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Fusion gene ID: 36884 |
FusionGeneSummary for SYN1_GAB1 |
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Fusion gene information | Fusion gene name: SYN1_GAB1 | Fusion gene ID: 36884 | Hgene | Tgene | Gene symbol | SYN1 | GAB1 | Gene ID | 6853 | 128869 |
Gene name | synapsin I | phosphatidylinositol glycan anchor biosynthesis class U | |
Synonyms | SYN1a|SYN1b|SYNI | CDC91L1|GAB1 | |
Cytomap | Xp11.3-p11.23 | 20q11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | synapsin-1brain protein 4.1synapsin Ib | phosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P17600 | Q13480 | |
Ensembl transtripts involved in fusion gene | ENST00000340666, ENST00000295987, | ENST00000262995, ENST00000262994, ENST00000505913, ENST00000515388, | |
Fusion gene scores | * DoF score | 9 X 9 X 2=162 | 6 X 4 X 4=96 |
# samples | 9 | 6 | |
** MAII score | log2(9/162*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SYN1 [Title/Abstract] AND GAB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GAB1 | GO:0006506 | GPI anchor biosynthetic process | 15034568 |
Tgene | GAB1 | GO:0046425 | regulation of JAK-STAT cascade | 15034568 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW897752 | SYN1 | chrX | 47431688 | - | GAB1 | chr4 | 144285280 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000340666 | ENST00000262995 | SYN1 | chrX | 47431688 | - | GAB1 | chr4 | 144285280 | - |
intron-intron | ENST00000340666 | ENST00000262994 | SYN1 | chrX | 47431688 | - | GAB1 | chr4 | 144285280 | - |
intron-intron | ENST00000340666 | ENST00000505913 | SYN1 | chrX | 47431688 | - | GAB1 | chr4 | 144285280 | - |
intron-intron | ENST00000340666 | ENST00000515388 | SYN1 | chrX | 47431688 | - | GAB1 | chr4 | 144285280 | - |
intron-intron | ENST00000295987 | ENST00000262995 | SYN1 | chrX | 47431688 | - | GAB1 | chr4 | 144285280 | - |
intron-intron | ENST00000295987 | ENST00000262994 | SYN1 | chrX | 47431688 | - | GAB1 | chr4 | 144285280 | - |
intron-intron | ENST00000295987 | ENST00000505913 | SYN1 | chrX | 47431688 | - | GAB1 | chr4 | 144285280 | - |
intron-intron | ENST00000295987 | ENST00000515388 | SYN1 | chrX | 47431688 | - | GAB1 | chr4 | 144285280 | - |
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FusionProtFeatures for SYN1_GAB1 |
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Hgene | Tgene |
SYN1 | GAB1 |
Neuronal phosphoprotein that coats synaptic vesicles,binds to the cytoskeleton, and is believed to function in theregulation of neurotransmitter release. The complex formed withNOS1 and CAPON proteins is necessary for specific nitric-oxidfunctions at a presynaptic level. | Adapter protein that plays a role in intracellularsignaling cascades triggered by activated receptor-type kinases.Plays a role in FGFR1 signaling. Probably involved in signaling bythe epidermal growth factor receptor (EGFR) and the insulinreceptor (INSR). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SYN1_GAB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SYN1_GAB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SYN1_GAB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SYN1_GAB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SYN1 | C0011570 | Mental Depression | 4 | PSYGENET |
Hgene | SYN1 | C0011581 | Depressive disorder | 4 | PSYGENET |
Hgene | SYN1 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | GAB1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |