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Fusion gene ID: 36793 |
FusionGeneSummary for SUPT6H_TJP1 |
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Fusion gene information | Fusion gene name: SUPT6H_TJP1 | Fusion gene ID: 36793 | Hgene | Tgene | Gene symbol | SUPT6H | TJP1 | Gene ID | 6830 | 7082 |
Gene name | SPT6 homolog, histone chaperone | tight junction protein 1 | |
Synonyms | SPT6|SPT6H|emb-5 | ZO-1 | |
Cytomap | 17q11.2 | 15q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription elongation factor SPT6histone chaperone suppressor of Ty6suppressor of Ty 6 homologtat-CT2 proteintat-cotransactivator 2 protein | tight junction protein ZO-1zona occludens 1zonula occludens 1 protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q7KZ85 | Q07157 | |
Ensembl transtripts involved in fusion gene | ENST00000314616, ENST00000347486, | ENST00000346128, ENST00000400011, ENST00000356107, ENST00000545208, ENST00000495972, | |
Fusion gene scores | * DoF score | 9 X 10 X 4=360 | 5 X 6 X 3=90 |
# samples | 10 | 6 | |
** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SUPT6H [Title/Abstract] AND TJP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AR-A250-01A | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000314616 | ENST00000346128 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
5CDS-intron | ENST00000314616 | ENST00000400011 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
5CDS-intron | ENST00000314616 | ENST00000356107 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
5CDS-intron | ENST00000314616 | ENST00000545208 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
5CDS-intron | ENST00000314616 | ENST00000495972 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
5CDS-intron | ENST00000347486 | ENST00000346128 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
5CDS-intron | ENST00000347486 | ENST00000400011 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
5CDS-intron | ENST00000347486 | ENST00000356107 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
5CDS-intron | ENST00000347486 | ENST00000545208 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
5CDS-intron | ENST00000347486 | ENST00000495972 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
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FusionProtFeatures for SUPT6H_TJP1 |
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Hgene | Tgene |
SUPT6H | TJP1 |
TJP1, TJP2, and TJP3 are closely related scaffoldingproteins that link tight junction (TJ) transmembrane proteins suchas claudins, junctional adhesion molecules, and occludin to theactin cytoskeleton (PubMed:7798316, PubMed:9792688). The tightjunction acts to limit movement of substances through theparacellular space and as a boundary between the compositionallydistinct apical and basolateral plasma membrane domains ofepithelial and endothelial cells. Necessary for lumenogenesis, andparticularly efficient epithelial polarization and barrierformation (By similarity). Plays a role in the regulation of cellmigration by targeting CDC42BPB to the leading edge of migratingcells (PubMed:21240187). Plays an important role in podosomeformation and associated function, thus regulating cell adhesionand matrix remodeling (PubMed:20930113). With TJP2 and TJP3,participates to the junctional retention and stability of thetranscription factor DBPA, but is not involved in its shuttling tothe nucleus (By similarity). {ECO:0000250|UniProtKB:O97758,ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SUPT6H_TJP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SUPT6H_TJP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SUPT6H | WDR48, TCEA1, IWS1, POLR2A, SIRT7, PAAF1, BRCA1, MDC1, POLR2C, CSNK2A1, ERBB2, CDKN1A, CEP250, HAUS2, CEP57, CEP76, EMD, TP53, TUBG1, TUBGCP3, VCP, CUL7, OBSL1, EED, BMI1, PIH1D1, RPRD1B, DEGS1, PVRIG, SLC39A1, TTC29, PPP1CA, POLR2M, SKAP1, DDB2, TBC1D22A, S100A10, ANAPC7, NCL, SUPT4H1, SUPT5H, EXOSC10, PDCD11, ESR1, RNF20, RNF40, HIST1H3E, TMPO, RIOK3, CTR9, POLR1A, ATL3, GMNN, POLR3E, SGOL1, FBXW7, NFATC2, LMO2, H2AFX, VBP1, SSRP1, WSB2, PFDN2, TMA16, UXT, POLR2E, FBXW4, STRAP, TRIM25, MCPH1, URI1 | TJP1 | F11R, JAM2, JAM3, KIRREL, PTPN14, GJA8, GJA3, EGFR, RAB8B, TJP2, TJP3, GJA1, CGN, OCLN, MLLT4, CLDN1, CLDN2, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, GJD3, HSP90AA1, RAE1, KBTBD7, YBX3, ACTN1, ACTN4, ACTB, ANXA6, KRT8, KRT10, KRT1, FLNA, TUBB, TUBB4A, TUBA1C, PLEC, SPTAN1, VIM, SSTR3, ELAVL1, SIRT7, KHDRBS1, PARD6A, PRKCI, PARD3, STRN, NDUFS6, RTN4, VAPA, ZPR1, VAPB, NDUFV2, NOTCH2, SCO2, SUGP1, DTNA, PAN2, LATS2, VMP1, RAPGEF2, CUL7, OBSL1, CCDC8, LUZP4, MAGIX, RNF166, IFI30, GRHPR, PIN1, THOC5, WDR3, NTRK1, IFI16, BTRC, B9D2, CEP104, CEP152, CEP128, CEP135, CNTRL, FBF1, NIN, ODF2, RPGRIP1L, SASS6, XPO1, MYO1C, PPP1CB, MYO19, CDH1, CDC14A, CTDSPL, CCDC102B, DEFA1, CRYBA4, UQCRB, SUN2, DLST, RNF168 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SUPT6H_TJP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SUPT6H_TJP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |