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Fusion gene ID: 36851 |
FusionGeneSummary for SWAP70_WEE1 |
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Fusion gene information | Fusion gene name: SWAP70_WEE1 | Fusion gene ID: 36851 | Hgene | Tgene | Gene symbol | SWAP70 | WEE1 | Gene ID | 23075 | 7465 |
Gene name | switching B cell complex subunit SWAP70 | WEE1 G2 checkpoint kinase | |
Synonyms | HSPC321|SWAP-70 | WEE1A|WEE1hu | |
Cytomap | 11p15.4 | 11p15.4 | |
Type of gene | protein-coding | protein-coding | |
Description | switch-associated protein 70SWAP switching B-cell complex 70kDa subunitSWAP switching B-cell complex subunit 70 | wee1-like protein kinaseWEE1 homologWEE1+ homologwee1A kinase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UH65 | P30291 | |
Ensembl transtripts involved in fusion gene | ENST00000447399, ENST00000318950, | ENST00000450114, ENST00000299613, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 4 X 3 X 5=60 |
# samples | 7 | 5 | |
** MAII score | log2(7/48*10)=0.54432051622381 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SWAP70 [Title/Abstract] AND WEE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. Kinase involved fusion gene, inframe and retained kinase domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-DQ-5630-01A | SWAP70 | chr11 | 9715833 | + | WEE1 | chr11 | 9603079 | + |
TCGA | RV | LUAD | TCGA-05-4427-01A | SWAP70 | chr11 | 9685825 | + | WEE1 | chr11 | 9597435 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000447399 | ENST00000450114 | SWAP70 | chr11 | 9715833 | + | WEE1 | chr11 | 9603079 | + |
Frame-shift | ENST00000447399 | ENST00000299613 | SWAP70 | chr11 | 9715833 | + | WEE1 | chr11 | 9603079 | + |
Frame-shift | ENST00000318950 | ENST00000450114 | SWAP70 | chr11 | 9715833 | + | WEE1 | chr11 | 9603079 | + |
Frame-shift | ENST00000318950 | ENST00000299613 | SWAP70 | chr11 | 9715833 | + | WEE1 | chr11 | 9603079 | + |
In-frame | ENST00000447399 | ENST00000450114 | SWAP70 | chr11 | 9685825 | + | WEE1 | chr11 | 9597435 | + |
5CDS-5UTR | ENST00000447399 | ENST00000299613 | SWAP70 | chr11 | 9685825 | + | WEE1 | chr11 | 9597435 | + |
In-frame | ENST00000318950 | ENST00000450114 | SWAP70 | chr11 | 9685825 | + | WEE1 | chr11 | 9597435 | + |
5CDS-5UTR | ENST00000318950 | ENST00000299613 | SWAP70 | chr11 | 9685825 | + | WEE1 | chr11 | 9597435 | + |
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FusionProtFeatures for SWAP70_WEE1 |
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Hgene | Tgene |
SWAP70 | WEE1 |
Phosphatidylinositol 3,4,5-trisphosphate-dependentguanine nucleotide exchange factor (GEF) which, independently ofRAS, transduces signals from tyrosine kinase receptors to RAC. Italso mediates signaling of membrane ruffling. Regulates the actincytoskeleton as an effector or adapter protein in response toagonist stimulated phosphatidylinositol (3,4)-bisphosphateproduction and cell protrusion (By similarity). {ECO:0000250,ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}. | Acts as a negative regulator of entry into mitosis (G2to M transition) by protecting the nucleus from cytoplasmicallyactivated cyclin B1-complexed CDK1 before the onset of mitosis bymediating phosphorylation of CDK1 on 'Tyr-15'. Specificallyphosphorylates and inactivates cyclin B1-complexed CDK1 reaching amaximum during G2 phase and a minimum as cells enter M phase.Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15'and phosphorylation of monomeric CDK1 does not occur. Its activityincreases during S and G2 phases and decreases at M phase when itis hyperphosphorylated. A correlated decrease in protein leveloccurs at M/G1 phase, probably due to its degradation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >WEE1 | chr11:9685825 | chr11:9597435 | ENST00000299613 | + | 0 | 11 | 34_43 | -22 | 433 | Compositional bias | Note=Poly-Glu |
Tgene | >WEE1 | chr11:9685825 | chr11:9597435 | ENST00000299613 | + | 0 | 11 | 9_12 | -22 | 433 | Compositional bias | Note=Poly-Pro |
Tgene | >WEE1 | chr11:9685825 | chr11:9597435 | ENST00000299613 | + | 0 | 11 | 299_569 | -22 | 433 | Domain | Protein kinase |
Tgene | >WEE1 | chr11:9685825 | chr11:9597435 | ENST00000450114 | + | 0 | 11 | 299_569 | 192 | 647 | Domain | Protein kinase |
Tgene | >WEE1 | chr11:9685825 | chr11:9597435 | ENST00000299613 | + | 0 | 11 | 305_313 | -22 | 433 | Nucleotide binding | ATP |
Tgene | >WEE1 | chr11:9685825 | chr11:9597435 | ENST00000450114 | + | 0 | 11 | 305_313 | 192 | 647 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SWAP70 | chr11:9685825 | chr11:9597435 | ENST00000318950 | + | 1 | 12 | 316_539 | 33 | 586 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >SWAP70 | chr11:9685825 | chr11:9597435 | ENST00000318950 | + | 1 | 12 | 291_294 | 33 | 586 | Compositional bias | Note=Poly-Lys |
Hgene | >SWAP70 | chr11:9685825 | chr11:9597435 | ENST00000318950 | + | 1 | 12 | 210_306 | 33 | 586 | Domain | PH |
Tgene | WEE1 | chr11:9685825 | chr11:9597435 | ENST00000450114 | + | 0 | 11 | 34_43 | 192 | 647 | Compositional bias | Note=Poly-Glu |
Tgene | WEE1 | chr11:9685825 | chr11:9597435 | ENST00000450114 | + | 0 | 11 | 9_12 | 192 | 647 | Compositional bias | Note=Poly-Pro |
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FusionGeneSequence for SWAP70_WEE1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SWAP70_WEE1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SWAP70 | NPM1, NCL, PARP1, CELSR3, C18orf8, RANBP3, SUPT5H, ATP6V1B2, ASUN, CORO1B, CRMP1, CUL1, FAF1, FARSB, GANAB, GART, JMJD6, OSBP, OTUD6B, PACSIN2, PAICS, PLOD2, PPP2R5C, SET, XRCC6, ZRANB2, RAPGEF4, ZBTB5, NAA20, SCLT1, CDH1 | WEE1 | SFN, CDCA3, YWHAB, PIN1, CRK, FBXW11, BTRC, SKP2, NEDD4, ARRB2, MYC, MUS81, CSNK2B, CSNK2A1, BRSK2, PLK1, CDK1, PAXIP1, YWHAQ, CNBP, EEF2, PCBP1, SPTBN1, YEATS4, NUP160, XPO1, RUSC2, CEP350, WDFY3, BRPF3, CCNYL1, BRCA1, KDM5C, SMAD4, GATA3, RRM2, PIK3R1, HSP90AA1, CSNK1A1, KCTD3, BCR, USP15, KIF13B, SPAG9, MCM2, MCM4, CGN, DENND4C, CBY1, CHEK2, CHEK1, ADA, TOP1, TOP2A, TOP3A, DHFR, CDC73, TTN, RB1, ING4, FZR1, WRN, BLM, ATAD5, BRD4, FH, WEE1, CDKN1B, XRCC3, CDK12, CDC6, IMPDH1, TUBA1A, MTOR, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SWAP70_WEE1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SWAP70_WEE1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | WEE1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |