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Fusion gene ID: 36744 |
FusionGeneSummary for SULF2_WFDC3 |
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Fusion gene information | Fusion gene name: SULF2_WFDC3 | Fusion gene ID: 36744 | Hgene | Tgene | Gene symbol | SULF2 | WFDC3 | Gene ID | 55959 | 140686 |
Gene name | sulfatase 2 | WAP four-disulfide core domain 3 | |
Synonyms | HSULF-2 | WAP14|dJ447F3.3 | |
Cytomap | 20q13.12 | 20q13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | extracellular sulfatase Sulf-2 | WAP four-disulfide core domain protein 3protease inhibitor WAP14putative protease inhibitor WAP14whey acidic protein 14 | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | Q8IWU5 | Q8IUB2 | |
Ensembl transtripts involved in fusion gene | ENST00000359930, ENST00000484875, ENST00000361612, ENST00000467815, ENST00000478766, | ENST00000481847, ENST00000243938, ENST00000372632, ENST00000372630, | |
Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 2 X 2 X 2=8 |
# samples | 6 | 2 | |
** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SULF2 [Title/Abstract] AND WFDC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SULF2 | GO:0030177 | positive regulation of Wnt signaling pathway | 19520866 |
Hgene | SULF2 | GO:0030201 | heparan sulfate proteoglycan metabolic process | 18687675 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-AB2P-01A | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000359930 | ENST00000481847 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000359930 | ENST00000243938 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000359930 | ENST00000372632 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000359930 | ENST00000372630 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000484875 | ENST00000481847 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000484875 | ENST00000243938 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000484875 | ENST00000372632 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000484875 | ENST00000372630 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000361612 | ENST00000481847 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000361612 | ENST00000243938 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000361612 | ENST00000372632 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000361612 | ENST00000372630 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000467815 | ENST00000481847 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000467815 | ENST00000243938 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000467815 | ENST00000372632 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5CDS-5UTR | ENST00000467815 | ENST00000372630 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5UTR-5UTR | ENST00000478766 | ENST00000481847 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5UTR-5UTR | ENST00000478766 | ENST00000243938 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5UTR-5UTR | ENST00000478766 | ENST00000372632 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
5UTR-5UTR | ENST00000478766 | ENST00000372630 | SULF2 | chr20 | 46365447 | - | WFDC3 | chr20 | 44404241 | - |
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FusionProtFeatures for SULF2_WFDC3 |
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Hgene | Tgene |
SULF2 | WFDC3 |
Exhibits arylsulfatase activity and highly specificendoglucosamine-6-sulfatase activity. It can remove sulfate fromthe C-6 position of glucosamine within specific subregions ofintact heparin. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SULF2_WFDC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SULF2_WFDC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SULF2 | MYC, PTCH1, CASQ2, NAAA, PON2, CSGALNACT2, APP, LRRC4C, DEFA1, GPR156, OS9, KBTBD7, SDC2, DKK3, DEFA5, TRPC4AP, GNS | WFDC3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SULF2_WFDC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SULF2_WFDC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SULF2 | C0014175 | Endometriosis | 2 | CTD_human |