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Fusion gene ID: 36887 |
FusionGeneSummary for SYN1_RDH14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYN1_RDH14 | Fusion gene ID: 36887 | Hgene | Tgene | Gene symbol | SYN1 | RDH14 | Gene ID | 6853 | 57665 |
| Gene name | synapsin I | retinol dehydrogenase 14 | |
| Synonyms | SYN1a|SYN1b|SYNI | PAN2|SDR7C4 | |
| Cytomap | Xp11.3-p11.23 | 2p24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | synapsin-1brain protein 4.1synapsin Ib | retinol dehydrogenase 14alcohol dehydrogenase PAN2pancreas protein 2retinol dehydrogenase 14 (all-trans and 9-cis)retinol dehydrogenase 14 (all-trans/9-cis/11-cis)short chain dehydrogenase/reductase family 7C member 4 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P17600 | Q9HBH5 | |
| Ensembl transtripts involved in fusion gene | ENST00000340666, ENST00000295987, | ENST00000381249, ENST00000468071, | |
| Fusion gene scores | * DoF score | 9 X 9 X 2=162 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/162*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SYN1 [Title/Abstract] AND RDH14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW965197 | SYN1 | chrX | 47446105 | - | RDH14 | chr2 | 18736702 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000340666 | ENST00000381249 | SYN1 | chrX | 47446105 | - | RDH14 | chr2 | 18736702 | + |
| intron-5UTR | ENST00000340666 | ENST00000468071 | SYN1 | chrX | 47446105 | - | RDH14 | chr2 | 18736702 | + |
| intron-3CDS | ENST00000295987 | ENST00000381249 | SYN1 | chrX | 47446105 | - | RDH14 | chr2 | 18736702 | + |
| intron-5UTR | ENST00000295987 | ENST00000468071 | SYN1 | chrX | 47446105 | - | RDH14 | chr2 | 18736702 | + |
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FusionProtFeatures for SYN1_RDH14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYN1 | RDH14 |
| Neuronal phosphoprotein that coats synaptic vesicles,binds to the cytoskeleton, and is believed to function in theregulation of neurotransmitter release. The complex formed withNOS1 and CAPON proteins is necessary for specific nitric-oxidfunctions at a presynaptic level. | Exhibits an oxidoreductive catalytic activity towardsretinoids. Most efficient as an NADPH-dependent retinal reductase.Displays high activity toward 9-cis and all-trans-retinol. Nosteroid dehydrogenase activity detected.{ECO:0000269|PubMed:12226107}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SYN1_RDH14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SYN1_RDH14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SYN1_RDH14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | RDH14 | Q9HBH5 | DB00162 | Vitamin A | Retinol dehydrogenase 14 | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for SYN1_RDH14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SYN1 | C0011570 | Mental Depression | 4 | PSYGENET |
| Hgene | SYN1 | C0011581 | Depressive disorder | 4 | PSYGENET |
| Hgene | SYN1 | C0036341 | Schizophrenia | 2 | PSYGENET |
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