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Fusion gene ID: 3684 |
FusionGeneSummary for AZIN1_TRIM46 |
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Fusion gene information | Fusion gene name: AZIN1_TRIM46 | Fusion gene ID: 3684 | Hgene | Tgene | Gene symbol | AZIN1 | TRIM46 | Gene ID | 51582 | 80128 |
Gene name | antizyme inhibitor 1 | tripartite motif containing 46 | |
Synonyms | AZI|AZI1|AZIA1|OAZI|OAZIN|ODC1L | GENEY|TRIFIC | |
Cytomap | 8q22.3 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | antizyme inhibitor 1ornithine decarboxylase antizyme inhibitor | tripartite motif-containing protein 46gene Y proteintripartite, fibronectin type-III and C-terminal SPRY motif protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O14977 | Q7Z4K8 | |
Ensembl transtripts involved in fusion gene | ENST00000337198, ENST00000347770, ENST00000522311, | ENST00000543729, ENST00000368385, ENST00000545012, ENST00000392451, ENST00000368383, ENST00000368382, ENST00000334634, ENST00000468878, | |
Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: AZIN1 [Title/Abstract] AND TRIM46 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AZIN1 | GO:0042177 | negative regulation of protein catabolic process | 17900240 |
Hgene | AZIN1 | GO:1902269 | positive regulation of polyamine transmembrane transport | 18508777 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA493026 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000337198 | ENST00000543729 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-intron | ENST00000337198 | ENST00000368385 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000337198 | ENST00000545012 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000337198 | ENST00000392451 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-intron | ENST00000337198 | ENST00000368383 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000337198 | ENST00000368382 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000337198 | ENST00000334634 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000337198 | ENST00000468878 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-intron | ENST00000347770 | ENST00000543729 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-intron | ENST00000347770 | ENST00000368385 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000347770 | ENST00000545012 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000347770 | ENST00000392451 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-intron | ENST00000347770 | ENST00000368383 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000347770 | ENST00000368382 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000347770 | ENST00000334634 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000347770 | ENST00000468878 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-intron | ENST00000522311 | ENST00000543729 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-intron | ENST00000522311 | ENST00000368385 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000522311 | ENST00000545012 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000522311 | ENST00000392451 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-intron | ENST00000522311 | ENST00000368383 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000522311 | ENST00000368382 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000522311 | ENST00000334634 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
intron-3UTR | ENST00000522311 | ENST00000468878 | AZIN1 | chr8 | 103876067 | - | TRIM46 | chr1 | 155156687 | + |
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FusionProtFeatures for AZIN1_TRIM46 |
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Hgene | Tgene |
AZIN1 | TRIM46 |
Antizyme inhibitor (AZI) protein that positivelyregulates ornithine decarboxylase (ODC) activity and polyamineuptake. AZI is an enzymatically inactive ODC homolog thatcounteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from theirinactive complex with antizymes, leading to formation of thecatalytically active ODC homodimer and restoring polyamineproduction (PubMed:17900240). {ECO:0000269|PubMed:17900240,ECO:0000269|PubMed:26305948}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AZIN1_TRIM46 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AZIN1_TRIM46 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AZIN1_TRIM46 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AZIN1_TRIM46 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |