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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36778

FusionGeneSummary for SUPT5H_CTSB

check button Fusion gene summary
Fusion gene informationFusion gene name: SUPT5H_CTSB
Fusion gene ID: 36778
HgeneTgene
Gene symbol

SUPT5H

CTSB

Gene ID

6829

1508

Gene nameSPT5 homolog, DSIF elongation factor subunitcathepsin B
SynonymsSPT5|SPT5H|Tat-CT1APPS|CPSB
Cytomap

19q13.2

8p23.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription elongation factor SPT5DRB sensitivity-inducing factor 160 kDa subunitDRB sensitivity-inducing factor large subunitDSIF large subunitDSIF p160Tat-cotransactivator 1 proteinhSPT5suppressor of Ty 5 homologcathepsin BAPP secretaseamyloid precursor protein secretasecathepsin B1cysteine protease
Modification date2018052320180523
UniProtAcc

O00267

P07858

Ensembl transtripts involved in fusion geneENST00000599117, ENST00000432763, 
ENST00000402194, ENST00000359191, 
ENST00000598725, 		ENST00000434271, 
ENST00000353047, ENST00000530640, 
ENST00000531089, ENST00000453527, 
ENST00000415599, ENST00000345125, 
ENST00000533455, ENST00000534510, 
ENST00000525076, 
Fusion gene scores* DoF score13 X 9 X 8=9368 X 8 X 2=128
# samples 129
** MAII scorelog2(12/936*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/128*10)=-0.508146903670325
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SUPT5H [Title/Abstract] AND CTSB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSUPT5H

GO:0000122

negative regulation of transcription by RNA polymerase II

9450929

HgeneSUPT5H

GO:0006368

transcription elongation from RNA polymerase II promoter

9450929

HgeneSUPT5H

GO:0032785

negative regulation of DNA-templated transcription, elongation

9450929

HgeneSUPT5H

GO:0032786

positive regulation of DNA-templated transcription, elongation

9450929

HgeneSUPT5H

GO:0045944

positive regulation of transcription by RNA polymerase II

9450929

TgeneCTSB

GO:0006508

proteolysis

7890620|8811434

TgeneCTSB

GO:0030574

collagen catabolic process

22952693

TgeneCTSB

GO:0051603

proteolysis involved in cellular protein catabolic process

22952693


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF754892SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000599117ENST00000434271SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000599117ENST00000353047SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000599117ENST00000530640SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000599117ENST00000531089SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000599117ENST00000453527SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000599117ENST00000415599SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000599117ENST00000345125SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000599117ENST00000533455SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000599117ENST00000534510SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000599117ENST00000525076SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000432763ENST00000434271SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000432763ENST00000353047SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000432763ENST00000530640SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000432763ENST00000531089SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000432763ENST00000453527SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000432763ENST00000415599SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000432763ENST00000345125SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000432763ENST00000533455SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000432763ENST00000534510SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000432763ENST00000525076SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000402194ENST00000434271SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000402194ENST00000353047SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000402194ENST00000530640SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000402194ENST00000531089SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000402194ENST00000453527SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000402194ENST00000415599SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000402194ENST00000345125SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000402194ENST00000533455SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000402194ENST00000534510SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000402194ENST00000525076SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000359191ENST00000434271SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000359191ENST00000353047SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000359191ENST00000530640SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000359191ENST00000531089SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000359191ENST00000453527SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000359191ENST00000415599SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000359191ENST00000345125SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000359191ENST00000533455SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000359191ENST00000534510SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000359191ENST00000525076SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000598725ENST00000434271SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000598725ENST00000353047SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000598725ENST00000530640SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-3UTRENST00000598725ENST00000531089SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000598725ENST00000453527SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000598725ENST00000415599SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000598725ENST00000345125SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000598725ENST00000533455SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000598725ENST00000534510SUPT5Hchr19

39959434

-CTSBchr8

11701700

+
5CDS-intronENST00000598725ENST00000525076SUPT5Hchr19

39959434

-CTSBchr8

11701700

+

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FusionProtFeatures for SUPT5H_CTSB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SUPT5H

O00267

CTSB

P07858

Component of the DRB sensitivity-inducing factor complex(DSIF complex), which regulates mRNA processing and transcriptionelongation by RNA polymerase II. DSIF positively regulates mRNAcapping by stimulating the mRNA guanylyltransferase activity ofRNGTT/CAP1A. DSIF also acts cooperatively with the negativeelongation factor complex (NELF complex) to enhancetranscriptional pausing at sites proximal to the promoter.Transcriptional pausing may facilitate the assembly of anelongation competent RNA polymerase II complex. DSIF and NELFpromote pausing by inhibition of the transcription elongationfactor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II attranscription pause sites and stimulates the weak intrinsicnuclease activity of the enzyme. Cleavage of blocked transcriptsby RNA polymerase II promotes the resumption of transcription fromthe new 3' terminus and may allow repeated attempts attranscription through natural pause sites. DSIF can alsopositively regulate transcriptional elongation and is required forthe efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppresstranscriptional pausing in transcripts derived from the HIV-1 LTRand blocks premature release of HIV-1 transcripts at terminatorsequences. {ECO:0000269|PubMed:10075709,ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184,ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543,ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001,ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615,ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964,ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750,ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072,ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:9450929,ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. Thiol protease which is believed to participate inintracellular degradation and turnover of proteins. Has also beenimplicated in tumor invasion and metastasis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SUPT5H_CTSB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SUPT5H_CTSB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SUPT5H_CTSB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SUPT5H_CTSB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCTSBC0027626Neoplasm Invasiveness2CTD_human
TgeneCTSBC0007134Renal Cell Carcinoma1CTD_human
TgeneCTSBC0017636Glioblastoma1CTD_human
TgeneCTSBC0026848Myopathy1CTD_human
TgeneCTSBC0027540Necrosis1CTD_human
TgeneCTSBC0033578Prostatic Neoplasms1CTD_human
TgeneCTSBC0033687Proteinuria1CTD_human