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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36743

FusionGeneSummary for SULF2_TSHZ2

check button Fusion gene summary
Fusion gene informationFusion gene name: SULF2_TSHZ2
Fusion gene ID: 36743
HgeneTgene
Gene symbol

SULF2

TSHZ2

Gene ID

55959

128553

Gene namesulfatase 2teashirt zinc finger homeobox 2
SynonymsHSULF-2C20orf17|OVC10-2|TSH2|ZABC2|ZNF218
Cytomap

20q13.12

20q13.2

Type of geneprotein-codingprotein-coding
Descriptionextracellular sulfatase Sulf-2teashirt homolog 2cell growth-inhibiting protein 7ovarian cancer-related protein 10-2serologically defined colon cancer antigen 33 liketeashirt family zinc finger 2zinc finger protein 218
Modification date2018051920180523
UniProtAcc

Q8IWU5

Q9NRE2

Ensembl transtripts involved in fusion geneENST00000359930, ENST00000484875, 
ENST00000361612, ENST00000467815, 
ENST00000478766, 
ENST00000371497, 
ENST00000603338, ENST00000329613, 
Fusion gene scores* DoF score6 X 4 X 4=9622 X 6 X 8=1056
# samples 626
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(26/1056*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SULF2 [Title/Abstract] AND TSHZ2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSULF2

GO:0030177

positive regulation of Wnt signaling pathway

19520866

HgeneSULF2

GO:0030201

heparan sulfate proteoglycan metabolic process

18687675


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-K1-A6RU-01ASULF2chr20

46365447

-TSHZ2chr20

52103683

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000359930ENST00000371497SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-3UTRENST00000359930ENST00000603338SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-intronENST00000359930ENST00000329613SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-3UTRENST00000484875ENST00000371497SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-3UTRENST00000484875ENST00000603338SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-intronENST00000484875ENST00000329613SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-3UTRENST00000361612ENST00000371497SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-3UTRENST00000361612ENST00000603338SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-intronENST00000361612ENST00000329613SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-3UTRENST00000467815ENST00000371497SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-3UTRENST00000467815ENST00000603338SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5CDS-intronENST00000467815ENST00000329613SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5UTR-3UTRENST00000478766ENST00000371497SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5UTR-3UTRENST00000478766ENST00000603338SULF2chr20

46365447

-TSHZ2chr20

52103683

+
5UTR-intronENST00000478766ENST00000329613SULF2chr20

46365447

-TSHZ2chr20

52103683

+

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FusionProtFeatures for SULF2_TSHZ2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SULF2

Q8IWU5

TSHZ2

Q9NRE2

Exhibits arylsulfatase activity and highly specificendoglucosamine-6-sulfatase activity. It can remove sulfate fromthe C-6 position of glucosamine within specific subregions ofintact heparin. Probable transcriptional regulator involved indevelopmental processes. May act as a transcriptional repressor(Potential). {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SULF2_TSHZ2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SULF2_TSHZ2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SULF2MYC, PTCH1, CASQ2, NAAA, PON2, CSGALNACT2, APP, LRRC4C, DEFA1, GPR156, OS9, KBTBD7, SDC2, DKK3, DEFA5, TRPC4AP, GNSTSHZ2APBB1, PYCARD, UBE2I


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SULF2_TSHZ2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SULF2_TSHZ2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSULF2C0014175Endometriosis2CTD_human