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Fusion gene ID: 36833 |
FusionGeneSummary for SV2A_LIMCH1 |
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Fusion gene information | Fusion gene name: SV2A_LIMCH1 | Fusion gene ID: 36833 | Hgene | Tgene | Gene symbol | SV2A | LIMCH1 | Gene ID | 9900 | 22998 |
Gene name | synaptic vesicle glycoprotein 2A | LIM and calponin homology domains 1 | |
Synonyms | SV2 | LIMCH1A|LMO7B | |
Cytomap | 1q21.2 | 4p13 | |
Type of gene | protein-coding | protein-coding | |
Description | synaptic vesicle glycoprotein 2A | LIM and calponin homology domains-containing protein 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q7L0J3 | Q9UPQ0 | |
Ensembl transtripts involved in fusion gene | ENST00000369146, ENST00000369145, | ENST00000513024, ENST00000509638, ENST00000508501, ENST00000512946, ENST00000313860, ENST00000512632, ENST00000512820, ENST00000503057, ENST00000511496, ENST00000514096, ENST00000509277, ENST00000396595, ENST00000381753, ENST00000509454, ENST00000515785, | |
Fusion gene scores | * DoF score | 5 X 5 X 1=25 | 10 X 10 X 6=600 |
# samples | 5 | 10 | |
** MAII score | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/600*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SV2A [Title/Abstract] AND LIMCH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA582263 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000369146 | ENST00000513024 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000509638 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000508501 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000512946 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000313860 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000512632 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000512820 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000503057 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000511496 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000514096 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000509277 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000396595 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000381753 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000509454 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369146 | ENST00000515785 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000513024 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000509638 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000508501 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000512946 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000313860 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000512632 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000512820 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000503057 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000511496 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000514096 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000509277 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000396595 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000381753 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000509454 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
intron-intron | ENST00000369145 | ENST00000515785 | SV2A | chr1 | 149875217 | + | LIMCH1 | chr4 | 41643447 | + |
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FusionProtFeatures for SV2A_LIMCH1 |
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Hgene | Tgene |
SV2A | LIMCH1 |
Plays a role in the control of regulated secretion inneural and endocrine cells, enhancing selectively low-frequencyneurotransmission. Positively regulates vesicle fusion bymaintaining the readily releasable pool of secretory vesicles (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SV2A_LIMCH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SV2A_LIMCH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SV2A_LIMCH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SV2A | Q7L0J3 | DB01202 | Levetiracetam | Synaptic vesicle glycoprotein 2A | small molecule | approved|investigational |
Hgene | SV2A | Q7L0J3 | DB05541 | Brivaracetam | Synaptic vesicle glycoprotein 2A | small molecule | approved|investigational |
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RelatedDiseases for SV2A_LIMCH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SV2A | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | LIMCH1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Tgene | LIMCH1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |