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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36865

FusionGeneSummary for SYDE2_SYDE2

check button Fusion gene summary
Fusion gene informationFusion gene name: SYDE2_SYDE2
Fusion gene ID: 36865
HgeneTgene
Gene symbol

SYDE2

SYDE2

Gene ID

84144

84144

Gene namesynapse defective Rho GTPase homolog 2synapse defective Rho GTPase homolog 2
Synonyms--
Cytomap

1p22.3

1p22.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein SYDE2protein syd-1 homolog 2synapse defective 1, Rho GTPase, homolog 2synapse defective protein 1 homolog 2rho GTPase-activating protein SYDE2protein syd-1 homolog 2synapse defective 1, Rho GTPase, homolog 2synapse defective protein 1 homolog 2
Modification date2018051920180519
UniProtAcc

Q5VT97

Q5VT97

Ensembl transtripts involved in fusion geneENST00000341460, ENST00000341460, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 32
** MAII scorelog2(3/8*10)=1.90689059560852log2(2/1*10)=4.32192809488736
Context

PubMed: SYDE2 [Title/Abstract] AND SYDE2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AU141312SYDE2chr1

85648270

-SYDE2chr1

85666456

-
ChiTaRS3.1AK023877SYDE2chr1

85648270

-SYDE2chr1

85666456

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341460ENST00000341460SYDE2chr1

85648270

-SYDE2chr1

85666456

-

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FusionProtFeatures for SYDE2_SYDE2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SYDE2

Q5VT97

SYDE2

Q5VT97

GTPase activator for the Rho-type GTPases by convertingthem to an inactive GDP-bound state. {ECO:0000250}. GTPase activator for the Rho-type GTPases by convertingthem to an inactive GDP-bound state. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SYDE2_SYDE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SYDE2_SYDE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SYDE2_SYDE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SYDE2_SYDE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource