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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36771

FusionGeneSummary for SUPT3H_TDRG1

check button Fusion gene summary
Fusion gene informationFusion gene name: SUPT3H_TDRG1
Fusion gene ID: 36771
HgeneTgene
Gene symbol

SUPT3H

TDRG1

Gene ID

8464

732253

Gene nameSPT3 homolog, SAGA and STAGA complex componenttestis development related 1
SynonymsSPT3|SPT3LLINC00532|lincRNA-NR_024015
Cytomap

6p21.1

6p21.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription initiation protein SPT3 homologSPT3-like proteinsuppressor of Ty 3 homologtestis development-related protein 1long intergenic non-protein coding RNA 532testis development related 1 (non-protein coding)testis development related protein 1
Modification date2018052320180425
UniProtAcc

O75486

Ensembl transtripts involved in fusion geneENST00000371460, ENST00000371459, 
ENST00000371461, ENST00000306867, 
ENST00000371458, ENST00000459689, 
ENST00000451810, ENST00000448559, 
ENST00000448433, ENST00000373170, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 1 X 2=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: SUPT3H [Title/Abstract] AND TDRG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSUPT3H

GO:0016578

histone deubiquitination

18206972

HgeneSUPT3H

GO:0043966

histone H3 acetylation

11564863


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-E1-A7YI-01ASUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000371460ENST00000451810SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5UTR-3UTRENST00000371460ENST00000448559SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5UTR-3UTRENST00000371460ENST00000448433SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5UTR-3UTRENST00000371460ENST00000373170SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5CDS-3UTRENST00000371459ENST00000451810SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5CDS-3UTRENST00000371459ENST00000448559SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5CDS-3UTRENST00000371459ENST00000448433SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5CDS-3UTRENST00000371459ENST00000373170SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
intron-3UTRENST00000371461ENST00000451810SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
intron-3UTRENST00000371461ENST00000448559SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
intron-3UTRENST00000371461ENST00000448433SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
intron-3UTRENST00000371461ENST00000373170SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5CDS-3UTRENST00000306867ENST00000451810SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5CDS-3UTRENST00000306867ENST00000448559SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5CDS-3UTRENST00000306867ENST00000448433SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5CDS-3UTRENST00000306867ENST00000373170SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
intron-3UTRENST00000371458ENST00000451810SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
intron-3UTRENST00000371458ENST00000448559SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
intron-3UTRENST00000371458ENST00000448433SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
intron-3UTRENST00000371458ENST00000373170SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5UTR-3UTRENST00000459689ENST00000451810SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5UTR-3UTRENST00000459689ENST00000448559SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5UTR-3UTRENST00000459689ENST00000448433SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+
5UTR-3UTRENST00000459689ENST00000373170SUPT3Hchr6

45332938

-TDRG1chr6

40347021

+

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FusionProtFeatures for SUPT3H_TDRG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SUPT3H

O75486

TDRG1

Probable transcriptional activator.{ECO:0000269|PubMed:9787080}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SUPT3H_TDRG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SUPT3H_TDRG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SUPT3HMYC, TAF4, TAF5, KAT2A, TAF10, TRRAP, TAF6L, TAF5L, TADA3, TADA1, SF3B3, SUPT7L, TAF9, TAF12, DDB1, DDB2, ATXN7L3, USP22, ATXN7, TP53, KAT2B, MED1, MED16, MED17, MED13, MED12, PYGO2, TADA2B, CCDC101, SAP130, TADA2A, TCF3, HIST3H3, SUPT20H, SSSCA1, TRIM25TDRG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SUPT3H_TDRG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SUPT3H_TDRG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource