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Fusion gene ID: 36825 |
FusionGeneSummary for SUZ12_LRRC37B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SUZ12_LRRC37B | Fusion gene ID: 36825 | Hgene | Tgene | Gene symbol | SUZ12 | LRRC37B | Gene ID | 23512 | 114659 |
| Gene name | SUZ12, polycomb repressive complex 2 subunit | leucine rich repeat containing 37B | |
| Synonyms | CHET9|JJAZ1 | LRRC37 | |
| Cytomap | 17q11.2 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | polycomb protein SUZ12chET 9 proteinchromatin precipitated E2F target 9 proteinjoined to JAZF1 proteinsuppressor of zeste 12 protein homolog | leucine-rich repeat-containing protein 37BC66 SLIT-like testicular protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q15022 | Q96QE4 | |
| Ensembl transtripts involved in fusion gene | ENST00000322652, ENST00000580398, | ENST00000543378, ENST00000327564, ENST00000394713, ENST00000584368, ENST00000341671, ENST00000581786, | |
| Fusion gene scores | * DoF score | 7 X 8 X 8=448 | 6 X 6 X 6=216 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/448*10)=-2.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SUZ12 [Title/Abstract] AND LRRC37B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-MZ-A5BI-01A | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000322652 | ENST00000543378 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| In-frame | ENST00000322652 | ENST00000327564 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| In-frame | ENST00000322652 | ENST00000394713 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| In-frame | ENST00000322652 | ENST00000584368 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| In-frame | ENST00000322652 | ENST00000341671 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| 5CDS-intron | ENST00000322652 | ENST00000581786 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| In-frame | ENST00000580398 | ENST00000543378 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| In-frame | ENST00000580398 | ENST00000327564 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| In-frame | ENST00000580398 | ENST00000394713 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| In-frame | ENST00000580398 | ENST00000584368 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| In-frame | ENST00000580398 | ENST00000341671 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
| 5CDS-intron | ENST00000580398 | ENST00000581786 | SUZ12 | chr17 | 30315516 | + | LRRC37B | chr17 | 30380285 | + |
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FusionProtFeatures for SUZ12_LRRC37B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SUZ12 | LRRC37B |
| Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27'(H3K27me) of histone H3, leading to transcriptional repression ofthe affected target gene. The PRC2/EED-EZH2 complex may also serveas a recruiting platform for DNA methyltransferases, therebylinking two epigenetic repression systems. Genes repressed by thePRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.{ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737,ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16618801,ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464,ECO:0000269|PubMed:28229514}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SUZ12 | chr17:30315516 | chr17:30380285 | ENST00000322652 | + | 10 | 16 | 51_59 | 400 | 740 | Compositional bias | Note=Poly-Ser |
| Hgene | SUZ12 | chr17:30315516 | chr17:30380285 | ENST00000322652 | + | 10 | 16 | 60_67 | 400 | 740 | Compositional bias | Note=Poly-Ala |
| Hgene | SUZ12 | chr17:30315516 | chr17:30380285 | ENST00000322652 | + | 10 | 16 | 7_50 | 400 | 740 | Compositional bias | Note=Gly-rich |
| Tgene | >LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 927_947 | 927 | 948 | Topological domain | Cytoplasmic |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SUZ12 | chr17:30315516 | chr17:30380285 | ENST00000322652 | + | 10 | 16 | 563_639 | 400 | 740 | Region | Note=VEFS-box |
| Hgene | >SUZ12 | chr17:30315516 | chr17:30380285 | ENST00000322652 | + | 10 | 16 | 448_471 | 400 | 740 | Zinc finger | Note=C2H2-type |
| Tgene | LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 867_897 | 927 | 948 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 556_577 | 927 | 948 | Repeat | Note=LRR 1 |
| Tgene | LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 580_601 | 927 | 948 | Repeat | Note=LRR 2 |
| Tgene | LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 604_625 | 927 | 948 | Repeat | Note=LRR 3 |
| Tgene | LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 628_649 | 927 | 948 | Repeat | Note=LRR 4 |
| Tgene | LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 655_676 | 927 | 948 | Repeat | Note=LRR 5 |
| Tgene | LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 679_699 | 927 | 948 | Repeat | Note=LRR 6 |
| Tgene | LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 28_905 | 927 | 948 | Topological domain | Extracellular |
| Tgene | LRRC37B | chr17:30315516 | chr17:30380285 | ENST00000341671 | + | 10 | 12 | 906_926 | 927 | 948 | Transmembrane | Helical |
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FusionGeneSequence for SUZ12_LRRC37B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SUZ12_LRRC37B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SUZ12 | SETDB1, EED, AEBP2, RBBP4, EZH2, VAV1, WDR77, GTF2I, SNAI1, UBE2I, CTCF, JARID2, MTF2, EZH1, SUZ12, CREB1, EWSR1, HIST1H1A, HIST1H1C, KDM5A, SETD8, SIRT1, PHF1, WT1, DNMT1, PPP1R8, USP7, RARG, GATA4, PJA1, CDYL, HIST3H3, RELA, RELB, ELAVL1, CDK19, CDK8, MED6, MED17, UHRF1, HIC1, PML, RARA, HDAC2, PAXIP1, CBX5, SS18, SSX2, DNMT3B, BTRC, BRCA1, FBXW11, RBBP7, PLEC, THRAP3, HIST4H4, ACTG1, MTOR, ERH, ILF3, EIF4A3, PCNT, LUC7L2, ACIN1, NCL, DDX5, H2AFY, PRPF8, BCLAF1, SRSF1, PRMT1, SNRNP200, LIMA1, CDKAL1, UBB, SON, AKAP9, YBX1, PABPC4, RNPS1, TRA2A, TAF15, TRIM28, ARG1, DHX9, HIST1H3D, MYH14, NUMA1, SF3B1, SRSF10, PKP1, AR, RBM14, MLST8, H1F0, GCN1L1, EFTUD2, DYNC1H1, SRSF9, FMR1, ATP5B, DDX3X, CHTOP, HP1BP3, LARP1, IMMT, NCBP1, SNRPN, SNRNP70, ILF2, SAFB2, GNB2L1, PHF19, MAGOH, SRSF5, SF3B2, ATP2A2, SORBS2, DDX39B, U2AF2, HIST1H2BB, NOP58, UPF1, SRSF6, SF3B3, LUC7L, RALY, FBL, SRSF3, XRCC5, HIST1H2BA, ALYREF, SNRPA, C17orf85, MYO1C, PPP1R9B, NAT10, RBM8A, ZNF326, CHCHD3, ADAR, DBN1, FXR2, XAB2, SLTM, SRSF8, SNRPD3, ATAD3A, CHD4, C1QBP, YBX3, HIST2H2AA3, PABPN1, RBM39, U2AF1, FYTTD1, ATP5C1, CRNKL1, HSPA1A, SRSF7, SFXN1, VCP, CBX8, H2AFY2, TUFM, KHSRP, RAN, VGF, PRDX1, PHF5A, PTBP1, PKM, RCC1, CCT3, CALR, CNBP, CBX3, CPSF7, EIF2S2, FXR1, SAP18, LMNB2, MYL6, FIP1L1, SNRPD1, SNRPA1, CDK5RAP2, PHGDH, TRIM25, EIF2AK3, LGALS7, LDHB, NHP2L1, PDLIM5, NDRG1, NOP2, RCN1, RSL1D1, RUVBL2, SF1, SMARCA5, THOC2, TPI1, ZC3H13, SLC39A7, ACACA, AKAP8L, PRKAR2A, CSNK2B, CEP57, MCM7, RANBP2, FLNB, HIST1H2AE, AQR, KHDRBS1, MFAP1, PTCD3, PLG, CDC40, PDIA3, SPRR2G, SF3A1, GATAD2B, YY1, ABLIM1, AIFM1, ATP5O, CPSF6, COPA, CKMT1A, DNAJA1, RNF2, FUBP3, GSDMA, NHP2, DKC1, HEATR1, HIST2H2AB, LUC7L3, SSB, SYNE1, NUP93, NXF1, NOLC1, PPIB, PLRG1, SF3B6, PRPF19, BCAS2, DDX23, PHB, PHB2, DHX30, GLYR1, RCL1, RBM4, PGAM5, SNW1, SAMM50, SF3A3, STOML2, SMC3, TFAM, SART1, AFG3L2, AMOTL1, EPRS, CSRP1, DAZAP1, POLR2B, EMD, ERLIN1, GDAP1, HDAC1, C10orf12, IGLL5, KRR1, LPP, TIMM50, NGDN, NUP88, GTPBP4, ISY1, RBM22, DDX56, PDCD11, PYCR1, RBM34, MSI2, SNRPD2, SF3B4, SSR4, SNRNP40, DDX18, TM7SF2, DDOST, CSE1L, ALDOA, GLDC, C15orf52, KLK2, MTA1, SLC25A11, EBNA1BP2, RBM15B, RBM14-RBM4, REPIN1, FAM208A, RBM4B, RBM5, SKP1, SDF2L1, THOC6, TRAF4, UFD1L, EPB41L5, CANX, DNAJC9, ERGIC1, TBL1Y, H1FX, NUP107, P4HB, G3BP2, RNF114, FUS, U2AF1L4, TBL2, UTP15, HIST1H2BG, TRIM37, PRDM14, DDB2, ESR1, PCGF1, DPPA4, NANOG, POU5F1, MDM2, HNF4A, C17orf96, INTU, LCOR, KHDRBS2, C9orf3, LATS2, MEX3B, UHRF2 | LRRC37B | ELAVL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SUZ12_LRRC37B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SUZ12_LRRC37B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SUZ12 | C0206727 | Nerve Sheath Tumors | 2 | CTD_human |
| Hgene | SUZ12 | C0001430 | Adenoma | 1 | CTD_human |
| Hgene | SUZ12 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | SUZ12 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | SUZ12 | C0017638 | Glioma | 1 | CTD_human |
| Hgene | SUZ12 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | SUZ12 | C0027809 | Neurilemmoma | 1 | CTD_human |
| Hgene | SUZ12 | C0027830 | neurofibroma | 1 | CTD_human |
| Hgene | SUZ12 | C0027962 | Melanocytic nevus | 1 | CTD_human |
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