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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36745

FusionGeneSummary for SULT1B1_CSN2

check button Fusion gene summary
Fusion gene informationFusion gene name: SULT1B1_CSN2
Fusion gene ID: 36745
HgeneTgene
Gene symbol

SULT1B1

CSN2

Gene ID

27284

9318

Gene namesulfotransferase family 1B member 1COP9 signalosome subunit 2
SynonymsST1B1|ST1B2|SULT1B2ALIEN|CSN2|SGN2|TRIP15
Cytomap

4q13.3

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionsulfotransferase family cytosolic 1B member 1sulfotransferase 1B1sulfotransferase 1B2sulfotransferase family, cytosolic, 1B, member 1thyroid hormone sulfotransferaseCOP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15
Modification date2018051920180523
UniProtAcc

O43704

P05814

Ensembl transtripts involved in fusion geneENST00000310613, ENST00000353151, 
Fusion gene scores* DoF score1 X 1 X 1=114 X 11 X 2=308
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/308*10)=-3.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SULT1B1 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSULT1B1

GO:0006068

ethanol catabolic process

23207770

HgeneSULT1B1

GO:0006805

xenobiotic metabolic process

20056724

HgeneSULT1B1

GO:0009812

flavonoid metabolic process

20056724

HgeneSULT1B1

GO:0018958

phenol-containing compound metabolic process

9463486

HgeneSULT1B1

GO:0042403

thyroid hormone metabolic process

9443824

HgeneSULT1B1

GO:0050427

3'-phosphoadenosine 5'-phosphosulfate metabolic process

23207770

HgeneSULT1B1

GO:0051923

sulfation

19548878|20056724|23207770

TgeneCSN2

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-JL-A3YW-01ASULT1B1chr4

70596219

-CSN2chr4

70824787

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000310613ENST00000353151SULT1B1chr4

70596219

-CSN2chr4

70824787

-

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FusionProtFeatures for SULT1B1_CSN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SULT1B1

O43704

CSN2

P05814

Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the sulfateconjugation of many hormones, neurotransmitters, drugs andxenobiotic compounds. Sulfonation increases the water solubilityof most compounds, and therefore their renal excretion, but it canalso result in bioactivation to form active metabolites. Sulfatesdopamine, small phenols such as 1-naphthol and p-nitrophenol andthyroid hormones, including 3,3'-diiodothyronine, triidothyronine,reverse triiodothyronine and thyroxine.{ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}. Important role in determination of the surfaceproperties of the casein micelles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSULT1B1chr4:70596219chr4:70824787ENST00000310613-78228_233259297Nucleotide bindingNote=PAPS
HgeneSULT1B1chr4:70596219chr4:70824787ENST00000310613-78258_260259297Nucleotide bindingNote=PAPS
HgeneSULT1B1chr4:70596219chr4:70824787ENST00000310613-7848_53259297Nucleotide bindingNote=PAPS
HgeneSULT1B1chr4:70596219chr4:70824787ENST00000310613-78107_109259297RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SULT1B1_CSN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SULT1B1_ENST00000310613_chr4_70596219_-_CSN2_ENST00000353151_chr4_70824787_-_201aa
ESITEYKQKVEKVKHEDQQQGEDEHQDKIYPSFQPQPLIYPFVEPIPYGFLPQNILPLAQPAVVLPVPQPEIMEVPKAKDTVYTKGRVMP
VLKSPTIPFFDPQIPKLTDLENLHLPLPLLQPLMQQVPQPIPQTLALPPQPLWSVPQPKVLPIPQQVVPYPQRAVPVQALLLNQELLLNP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SULT1B1_ENST00000310613_chr4_70596219_-_CSN2_ENST00000353151_chr4_70824787_-_603nt
GAATCTATTACAGAATACAAGCAGAAAGTTGAGAAGGTTAAACATGAGGACCAGCAGCAAGGAGAGGATGAACACCAGGATAAAATCTAC
CCCTCTTTCCAGCCACAGCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAAAACATTCTGCCTCTTGCTCAG
CCTGCTGTGGTGCTGCCTGTCCCTCAGCCTGAAATAATGGAAGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCCT
GTCCTTAAATCTCCAACGATACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCTC
CAGCCCTTGATGCAGCAGGTCCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGTC
CTGCCTATCCCCCAGCAAGTGGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SULT1B1_ENST00000310613_chr4_70596219_-_CSN2_ENST00000353151_chr4_70824787_-_2052nt
GGAACTTGCCTCATGTGTGTGTATGTGTGTGTGTGTGATTGTGGGTGTGGGTAGTTTAACCTTTTTATATCTTAGCTGCCTGTAAACTCA
GTGATTGCTACGTTCAGATCAAACCTTGAACTTTTTTTTTTCTGGTGCCAGGAGCCTTCCTGTGCTCCCCATTGCCTGCCAGAACCACCA
CCGTTTCCCATGGTTACTCTACAGCAGCTTCACTGCCTGAAAATGAAAACTGAACAAAGGGATTAAATTGTGAGAACAACTGTCAATCTA
TTATATATTTGTACAATCTGGTATTAAAATGCTTTCCCCAAAAGATATTCTGCGAAAAGATCTGAAGTTGGTCCATGGTTATCCCATGAC
CTGTGCTTTTGCAAGCAACTGGGAAAAAATTGAACAGTTCCATAGCAGACCAGATGACATTGTGATAGCCACTTATCCTAAATCAGGTAC
TACTTGGGTTAGTGAAATTATAGACATGATTCTAAATGATGGAGATATTGAAAAATGTAAGCGAGGTTTTATTACTGAAAAAGTTCCAAT
GTTGGAAATGACTCTCCCTGGATTAAGAACATCAGGTATAGAACAATTGGAGAAGAATCCATCACCCCGGATTGTGAAAACACATCTACC
GACTGATCTTCTTCCTAAATCTTTCTGGGAAAACAATTGCAAGATGATTTATCTGGCTCGTAATGCCAAGGATGTTTCAGTCTCATATTA
CCATTTTGACTTAATGAATAATTTACAGCCTTTTCCTGGTACCTGGGAAGAATATCTGGAGAAATTCTTAACTGGAAAAGTGGCCTATGG
TTCCTGGTTTACTCATGTTAAAAACTGGTGGAAGAAAAAGGAAGAACACCCAATACTTTTTTTGTACTATGAAGATATGAAAGAGAATCC
AAAGGAGGAAATCAAGAAGATCATTAGATTTCTAGAGAAGAACCTGAATGATGAGATCTTGGATAGGATCATCCATCACACCTCATTTGA
AGTGATGAAGGACAATCCTTTGGTAAATTATACACATCTACCAACTACAGTGATGGATCATAGCAAATCCCCTTTTATGCGTAAAGGAAT
CTATTACAGAATACAAGCAGAAAGTTGAGAAGGTTAAACATGAGGACCAGCAGCAAGGAGAGGATGAACACCAGGATAAAATCTACCCCT
CTTTCCAGCCACAGCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAAAACATTCTGCCTCTTGCTCAGCCTG
CTGTGGTGCTGCCTGTCCCTCAGCCTGAAATAATGGAAGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCCTGTCC
TTAAATCTCCAACGATACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCTCCAGC
CCTTGATGCAGCAGGTCCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGTCCTGC
CTATCCCCCAGCAAGTGGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCCCACCC
ACCAGATCTACCCTGTGACTCAGCCACTTGCCCCAGTTCATAACCCCATTAGTGTCTAAGAAGATTTCAAAGTTAATTTTCCCTCCTTAT
TTTTGAATTGACTGAGACTGGAAATATGATGCCTTTTCCGTCTTTGTATCACGTTACCCCAAATTAAGTATGTTTGAATGAGTTTATATG
GAAAAAATGAACTTTGTCCCTTTATTTATTTTATATATTATGTCATTCATTTAATTTGAAATTTGACTCATGAACTATTTACATTTTCCA
AATCTTAATTCAACTAGTACCACAGAAGTTCAATACTCATTTGGAAATGCTACAAACATATCAAACATATGTATACAAATTGTTTCTGGA


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FusionGenePPI for SULT1B1_CSN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SULT1B1POT1, SDCBP, SULT2B1, SULT2A1CSN2CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SULT1B1_CSN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SULT1B1_CSN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCSN2C0024667Animal Mammary Neoplasms2CTD_human
TgeneCSN2C0024668Mammary Neoplasms, Experimental2CTD_human