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Fusion gene ID: 36745 |
FusionGeneSummary for SULT1B1_CSN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SULT1B1_CSN2 | Fusion gene ID: 36745 | Hgene | Tgene | Gene symbol | SULT1B1 | CSN2 | Gene ID | 27284 | 9318 |
| Gene name | sulfotransferase family 1B member 1 | COP9 signalosome subunit 2 | |
| Synonyms | ST1B1|ST1B2|SULT1B2 | ALIEN|CSN2|SGN2|TRIP15 | |
| Cytomap | 4q13.3 | 15q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sulfotransferase family cytosolic 1B member 1sulfotransferase 1B1sulfotransferase 1B2sulfotransferase family, cytosolic, 1B, member 1thyroid hormone sulfotransferase | COP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O43704 | P05814 | |
| Ensembl transtripts involved in fusion gene | ENST00000310613, | ENST00000353151, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 14 X 11 X 2=308 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/308*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SULT1B1 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SULT1B1 | GO:0006068 | ethanol catabolic process | 23207770 |
| Hgene | SULT1B1 | GO:0006805 | xenobiotic metabolic process | 20056724 |
| Hgene | SULT1B1 | GO:0009812 | flavonoid metabolic process | 20056724 |
| Hgene | SULT1B1 | GO:0018958 | phenol-containing compound metabolic process | 9463486 |
| Hgene | SULT1B1 | GO:0042403 | thyroid hormone metabolic process | 9443824 |
| Hgene | SULT1B1 | GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | 23207770 |
| Hgene | SULT1B1 | GO:0051923 | sulfation | 19548878|20056724|23207770 |
| Tgene | CSN2 | GO:0000338 | protein deneddylation | 19141280 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-JL-A3YW-01A | SULT1B1 | chr4 | 70596219 | - | CSN2 | chr4 | 70824787 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000310613 | ENST00000353151 | SULT1B1 | chr4 | 70596219 | - | CSN2 | chr4 | 70824787 | - |
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FusionProtFeatures for SULT1B1_CSN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SULT1B1 | CSN2 |
| Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the sulfateconjugation of many hormones, neurotransmitters, drugs andxenobiotic compounds. Sulfonation increases the water solubilityof most compounds, and therefore their renal excretion, but it canalso result in bioactivation to form active metabolites. Sulfatesdopamine, small phenols such as 1-naphthol and p-nitrophenol andthyroid hormones, including 3,3'-diiodothyronine, triidothyronine,reverse triiodothyronine and thyroxine.{ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}. | Important role in determination of the surfaceproperties of the casein micelles. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SULT1B1 | chr4:70596219 | chr4:70824787 | ENST00000310613 | - | 7 | 8 | 228_233 | 259 | 297 | Nucleotide binding | Note=PAPS |
| Hgene | SULT1B1 | chr4:70596219 | chr4:70824787 | ENST00000310613 | - | 7 | 8 | 258_260 | 259 | 297 | Nucleotide binding | Note=PAPS |
| Hgene | SULT1B1 | chr4:70596219 | chr4:70824787 | ENST00000310613 | - | 7 | 8 | 48_53 | 259 | 297 | Nucleotide binding | Note=PAPS |
| Hgene | SULT1B1 | chr4:70596219 | chr4:70824787 | ENST00000310613 | - | 7 | 8 | 107_109 | 259 | 297 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SULT1B1_CSN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SULT1B1_ENST00000310613_chr4_70596219_-_CSN2_ENST00000353151_chr4_70824787_-_201aa ESITEYKQKVEKVKHEDQQQGEDEHQDKIYPSFQPQPLIYPFVEPIPYGFLPQNILPLAQPAVVLPVPQPEIMEVPKAKDTVYTKGRVMP VLKSPTIPFFDPQIPKLTDLENLHLPLPLLQPLMQQVPQPIPQTLALPPQPLWSVPQPKVLPIPQQVVPYPQRAVPVQALLLNQELLLNP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SULT1B1_ENST00000310613_chr4_70596219_-_CSN2_ENST00000353151_chr4_70824787_-_603nt GAATCTATTACAGAATACAAGCAGAAAGTTGAGAAGGTTAAACATGAGGACCAGCAGCAAGGAGAGGATGAACACCAGGATAAAATCTAC CCCTCTTTCCAGCCACAGCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAAAACATTCTGCCTCTTGCTCAG CCTGCTGTGGTGCTGCCTGTCCCTCAGCCTGAAATAATGGAAGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCCT GTCCTTAAATCTCCAACGATACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCTC CAGCCCTTGATGCAGCAGGTCCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGTC CTGCCTATCCCCCAGCAAGTGGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SULT1B1_ENST00000310613_chr4_70596219_-_CSN2_ENST00000353151_chr4_70824787_-_2052nt GGAACTTGCCTCATGTGTGTGTATGTGTGTGTGTGTGATTGTGGGTGTGGGTAGTTTAACCTTTTTATATCTTAGCTGCCTGTAAACTCA GTGATTGCTACGTTCAGATCAAACCTTGAACTTTTTTTTTTCTGGTGCCAGGAGCCTTCCTGTGCTCCCCATTGCCTGCCAGAACCACCA CCGTTTCCCATGGTTACTCTACAGCAGCTTCACTGCCTGAAAATGAAAACTGAACAAAGGGATTAAATTGTGAGAACAACTGTCAATCTA TTATATATTTGTACAATCTGGTATTAAAATGCTTTCCCCAAAAGATATTCTGCGAAAAGATCTGAAGTTGGTCCATGGTTATCCCATGAC CTGTGCTTTTGCAAGCAACTGGGAAAAAATTGAACAGTTCCATAGCAGACCAGATGACATTGTGATAGCCACTTATCCTAAATCAGGTAC TACTTGGGTTAGTGAAATTATAGACATGATTCTAAATGATGGAGATATTGAAAAATGTAAGCGAGGTTTTATTACTGAAAAAGTTCCAAT GTTGGAAATGACTCTCCCTGGATTAAGAACATCAGGTATAGAACAATTGGAGAAGAATCCATCACCCCGGATTGTGAAAACACATCTACC GACTGATCTTCTTCCTAAATCTTTCTGGGAAAACAATTGCAAGATGATTTATCTGGCTCGTAATGCCAAGGATGTTTCAGTCTCATATTA CCATTTTGACTTAATGAATAATTTACAGCCTTTTCCTGGTACCTGGGAAGAATATCTGGAGAAATTCTTAACTGGAAAAGTGGCCTATGG TTCCTGGTTTACTCATGTTAAAAACTGGTGGAAGAAAAAGGAAGAACACCCAATACTTTTTTTGTACTATGAAGATATGAAAGAGAATCC AAAGGAGGAAATCAAGAAGATCATTAGATTTCTAGAGAAGAACCTGAATGATGAGATCTTGGATAGGATCATCCATCACACCTCATTTGA AGTGATGAAGGACAATCCTTTGGTAAATTATACACATCTACCAACTACAGTGATGGATCATAGCAAATCCCCTTTTATGCGTAAAGGAAT CTATTACAGAATACAAGCAGAAAGTTGAGAAGGTTAAACATGAGGACCAGCAGCAAGGAGAGGATGAACACCAGGATAAAATCTACCCCT CTTTCCAGCCACAGCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAAAACATTCTGCCTCTTGCTCAGCCTG CTGTGGTGCTGCCTGTCCCTCAGCCTGAAATAATGGAAGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCCTGTCC TTAAATCTCCAACGATACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCTCCAGC CCTTGATGCAGCAGGTCCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGTCCTGC CTATCCCCCAGCAAGTGGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCCCACCC ACCAGATCTACCCTGTGACTCAGCCACTTGCCCCAGTTCATAACCCCATTAGTGTCTAAGAAGATTTCAAAGTTAATTTTCCCTCCTTAT TTTTGAATTGACTGAGACTGGAAATATGATGCCTTTTCCGTCTTTGTATCACGTTACCCCAAATTAAGTATGTTTGAATGAGTTTATATG GAAAAAATGAACTTTGTCCCTTTATTTATTTTATATATTATGTCATTCATTTAATTTGAAATTTGACTCATGAACTATTTACATTTTCCA AATCTTAATTCAACTAGTACCACAGAAGTTCAATACTCATTTGGAAATGCTACAAACATATCAAACATATGTATACAAATTGTTTCTGGA |
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FusionGenePPI for SULT1B1_CSN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SULT1B1 | POT1, SDCBP, SULT2B1, SULT2A1 | CSN2 | CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SULT1B1_CSN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SULT1B1_CSN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CSN2 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Tgene | CSN2 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
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