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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 36782

FusionGeneSummary for SUPT5H_SAMD4B

check button Fusion gene summary
Fusion gene informationFusion gene name: SUPT5H_SAMD4B
Fusion gene ID: 36782
HgeneTgene
Gene symbol

SUPT5H

SAMD4B

Gene ID

6829

55095

Gene nameSPT5 homolog, DSIF elongation factor subunitsterile alpha motif domain containing 4B
SynonymsSPT5|SPT5H|Tat-CT1SMGB|Smaug2
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription elongation factor SPT5DRB sensitivity-inducing factor 160 kDa subunitDRB sensitivity-inducing factor large subunitDSIF large subunitDSIF p160Tat-cotransactivator 1 proteinhSPT5suppressor of Ty 5 homologprotein Smaug homolog 2SAM domain-containing protein 4Bsmaug 2smaug homolog Bsterile alpha motif domain-containing protein 4B
Modification date2018052320180523
UniProtAcc

O00267

Q5PRF9

Ensembl transtripts involved in fusion geneENST00000599117, ENST00000432763, 
ENST00000402194, ENST00000359191, 
ENST00000598725, 		ENST00000598913, 
ENST00000314471, ENST00000594204, 
ENST00000596368, 
Fusion gene scores* DoF score13 X 9 X 8=9364 X 4 X 4=64
# samples 124
** MAII scorelog2(12/936*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SUPT5H [Title/Abstract] AND SAMD4B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSUPT5H

GO:0000122

negative regulation of transcription by RNA polymerase II

9450929

HgeneSUPT5H

GO:0006368

transcription elongation from RNA polymerase II promoter

9450929

HgeneSUPT5H

GO:0032785

negative regulation of DNA-templated transcription, elongation

9450929

HgeneSUPT5H

GO:0032786

positive regulation of DNA-templated transcription, elongation

9450929

HgeneSUPT5H

GO:0045944

positive regulation of transcription by RNA polymerase II

9450929


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-IB-A7LX-01ASUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000599117ENST00000598913SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
In-frameENST00000599117ENST00000314471SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000599117ENST00000594204SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000599117ENST00000596368SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
In-frameENST00000432763ENST00000598913SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
In-frameENST00000432763ENST00000314471SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000432763ENST00000594204SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000432763ENST00000596368SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
In-frameENST00000402194ENST00000598913SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
In-frameENST00000402194ENST00000314471SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000402194ENST00000594204SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000402194ENST00000596368SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
In-frameENST00000359191ENST00000598913SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
In-frameENST00000359191ENST00000314471SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000359191ENST00000594204SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000359191ENST00000596368SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
In-frameENST00000598725ENST00000598913SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
In-frameENST00000598725ENST00000314471SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000598725ENST00000594204SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+
5CDS-intronENST00000598725ENST00000596368SUPT5Hchr19

39950600

+SAMD4Bchr19

39871630

+

Top

FusionProtFeatures for SUPT5H_SAMD4B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SUPT5H

O00267

SAMD4B

Q5PRF9

Component of the DRB sensitivity-inducing factor complex(DSIF complex), which regulates mRNA processing and transcriptionelongation by RNA polymerase II. DSIF positively regulates mRNAcapping by stimulating the mRNA guanylyltransferase activity ofRNGTT/CAP1A. DSIF also acts cooperatively with the negativeelongation factor complex (NELF complex) to enhancetranscriptional pausing at sites proximal to the promoter.Transcriptional pausing may facilitate the assembly of anelongation competent RNA polymerase II complex. DSIF and NELFpromote pausing by inhibition of the transcription elongationfactor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II attranscription pause sites and stimulates the weak intrinsicnuclease activity of the enzyme. Cleavage of blocked transcriptsby RNA polymerase II promotes the resumption of transcription fromthe new 3' terminus and may allow repeated attempts attranscription through natural pause sites. DSIF can alsopositively regulate transcriptional elongation and is required forthe efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppresstranscriptional pausing in transcripts derived from the HIV-1 LTRand blocks premature release of HIV-1 transcripts at terminatorsequences. {ECO:0000269|PubMed:10075709,ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184,ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543,ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001,ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615,ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964,ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750,ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072,ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:9450929,ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. Has transcriptional repressor activity. Overexpressioninhibits the transcriptional activities of AP-1, p53/TP53 andCDKN1A. {ECO:0000269|PubMed:20510020}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+82811_1062041084Compositional biasNote=Glu-rich
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+92911_1062041084Compositional biasNote=Glu-rich
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+103011_1062081088Compositional biasNote=Glu-rich
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+92911_1062081088Compositional biasNote=Glu-rich
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+113111_1062081088Compositional biasNote=Glu-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828844_9682041084Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929844_9682041084Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030844_9682081088Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929844_9682081088Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131844_9682081088Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828273_3062041084DomainNote=KOW 1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828420_4512041084DomainNote=KOW 2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828472_5032041084DomainNote=KOW 3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828594_6272041084DomainNote=KOW 4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828704_7372041084DomainNote=KOW 5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929273_3062041084DomainNote=KOW 1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929420_4512041084DomainNote=KOW 2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929472_5032041084DomainNote=KOW 3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929594_6272041084DomainNote=KOW 4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929704_7372041084DomainNote=KOW 5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030273_3062081088DomainNote=KOW 1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030420_4512081088DomainNote=KOW 2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030472_5032081088DomainNote=KOW 3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030594_6272081088DomainNote=KOW 4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030704_7372081088DomainNote=KOW 5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929273_3062081088DomainNote=KOW 1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929420_4512081088DomainNote=KOW 2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929472_5032081088DomainNote=KOW 3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929594_6272081088DomainNote=KOW 4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929704_7372081088DomainNote=KOW 5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131273_3062081088DomainNote=KOW 1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131420_4512081088DomainNote=KOW 2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131472_5032081088DomainNote=KOW 3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131594_6272081088DomainNote=KOW 4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131704_7372081088DomainNote=KOW 5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828754_8172041084RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828844_9502041084RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929754_8172041084RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929844_9502041084RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030754_8172081088RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030844_9502081088RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929754_8172081088RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929844_9502081088RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131754_8172081088RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131844_9502081088RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828754_7592041084RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828760_7652041084RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828766_7712041084RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828772_7782041084RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828781_7872041084RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828788_7942041084RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828796_8022041084RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828803_8092041084RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828811_8172041084RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828844_8512041084RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828854_8622041084RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828863_8692041084RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828881_8852041084RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828896_9022041084RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828904_9112041084RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828916_9212041084RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828924_9302041084RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828932_9392041084RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828943_9502041084RepeatNote=CTR2-10
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929754_7592041084RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929760_7652041084RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929766_7712041084RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929772_7782041084RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929781_7872041084RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929788_7942041084RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929796_8022041084RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929803_8092041084RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929811_8172041084RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929844_8512041084RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929854_8622041084RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929863_8692041084RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929881_8852041084RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929896_9022041084RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929904_9112041084RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929916_9212041084RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929924_9302041084RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929932_9392041084RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929943_9502041084RepeatNote=CTR2-10
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030754_7592081088RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030760_7652081088RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030766_7712081088RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030772_7782081088RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030781_7872081088RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030788_7942081088RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030796_8022081088RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030803_8092081088RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030811_8172081088RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030844_8512081088RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030854_8622081088RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030863_8692081088RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030881_8852081088RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030896_9022081088RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030904_9112081088RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030916_9212081088RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030924_9302081088RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030932_9392081088RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030943_9502081088RepeatNote=CTR2-10
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929754_7592081088RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929760_7652081088RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929766_7712081088RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929772_7782081088RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929781_7872081088RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929788_7942081088RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929796_8022081088RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929803_8092081088RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929811_8172081088RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929844_8512081088RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929854_8622081088RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929863_8692081088RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929881_8852081088RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929896_9022081088RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929904_9112081088RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929916_9212081088RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929924_9302081088RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929932_9392081088RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929943_9502081088RepeatNote=CTR2-10
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131754_7592081088RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131760_7652081088RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131766_7712081088RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131772_7782081088RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131781_7872081088RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131788_7942081088RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131796_8022081088RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131803_8092081088RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131811_8172081088RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131844_8512081088RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131854_8622081088RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131863_8692081088RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131881_8852081088RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131896_9022081088RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131904_9112081088RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131916_9212081088RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131924_9302081088RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131932_9392081088RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131943_9502081088RepeatNote=CTR2-10
TgeneSAMD4Bchr19:39950600chr19:39871630ENST00000314471+1216299_372616695DomainNote=SAM


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FusionGeneSequence for SUPT5H_SAMD4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SUPT5H_SAMD4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SUPT5HPRMT5, SUPT4H1, PRMT1, HTATSF1, POLR2A, PIN1, CDK9, CDK7, CCNT1, CCNH, PCBD1, IKBKG, SSBP3, MAML3, ZBTB3, ZNF496, SMC3, SIRT7, TERF1, CUL3, GTF2F2, HNRNPK, ILF2, NENF, CDH2, PPT2, HSP90AA1, NELFB, BARD1, MNAT1, POLR2C, FN1, CSNK2A1, ZFYVE9, ZNF512B, NSMF, SOX2, CCNT2, LMNA, SNX4, LMAN2, SIK1, CARM1, RANBP3, SEC24C, SF1, ATP6V1B2, CSDE1, FARSB, GANAB, GART, MSH2, MSH6, PAICS, PLOD2, SAMHD1, SET, SWAP70, XRCC6, BRCA1, ENO1, SHMT2, MOV10, NXF1, CUL7, OBSL1, RNF2, SIRT6, DOK4, VPS26B, PAK4, CDKL1, HSPB1, CSNK2B, CTR9, PAF1, POLR2B, CPSF2, CSNK2A2, EEF1D, LEO1, MRTO4, NCL, PAPOLA, POLR2E, POLR2F, POLR2H, RANGAP1, RTF1, SUB1, SUPT6H, TAF6, NTRK1, BLM, IFI16, CEP290, LCA5, OFD1, PCM1, POLR2D, POLR2G, POLR2I, POLR2J, POLR2L, FAN1, C17orf85, IWS1, CEP170P1, NELFA, WIPF1, NOLC1, MED14, SETX, SYNE2, RPRD2, PHF3, POC1A, MCM10, RPRD1B, CDC73, JADE1, WDR61, RNF214, NFATC2, UBR5, EGFR, EYA4, PPP4C, RNGTT, TENC1, PAK7, KHDRBS2, CPNE4, CPNE2, PLEKHO1, CPNE7, HNRNPF, AIPL1, MIOS, FGFR1OP, PDE5A, TRIM25SAMD4BYWHAB, YWHAZ, YWHAG, YWHAQ, ELAVL1, PTPN6, SOX2, MUS81, MKS1, CEP152, CEP89, NIN, XPO1, RGMA, NANOG, SAMD4A, PDP1, YWHAE, ACTA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828313_4202041084RNA polymerase II
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929313_4202041084RNA polymerase II
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030313_4202081088RNA polymerase II
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929313_4202081088RNA polymerase II
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131313_4202081088RNA polymerase II
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000359191+828176_2702041084SUPT4H1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000402194+929176_2702041084SUPT4H1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000432763+1030176_2702081088SUPT4H1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000598725+929176_2702081088SUPT4H1
HgeneSUPT5Hchr19:39950600chr19:39871630ENST00000599117+1131176_2702081088SUPT4H1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SUPT5H_SAMD4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SUPT5H_SAMD4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource