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Fusion gene ID: 36741 |
FusionGeneSummary for SULF2_GAB2 |
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Fusion gene information | Fusion gene name: SULF2_GAB2 | Fusion gene ID: 36741 | Hgene | Tgene | Gene symbol | SULF2 | GAB2 | Gene ID | 55959 | 9846 |
Gene name | sulfatase 2 | GRB2 associated binding protein 2 | |
Synonyms | HSULF-2 | - | |
Cytomap | 20q13.12 | 11q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | extracellular sulfatase Sulf-2 | GRB2-associated-binding protein 2Grb2-associated binder 2growth factor receptor bound protein 2-associated protein 2pp100 | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q8IWU5 | Q9UQC2 | |
Ensembl transtripts involved in fusion gene | ENST00000359930, ENST00000484875, ENST00000361612, ENST00000467815, ENST00000478766, | ENST00000340149, ENST00000361507, ENST00000526030, | |
Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 11 X 6 X 3=198 |
# samples | 6 | 14 | |
** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/198*10)=-0.500073603134643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SULF2 [Title/Abstract] AND GAB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SULF2 | GO:0030177 | positive regulation of Wnt signaling pathway | 19520866 |
Hgene | SULF2 | GO:0030201 | heparan sulfate proteoglycan metabolic process | 18687675 |
Tgene | GAB2 | GO:0008284 | positive regulation of cell proliferation | 19172738 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-BH-A0HL-01A | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000359930 | ENST00000340149 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000359930 | ENST00000361507 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000359930 | ENST00000526030 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000484875 | ENST00000340149 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000484875 | ENST00000361507 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000484875 | ENST00000526030 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000361612 | ENST00000340149 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000361612 | ENST00000361507 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000361612 | ENST00000526030 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000467815 | ENST00000340149 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000467815 | ENST00000361507 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
5CDS-5UTR | ENST00000467815 | ENST00000526030 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
intron-5UTR | ENST00000478766 | ENST00000340149 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
intron-5UTR | ENST00000478766 | ENST00000361507 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
intron-5UTR | ENST00000478766 | ENST00000526030 | SULF2 | chr20 | 46385933 | - | GAB2 | chr11 | 77991947 | - |
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FusionProtFeatures for SULF2_GAB2 |
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Hgene | Tgene |
SULF2 | GAB2 |
Exhibits arylsulfatase activity and highly specificendoglucosamine-6-sulfatase activity. It can remove sulfate fromthe C-6 position of glucosamine within specific subregions ofintact heparin. | Adapter protein which acts downstream of severalmembrane receptors including cytokine, antigen, hormone, cellmatrix and growth factor receptors to regulate multiple signalingpathways. Regulates osteoclast differentiation mediating theTNFRSF11A/RANK signaling. In allergic response, it plays a role inmast cells activation and degranulation through PI-3-kinaseregulation. Also involved in the regulation of cell proliferationand hematopoiesis. {ECO:0000269|PubMed:15750601,ECO:0000269|PubMed:19172738}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SULF2_GAB2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SULF2_GAB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SULF2 | MYC, PTCH1, CASQ2, NAAA, PON2, CSGALNACT2, APP, LRRC4C, DEFA1, GPR156, OS9, KBTBD7, SDC2, DKK3, DEFA5, TRPC4AP, GNS | GAB2 | BCR, GRB2, ETV6, ARHGAP32, LYN, PLCG2, PTPN11, SHC1, ZAP70, CD247, LAT, PTPN6, PIK3R1, AKT1, GRAP, SRC, NCK1, PLCG1, CRKL, MET, GRAP2, LRRK1, PIK3R2, CRK, PIK3CB, MAPK1, MAPK3, MARK2, GAB1, GAB2, YWHAE, NTRK1, XPO1, FRS2, TGM4, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, RTKN, MAST3, SYDE1, PPM1H, AGAP1, CDC25B, CDK16, FAM110B, USP21, ANKRD34A, FAM53C, CGN, FAM110A, DENND4C, HDAC4, MAPKAP1, TBC1D25, NF1, NADK, CBY1, RAB3IP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SULF2_GAB2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SULF2_GAB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SULF2 | C0014175 | Endometriosis | 2 | CTD_human |
Tgene | GAB2 | C0025202 | melanoma | 1 | CTD_human |
Tgene | GAB2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | GAB2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |