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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36875

FusionGeneSummary for SYMPK_MAP3K13

check button Fusion gene summary
Fusion gene informationFusion gene name: SYMPK_MAP3K13
Fusion gene ID: 36875
HgeneTgene
Gene symbol

SYMPK

MAP3K13

Gene ID

8189

9175

Gene namesymplekinmitogen-activated protein kinase kinase kinase 13
SynonymsSPK|SYMLZK|MEKK13|MLK
Cytomap

19q13.32

3q27.2

Type of geneprotein-codingprotein-coding
Descriptionsymplekinmitogen-activated protein kinase kinase kinase 13leucine zipper-bearing kinasemixed lineage kinase
Modification date2018051920180523
UniProtAcc

Q92797

O43283

Ensembl transtripts involved in fusion geneENST00000598155, ENST00000245934, 
ENST00000446828, ENST00000424227, 
ENST00000443863, ENST00000535426, 
ENST00000265026, ENST00000448876, 
ENST00000454237, ENST00000438798, 
Fusion gene scores* DoF score9 X 7 X 6=3787 X 7 X 8=392
# samples 89
** MAII scorelog2(8/378*10)=-2.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYMPK [Title/Abstract] AND MAP3K13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYMPK

GO:0035307

positive regulation of protein dephosphorylation

20861839

TgeneMAP3K13

GO:0000186

activation of MAPKK activity

11726277

TgeneMAP3K13

GO:0006468

protein phosphorylation

9353328|11726277

TgeneMAP3K13

GO:0007254

JNK cascade

9353328|11726277

TgeneMAP3K13

GO:0046777

protein autophosphorylation

9353328

TgeneMAP3K13

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12492477


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-44-7670-01ASYMPKchr19

46326014

-MAP3K13chr3

185155235

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000598155ENST00000446828SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5UTR-intronENST00000598155ENST00000424227SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5UTR-intronENST00000598155ENST00000443863SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5UTR-intronENST00000598155ENST00000535426SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5UTR-intronENST00000598155ENST00000265026SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5UTR-intronENST00000598155ENST00000448876SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5UTR-intronENST00000598155ENST00000454237SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5UTR-intronENST00000598155ENST00000438798SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5CDS-intronENST00000245934ENST00000446828SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5CDS-intronENST00000245934ENST00000424227SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5CDS-intronENST00000245934ENST00000443863SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5CDS-intronENST00000245934ENST00000535426SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5CDS-intronENST00000245934ENST00000265026SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5CDS-intronENST00000245934ENST00000448876SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5CDS-intronENST00000245934ENST00000454237SYMPKchr19

46326014

-MAP3K13chr3

185155235

+
5CDS-intronENST00000245934ENST00000438798SYMPKchr19

46326014

-MAP3K13chr3

185155235

+

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FusionProtFeatures for SYMPK_MAP3K13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SYMPK

Q92797

MAP3K13

O43283

Scaffold protein that functions as a component of amultimolecular complex involved in histone mRNA 3'-end processing.Specific component of the tight junction (TJ) plaque, but mightnot be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. EnhancesSSU72 phosphatase activity. {ECO:0000269|PubMed:16230528,ECO:0000269|PubMed:20861839}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SYMPK_MAP3K13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SYMPK_MAP3K13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SYMPKHSF1, CSTF2, SMARCAD1, SIRT7, TOP1, CPSF3, CPSF2, SSU72, WWOX, RPA1, RPA2, RPA3, KAT6A, KMT2A, VCP, UBE2I, BSG, TMEM171, LYPD3, RP2, KLHDC3, CPSF4, CPSF1, KHSRP, USP24, WDR33, NTRK1, RIN3, CLK1, CSTF3, FN1, P4HB, MKNK2, MAPK3, VPS26A, FIP1L1, KLC3, CEP170P1, ELMO3, FOXB1, FOXE1, FOXG1, FOXH1, FOXI2, FOXL1, FOXQ1, SNW1, CDC5L, CPEB1, CSTF2T, SIGLECL1, IL13RA2, PDHA1MAP3K13PRDX3, IKBKB, MAP3K13, MAP2K7, MAPK8IP1, MYC, GLO1, HLA-DRB3, STAT3, HIST2H2AC, INPPL1, KLHL20


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SYMPK_MAP3K13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SYMPK_MAP3K13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSYMPKC0038356Stomach Neoplasms1CTD_human