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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36884

FusionGeneSummary for SYN1_GAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: SYN1_GAB1
Fusion gene ID: 36884
HgeneTgene
Gene symbol

SYN1

GAB1

Gene ID

6853

128869

Gene namesynapsin Iphosphatidylinositol glycan anchor biosynthesis class U
SynonymsSYN1a|SYN1b|SYNICDC91L1|GAB1
Cytomap

Xp11.3-p11.23

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionsynapsin-1brain protein 4.1synapsin Ibphosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li
Modification date2018052720180523
UniProtAcc

P17600

Q13480

Ensembl transtripts involved in fusion geneENST00000340666, ENST00000295987, 
ENST00000262995, ENST00000262994, 
ENST00000505913, ENST00000515388, 
Fusion gene scores* DoF score9 X 9 X 2=1626 X 4 X 4=96
# samples 96
** MAII scorelog2(9/162*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYN1 [Title/Abstract] AND GAB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGAB1

GO:0006506

GPI anchor biosynthetic process

15034568

TgeneGAB1

GO:0046425

regulation of JAK-STAT cascade

15034568


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW897752SYN1chrX

47431688

-GAB1chr4

144285280

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000340666ENST00000262995SYN1chrX

47431688

-GAB1chr4

144285280

-
intron-intronENST00000340666ENST00000262994SYN1chrX

47431688

-GAB1chr4

144285280

-
intron-intronENST00000340666ENST00000505913SYN1chrX

47431688

-GAB1chr4

144285280

-
intron-intronENST00000340666ENST00000515388SYN1chrX

47431688

-GAB1chr4

144285280

-
intron-intronENST00000295987ENST00000262995SYN1chrX

47431688

-GAB1chr4

144285280

-
intron-intronENST00000295987ENST00000262994SYN1chrX

47431688

-GAB1chr4

144285280

-
intron-intronENST00000295987ENST00000505913SYN1chrX

47431688

-GAB1chr4

144285280

-
intron-intronENST00000295987ENST00000515388SYN1chrX

47431688

-GAB1chr4

144285280

-

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FusionProtFeatures for SYN1_GAB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SYN1

P17600

GAB1

Q13480

Neuronal phosphoprotein that coats synaptic vesicles,binds to the cytoskeleton, and is believed to function in theregulation of neurotransmitter release. The complex formed withNOS1 and CAPON proteins is necessary for specific nitric-oxidfunctions at a presynaptic level. Adapter protein that plays a role in intracellularsignaling cascades triggered by activated receptor-type kinases.Plays a role in FGFR1 signaling. Probably involved in signaling bythe epidermal growth factor receptor (EGFR) and the insulinreceptor (INSR).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SYN1_GAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SYN1_GAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SYN1_GAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SYN1_GAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSYN1C0011570Mental Depression4PSYGENET
HgeneSYN1C0011581Depressive disorder4PSYGENET
HgeneSYN1C0036341Schizophrenia2PSYGENET
TgeneGAB1C0032460Polycystic Ovary Syndrome1CTD_human