGGAGCACGAAGCCCTGGAGGAAGCACTGCAAAGCATGTGGT TCTGGGTGAAGGCCATTCAGGACAGACTGGCCTGTGCAGAGAGCACTCTTGGGAGCAAAGACACCCTGGAGAAACGGCTGTCACAAATAC AGGATATTCTCCTGATGAAAGGTGAAGGGGAAGTTAAGTTGAATATGGCCATTGGCAAGGGGGAACAGGCCTTGAGAAGTAGCAACAAAG AAGGTCAGAGGGTGATTCAGACTCAGTTAGAGACCCTTAAAGAAGTGTGGGCTGACATCATGAGCTCCTCCGTCCACGCTCAAAGCACTT TAGAGTCTGTGATTAGCCAATGGAATGACTATGTAGAGAGGAAAAACCAGTTGGAGCAGTGGATGGAATCAGTGGATCAAAAAATAGAAC ATCCCTTACAACCACAGCCAGGTCTGAAAGAGAAGTTCGTCCTGCTTGACCACCTCCAGTCCATCCTGTCTGAGGCAGAAGATCACACGA GAGCCCTTCACCGTCTAATTGCGAAGTCCAGGGAGCTCTACGAAAAGACAGAGGATGAGTCTTTCAAGGACACAGCTCAAGAGGAGCTGA AAACACAGTTTAATGATATAATGACTGTTGCCAAGGAAAAAATGAGGAAAGTGGAAGAGATTGTGAAAGATCATCTAATGTATTTAGATG CGGTCCACGAGTTCACAGATTGGCTCCATTCAGCAAAGGAAGAACTTCACCGGTGGTCAGATATGTCTGGAGATTCATCAGCCACCCAGA AAAAGTTATCAAAAATTAAGGAGCTGATAGATTCCAGAGAGATTGGTGCAAGCCGTCTCAGCAGAGTGGAGTCGCTGGCTCCCGAAGTGA AACAGAACACAACTGCCAGTGGGTGTGAGCTCATGCACACGGAGATGCAGGCCCTGCGTGCCGACTGGAAGCAGTGGGAAGACAGTGTAT TCCAAACGCAGAGCTGTTTGGAGAACCTGGTCAGCCAGATGGCCCTTTCGGAGCAGGAATTCTCAGGCCAAGTGGCTCAACTGGAGCAGG CCCTGGAACAGTTCAGTGCCCTTCTGAAAACCTGGGCTCAGCAGTTAACCCTCCTGGAAGGCAAGAACACGGATGAGGAGATAGTGGAAT GCTGGCACAAAGGACAAGAGATACTGGATGCTTTGCAAAAAGCAGAGCCTAGAACAGAGGATCTCAAGTCTCAGCTGAATGAACTTTGTC GATTTTCCAGAGACCTGAGTACCTACAGTGGAAAAGTTTCTGGCTTGATTAAAGAGTATAATTGTCTTTGTTTGCAAGCATCCAAGGGCT GCCAGAATAAAGAACAGATTTTACAGCAAAGATTTCGAAAGGCCTTCAGGGATTTCCAGCAGTGGTTGGTTAATGCAAAAATCACTACCG CCAAGTGTTTTGATATACCTCAAAATATAAGTGAAGTTTCAACTAGTCTTCAGAAAATACAGGAGTTTTTGTCAGAAAGTGAAAATGGAC AGCACAAGCTAAACATGATGCTGTCTAAAGGGGAACTTCTGAGTACCCTGCTGACCAAAGAGAAAGCGAAAGGGATCCAGGCCAAAGTTA CAGCTGCAAAAGAAGATTGGAAAAATTTTCATTCAAATCTCCACCAAAAAGAATCTGCTCTAGAGAATCTAAAGATCCAAATGAAGGACT TTGAAGTAAGTGCTGAGCCTATCCAGGACTGGCTGAGTAAAACTGAGAAGATGGTCCATGAAAGCAGCAATCGCCTCTATGATCTGCCAG CAAAGAGGAGGGAGCAGCAGAAGCTCCAGTCTGTCCTTGAGGAAATACACTGCTACGAGCCTCAGCTCAACAGGCTGAAAGAGAAAGCTC AGCAGCTGTGGGAAGGACAAGCTGCCAGCAAGAGCTTTAGGCACAGAGTGTCGCAGCTGTCTTCTCAGTATCTAGCGCTAAGCAATTTAA CAAAGGAGAAAGTGTCAAGACTGGATAGAATCGTTGCAGAACACAATCAGTTCTCTCTTGGGATTAAAGAATTACAAGACTGGATGACGG ATGCGATTCACATGCTGGATTCATACTGCCACCCGACATCCGACAAAAGTGTGCTGGACAGCAGGACGCTCAAGCTCGAGGCTCTATTAT CAGTCAAACAGGAAAAAGAGATTCAGATGAAAATGATAGTGACCAGGGGAGAATCTGTCCTTCAGAATACTTCTCCAGAAGGCATTCCCA CTATTCAGCAGCAGCTGCAGAGTGTGAAGGATATGTGGGCATCCCTTTTGTCTGCAGGGATTCGTTGTAAAAGCCAACTCGAAGGAGCTC TCTCCAAGTGGACAAGTTATCAGGATGGCGTTCGACAGTTCTCCGGTTGGATGGATAGTATGGAAGCCAACCTGAATGAATCAGAAAGGC AGCATGCGGAGCTGCGGGATAAAACAACGATGCTCGGAAAAGCCAAGTTATTAAATGAAGAAGTGCTGAGTTACAGCAGCTTGCTGGAGA CCATCGAAGTCAAAGGGGCTGGCATGACAGAACACTATGTCACCCAGCTAGAACTCCAGGATCTACAGGAACGATACAGAGCCATCCAAG AGAGGGCCAAGGAAGCCGTAACCAAGTCTGAAAAACTTGTCCGCCTGCACCAAGAGTATCAGAGAGACCTAAAGGCATTTGAAGTTTGGT TGGGGCAAGAACAAGAAAAGCTCGACCAGTATTCAGTTCTTGAAGGTGATGCCCACACTCATGAGACAACATTGCGTGATCTTCAGGAGC TACAGGTACACTGTGCAGAGGGGCAGGCCCTGTTGAACTCAGTGCTGCACACCAGAGAGGATGTGATCCCATCAGGTATCCCACAGGCAG AGGACCGGGCTTTAGAGTCTCTCCGGCAAGACTGGCAGGCTTACCAGCACAGGCTGTCCGAGACTCGAACTCAGTTCAATAACGTGGTGA ACAAATTGAGGCTAATGGAGCAAAAGTTTCAGCAAGTAGATGAATGGCTCAAAACAGCAGAGGAGAAAAAGTGGCACGAAGAAGTGACTG CATACAGAGATGAAGTTGAGGAAGTGGGAGCTAGAGCTCAGGAGATACTGGACGAGAGCCACGTGAACAGCAGAATGGGTTGCCAGGCCA CCCAGCTGACTTCCAGATACCAGGCCCTGCTTCTCCAAGTGCTGGAACAAATAAAATTCCTGGAGGAGGAGATTCAGAGTTTGGAGGAAT CAGAATCATCCCTCAGTTCCTATTCTGATTGGTATGGCTCTACTCATAAAAACTTCAAGAATGTGGCTACCAAGATTGACAAAGTAGATA CAGTAATGATGGGGAAGAAATTGAAGACGTTGGAGGTTTTGCTCAAAGACATGGAGAAAGGTCACAGTTTGCTGAAATCAGCCCGGGAGA AAGGAGAGAGGGCTGTTAAATACTTGGAGGAAGGCGAGGCAGAGAGGTTAAGAAAGGAGATTCATGATCACATGGAGCAGTTGAAGGAAC TGACCAGCACTGTCCGGAAAGAACACATGACGCTGGAAAAAGGTCTTCATTTAGCAAAGGAATTCTCAGATAAATGCAAAGCACTGACAC AGTGGATAGCAGAATACCAGGAAATTCTACATGTTCCTGAAGAACCCAAAATGGAATTATATGAGAAAAAAGCTCAGTTATCTAAATACA AGTCACTTCAACAAACGGTGCTGTCCCATGAACCATCAGTAAAGTCAGTGAGAGAGAAGGGTGAAGCTCTTTTGGAACTGGTGCAGGACG TCACTTTAAAGGACAAAATAGATCAACTTCAAAGTGATTACCAGGACCTGTGCAGCATAGGAAAGGCAATGATGGAAGAAATTGCTGGTT TTGAAGACCGTTTGAACAATCTTCAAATGAAAGGTGATACTTTGATTGGCCAATGTGCAGACCACCTGCAAGCGAAACTTAAACAAAACG TGCATGCTCATCTGCAGGGCACAAAGGACAGCTACTCAGCGATCTGCAGCACAGCTCAGAGGATGTACCAGAGTTTGGAACACGAACTTC AGAAGCACGTCAGCCGACAAGACACCCTGCAGCAGTGCCAGGCCTGGCTTTCTGCAGTCCAGCCGGATTTAGAGCCAAGTCCTCAACCAC CTCTTAGTAGGGCAGAAGCCATTAAGCAGGTCAAACACTTCAGAGCTTTGCAAGAGCAGGCAAGGACCTACCTAGATCTCCTTTGCTCCA TGTGTGACCTGTCAAATGCTTCGGTGAAAACCACAGCAAAAGACATTCAACAAACAGAGCAAACGATTGAACAAAAGCTTGTCCAGGCCC AGAACTTAACTCAGGGCTGGGAAGAGATCAAGCACCTGAAGTCTGAGCTCTGGATTTACCTGCAAGATGCTGATCAGCAACTGCAGAACA TGAAGAGGAGGCACTCTGAGCTGGAGCTGAACATTGCACAGAACATGGTTTCACAAGTTAAGGATTTTGTTAAGAAACTACAGAGCAAAC AGGCATCCGTGAACACCATAATAGAAAAGGTGAATAAGTTAACAAAGAAGGAGGAATCGCCTGAACACAAGGAAATAAATCATTTAAATG ATCAGTGGCTCGATTTGTGCCGTCAGTCTAACAACCTGTGCTTGCAAAGGGAAGAGGATCTTCAGAGAACAAGAGATTACCATGACTGTA TGAATGTTGTTGAAGTGTTCCTAGAAAAATTTACTACAGAATGGGATAACTTGGCCAGATCTGATGCAGAGAGTACAGCTGTCCACCTGG AAGCTTTGAAAAAGTTAGCATTGGCATTGCAGGAGAGAAAGTATGCTATTGAAGATCTGAAAGATCAAAAGCAGAAAATGATAGAGCATC TGAATTTAGATGACAAGGAGTTAGTCAAAGAACAGACGAGTCATTTAGAGCAACGTTGGTTTCAGCTTGAGGACCTCATTAAAAGGAAAA TCCAAGTGTCAGTCACCAACTTGGAGGAGTTAAATGTGGTGCAGTCCAGATTTCAGGAGCTAATGGAGTGGGCAGAAGAGCAACAACCCA ACATCGCCGAGGCCCTTAAGCAGAGCCCTCCTCCAGATATGGCTCAGAACCTTCTCATGGATCACCTGGCCATCTGCAGTGAACTGGAGG CCAAGCAGATGCTCCTGAAATCGCTTATAAAGGACGCAGACAGGGTCATGGCAGATCTTGGTCTCAATGAGCGACAGGTCATCCAGAAGG CTCTCTCTGATGCACAAAGCCACGTGAATTGTCTCAGTGACTTAGTGGGCCAGCGAAGAAAGTACTTAAACAAAGCCTTGTCCGAGAAAA CCCAGTTTCTCATGGCAGTGTTCCAGGCCACCAGCCAAATTCAGCAACATGAGCGAAAGATAATGTTCCGTGAACACATCTGTCTGTTAC CAGATGATGTGAGCAAACAAGTCAAAACATGTAAGAGTGCACAAGCCAGCCTCAAGACTTACCAAAATGAAGTCACTGGACTTTGGGCCC AGGGTCGCGAACTAATGAAGGAAGTCACAGAGCAGGAAAAGAGTGAAGTGCTGGGGAAGCTTCAGGAATTGCAGAGTGTCTATGACAGTG TTTTACAAAAGTGCAGTCACCGGTTACAAGAACTAGAGAAGAATTTGGTTTCTAGGAAGCATTTTAAGGAAGATTTTGATAAAGCTTGCC ACTGGCTAAAACAAGCAGATATTGTTACATTTCCTGAAATCAACCTAATGAATGAGAGTTCTGAGCTTCATACACAACTGGCTAAATACC AAAACATTCTTGAACAATCTCCAGAATATGAAAATCTTCTACTTACGCTGCAGAGAACTGGGCAGACCATATTACCATCGCTGAATGAAG TCGATCATTCCTACCTCAGTGAAAAGCTAAATGCTTTGCCTCGACAATTTAATGTAATTGTTGCCTTGGCTAAAGACAAGTTCTATAAAG TCCAGGAAGCAATTCTTGCTCGGAAGGAATATGCTTCCTTGATTGAGTTGACAACCCAGTCTCTGAGTGAACTTGAAGCCCAATTCTTGA GGATGAGCAAAGTTCCCACCGACCTGGCCGTTGAGGAGGCTCTTTCTCTGCAAGATGGTTGCAGAGCCATTCTGGACGAGGTGGCGGGCC TTGGGGAGGCGGTGGATGAACTGAACCAGAAAAAAGAAGGTTTTCGCAGCACAGGTCAGCCTTGGCAGCCAGACAAGATGCTGCACCTTG TCACCTTATATCACAGGCTGAAGCGACAAACAGAACAGAGGGTTAGCTTATTAGAAGACACCACCAGTGCTTACCAAGAACACGAGAAGA TGTGCCAACAGCTGGAGAGACAACTGAAGTCTGTAAAAGAGGAGCAGTCCAAAGTGAATGAGGAAACGCTGCCTGCAGAGGAGAAGCTCA AAATGTATCACTCCCTGGCAGGAAGTCTCCAGGACTCAGGGATTGTACTGAAACGAGTAACCATACATCTTGAAGATCTTGCCCCACACC TTGACCCCTTGGCTTATGAGAAAGCCAGGCATCAGATCCAGTCCTGGCAAGGGGAGTTAAAACTGTTGACTTCTGCCATTGGTGAGACGG TGACAGAATGTGAGAGCCGAATGGTGCAGAGTATAGACTTCCAGACTGAGATGAGTCGCTCCCTGGACTGGCTGAGGAGAGTGAAGGCAG AGCTCAGTGGGCCGGTGTACCTAGACCTCAACCTGCAGGACATCCAAGAGGAAATCAGAAAAATCCAAATTCATCAGGAAGAGGTCCAGT CCAGCTTGAGAATCATGAATGCGCTGAGTCACAAGGAAAAGGAGAAGTTCACAAAGGCCAAGGAGCTGATTTCTGCGGATTTAGAACACA GCCTCGCTGAGCTCTCAGAGCTGGATGGAGACATCCAGGAAGCCTTACGCACCAGACAGGCTACCTTGACTGAAATATATAGCCAGTGTC AAAGGTATTATCAGGTATTTCAAGCAGCCAATGACTGGCTTGAGGATGCCCAAGAATTGTTACAGCTGGCAGGCAATGGCCTAGACGTGG AGAGCGCAGAGGAAAATCTCAAAAGCCACATGGAATTTTTCAGTACAGAGGATCAGTTCCATAGTAACCTGGAGGAGCTCCACAGCCTGG TAGCCACCCTGGACCCACTCATCAAGCCAACCGGCAAAGAAGACCTAGAACAGAAAGTGGCTTCTCTGGAACTCAGGAGCCAGAGGATGA GCCGGGACTCTGGTGCCCAAGTGGATCTCTTGCAGAGATGCACAGCTCAATGGCACGATTACCAGAAAGCAAGGGAAGAGGTTATTGAAT TGATGAATGATACAGAAAAGAAATTGTCTGAGTTTTCTTTGTTGAAGACTTCGTCTAGTCATGAAGCGGAAGAAAAATTGTCAGAACACA AGGCTTTAGTGTCAGTGGTTAACTCTTTCCATGAGAAAATTGTGGCCCTTGAGGAAAAAGCTTCACAACTGGAGAAAACCGGAAATGATG CCAGCAAAGCCACCCTGAGCAGGTCAATGACCACCGTCTGGCAGCGCTGGACACGCCTTCGAGCTGTGGCCCAGGACCAGGAGAAGATCC TGGAAGATGCAGTGGATGAGTGGACGGGCTTTAACAACAAGGTTAAAAAGGCCACTGAAATGATTGATCAGCTGCAAGATAAGTTACCTG GAAGTTCAGCAGAGAAAGCATCGAAAGCAGAGCTCTTAACTCTTCTTGAATACCACGACACGTTCGTTCTGGAGCTGGAGCAGCAGCAGT CGGCCTTGGGCATGCTGCGGCAGCAAACCCTGAGCATGCTCCAGGATGGAGCCGCCCCAACCCCTGGGGAAGAGCCTCCGCTCATGCAGG AAATCACCGCCATGCAAGATCGGTGCCTGAACATGCAGGAGAAAGTGAAGACTAATGGAAAGTTGGTGAAGCAAGAGCTGAAGGACCGAG AAATGGTGGAGACTCAGATCAATTCTGTGAAATGTTGGGTTCAGGAAACGAAAGAATATTTAGGGAATCCAACAATAGAAATAGATGCTC AACTTGAAGAACTTCAGATTCTCCTAACAGAAGCCACAAATCACCGACAGAACATTGAAAAAATGGCAGAAGAACAGAAGGAGAAGTACT TAGGTCTTTATACCATATTACCTTCTGAACTCTCCCTTCAGTTGGCTGAAGTGGCGTTAGATCTAAAGATCCGAGATCAGATCCAAGACA AAATAAAAGAAGTTGAGCAGAGCAAGGCCACGAGCCAGGAACTCAGCCGGCAAATTCAGAAGTTAGCTAAAGACCTCACAACTATTCTAA CTAAGCTGAAAGCGAAGACAGATAATGTAGTTCAAGCTAAAACTGACCAAAAGGTGCTGGGAGAGGAATTAGATGGCTGTAATTCAAAGT TAATGGAATTAGATGCAGCAGTACAGAAATTCTTGGAACAGAATGGCCAACTGGGTAAGCCACTGGCCAAGAAGATAGGAAAACTGACTG AACTTCACCAGCAGACCATTAGACAAGCTGAGAATCGGCTCTCCAAGCTCAATCAGGCAGCATCACATTTAGAAGAATACAATGAAATGC TTGAATTAATTTTGAAGTGGATTGAAAAAGCTAAAGTCTTGGCTCATGGAACTATTGCATGGAATTCTGCAAGCCAGCTTCGGGAACAAT ATATTTTGCATCAGACCCTGCTAGAAGAATCCAAAGAAATTGACAGTGAGCTGGAAGCAATGACTGAGAAATTACAGTACCTCACTAGCG TGTACTGTACAGAAAAAATGTCTCAGCAAGTGGCAGAACTGGGACGGGAGACTGAGGAGTTGCGACAGATGATCAAAATTCGTTTGCAGA ACCTCCAAGATGCAGCTAAGGATATGAAAAAATTTGAAGCAGAGTTGAAAAAGTTACAAGCTGCCTTGGAGCAAGCCCAGGCAACACTGA CTTCTCCAGAAGTTGGACGTCTCAGTCTCAAGGAGCAGCTCTCTCATCGGCAGCATTTGTTGTCTGAGATGGAGTCACTGAAGCCGAAGG TGCAAGCAGTGCAGCTCTGCCAGAGTGCCCTCCGGATCCCCGAGGATGTGGTTGCCAGCTTACCTCTCTGTCATGCTGCTCTGCGGCTGC AGGAAGAGGCCAGCCGGCTGCAGCACACCGCCATCCAGCAGTGTAACATCATGCAGGCAGCTGTGGTACAATATGAACAATATGAGCAAG AAATGAAACATCTCCAGCAACTGATAGAAGGAGCTCACAGAGAGATTGAGGATAAACCTGTTGCCACCAGTAACATACAGGAGCTGCAGG CTCAGATTTCTCGGCATGAGGAGCTGGCGCAGAAAATTAAGGGCTACCAGGAGCAGATCGCTTCTTTGAATTCCAAGTGCAAGATGCTGA CGATGAAAGCCAAGCACGCCACCATGCTGCTGACGGTGACCGAGGTCGAGGGGCTGGCGGAAGGGACAGAGGACCTGGATGGGGAGCTCC TCCCCACGCCTTCGGCCCACCCCTCTGTGGTCATGATGACTGCAGGTCGCTGTCACACTTTGCTGTCACCGGTCACTGAGGAGTCTGGGG AGGAGGGAACCAACAGTGAGATTTCCTCTCCACCTGCCTGTCGCTCCCCTTCACCTGTGGCTAATACAGATGCTTCTGTTAACCAGGACA TTGCATATTACCAAGCCTTGTCTGCTGAGAGGTTGCAGACAGATGCTGCAAAAATTCACCCCAGCACATCCGCATCCCAGGAGTTCTATG AACCGGGATTGGAGCCATCCGCTACTGCCAAACTGGGTGATTTGCAGCGTTCTTGGGAAACCTTAAAGAATGTGATCAGTGAGAAGCAGC GCACACTCTATGAAGCTTTGGAACGCCAGCAGAAGTACCAGGACTCCCTCCAGTCCATCTCTACGAAGATGGAGGCCATTGAGCTGAAAC TCAGTGAGAGCCCAGAGCCTGGCAGGAGTCCAGAAAGCCAGATGGCTGAACATCAGGCATTGATGGATGAGATTCTCATGCTCCAGGATG AAATCAATGAGCTCCAGTCCTCTCTCGCAGAGGAGCTGGTATCCGAGTCTTGTGAGGCCGACCCTGCGGAGCAGCTGGCCTTGCAGTCCA CGCTCACTGTCTTAGCCGAGCGAATGTCCACCATCAGGATGAAAGCCTCGGGGAAACGGCAGCTTTTGGAGGAGAAGTTGAATGATCAGC TGGAGGAACAAAGGCAGGAACAGGCCCTGCAGAGGTATCGCTGTGAAGCCGATGAGCTGGACAGCTGGCTCTTGAGTACCAAGGCCACTC TGGACACTGCGCTGAGTCCACCCAAGGAGCCCATGGACATGGAGGCCCAGCTTATGGACTGCCAGAATATGCTGGTGGAAATAGAGCAGA AGGTGGTGGCTTTATCAGAACTGTCAGTCCACAATGAGAACCTGCTGCTGGAGGGCAAAGCTCACACCAAGGACGAGGCCGAGCAGCTGG CTGGAAAGCTGAGAAGGCTCAAGGGGAGCCTGCTGGAGCTGCAGAGAGCCCTGCATGATAAGCAGCTCAACATGCAGGGAACAGCACAGG AGAAGGAGGAGAGCGATGTTGACCTAACAGCCACGCAGAGCCCCGGCGTCCAGGAATGGCTGGCCCAAGCTCGCACCACATGGACCCAGC AGCGGCAGAGCAGTCTCCAGCAACAAAAAGAGTTAGAACAGGAATTAGCCGAGCAGAAGAGTCTCCTTCGCTCAGTAGCCAGTCGTGGAG AGGAGATTCTAATTCAACATTCGGCGGCAGAGACCTCTGGTGATGCTGGCGAAAAACCTGATGTGTTATCCCAGGAGTTGGGGATGGAAG GGGAGAAATCATCCGCTGAAGACCAGATGAGAATGAAATGGGAAAGCCTACATCAAGAATTTAGTACCAAGCAGAAACTACTACAGAATG TTCTGGAACAGGAACAAGAGCAAGTGCTTTATAGCAGGCCAAATCGACTCTTGTCTGGTGTGCCACTGTACAAAGGGGACGTGCCAACCC AAGATAAATCTGCAGTTACATCTTTGCTGGATGGACTGAACCAAGCCTTCGAGGAGGTTTCATCCCAGAGTGGAGGGGCAAAGAGGCAGA GTATACACTTGGAGCAGAAGTTGTATGATGGAGTCTCAGCCACCTCTACTTGGTTGGATGACGTTGAAGAACGTTTATTTGTTGCCACAG CACTTTTACCAGAAGAAACAGAGACTTGTCTCTTCAACCAAGAGATTCTTGCCAAAGACATTAAGGAAATGTCTGAAGAAATGGATAAGA ACAAAAACTTGTTTTCCCAAGCTTTTCCAGAGAATGGTGATAATCGAGATGTTATTGAAGATACTTTGGGTTGTCTTTTGGGCAGGTTAT CCTTGCTAGACTCAGTAGTGAATCAACGATGTCATCAGATGAAAGAAAGACTTCAGCAAATACTAAATTTCCAGAATGATCTGAAAGTGC TGTTTACATCACTGGCTGACAACAAATACATCATTCTGCAAAAACTGGCAAATGTGTTTGAACAGCCCGTAGCAGAACAAATAGAGATTG ACGTTCTCAAGGCAGATCTGGAAAGTGCAGAATGGAAAGTTTTGGAAAATCTTATTCTGGAAGATGTTCTTGAGCAGATTGGACAGCTCA TCTTTGAGATCCATCTCCACTGGCCTGGGTTTGAGGTCAGTGGCAGTGACAGCAGCGTTGTGCGGTTCTGGTACAGCCTTCTCAAAGAGT TAGAACAAAAGGATTTCAGGCTTTTTCACAGTTACAAAGACTTATCTAAACCTCAGCTATTCTTGAAGAAAGACATTTTCAATGCAAGTA |
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FusionGenePPI for SYNE1_METTL24 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SYNE1 | SYNE1, DISC1, MUSK, LMNA, EMD, APC, CDC42, TERF2, CDC5L, DTNBP1, CEP63, NDEL1, SH3BP5, TNIK, SUN1, SUN2, KIAA0368, OBSL1, EZH2, SUZ12, RNF2, BMI1, IFT57, NLN, NTRK1, IFI16, NUP107, NUP35, PPME1, TRIM29, GAN, MCM2, USP21, HEY1 | METTL24 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SYNE1_METTL24 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SYNE1_METTL24 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SYNE1 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
| Hgene | SYNE1 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Hgene | SYNE1 | C0154409 | Recurrent major depressive episodes | 1 | PSYGENET |
| Hgene | SYNE1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Hgene | SYNE1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | SYNE1 | C2751807 | Emery-Dreifuss Muscular Dystrophy 4 | 1 | UNIPROT |
| Hgene | SYNE1 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
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